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The map label for this gene is cyoB [H]

Identifier: 73540686

GI number: 73540686

Start: 1071038

End: 1073011

Strand: Direct

Name: cyoB [H]

Synonym: Reut_A0983

Alternate gene names: 73540686

Gene position: 1071038-1073011 (Clockwise)

Preceding gene: 73540685

Following gene: 73540687

Centisome position: 28.14

GC content: 62.46

Gene sequence:

>1974_bases
ATGTTTGGCAAATTGAGTTTGTCGGCGATTCCGTTTCATGAGCCGATCATCATGGTCGTACTGGCCGGCGTCGCCCTCGG
CGGCGCTGCGCTGCTAGGCGCGATCACGTATTTCAAGAAGTGGGGCTACCTCTGGAATGAGTGGTTCACTTCCGTCGATC
ACAAGAAGATCGGCGTGATGTACTGCCTGGTCGCGCTGGTCATGCTGCTGCGCGGCTTTTCCGACGCGGTCATGATGCGC
GCCCAGCTGGCGCTCGCCACGAACGGTGCCCACGGCGTCCTGCCGCCGGAACACTACGACCAGATCTTCACCGCCCACGG
CGTGATCATGATCTTCTTCGTGGCCATGCCGCTGATGACAGGTCTGATGAACCTCGTGGTGCCGCTGCAGATCGGCGCGC
GCGACGTGGCCTTCCCGTTCCTGAACACGCTGTCGTTCTGGCTGTTCGTGTCGGGCGCCATGCTGGTCAACATCTCGCTG
GGCGTTGGCGAATTCGCCAAGACCGGCTGGCTCGCCTACCCGCCGCTGTCGGGCCTCGATTTCAGCCCGGGCGTAGGGGT
GGACTACTACCTCTGGTCCTTGCAGATCTCAGGGTTGGGCACGCTGCTGACCGGCGTGAACTTCCTGGTGACGATTCTGA
AGATGCGCGCCCCGGGCATGACCCTGATGCGCATGCCGGTGTTCACCTGGACCGCCCTGTGCACCAACGTGCTGATCGTG
GCCGCCTTCCCGGTGCTGACCGTGTCGCTGGCACTGCTGGGTCTGGACCGCTACTTCGACATGCACTTCTTCACGAACGA
TGGCGGCGGCAATGCCATGATGTACGTGAACCTGATCTGGATTTGGGGCCACCCCGAGGTGTACATCCTGATCCTGCCGG
CGTTCGGTATCTTCTCTGAAGTCATCGCCACGTTCTCGGGCAAGAAGCTGTTCGGCTACAAGGGCATGGTGTACGCGACC
GCGGCCATCATGGTGCTGTCGTTCATCGTGTGGCTGCACCACTTCTTCACGATGGGCTCGGGTGCGAACGTCAACGCGTT
CTTCGGTATCACGACCATGATCATCTCCATCCCGACCGGGGTGAAGATCTTCAACTGGCTGTTCACGATGTACCGCGGCC
GTGTGCAGATGACCACGCCGGTACTGTGGACGCTGGGCTTCATGATCACCTTCGTGATCGGCGGCATGACCGGTGTGCTG
ATGGCCGTTCCGGCAGCCGACTTCGTGCTGCACAACAGCCTGTTCCTGATCGCCCACTTCCACAACGTGATCATCGGCGG
CGTGCTGTTCGGCTACCTGGCCGGCATCACCTACTGGTGGCCGAAGGCGTTCGGCTTCACGCTGAACGAGCGACTGGGCA
AGTACGCGTTCTGGTGCTGGCTGGTGGGCTTCTACTTCGCCTTCATGCCGCTGTACGTGCTGGGCCTGATGGGCATGACT
CGTCGTCTGAACCACACCGACAACCCGGCCTGGACGCCGTGGCTGTACCTGGCCGTGGTTGGCGTGGTCTTCGTGGCGCT
GGGCATCTTCTTCCAGGTGCTGCAGATCGTCGTGTCGATCCGCGACCGCAAGAAGCTGGCCGACGTGACCGGCGACCCGT
GGGGTGGCCGCACGCTGGAATGGGCTACCTCGTCGCCGCCGCCGTTCTACAACTTCGCGCACACCCCGGTGGTGCGTGAC
CTGGACGCGTTCGCCGACATGAAGGCCCGTGGCGAAACCATCCCGACCAGCGGCTACGAGCAGATCCACATGCCGAAGAA
CACCGGCGCTGGCTTCTGGATGGGCCTGTTCAGCCTGGTGCTGGGCTTCGCCCTGGTCTGGCACATCTGGTGGCTTGCCG
CCGTGGGCCTGGTCGGCATGGTGGTGTCGTTCATCCGCCGCGCCAACGATGACCACATCGACTATTACGTGCCGGCCGCA
GAGGTCGAGCAGATTGAAACGCGCCAACTGCAGCGCATTGCTTCGCAGGCCTGA

