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The map label for this gene is msrA [H]

Identifier: 73540515

GI number: 73540515

Start: 881532

End: 882074

Strand: Direct

Name: msrA [H]

Synonym: Reut_A0812

Alternate gene names: 73540515

Gene position: 881532-882074 (Clockwise)

Preceding gene: 73540513

Following gene: 73540521

Centisome position: 23.16

GC content: 61.69

Gene sequence:

>543_bases
ATGGAACATGGACTCGATACGGCGACCCTCGGCGGAGGATGTTTCTGGTGCCTGGAGGCGGTGTACCAGCAGGTCAATGG
CGTGCGTGCCGTGGAATCGGGCTACACCGGCGGGCATGTGAGCCATCCCAGCTACCAGCAGGTTTCCGAAGGCGATACGG
GCCATGCCGAAGTCATCCGCGTGACGTTCGATCCGGCGGTCATCAACTATCGCGAGATCATCGAGATTTTCTTTGCGATC
CATGATCCGACCACGCTGAACCGGCAGGGGAACGACGTTGGCCCGCAATATCGCTCGATCATCTTCACGCACTCCGAAGC
GCAGCGCGCCGTGGCGGAGTACGTCATGCGCGAACTGGTCGCCAACAAGGTCTTCGACGCACCCATCGTCACGCAGATCG
AGCCGGAGCAGCCGTACTGGCGTGCCGAGGCGAGCCACCAGAACTACTTCCAGGAGCATCCGAGCCAGGGATACTGCGCG
TTCGTCATCTCGCCCAAGGTCGCCAAGTTCCGCGAGAGGTTTGCCAGCAAGCTGCGCCGGTAG

Upstream 100 bases:

>100_bases
CTGACCGCGCTTGGGGATAACCCGCCGGCAGATTGCCTTATCTGCGCTTATGCTTAGGAACGGTACATCGACACAACGCG
TGAACCCCGGGAGCGGCGAC

Downstream 100 bases:

>100_bases
CGGCGCGGCACCGTGCCATTACAGGCGCGCGGCGATGGCCTCGGCCAGCCGTATGCACGTGAGCGGCGCGGAGCCTTCGG
CCTTGTTGCTGATGATGACA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MEHGLDTATLGGGCFWCLEAVYQQVNGVRAVESGYTGGHVSHPSYQQVSEGDTGHAEVIRVTFDPAVINYREIIEIFFAI
HDPTTLNRQGNDVGPQYRSIIFTHSEAQRAVAEYVMRELVANKVFDAPIVTQIEPEQPYWRAEASHQNYFQEHPSQGYCA
FVISPKVAKFRERFASKLRR

Sequences:

>Translated_180_residues
MEHGLDTATLGGGCFWCLEAVYQQVNGVRAVESGYTGGHVSHPSYQQVSEGDTGHAEVIRVTFDPAVINYREIIEIFFAI
HDPTTLNRQGNDVGPQYRSIIFTHSEAQRAVAEYVMRELVANKVFDAPIVTQIEPEQPYWRAEASHQNYFQEHPSQGYCA
FVISPKVAKFRERFASKLRR
>Mature_180_residues
MEHGLDTATLGGGCFWCLEAVYQQVNGVRAVESGYTGGHVSHPSYQQVSEGDTGHAEVIRVTFDPAVINYREIIEIFFAI
HDPTTLNRQGNDVGPQYRSIIFTHSEAQRAVAEYVMRELVANKVFDAPIVTQIEPEQPYWRAEASHQNYFQEHPSQGYCA
FVISPKVAKFRERFASKLRR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=38.125, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=38.125, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI208609993, Length=144, Percent_Identity=37.5, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=39.6103896103896, Blast_Score=130, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=32.1917808219178, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=41.1392405063291, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24664627, Length=166, Percent_Identity=33.7349397590361, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664631, Length=166, Percent_Identity=33.1325301204819, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=32.5, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20379; Mature: 20379

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHGLDTATLGGGCFWCLEAVYQQVNGVRAVESGYTGGHVSHPSYQQVSEGDTGHAEVIR
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEE
VTFDPAVINYREIIEIFFAIHDPTTLNRQGNDVGPQYRSIIFTHSEAQRAVAEYVMRELV
EEECCHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEECHHHHHHHHHHHHHHHH
ANKVFDAPIVTQIEPEQPYWRAEASHQNYFQEHPSQGYCAFVISPKVAKFRERFASKLRR
HHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHGLDTATLGGGCFWCLEAVYQQVNGVRAVESGYTGGHVSHPSYQQVSEGDTGHAEVIR
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEE
VTFDPAVINYREIIEIFFAIHDPTTLNRQGNDVGPQYRSIIFTHSEAQRAVAEYVMRELV
EEECCHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEECHHHHHHHHHHHHHHHH
ANKVFDAPIVTQIEPEQPYWRAEASHQNYFQEHPSQGYCAFVISPKVAKFRERFASKLRR
HHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]