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The map label for this gene is uvrD [H]

Identifier: 73540567

GI number: 73540567

Start: 936381

End: 938741

Strand: Direct

Name: uvrD [H]

Synonym: Reut_A0864

Alternate gene names: 73540567

Gene position: 936381-938741 (Clockwise)

Preceding gene: 73540564

Following gene: 73540571

Centisome position: 24.6

GC content: 65.44

Gene sequence:

>2361_bases
ATGTCCGATCTGCTCGCCAACCTGAACGCCGAACAACTCGCCGCCGTCACGCTGCCTGACGAGCCGGCCCTGATCCTGGC
CGGCGCGGGCAGCGGCAAGACGCGCGTGCTGACAACGCGCATCGCGTGGCTGATCCAGAACGGACGGGTGTCGCCGGCGG
GCATCCTGGCCGTGACCTTCACCAACAAGGCCGCCAAGGAAATGCAGACGCGCCTGTCCTCGATGCTGCCGATCAACACG
CGCGGCATGTGGATCGGCACTTTCCACGGCCTCTGCAACCGCATGCTGCGCGCGCATTTCCGCGACGCGGGCCTGCCGCA
GACGTTTGCCATCCTCGACAGCCAGGACCAGCTTTCGGCGCTCAAGCGCCTGCTGAAAGCGCTCAATGTCGATGACGAGA
AGTACCCGGCCAAGAACCTCCAGTACTTCATCAACAACGCCAAGGAGCAGGGCCTGCGTCCTGCCGACGTGGAGGCGAAC
GACGACTTCAACCGCCGTTTCGTCGACCTGTACGCCGCATACGATCAGCAATGCCAGCGCGAGGGCGTGGTGGACTTCGC
CGAGTTGCTGCTGCGCTGCTATGAGCTGCTACGTTACAACGACGCCATTCGCCAGCACTACCAGCACCGCTTCAGCCATG
TGCTGGTGGACGAGTTCCAGGACACCAACGTGCTGCAGTACCAGTGGCTCAAGCTGCTGGCCGGCCATGGCACGCAGAAT
CCGGCGGCGGTGTTTGCGGTCGGCGACGACGACCAGAGCATCTACGCGTTCCGTGGCGCGAATGTCGGCAATATGCGCGA
TTTCGAGCATGAGTTCCGCGTGCGCAAGCTGATCAAGCTCGAACAGAACTACCGCTCGCACGGCCATATCCTCGATTCGG
CCAATCACCTGATCTCGCATAACTCCCGACGCCTCGGCAAGAACCTGCGTACCGATGCGGGCCACGGCGAACCGGTGCGC
GTGTTCCAGGCGGGATCGGACGGCCAGGAGGCGTCGTGGCTGGTCGAGGAGATCCGCGACCAGATTGCGCAGGGCATGAG
CCGGTCGGAGATTGCGATCCTGTATCGCAGCAACGCGCAGTCGCGCGTGATTGAGCATGCGTTGTTTTCGGCGGGCATTG
CGTATCGCGTGTATGGCGGCCTGCGCTTCTTCGAGCGCGCTGAAATCAAGCACGCGCTCGCCTACCTGCAATTGCTGGAG
AACCCGCGCAACGATGCGGCCTTTGGCCGCGTGGTGAATTTCCCCGCGCGCGGCATTGGCGCGCGCTCGCTGGAGCAACT
GCAGGATGCCGCGCGCCAGTACAACTGCTCGCTGGCCGAGGCCGTGGCCTATGTGCCGGGCGCGGCCGGCAGCAAGCTCG
CCGCATTCGTCCGCCTGATCGAGCAGATGCGCGCCGAGACGCGTCGCATGACGCTGGCCGAGGTCGTGGAGCACGTGACC
AATGCCAGCGGACTGATCACGCATTACCGCGGCGAGAAGGAAGGCCAGGATCGCATCGAGAACTTGCAGGAACTGGTGAC
CGCCGCGCAGGCATTCGTCGTGGAAGAGGGCTACGGGCTGGAGGCGCTGGCCGCGGTGATCCCGGTCGGCTTCGAATCGC
GCGCGGTCCAGGCCGTGCAGCAGCTTGCCGAAGGCGATCAGGCCCAGCAGGTGCTGGACCCCGAAGCGCTGCCCGTGGTG
ATGACGCCGCTGGTGGCCTTCCTCACGCACGCCTCGCTCGAGGCCGGCGACAACCAGGCGCAGGCGGGCCAGGACGCGGT
GCAGATGATGACCGTACACGCCGCCAAGGGCCTCGAGTTCAACGTGGTCTTCATCACCGGGCTCGAAGAGGGCTTGTTCC
CGCACGAGAACAGCGCGATGGAGCAGGACGGTCTTGAGGAAGAGCGCCGGCTGATGTACGTGGCGATCACGCGTGCGCGC
GAGCGGCTGTACCTGTCCTTCGCGCAGAGCCGAGTGTTGCACGGCCAGATGCGTTACCACGTGCGCTCGCGCTTCTTCGA
AGAGCTGCCGGAAGAGGCGCTCAAGTGGCTCACGCCGCAGCAGCAGAGCTACGGCGGCGTGCGCCGCCAGGAACGTGACA
ACGCATGGGGCCGCGACTGGTTCCGCAAGCCCGAGGACGTCCCGTATTCGGGCAACAAGCCGACCGGCGGCATGGACACG
GGCAACGGCTATGCCGATGCCAAGCGCGAAGCCGGCACCGGTTTCCGCGTGGGCCAGCAGGTGTTCCACAACAAGTTCGG
CGAGGGCGTGATCAAGGCGCTCGAAGGCGATGGCGCGGATGCGCGGGCCCAGATCGACTTCAAGCGCCACGGCGCCAAGT
GGCTCGCGCTGTCGGTGGCGAAGCTGGACCCGATCAACTGA