Upstream 100 bases:

>100_bases
GCGGCCCGATCTGCACGTCGCGTAACACGCTCGGCGAAGAGCGGGTGTCCATGGCCACGCCGGCCAAGCCGGCGCTGGGC
GCGCAATCCTAGGAGCAATG

Downstream 100 bases:

>100_bases
TGACCATGTCGACAGAAGTCCTTGATCGCTTCGGGGCGGCGCAAGCCCCGGCTCATGCGCACTCGCACGACGAGACGCAC
GACCACGCGCACCACGACAC

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MFGKLSLSAIPFHEPIIMVVLAGVALGGAALLGAITYFKKWGYLWNEWFTSVDHKKIGVMYCLVALVMLLRGFSDAVMMR
AQLALATNGAHGVLPPEHYDQIFTAHGVIMIFFVAMPLMTGLMNLVVPLQIGARDVAFPFLNTLSFWLFVSGAMLVNISL
GVGEFAKTGWLAYPPLSGLDFSPGVGVDYYLWSLQISGLGTLLTGVNFLVTILKMRAPGMTLMRMPVFTWTALCTNVLIV
AAFPVLTVSLALLGLDRYFDMHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSEVIATFSGKKLFGYKGMVYAT
AAIMVLSFIVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMYRGRVQMTTPVLWTLGFMITFVIGGMTGVL
MAVPAADFVLHNSLFLIAHFHNVIIGGVLFGYLAGITYWWPKAFGFTLNERLGKYAFWCWLVGFYFAFMPLYVLGLMGMT
RRLNHTDNPAWTPWLYLAVVGVVFVALGIFFQVLQIVVSIRDRKKLADVTGDPWGGRTLEWATSSPPPFYNFAHTPVVRD
LDAFADMKARGETIPTSGYEQIHMPKNTGAGFWMGLFSLVLGFALVWHIWWLAAVGLVGMVVSFIRRANDDHIDYYVPAA
EVEQIETRQLQRIASQA

Sequences:

>Translated_657_residues
MFGKLSLSAIPFHEPIIMVVLAGVALGGAALLGAITYFKKWGYLWNEWFTSVDHKKIGVMYCLVALVMLLRGFSDAVMMR
AQLALATNGAHGVLPPEHYDQIFTAHGVIMIFFVAMPLMTGLMNLVVPLQIGARDVAFPFLNTLSFWLFVSGAMLVNISL
GVGEFAKTGWLAYPPLSGLDFSPGVGVDYYLWSLQISGLGTLLTGVNFLVTILKMRAPGMTLMRMPVFTWTALCTNVLIV
AAFPVLTVSLALLGLDRYFDMHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSEVIATFSGKKLFGYKGMVYAT
AAIMVLSFIVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMYRGRVQMTTPVLWTLGFMITFVIGGMTGVL
MAVPAADFVLHNSLFLIAHFHNVIIGGVLFGYLAGITYWWPKAFGFTLNERLGKYAFWCWLVGFYFAFMPLYVLGLMGMT
RRLNHTDNPAWTPWLYLAVVGVVFVALGIFFQVLQIVVSIRDRKKLADVTGDPWGGRTLEWATSSPPPFYNFAHTPVVRD
LDAFADMKARGETIPTSGYEQIHMPKNTGAGFWMGLFSLVLGFALVWHIWWLAAVGLVGMVVSFIRRANDDHIDYYVPAA
EVEQIETRQLQRIASQA
>Mature_657_residues
MFGKLSLSAIPFHEPIIMVVLAGVALGGAALLGAITYFKKWGYLWNEWFTSVDHKKIGVMYCLVALVMLLRGFSDAVMMR
AQLALATNGAHGVLPPEHYDQIFTAHGVIMIFFVAMPLMTGLMNLVVPLQIGARDVAFPFLNTLSFWLFVSGAMLVNISL
GVGEFAKTGWLAYPPLSGLDFSPGVGVDYYLWSLQISGLGTLLTGVNFLVTILKMRAPGMTLMRMPVFTWTALCTNVLIV
AAFPVLTVSLALLGLDRYFDMHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSEVIATFSGKKLFGYKGMVYAT
AAIMVLSFIVWLHHFFTMGSGANVNAFFGITTMIISIPTGVKIFNWLFTMYRGRVQMTTPVLWTLGFMITFVIGGMTGVL
MAVPAADFVLHNSLFLIAHFHNVIIGGVLFGYLAGITYWWPKAFGFTLNERLGKYAFWCWLVGFYFAFMPLYVLGLMGMT
RRLNHTDNPAWTPWLYLAVVGVVFVALGIFFQVLQIVVSIRDRKKLADVTGDPWGGRTLEWATSSPPPFYNFAHTPVVRD
LDAFADMKARGETIPTSGYEQIHMPKNTGAGFWMGLFSLVLGFALVWHIWWLAAVGLVGMVVSFIRRANDDHIDYYVPAA
EVEQIETRQLQRIASQA

