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The map label for this gene is hemH [H]

Identifier: 73540740

GI number: 73540740

Start: 1132082

End: 1133197

Strand: Direct

Name: hemH [H]

Synonym: Reut_A1037

Alternate gene names: 73540740

Gene position: 1132082-1133197 (Clockwise)

Preceding gene: 73540739

Following gene: 73540741

Centisome position: 29.74

GC content: 63.62

Gene sequence:

>1116_bases
ATGACGTTTTCTCCCGAACCGGCCTACCAGCACGGCCAGGCGCCGCGCACGGCCATTTTGCTAGTCAACTTAGGCACCCC
CGATGCGCCGACCCCGAAGGCGGTGGGGCGCTATCTGAAGGAATTCCTGTCCGATCCGCGCGTGGTCGAGATTCCGCGCC
TGGCCTGGCTGCCGTTGCTGTACGGTGTGATTCTGCCGCTGCGCGCGCGTGCGTCGGCACTCAAGTACGAATCGATCTGG
CTGCGCGAGGCGCATATGACCGGATCGCCGCTGCTCGTGTACAGCGAGCGCCAGGCGCACGCGCTGCAGCGCCTGCTGAA
CCAGCAGGGCTACGAGCTTACAGTTGCATGCGCAATGCGCTACGGCAATCCGTCGATTGCTTCCGTGCTGGAAGCACTGC
GCCGCCAGGGCACGGAACAGGTTCTGGTGCTGCCCATGTACCCGCAGTACTCCGGTACCACCACGGCCACCGCATTCGAC
GAGGTGTTTCGCGTGCTCGGCCAGTGGCGCAACCAGCCAGAAATCCGGCTCGTGAAGCATTTCCATGACCATCCCGCCTA
TATCGCGGCGCTCCACCAGCAGGTCGGCGCATACTGGGCGCAGCACGGCACGCCTGATTTCGCGCGCGGCGATAAGCTGA
TCCTGTCGTTTCACGGCGTGCCGCGCCGAACGCTGGAATTAGGCGATCCCTACCATTGCGAGTGCCTGAAGACCGGCCGG
CTGCTTGGCGACGCCCTGGGCTTGCAGCCGGGGCAGTATCAGGTGACGTTTCAGTCTCGCTTTGGCAAAGCCGAGTGGTT
GCAGCCCTATACCGCCCCGACATTGGCCGAACTCGGCAAGGTCGGTGCGGGCCGGGTCGATGTGTTTTGCCCGGGTTTTC
CGGCTGACTGCATCGAGACACTGGAAGAAATCGCCATGGAAGGGCAAACCGAATTTATGGTCGCCGGCGGCAAGACGTTC
CATTTCATCCCATGCATGAACGACGCGCAGCCCTGGATTTCCGCACTGGCCGAGATTGCCTTGCAGCACGTGCAGGGCTG
GCCGCTGAACATGCCGCATGCGCATGAACTCGAAGCGCGCCGCAGTCGCGCGCAGACCCGTGGAGCCGCAGCATGA

Upstream 100 bases:

>100_bases
GCACTGAGCCAGAACTAGGACCCGTCCGACGGGTCACACAGTCTGCGTCCCCATTTCCACAGCCCGGCGGCCTTGGCTGC
CCGGCCATACCGGAAGCGAC

Downstream 100 bases:

>100_bases
ATGTCAGTTTCGAACCCGATGCCCGCCTGCGTATCGACAAATGGTTATGGTGCGCGCGCTTCTTCAAGACGCGCTCGTTG
GCGGCCGAGGCCGTGGAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTFSPEPAYQHGQAPRTAILLVNLGTPDAPTPKAVGRYLKEFLSDPRVVEIPRLAWLPLLYGVILPLRARASALKYESIW
LREAHMTGSPLLVYSERQAHALQRLLNQQGYELTVACAMRYGNPSIASVLEALRRQGTEQVLVLPMYPQYSGTTTATAFD
EVFRVLGQWRNQPEIRLVKHFHDHPAYIAALHQQVGAYWAQHGTPDFARGDKLILSFHGVPRRTLELGDPYHCECLKTGR
LLGDALGLQPGQYQVTFQSRFGKAEWLQPYTAPTLAELGKVGAGRVDVFCPGFPADCIETLEEIAMEGQTEFMVAGGKTF
HFIPCMNDAQPWISALAEIALQHVQGWPLNMPHAHELEARRSRAQTRGAAA

