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The map label for this gene is paaH [H]

Identifier: 73540713

GI number: 73540713

Start: 1098446

End: 1099969

Strand: Reverse

Name: paaH [H]

Synonym: Reut_A1010

Alternate gene names: 73540713

Gene position: 1099969-1098446 (Counterclockwise)

Preceding gene: 73540715

Following gene: 73540712

Centisome position: 28.9

GC content: 67.32

Gene sequence:

>1524_bases
ATGAGCACTTTCACCATCGAGACGCTCGGCATCGTGGGAACGGGCGCCATGGGCCGCGGTATCGCCCAGATCGCGGCGCA
GGCTGGCCTGACCGTCAACCTGTACGACGCCAACCCGCAAGCCGTGGAAGCCGCGCGCAAGTATCTGCAGGATACGCTTG
GCAAGCTCGCTGAAAAAGGCAAGATCTCGGCGGCCGATGCCGATGCCACGCTGGCTCGCGTGAAGCCGTGCGGCGCGCTC
GAAGACCTGTCCCGCTGCGACATGGTGGTGGAGGCGATCGTCGAGCGGCTCGACGTGAAGCGCGATCTCGTCGCCAAGCT
GGAGGCCGTGCTGCGCCCCGACGCGATCATCGCGTCGAACACCTCGTCGCTGTCGATCACCGCGATTGCGGTCGGTGCGA
AGGAACCGGGCCGCGTCGTCGGCTACCACTTCTTCAATCCGGTGCCGCTGATGAAGGTGGTCGAGGTCATCGACGGCCTG
TCGGGCAATCCGGCCGTGGGCGATGCGCTGATGGCGCTGTCGCGCCGCATGGGCCATACGCCGGTGCGATGCAAGGACAT
GCCGGGCTTTATCGTCAACCACGCCGGCCGTGGCATGAATATCGAAGGCATCAAGGTCGCGCAGGAAGGGGTGGCCGAAT
TTGTCGATATCGACAACATCATGCGCGAGCAGGCCGGCTTCCGCATGGGGCCGTTCGAGCTGATGGACCTGACCGGACTC
GATGTGTCGCACCCGGTCATGGAATCGATCTACAACCAGTTCTACCAGGAGCCGCGCTACCGCCCGTCGCCGATCACGGC
GATCCGCTCGGTGGGCGGGCTGGTCGGGCGCAAGGCAGGCGCCGGTTTCTATCGCTACGTGGACGGCCAGAAGCAGGTCC
CGGCCGTTGCCGCCGTCCCGTCGGCGCGTCCGGCCAGCGTGTGGGTCAGCCGCGCGAGCGAGCGTGGCCATGCGATGGTC
ACGAAGCTGCTCGGCGCGATGGGCGTGACGCCCGAGAGCGGTGAACAGCCATCAGCCGATGCACTGATCGTCGTCACGCC
GCTGGGCCTCGACGCCACGACTACCGCGCTCCAGCAGGGTCTGGATGCCTCGCGCACGGTGGCCATCGACACGCTGCTGC
CGTTCGAAGCCACCAAGCGCCGCACGCTGATGACCACACCCGCCACAAGCGCTGCCGCACGCAACGCCGCGCACGGCCTG
TTCGCGAGCGACGGCGTGCCGGTCACGGTGATCCGCGATTCGGCCGGCTTCGTGGCCCAGCGCGTGCTCTGCTGCATCAT
CAACATCGCCAGCGACATCGCGCAGCAGCGCATTGCCTCGCCGGCCGACATCGACCTGGCCGTGAACCTCGGCCTCGGCT
ACCCGAAGGGTCCGCTGGCGCTTGGAGACGCCGTCGGCCCGCAACTGGTGCTGGAAACGCTGCGCAATATGGAAGCCCTG
ACCGGCGACATGCGCTACCGCCCGAGCCCGTGGCTGTGGCGCCGTGCCGGTCTCGGCCTGTCGCTGCTGACCGAAGAGAA
CTGA

