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The map label for this gene is aspC [H]

Identifier: 73540753

GI number: 73540753

Start: 1142580

End: 1143776

Strand: Reverse

Name: aspC [H]

Synonym: Reut_A1050

Alternate gene names: 73540753

Gene position: 1143776-1142580 (Counterclockwise)

Preceding gene: 73540768

Following gene: 73540752

Centisome position: 30.05

GC content: 64.41

Gene sequence:

>1197_bases
ATGAGTTTGTTTTCTGCCGTCGAAATGGCCCCGCGCGACCCGATCCTGGGCCTGAATGAAGCTTTCAATGCCGACACCCG
CGCCACCAAGGTGAACCTGGGCGTTGGCGTTTACTTCACCGACGAAGGGAAAATTCCGCTGCTGCGCGCCGTGCAGGAAG
CGGAAAAGGCGCGCCTGACCACCGCCACGCCGCGCGGCTACCTGCCGATCGAAGGCATTGCCGCCTATGACCAGGCCGTG
CAGTCGCTGCTGTTCGGCAAGGAATCGCCGCTGATCACGGAAGGCCGTGTTGTGACGGCTCAGGCACTGGGCGGTACCGG
CGCGCTGAAGATCGGCGCCGACTTCCTGAAGCGCCTCTACCCGACTTCGAAGGTCGCGATCAGCGACCCGAGCTGGGAAA
ACCACCGCGCGCTGTTCGAAGCCGCCGGCTTTGAGGTCGTGAACTACGCCTACTACGACGCCCCGACCCACGGCCTGAAC
TTCGCCGGCATGGTGGAATCGCTGAAGTCGTATCCGGCCAACACCATCGTCGTGCTGCACGCTTGCTGCCACAACCCGAC
CGGCGTCGACCTGTCGGCCGACCAGTGGAAGGAAGTGGTCGCGCTGATCAAGGAACGCAACCTGATCCCGTTCCTCGACA
TGGCCTACCAGGGCTTTGCCGACGGCATCGACCCGGACGGCGCAGCCGTGCGCCTGTTCGCGGATTCGGGGCTGCCGTTC
TTCGTGTCGAGCTCGTTCTCGAAGAGCTTCTCGCTGTACGGCGAACGCGTGGGCGCCCTGTCGATCGTCACGACCGGCAA
GGAAGAAGCGCAGCGCGTGCTGTCGCAGGTCAAGCGCGTCATTCGCACCAACTACTCGAACCCGCCGACGCACGGCGGCA
CCGTGGTAGCTACCGTGCTGAACAGCCCGGAACTGCGCGCCATGTGGGAAGAGGAACTGGCCGAAATGCGCGACCGCATC
AAGCTGATGCGCCACGCGCTGGTCGACAAGCTGGCCGCCAAGGGCGTGAAGACGGACTTTTCGTTCGTGAAGGCGCAGCG
CGGCATGTTCTCGTACTCGGGCCTGACCTCGGCGCAAGTCGACCGCCTGCGTAACGAGCATGGCATCTACGCCGTCGGCA
CCGGCCGCATCTGCGTGGCCGCGCTGAACAGCCGCAATATCGACGCCGTCGTCGACGCTATCGCGGCAGTGCTGTAA

Upstream 100 bases:

>100_bases
CAGTCAACGCCCGCAAGCAGGTCTGCCGCACGCCCCCCAGCGCAGTCCGAAGCATTCTACGCCTTCCCGTTTTCTTACAT
TGCCGACCACGAGAGTCCAA

Downstream 100 bases:

>100_bases
AGACCGCATTGTGAAGTGCTGCCGACACGCCGGCAGCACTGGCATGATGCATGCGTCATCAAAAGGCAGCTACGTGCTGC
CTTTTTCTTTTTGTCATTCC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLTTATPRGYLPIEGIAAYDQAV
QSLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLYPTSKVAISDPSWENHRALFEAAGFEVVNYAYYDAPTHGLN
FAGMVESLKSYPANTIVVLHACCHNPTGVDLSADQWKEVVALIKERNLIPFLDMAYQGFADGIDPDGAAVRLFADSGLPF
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVLSQVKRVIRTNYSNPPTHGGTVVATVLNSPELRAMWEEELAEMRDRI
KLMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLTSAQVDRLRNEHGIYAVGTGRICVAALNSRNIDAVVDAIAAVL