Upstream 100 bases:

>100_bases
GACTCGCCGGCTACGCCGGCGAAACAGCAGCGCCCGCCAAGAACCACCAACCTCCAAAACACCAAAACCGACAAACCGCC
ATTCACCCCCTACATCCTGA

Downstream 100 bases:

>100_bases
GCGGGCCCGGCCTCGCATGCCGGATCAGGGGAAGGCCGGACGCACCTCGGCCGCCTTTTCCTCTGGCGTATCGACGGTCT
TCAGCGGATTGATGAACAAC

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 785

Protein sequence:

>786_residues
MSDLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTFTNKAAKEMQTRLSSMLPINT
RGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSALKRLLKALNVDDEKYPAKNLQYFINNAKEQGLRPADVEAN
DDFNRRFVDLYAAYDQQCQREGVVDFAELLLRCYELLRYNDAIRQHYQHRFSHVLVDEFQDTNVLQYQWLKLLAGHGTQN
PAAVFAVGDDDQSIYAFRGANVGNMRDFEHEFRVRKLIKLEQNYRSHGHILDSANHLISHNSRRLGKNLRTDAGHGEPVR
VFQAGSDGQEASWLVEEIRDQIAQGMSRSEIAILYRSNAQSRVIEHALFSAGIAYRVYGGLRFFERAEIKHALAYLQLLE
NPRNDAAFGRVVNFPARGIGARSLEQLQDAARQYNCSLAEAVAYVPGAAGSKLAAFVRLIEQMRAETRRMTLAEVVEHVT
NASGLITHYRGEKEGQDRIENLQELVTAAQAFVVEEGYGLEALAAVIPVGFESRAVQAVQQLAEGDQAQQVLDPEALPVV
MTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFITGLEEGLFPHENSAMEQDGLEEERRLMYVAITRAR
ERLYLSFAQSRVLHGQMRYHVRSRFFEELPEEALKWLTPQQQSYGGVRRQERDNAWGRDWFRKPEDVPYSGNKPTGGMDT
GNGYADAKREAGTGFRVGQQVFHNKFGEGVIKALEGDGADARAQIDFKRHGAKWLALSVAKLDPIN

Sequences:

>Translated_786_residues
MSDLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTFTNKAAKEMQTRLSSMLPINT
RGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSALKRLLKALNVDDEKYPAKNLQYFINNAKEQGLRPADVEAN
DDFNRRFVDLYAAYDQQCQREGVVDFAELLLRCYELLRYNDAIRQHYQHRFSHVLVDEFQDTNVLQYQWLKLLAGHGTQN
PAAVFAVGDDDQSIYAFRGANVGNMRDFEHEFRVRKLIKLEQNYRSHGHILDSANHLISHNSRRLGKNLRTDAGHGEPVR
VFQAGSDGQEASWLVEEIRDQIAQGMSRSEIAILYRSNAQSRVIEHALFSAGIAYRVYGGLRFFERAEIKHALAYLQLLE
NPRNDAAFGRVVNFPARGIGARSLEQLQDAARQYNCSLAEAVAYVPGAAGSKLAAFVRLIEQMRAETRRMTLAEVVEHVT
NASGLITHYRGEKEGQDRIENLQELVTAAQAFVVEEGYGLEALAAVIPVGFESRAVQAVQQLAEGDQAQQVLDPEALPVV
MTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFITGLEEGLFPHENSAMEQDGLEEERRLMYVAITRAR
ERLYLSFAQSRVLHGQMRYHVRSRFFEELPEEALKWLTPQQQSYGGVRRQERDNAWGRDWFRKPEDVPYSGNKPTGGMDT
GNGYADAKREAGTGFRVGQQVFHNKFGEGVIKALEGDGADARAQIDFKRHGAKWLALSVAKLDPIN
>Mature_785_residues
SDLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTFTNKAAKEMQTRLSSMLPINTR
GMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSALKRLLKALNVDDEKYPAKNLQYFINNAKEQGLRPADVEAND
DFNRRFVDLYAAYDQQCQREGVVDFAELLLRCYELLRYNDAIRQHYQHRFSHVLVDEFQDTNVLQYQWLKLLAGHGTQNP
AAVFAVGDDDQSIYAFRGANVGNMRDFEHEFRVRKLIKLEQNYRSHGHILDSANHLISHNSRRLGKNLRTDAGHGEPVRV
FQAGSDGQEASWLVEEIRDQIAQGMSRSEIAILYRSNAQSRVIEHALFSAGIAYRVYGGLRFFERAEIKHALAYLQLLEN
PRNDAAFGRVVNFPARGIGARSLEQLQDAARQYNCSLAEAVAYVPGAAGSKLAAFVRLIEQMRAETRRMTLAEVVEHVTN
ASGLITHYRGEKEGQDRIENLQELVTAAQAFVVEEGYGLEALAAVIPVGFESRAVQAVQQLAEGDQAQQVLDPEALPVVM
TPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFITGLEEGLFPHENSAMEQDGLEEERRLMYVAITRARE
RLYLSFAQSRVLHGQMRYHVRSRFFEELPEEALKWLTPQQQSYGGVRRQERDNAWGRDWFRKPEDVPYSGNKPTGGMDTG
NGYADAKREAGTGFRVGQQVFHNKFGEGVIKALEGDGADARAQIDFKRHGAKWLALSVAKLDPIN