Sequences:

>Translated_371_residues
MTFSPEPAYQHGQAPRTAILLVNLGTPDAPTPKAVGRYLKEFLSDPRVVEIPRLAWLPLLYGVILPLRARASALKYESIW
LREAHMTGSPLLVYSERQAHALQRLLNQQGYELTVACAMRYGNPSIASVLEALRRQGTEQVLVLPMYPQYSGTTTATAFD
EVFRVLGQWRNQPEIRLVKHFHDHPAYIAALHQQVGAYWAQHGTPDFARGDKLILSFHGVPRRTLELGDPYHCECLKTGR
LLGDALGLQPGQYQVTFQSRFGKAEWLQPYTAPTLAELGKVGAGRVDVFCPGFPADCIETLEEIAMEGQTEFMVAGGKTF
HFIPCMNDAQPWISALAEIALQHVQGWPLNMPHAHELEARRSRAQTRGAAA
>Mature_370_residues
TFSPEPAYQHGQAPRTAILLVNLGTPDAPTPKAVGRYLKEFLSDPRVVEIPRLAWLPLLYGVILPLRARASALKYESIWL
REAHMTGSPLLVYSERQAHALQRLLNQQGYELTVACAMRYGNPSIASVLEALRRQGTEQVLVLPMYPQYSGTTTATAFDE
VFRVLGQWRNQPEIRLVKHFHDHPAYIAALHQQVGAYWAQHGTPDFARGDKLILSFHGVPRRTLELGDPYHCECLKTGRL
LGDALGLQPGQYQVTFQSRFGKAEWLQPYTAPTLAELGKVGAGRVDVFCPGFPADCIETLEEIAMEGQTEFMVAGGKTFH
FIPCMNDAQPWISALAEIALQHVQGWPLNMPHAHELEARRSRAQTRGAAA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=364, Percent_Identity=24.1758241758242, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI60499021, Length=355, Percent_Identity=24.2253521126761, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=47.2222222222222, Blast_Score=285, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17864156, Length=346, Percent_Identity=26.0115606936416, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=27.037037037037, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 41342; Mature: 41211

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSPEPAYQHGQAPRTAILLVNLGTPDAPTPKAVGRYLKEFLSDPRVVEIPRLAWLPLL
CCCCCCCCHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
YGVILPLRARASALKYESIWLREAHMTGSPLLVYSERQAHALQRLLNQQGYELTVACAMR
HHHHHHHHHHHHHHHHHHHEEEHHCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEEE
YGNPSIASVLEALRRQGTEQVLVLPMYPQYSGTTTATAFDEVFRVLGQWRNQPEIRLVKH
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDHPAYIAALHQQVGAYWAQHGTPDFARGDKLILSFHGVPRRTLELGDPYHCECLKTGR
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHH
LLGDALGLQPGQYQVTFQSRFGKAEWLQPYTAPTLAELGKVGAGRVDVFCPGFPADCIET
HHHHHHCCCCCCEEEEEHHCCCCHHHCCCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHH
LEEIAMEGQTEFMVAGGKTFHFIPCMNDAQPWISALAEIALQHVQGWPLNMPHAHELEAR
HHHHHHCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
RSRAQTRGAAA
HHHHHHCCCCC
>Mature Secondary Structure 
TFSPEPAYQHGQAPRTAILLVNLGTPDAPTPKAVGRYLKEFLSDPRVVEIPRLAWLPLL
CCCCCCCHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
YGVILPLRARASALKYESIWLREAHMTGSPLLVYSERQAHALQRLLNQQGYELTVACAMR
HHHHHHHHHHHHHHHHHHHEEEHHCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEEE
YGNPSIASVLEALRRQGTEQVLVLPMYPQYSGTTTATAFDEVFRVLGQWRNQPEIRLVKH
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDHPAYIAALHQQVGAYWAQHGTPDFARGDKLILSFHGVPRRTLELGDPYHCECLKTGR
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHH
LLGDALGLQPGQYQVTFQSRFGKAEWLQPYTAPTLAELGKVGAGRVDVFCPGFPADCIET
HHHHHHCCCCCCEEEEEHHCCCCHHHCCCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHH
LEEIAMEGQTEFMVAGGKTFHFIPCMNDAQPWISALAEIALQHVQGWPLNMPHAHELEAR
HHHHHHCCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
RSRAQTRGAAA
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA