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The map label for this gene is lolC [H]

Identifier: 73540778

GI number: 73540778

Start: 1167169

End: 1168419

Strand: Direct

Name: lolC [H]

Synonym: Reut_A1076

Alternate gene names: 73540778

Gene position: 1167169-1168419 (Clockwise)

Preceding gene: 73540775

Following gene: 73540779

Centisome position: 30.66

GC content: 63.95

Gene sequence:

>1251_bases
TTGAAATTTCCCTACGAGTGGCAGATTGGCTGGCGATACACCCGCGCAAGCAAGCGCGCCAGCCGCAATACGTTCATATC
GTTCATCTCGATGATCTCGATGCTCGGCATCGCGCTGGGCGTGGCCGCGCTGATCGTGGTGCTGTCGGTGATGAACGGCT
TCCAGAAGGAAGTGCGCGACCGCATGCTCTCGGTGCTGTCTCACATCGAGGTGATCGGCCCGTCGGCGCTGCCCGACTGG
CAGCGCACCGCGGCAGAGGCCATGCGGAACAAGGAAGTCATCGGTGCCGCGCCGTACGTGGCCGCCCAGGCCATGCTCAC
GCGCGAGGACGCTGTGCGCGGCGTGCTGCTGCGCGGCGTGGACCCGGCGGAAGAACCGAAGGTCTCGGACATCGGCAAGC
AGTTCAAGGCTGGCCATATGGAAAGCCTGCAGCCGGGTGAGTTCGGCATTGCGCTCGGCAATGAACTGGCCAACGCCATG
GGCGTGCAGGTCGGCGACAAGATCACGCTGCTGGCGCCGCAGGGCACCATCACGCCGGCCGGCGTGTTGCCGCGGCTGAA
GCAGTTCACCGTGGTCGGCGTGTTCTCTTCGGGCCATTTCGAATTCGACAGCGCGCTCGCGCTCGTCAATATCCGCGATG
CCGAGACGCTGTTCCGCATGACCGGCCCGACCGGCGTGCGGCTGAAGCTCGCGGACATGCAGCGTGCGCCGCAGGTTGCC
AACGAACTGGCCGGCACGATGTCGGGCGAGCTTTATCTGCGCGACTGGTCCAAGCAGAACCGCAACTGGTTCGCGGCCGT
GCAGACCGAGAAGCGCATGATGTTCATCATCCTGACGCTGATCATCGCCGTCGCTGCGTTCAACCTGGTGTCGACGCTGG
TGATGACCGTGACCGACAAGCAGGCTGACATCGCCATCCTGCGCACGATGGGCGCGCAACCCGGTTCGATCATGAAGATC
TTCATCGTGCAGGGCGTGGCCATCGGCTTTATCGGCACGTTGCTGGGCGTCGCGGGCGGCACGCTGATCGCCACCAATAT
CGACGTGATCGTGCCTTTCATCGAGCGGCTGCTGCACGTGCAGTTCCTGCCGCGCGACATCTATTTCATCAGCGAACTGC
CTTCGGACCCGCGTGTGAACGATATCGCCACCATCGGCATCATTTCCTTCGTGCTGGCCACGCTGGCAACCCTCTACCCA
AGCTGGCGCGCCGCCCGCGTCAATCCGGCGGAGGCGCTGCGCTATGAGTGA

Upstream 100 bases:

>100_bases
CGAGATTGTAAACTTCCGGCTGGCCGGCGCCAGCCTGGCGTGTGGCGCGGGACACCTGCGCCACCGCCCCGTGCGCTTTC
CCGAAACAACAGGAACCCTC

Downstream 100 bases:

>100_bases
AGCGATGCTGCAAGCCGATACGAAGCCCGTCACCGGGCAACAGCCGGGTACGCCGGTGCTGATGGGCGAAGGCCTGTTCA
AGCGTTTCCGCCAGGGCGGG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKFPYEWQIGWRYTRASKRASRNTFISFISMISMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLSHIEVIGPSALPDW
QRTAAEAMRNKEVIGAAPYVAAQAMLTREDAVRGVLLRGVDPAEEPKVSDIGKQFKAGHMESLQPGEFGIALGNELANAM
GVQVGDKITLLAPQGTITPAGVLPRLKQFTVVGVFSSGHFEFDSALALVNIRDAETLFRMTGPTGVRLKLADMQRAPQVA
NELAGTMSGELYLRDWSKQNRNWFAAVQTEKRMMFIILTLIIAVAAFNLVSTLVMTVTDKQADIAILRTMGAQPGSIMKI
FIVQGVAIGFIGTLLGVAGGTLIATNIDVIVPFIERLLHVQFLPRDIYFISELPSDPRVNDIATIGIISFVLATLATLYP
SWRAARVNPAEALRYE