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=794, Percent_Identity=44.9622166246851, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=35.672514619883, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1787196, Length=343, Percent_Identity=30.3206997084548, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789183, Length=544, Percent_Identity=22.9779411764706, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322369, Length=777, Percent_Identity=27.6705276705277, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6324477, Length=707, Percent_Identity=23.7623762376238, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87906; Mature: 87775

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTF
CCCHHHCCCHHHEEEEECCCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAKEMQTRLSSMLPINTRGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
LKRLLKALNVDDEKYPAKNLQYFINNAKEQGLRPADVEANDDFNRRFVDLYAAYDQQCQR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EGVVDFAELLLRCYELLRYNDAIRQHYQHRFSHVLVDEFQDTNVLQYQWLKLLAGHGTQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
PAAVFAVGDDDQSIYAFRGANVGNMRDFEHEFRVRKLIKLEQNYRSHGHILDSANHLISH
CEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
NSRRLGKNLRTDAGHGEPVRVFQAGSDGQEASWLVEEIRDQIAQGMSRSEIAILYRSNAQ
CCHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
SRVIEHALFSAGIAYRVYGGLRFFERAEIKHALAYLQLLENPRNDAAFGRVVNFPARGIG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
ARSLEQLQDAARQYNCSLAEAVAYVPGAAGSKLAAFVRLIEQMRAETRRMTLAEVVEHVT
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NASGLITHYRGEKEGQDRIENLQELVTAAQAFVVEEGYGLEALAAVIPVGFESRAVQAVQ
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHH
QLAEGDQAQQVLDPEALPVVMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEF
HHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEE
NVVFITGLEEGLFPHENSAMEQDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQMRYH
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSRFFEELPEEALKWLTPQQQSYGGVRRQERDNAWGRDWFRKPEDVPYSGNKPTGGMDT
HHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCC
GNGYADAKREAGTGFRVGQQVFHNKFGEGVIKALEGDGADARAQIDFKRHGAKWLALSVA
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCEEEEEEEH
KLDPIN
HCCCCC
>Mature Secondary Structure 
SDLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTF
CCHHHCCCHHHEEEEECCCCCCEEEEECCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAKEMQTRLSSMLPINTRGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
LKRLLKALNVDDEKYPAKNLQYFINNAKEQGLRPADVEANDDFNRRFVDLYAAYDQQCQR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EGVVDFAELLLRCYELLRYNDAIRQHYQHRFSHVLVDEFQDTNVLQYQWLKLLAGHGTQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
PAAVFAVGDDDQSIYAFRGANVGNMRDFEHEFRVRKLIKLEQNYRSHGHILDSANHLISH
CEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
NSRRLGKNLRTDAGHGEPVRVFQAGSDGQEASWLVEEIRDQIAQGMSRSEIAILYRSNAQ
CCHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
SRVIEHALFSAGIAYRVYGGLRFFERAEIKHALAYLQLLENPRNDAAFGRVVNFPARGIG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
ARSLEQLQDAARQYNCSLAEAVAYVPGAAGSKLAAFVRLIEQMRAETRRMTLAEVVEHVT
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NASGLITHYRGEKEGQDRIENLQELVTAAQAFVVEEGYGLEALAAVIPVGFESRAVQAVQ
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHH
QLAEGDQAQQVLDPEALPVVMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEF
HHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEE
NVVFITGLEEGLFPHENSAMEQDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQMRYH
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSRFFEELPEEALKWLTPQQQSYGGVRRQERDNAWGRDWFRKPEDVPYSGNKPTGGMDT
HHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCC
GNGYADAKREAGTGFRVGQQVFHNKFGEGVIKALEGDGADARAQIDFKRHGAKWLALSVA
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCEEEEEEEH
KLDPIN
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]