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The map label for this gene is iclR [H]

Identifier: 73540571

GI number: 73540571

Start: 943522

End: 944280

Strand: Direct

Name: iclR [H]

Synonym: Reut_A0868

Alternate gene names: 73540571

Gene position: 943522-944280 (Clockwise)

Preceding gene: 73540567

Following gene: 73540576

Centisome position: 24.79

GC content: 63.64

Gene sequence:

>759_bases
ATGAGCAATCACTCGAACGCCGCCGCGGTGCGCGCCTTCCGCATCCTCGAGATCCTGTCCATGGCCGAGGAGCCGCTTTC
GCTCGCGGACATCGTGCAGGAGATCGGGCTGCCGAAGCAGACCGTGCATCGCCTGCTCAAGCAGCTCGAAAGCACGTGGC
TGGTGTCGCGCACGGCGGGCAGCCGGTATTACGAGTGCTCGTCACGCGTGCGGCAGTTCGCGGTCAATGTGCTGATGCAA
GCGGGACCTGCGGCGGCGCGGCATGCGATCCTGCAGCAACTGGTCGACAAGGTTGGCGAGACCTGCAACCTCACGATGCT
GTCGGGTGACGATGTGGTTTATCTCGATCGCGTGGAGACGCAGTGGCCGTTGCGGATGCATCTGCAGCCGGGATCGCGTG
TGCCGCTGCATTGCTCGGCGAGCGGGAAGTTGCTGCTGGCGTTCTTACCTTGTGCGCAGCGGGAGAGGGTGATCGCGGGG
TTGCCGTTGCGGGCGCAGTCGGCTAACACCATTACGGACGTCGAGGTTCTCCGTTCCGAACTTGCCGAGACGCGGCGGCG
TCGGCTTGGGGTCAATAATCAGGAGAACCTGCAGGGGATGATTGCTGTGGCGGTGCCGGTGATGCTGAACCGCAATCGCG
CTTGCGCTGCTATCGCTGTGCAGGCGCCGCTGGCGCGGATGTCGATGGATCGGTTGTATGAGTTCGTGCCGGATTTGAGG
TCGGCAGCGGAGGAGATGGGAAGGACGTTCAGCGAGTGA

Upstream 100 bases:

>100_bases
CGTCCCAATTTGTGCGCTTTCGCGAGCGCTCGAACGGCATGCAGCACGGATCGCAGTTTTCGGGACGTCAGGGCGTCCCG
GAATCCTATAAATTGAATCC

Downstream 100 bases:

>100_bases
AGAGCGCTGCAAGCGGCAGCCTTCAAAGACCGGCATGACGCCGGCCTTTTCGATATGCAATTCAGGTCGTTGCGCCCTGT
TCCGCGGGCACCACGTTAAA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSNHSNAAAVRAFRILEILSMAEEPLSLADIVQEIGLPKQTVHRLLKQLESTWLVSRTAGSRYYECSSRVRQFAVNVLMQ
AGPAAARHAILQQLVDKVGETCNLTMLSGDDVVYLDRVETQWPLRMHLQPGSRVPLHCSASGKLLLAFLPCAQRERVIAG
LPLRAQSANTITDVEVLRSELAETRRRRLGVNNQENLQGMIAVAVPVMLNRNRACAAIAVQAPLARMSMDRLYEFVPDLR
SAAEEMGRTFSE

Sequences:

>Translated_252_residues
MSNHSNAAAVRAFRILEILSMAEEPLSLADIVQEIGLPKQTVHRLLKQLESTWLVSRTAGSRYYECSSRVRQFAVNVLMQ
AGPAAARHAILQQLVDKVGETCNLTMLSGDDVVYLDRVETQWPLRMHLQPGSRVPLHCSASGKLLLAFLPCAQRERVIAG
LPLRAQSANTITDVEVLRSELAETRRRRLGVNNQENLQGMIAVAVPVMLNRNRACAAIAVQAPLARMSMDRLYEFVPDLR
SAAEEMGRTFSE
>Mature_251_residues
SNHSNAAAVRAFRILEILSMAEEPLSLADIVQEIGLPKQTVHRLLKQLESTWLVSRTAGSRYYECSSRVRQFAVNVLMQA
GPAAARHAILQQLVDKVGETCNLTMLSGDDVVYLDRVETQWPLRMHLQPGSRVPLHCSASGKLLLAFLPCAQRERVIAGL
PLRAQSANTITDVEVLRSELAETRRRRLGVNNQENLQGMIAVAVPVMLNRNRACAAIAVQAPLARMSMDRLYEFVPDLRS
AAEEMGRTFSE

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=242, Percent_Identity=26.4462809917355, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082359, Length=239, Percent_Identity=26.7782426778243, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786468, Length=241, Percent_Identity=27.3858921161826, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786715, Length=230, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788581, Length=214, Percent_Identity=29.4392523364486, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789999, Length=259, Percent_Identity=28.1853281853282, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790752, Length=246, Percent_Identity=24.390243902439, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27988; Mature: 27857

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHSNAAAVRAFRILEILSMAEEPLSLADIVQEIGLPKQTVHRLLKQLESTWLVSRTAG
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
SRYYECSSRVRQFAVNVLMQAGPAAARHAILQQLVDKVGETCNLTMLSGDDVVYLDRVET
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCC
QWPLRMHLQPGSRVPLHCSASGKLLLAFLPCAQRERVIAGLPLRAQSANTITDVEVLRSE
CCCEEEEECCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LAETRRRRLGVNNQENLQGMIAVAVPVMLNRNRACAAIAVQAPLARMSMDRLYEFVPDLR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAEEMGRTFSE
HHHHHHHHHCCC
>Mature Secondary Structure 
SNHSNAAAVRAFRILEILSMAEEPLSLADIVQEIGLPKQTVHRLLKQLESTWLVSRTAG
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
SRYYECSSRVRQFAVNVLMQAGPAAARHAILQQLVDKVGETCNLTMLSGDDVVYLDRVET
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCC
QWPLRMHLQPGSRVPLHCSASGKLLLAFLPCAQRERVIAGLPLRAQSANTITDVEVLRSE
CCCEEEEECCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LAETRRRRLGVNNQENLQGMIAVAVPVMLNRNRACAAIAVQAPLARMSMDRLYEFVPDLR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAEEMGRTFSE
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]