Sequences:

>Translated_398_residues
MSLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLTTATPRGYLPIEGIAAYDQAV
QSLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLYPTSKVAISDPSWENHRALFEAAGFEVVNYAYYDAPTHGLN
FAGMVESLKSYPANTIVVLHACCHNPTGVDLSADQWKEVVALIKERNLIPFLDMAYQGFADGIDPDGAAVRLFADSGLPF
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVLSQVKRVIRTNYSNPPTHGGTVVATVLNSPELRAMWEEELAEMRDRI
KLMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLTSAQVDRLRNEHGIYAVGTGRICVAALNSRNIDAVVDAIAAVL
>Mature_397_residues
SLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLTTATPRGYLPIEGIAAYDQAVQ
SLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLYPTSKVAISDPSWENHRALFEAAGFEVVNYAYYDAPTHGLNF
AGMVESLKSYPANTIVVLHACCHNPTGVDLSADQWKEVVALIKERNLIPFLDMAYQGFADGIDPDGAAVRLFADSGLPFF
VSSSFSKSFSLYGERVGALSIVTTGKEEAQRVLSQVKRVIRTNYSNPPTHGGTVVATVLNSPELRAMWEEELAEMRDRIK
LMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLTSAQVDRLRNEHGIYAVGTGRICVAALNSRNIDAVVDAIAAVL

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=44.6969696969697, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI4504067, Length=401, Percent_Identity=42.643391521197, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI117414139, Length=383, Percent_Identity=28.4595300261097, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1790488, Length=399, Percent_Identity=52.8822055137845, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=48.4848484848485, Blast_Score=404, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71981858, Length=398, Percent_Identity=41.9597989949749, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=42.8211586901763, Blast_Score=337, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17569539, Length=398, Percent_Identity=40.7035175879397, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17569537, Length=398, Percent_Identity=32.9145728643216, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17550384, Length=265, Percent_Identity=36.6037735849057, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=41.7840375586854, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323055, Length=406, Percent_Identity=38.6699507389163, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322743, Length=434, Percent_Identity=33.4101382488479, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=44.4723618090452, Blast_Score=351, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=44.4723618090452, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=44.5012787723785, Blast_Score=343, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24654046, Length=402, Percent_Identity=40.0497512437811, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI19922362, Length=401, Percent_Identity=39.9002493765586, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 43127; Mature: 42996

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLT
CCHHHHHHCCCCCCCCCCHHHCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHEE
TATPRGYLPIEGIAAYDQAVQSLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLY
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCEEEEEEECCCCCEEHHHHHHHHHHC
PTSKVAISDPSWENHRALFEAAGFEVVNYAYYDAPTHGLNFAGMVESLKSYPANTIVVLH
CCCEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEE
ACCHNPTGVDLSADQWKEVVALIKERNLIPFLDMAYQGFADGIDPDGAAVRLFADSGLPF
EHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCE
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVLSQVKRVIRTNYSNPPTHGGTVVATVL
EEECCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
NSPELRAMWEEELAEMRDRIKLMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLTSAQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHH
DRLRNEHGIYAVGTGRICVAALNSRNIDAVVDAIAAVL
HHHHCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SLFSAVEMAPRDPILGLNEAFNADTRATKVNLGVGVYFTDEGKIPLLRAVQEAEKARLT
CHHHHHHCCCCCCCCCCHHHCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHEE
TATPRGYLPIEGIAAYDQAVQSLLFGKESPLITEGRVVTAQALGGTGALKIGADFLKRLY
ECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCEEEEEEECCCCCEEHHHHHHHHHHC
PTSKVAISDPSWENHRALFEAAGFEVVNYAYYDAPTHGLNFAGMVESLKSYPANTIVVLH
CCCEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEE
ACCHNPTGVDLSADQWKEVVALIKERNLIPFLDMAYQGFADGIDPDGAAVRLFADSGLPF
EHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCE
FVSSSFSKSFSLYGERVGALSIVTTGKEEAQRVLSQVKRVIRTNYSNPPTHGGTVVATVL
EEECCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
NSPELRAMWEEELAEMRDRIKLMRHALVDKLAAKGVKTDFSFVKAQRGMFSYSGLTSAQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHH
DRLRNEHGIYAVGTGRICVAALNSRNIDAVVDAIAAVL
HHHHCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]