Upstream 100 bases:

>100_bases
ACTGGCCGATCAGCGCACGCCGCCTGCCTTCCGGCCATTTCCGGAAAGATGCAAAAAACGTACGATCGTGCTAATTTAAC
CACAACTTCAGGGACAAAAA

Downstream 100 bases:

>100_bases
GGAGCGTGGCTCCCCTGCCCCCGCAATATCCCGAGGCCGTCCATGACCGCACAGTTGCTTACGTCCCGCGTTGATTCGAC
GCTGGTGCTGACCATCTCGA

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSTFTIETLGIVGTGAMGRGIAQIAAQAGLTVNLYDANPQAVEAARKYLQDTLGKLAEKGKISAADADATLARVKPCGAL
EDLSRCDMVVEAIVERLDVKRDLVAKLEAVLRPDAIIASNTSSLSITAIAVGAKEPGRVVGYHFFNPVPLMKVVEVIDGL
SGNPAVGDALMALSRRMGHTPVRCKDMPGFIVNHAGRGMNIEGIKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
DVSHPVMESIYNQFYQEPRYRPSPITAIRSVGGLVGRKAGAGFYRYVDGQKQVPAVAAVPSARPASVWVSRASERGHAMV
TKLLGAMGVTPESGEQPSADALIVVTPLGLDATTTALQQGLDASRTVAIDTLLPFEATKRRTLMTTPATSAAARNAAHGL
FASDGVPVTVIRDSAGFVAQRVLCCIINIASDIAQQRIASPADIDLAVNLGLGYPKGPLALGDAVGPQLVLETLRNMEAL
TGDMRYRPSPWLWRRAGLGLSLLTEEN

Sequences:

>Translated_507_residues
MSTFTIETLGIVGTGAMGRGIAQIAAQAGLTVNLYDANPQAVEAARKYLQDTLGKLAEKGKISAADADATLARVKPCGAL
EDLSRCDMVVEAIVERLDVKRDLVAKLEAVLRPDAIIASNTSSLSITAIAVGAKEPGRVVGYHFFNPVPLMKVVEVIDGL
SGNPAVGDALMALSRRMGHTPVRCKDMPGFIVNHAGRGMNIEGIKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
DVSHPVMESIYNQFYQEPRYRPSPITAIRSVGGLVGRKAGAGFYRYVDGQKQVPAVAAVPSARPASVWVSRASERGHAMV
TKLLGAMGVTPESGEQPSADALIVVTPLGLDATTTALQQGLDASRTVAIDTLLPFEATKRRTLMTTPATSAAARNAAHGL
FASDGVPVTVIRDSAGFVAQRVLCCIINIASDIAQQRIASPADIDLAVNLGLGYPKGPLALGDAVGPQLVLETLRNMEAL
TGDMRYRPSPWLWRRAGLGLSLLTEEN
>Mature_506_residues
STFTIETLGIVGTGAMGRGIAQIAAQAGLTVNLYDANPQAVEAARKYLQDTLGKLAEKGKISAADADATLARVKPCGALE
DLSRCDMVVEAIVERLDVKRDLVAKLEAVLRPDAIIASNTSSLSITAIAVGAKEPGRVVGYHFFNPVPLMKVVEVIDGLS
GNPAVGDALMALSRRMGHTPVRCKDMPGFIVNHAGRGMNIEGIKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGLD
VSHPVMESIYNQFYQEPRYRPSPITAIRSVGGLVGRKAGAGFYRYVDGQKQVPAVAAVPSARPASVWVSRASERGHAMVT
KLLGAMGVTPESGEQPSADALIVVTPLGLDATTTALQQGLDASRTVAIDTLLPFEATKRRTLMTTPATSAAARNAAHGLF
ASDGVPVTVIRDSAGFVAQRVLCCIINIASDIAQQRIASPADIDLAVNLGLGYPKGPLALGDAVGPQLVLETLRNMEALT
GDMRYRPSPWLWRRAGLGLSLLTEEN