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=513, Percent_Identity=39.9610136452242, Blast_Score=348, Evalue=8e-96,
Organism=Escherichia coli, GI1786634, Length=656, Percent_Identity=69.8170731707317, Blast_Score=963, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=36.4990689013035, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6226524, Length=324, Percent_Identity=41.358024691358, Blast_Score=243, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=34.6774193548387, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 73081; Mature: 73081

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLSLSAIPFHEPIIMVVLAGVALGGAALLGAITYFKKWGYLWNEWFTSVDHKKIGVM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHH
YCLVALVMLLRGFSDAVMMRAQLALATNGAHGVLPPEHYDQIFTAHGVIMIFFVAMPLMT
HHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GLMNLVVPLQIGARDVAFPFLNTLSFWLFVSGAMLVNISLGVGEFAKTGWLAYPPLSGLD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHCCCEECCCCCCCC
FSPGVGVDYYLWSLQISGLGTLLTGVNFLVTILKMRAPGMTLMRMPVFTWTALCTNVLIV
CCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAFPVLTVSLALLGLDRYFDMHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSE
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEEEEEECCCCEEEEEECHHHHHHH
VIATFSGKKLFGYKGMVYATAAIMVLSFIVWLHHFFTMGSGANVNAFFGITTMIISIPTG
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VKIFNWLFTMYRGRVQMTTPVLWTLGFMITFVIGGMTGVLMAVPAADFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HNVIIGGVLFGYLAGITYWWPKAFGFTLNERLGKYAFWCWLVGFYFAFMPLYVLGLMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLNHTDNPAWTPWLYLAVVGVVFVALGIFFQVLQIVVSIRDRKKLADVTGDPWGGRTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
WATSSPPPFYNFAHTPVVRDLDAFADMKARGETIPTSGYEQIHMPKNTGAGFWMGLFSLV
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHH
LGFALVWHIWWLAAVGLVGMVVSFIRRANDDHIDYYVPAAEVEQIETRQLQRIASQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFGKLSLSAIPFHEPIIMVVLAGVALGGAALLGAITYFKKWGYLWNEWFTSVDHKKIGVM
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHH
YCLVALVMLLRGFSDAVMMRAQLALATNGAHGVLPPEHYDQIFTAHGVIMIFFVAMPLMT
HHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GLMNLVVPLQIGARDVAFPFLNTLSFWLFVSGAMLVNISLGVGEFAKTGWLAYPPLSGLD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEEEECCCCHHHHCCCEECCCCCCCC
FSPGVGVDYYLWSLQISGLGTLLTGVNFLVTILKMRAPGMTLMRMPVFTWTALCTNVLIV
CCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAFPVLTVSLALLGLDRYFDMHFFTNDGGGNAMMYVNLIWIWGHPEVYILILPAFGIFSE
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEEEEEECCCCEEEEEECHHHHHHH
VIATFSGKKLFGYKGMVYATAAIMVLSFIVWLHHFFTMGSGANVNAFFGITTMIISIPTG
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
VKIFNWLFTMYRGRVQMTTPVLWTLGFMITFVIGGMTGVLMAVPAADFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HNVIIGGVLFGYLAGITYWWPKAFGFTLNERLGKYAFWCWLVGFYFAFMPLYVLGLMGMT
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLNHTDNPAWTPWLYLAVVGVVFVALGIFFQVLQIVVSIRDRKKLADVTGDPWGGRTLE
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
WATSSPPPFYNFAHTPVVRDLDAFADMKARGETIPTSGYEQIHMPKNTGAGFWMGLFSLV
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHH
LGFALVWHIWWLAAVGLVGMVVSFIRRANDDHIDYYVPAAEVEQIETRQLQRIASQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]