Sequences:

>Translated_416_residues
MKFPYEWQIGWRYTRASKRASRNTFISFISMISMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLSHIEVIGPSALPDW
QRTAAEAMRNKEVIGAAPYVAAQAMLTREDAVRGVLLRGVDPAEEPKVSDIGKQFKAGHMESLQPGEFGIALGNELANAM
GVQVGDKITLLAPQGTITPAGVLPRLKQFTVVGVFSSGHFEFDSALALVNIRDAETLFRMTGPTGVRLKLADMQRAPQVA
NELAGTMSGELYLRDWSKQNRNWFAAVQTEKRMMFIILTLIIAVAAFNLVSTLVMTVTDKQADIAILRTMGAQPGSIMKI
FIVQGVAIGFIGTLLGVAGGTLIATNIDVIVPFIERLLHVQFLPRDIYFISELPSDPRVNDIATIGIISFVLATLATLYP
SWRAARVNPAEALRYE
>Mature_416_residues
MKFPYEWQIGWRYTRASKRASRNTFISFISMISMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLSHIEVIGPSALPDW
QRTAAEAMRNKEVIGAAPYVAAQAMLTREDAVRGVLLRGVDPAEEPKVSDIGKQFKAGHMESLQPGEFGIALGNELANAM
GVQVGDKITLLAPQGTITPAGVLPRLKQFTVVGVFSSGHFEFDSALALVNIRDAETLFRMTGPTGVRLKLADMQRAPQVA
NELAGTMSGELYLRDWSKQNRNWFAAVQTEKRMMFIILTLIIAVAAFNLVSTLVMTVTDKQADIAILRTMGAQPGSIMKI
FIVQGVAIGFIGTLLGVAGGTLIATNIDVIVPFIERLLHVQFLPRDIYFISELPSDPRVNDIATIGIISFVLATLATLYP
SWRAARVNPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=416, Percent_Identity=32.4519230769231, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI1787360, Length=419, Percent_Identity=35.5608591885441, Blast_Score=203, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45464; Mature: 45464

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFPYEWQIGWRYTRASKRASRNTFISFISMISMLGIALGVAALIVVLSVMNGFQKEVRD
CCCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLSHIEVIGPSALPDWQRTAAEAMRNKEVIGAAPYVAAQAMLTREDAVRGVLLRGV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DPAEEPKVSDIGKQFKAGHMESLQPGEFGIALGNELANAMGVQVGDKITLLAPQGTITPA
CCCCCCCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
GVLPRLKQFTVVGVFSSGHFEFDSALALVNIRDAETLFRMTGPTGVRLKLADMQRAPQVA
HHHHHHHHEEEEEEECCCCEECCCEEEEEEECCHHHHHHCCCCCCCEEEEHHHHHHHHHH
NELAGTMSGELYLRDWSKQNRNWFAAVQTEKRMMFIILTLIIAVAAFNLVSTLVMTVTDK
HHHHHHCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QADIAILRTMGAQPGSIMKIFIVQGVAIGFIGTLLGVAGGTLIATNIDVIVPFIERLLHV
CHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
QFLPRDIYFISELPSDPRVNDIATIGIISFVLATLATLYPSWRAARVNPAEALRYE
HHCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MKFPYEWQIGWRYTRASKRASRNTFISFISMISMLGIALGVAALIVVLSVMNGFQKEVRD
CCCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLSHIEVIGPSALPDWQRTAAEAMRNKEVIGAAPYVAAQAMLTREDAVRGVLLRGV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DPAEEPKVSDIGKQFKAGHMESLQPGEFGIALGNELANAMGVQVGDKITLLAPQGTITPA
CCCCCCCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
GVLPRLKQFTVVGVFSSGHFEFDSALALVNIRDAETLFRMTGPTGVRLKLADMQRAPQVA
HHHHHHHHEEEEEEECCCCEECCCEEEEEEECCHHHHHHCCCCCCCEEEEHHHHHHHHHH
NELAGTMSGELYLRDWSKQNRNWFAAVQTEKRMMFIILTLIIAVAAFNLVSTLVMTVTDK
HHHHHHCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QADIAILRTMGAQPGSIMKIFIVQGVAIGFIGTLLGVAGGTLIATNIDVIVPFIERLLHV
CHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
QFLPRDIYFISELPSDPRVNDIATIGIISFVLATLATLYPSWRAARVNPAEALRYE
HHCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]