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=37.9790940766551, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=35.8552631578947, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI20127408, Length=290, Percent_Identity=31.7241379310345, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=30.3754266211604, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=30.3754266211604, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=26.3829787234043, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI1787661, Length=495, Percent_Identity=36.1616161616162, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1790281, Length=273, Percent_Identity=32.967032967033, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=38.6759581881533, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=35.8885017421603, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=32.7586206896552, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=337, Percent_Identity=30.5637982195846, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17508953, Length=363, Percent_Identity=29.4765840220386, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17508951, Length=363, Percent_Identity=29.4765840220386, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71985923, Length=290, Percent_Identity=28.6206896551724, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=290, Percent_Identity=31.7241379310345, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=286, Percent_Identity=27.972027972028, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19921000, Length=319, Percent_Identity=30.0940438871473, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583077, Length=319, Percent_Identity=30.0940438871473, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583079, Length=319, Percent_Identity=30.0940438871473, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45549573, Length=242, Percent_Identity=30.5785123966942, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20129993, Length=228, Percent_Identity=26.3157894736842, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53706; Mature: 53574

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFTIETLGIVGTGAMGRGIAQIAAQAGLTVNLYDANPQAVEAARKYLQDTLGKLAEKG
CCEEEEEEECEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
KISAADADATLARVKPCGALEDLSRCDMVVEAIVERLDVKRDLVAKLEAVLRPDAIIASN
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
TSSLSITAIAVGAKEPGRVVGYHFFNPVPLMKVVEVIDGLSGNPAVGDALMALSRRMGHT
CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
PVRCKDMPGFIVNHAGRGMNIEGIKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
CCEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCC
DVSHPVMESIYNQFYQEPRYRPSPITAIRSVGGLVGRKAGAGFYRYVDGQKQVPAVAAVP
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECC
SARPASVWVSRASERGHAMVTKLLGAMGVTPESGEQPSADALIVVTPLGLDATTTALQQG
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHC
LDASRTVAIDTLLPFEATKRRTLMTTPATSAAARNAAHGLFASDGVPVTVIRDSAGFVAQ
CCCCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCEECCCCEEEEEECCCHHHHH
RVLCCIINIASDIAQQRIASPADIDLAVNLGLGYPKGPLALGDAVGPQLVLETLRNMEAL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TGDMRYRPSPWLWRRAGLGLSLLTEEN
HCCCCCCCCCCHHHHHCCCEEEEECCC
>Mature Secondary Structure 
STFTIETLGIVGTGAMGRGIAQIAAQAGLTVNLYDANPQAVEAARKYLQDTLGKLAEKG
CEEEEEEECEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
KISAADADATLARVKPCGALEDLSRCDMVVEAIVERLDVKRDLVAKLEAVLRPDAIIASN
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
TSSLSITAIAVGAKEPGRVVGYHFFNPVPLMKVVEVIDGLSGNPAVGDALMALSRRMGHT
CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
PVRCKDMPGFIVNHAGRGMNIEGIKVAQEGVAEFVDIDNIMREQAGFRMGPFELMDLTGL
CCEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCC
DVSHPVMESIYNQFYQEPRYRPSPITAIRSVGGLVGRKAGAGFYRYVDGQKQVPAVAAVP
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECC
SARPASVWVSRASERGHAMVTKLLGAMGVTPESGEQPSADALIVVTPLGLDATTTALQQG
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHC
LDASRTVAIDTLLPFEATKRRTLMTTPATSAAARNAAHGLFASDGVPVTVIRDSAGFVAQ
CCCCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCEECCCCEEEEEECCCHHHHH
RVLCCIINIASDIAQQRIASPADIDLAVNLGLGYPKGPLALGDAVGPQLVLETLRNMEAL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TGDMRYRPSPWLWRRAGLGLSLLTEEN
HCCCCCCCCCCHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]