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The map label for this gene is pdxA

Identifier: 73540205

GI number: 73540205

Start: 543248

End: 544291

Strand: Direct

Name: pdxA

Synonym: Reut_A0499

Alternate gene names: 73540205

Gene position: 543248-544291 (Clockwise)

Preceding gene: 73540204

Following gene: 73540206

Centisome position: 14.27

GC content: 69.83

Gene sequence:

>1044_bases
ATGCCCGACCCGCTTGCGCTAGCCATTTCTACCGGTGAACCCGCCGGTATCGGCCCTGACATCACCATCGGGGCGCTGCT
GCAACTCGCGGGTCAGAACGGGCACGCCCGTTACCATGTGCTTGGTGATGCGCACCTGCTGGCCTCCCGGGCCGCGGCGC
TGGGCGTTGCGCATGCGTGGGAGCGCCGCATCGCCGAGGGCGAAGTGGTCATCCATCATGTGCCGTTGGCCGTCGCGTGC
GAGCCGGGCCGGCTCGATGCGCGCAACGGTCCCTATGTGCTGTCGATGCTCGATGCCGCGATTGCGGGCTGCCGCACGCA
TGCCGGCGCACCGGCGCGCTTTGCCGCCATGGTCACGGCGCCCGTGCAGAAGAGCACGATCAACGATGCCGGCGTGCCGT
TCACCGGCCATACCGAATACCTCGCCGAAGCCGCGGGCGTACCGCGCGTGGTGATGATGCTGGCCGGCCCGCAGCCGGCG
CACGCCAACGCCATGCTGCGCGTGGCGCTGGCCACGACCCACCTGCCGCTGCGCGCCGTGGCCGACGCCGTGACGGTGCC
GCTGCTGCTGGAGACGCTGTCGATCATCGACGCCGACCTGCGCCGCTGGTTCGGCATTGCACGCCCCCGCATCCTGGTGA
CCGGACTCAATCCCCACGCGGGAGAGAGCGGTCACATGGGTCGCGAGGAAATCAACGTCATCGAACCGGCGCTGGCGCAG
GCGCGCGATGCCGGCATCGACGCGCGCGGCCCGTACCCGGCCGACACGCTGTTCCAGCCGCGCCACCTGCGCGACGCCGA
CTGCGTACTGGCGATGTACCATGACCAGGGGCTCGCGCCCCTGAAGTACGGCACGTTCGGGCACGGCGTGAATATCACGC
TGGGCCTGCCCTTTATCCGCACCTCGGTCGACCACGGCACCGCGCTCGACCTGGCCGGCAGCGGCCAGGCCGAGCATGGC
AGCATGATCGAGGCTATCCGCAGTGCGGTCACCATGGCCGGACATGCCAACGGCAGGCATGCTTCAGCCAGGGTGCCGCA
CTAG

Upstream 100 bases:

>100_bases
CAGCTGCGTTCGCAGGCGTACGTCGAGTACCGCGTCAACCGACAGCGCTGAGGTACCCGCCGCCCCCGCCGCCCCCGCCG
CCCCGTAGCACGACCACGAC

Downstream 100 bases:

>100_bases
TGGTGTATTCCTCCATGCGTTCAAACATGCACCAGGGCCACGTGGCCCGCAAGCGATTCGGCCAGAACTTCCTGGTCGAC
GATTCCATCATTCACGGCAT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MPDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVAHAWERRIAEGEVVIHHVPLAVAC
EPGRLDARNGPYVLSMLDAAIAGCRTHAGAPARFAAMVTAPVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPA
HANAMLRVALATTHLPLRAVADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEINVIEPALAQ
ARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFIRTSVDHGTALDLAGSGQAEHG
SMIEAIRSAVTMAGHANGRHASARVPH

Sequences:

>Translated_347_residues
MPDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVAHAWERRIAEGEVVIHHVPLAVAC
EPGRLDARNGPYVLSMLDAAIAGCRTHAGAPARFAAMVTAPVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPA
HANAMLRVALATTHLPLRAVADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEINVIEPALAQ
ARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFIRTSVDHGTALDLAGSGQAEHG
SMIEAIRSAVTMAGHANGRHASARVPH
>Mature_346_residues
PDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVAHAWERRIAEGEVVIHHVPLAVACE
PGRLDARNGPYVLSMLDAAIAGCRTHAGAPARFAAMVTAPVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPAH
ANAMLRVALATTHLPLRAVADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEINVIEPALAQA
RDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFIRTSVDHGTALDLAGSGQAEHGS
MIEAIRSAVTMAGHANGRHASARVPH

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=334, Percent_Identity=52.3952095808383, Blast_Score=306, Evalue=9e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_CUPPJ (Q475Q2)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_294725.1
- ProteinModelPortal:   Q475Q2
- SMR:   Q475Q2
- GeneID:   3611803
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0499
- NMPDR:   fig|264198.3.peg.1011
- HOGENOM:   HBG451136
- OMA:   LETAYQM
- ProtClustDB:   PRK01909
- BioCyc:   REUT264198:REUT_A0499-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36297; Mature: 36166

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: BINDING 137-137 BINDING 138-138 BINDING 282-282 BINDING 291-291 BINDING 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVAHAW
CCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
ERRIAEGEVVIHHVPLAVACEPGRLDARNGPYVLSMLDAAIAGCRTHAGAPARFAAMVTA
HHHCCCCCEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEEEEEC
PVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPAHANAMLRVALATTHLPLRAV
CCHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEHHHCCCCHHHH
ADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEINVIEPALAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
ARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFIR
HHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCCCCEEEEEECCHHE
TSVDHGTALDLAGSGQAEHGSMIEAIRSAVTMAGHANGRHASARVPH
ECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVAHAW
CCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
ERRIAEGEVVIHHVPLAVACEPGRLDARNGPYVLSMLDAAIAGCRTHAGAPARFAAMVTA
HHHCCCCCEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEEEEEC
PVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPAHANAMLRVALATTHLPLRAV
CCHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEHHHCCCCHHHH
ADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEINVIEPALAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
ARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFIR
HHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCCCCEEEEEECCHHE
TSVDHGTALDLAGSGQAEHGSMIEAIRSAVTMAGHANGRHASARVPH
ECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA