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The map label for this gene is cah [H]

Identifier: 73539736

GI number: 73539736

Start: 42567

End: 43316

Strand: Reverse

Name: cah [H]

Synonym: Reut_A0030

Alternate gene names: 73539736

Gene position: 43316-42567 (Counterclockwise)

Preceding gene: 73539737

Following gene: 73539734

Centisome position: 1.14

GC content: 64.0

Gene sequence:

>750_bases
ATGAAGACACGCATTGCGTTTGCAGCATTGGGCACACTGTTCTGCACGACACTTGCCAGCGCCGCAGAAGCTCCGCACTG
GACCTACCAGGGCAAGACCGGCGCAAGCCACTGGGCCGGCCTTGAATCCGACTACGCCGTTTGCGGCACCGGACAACGCC
AGTCGCCGATCAACATCGAAACGCGCAAGGTGACCGGCACCACGGCGCAACCGGTTAGCCTGGCCTATGCGCCGGCCAGC
GCCGAAGTGATCAACAACGGCCACACCATCCAGGTCGAGCCGGCCAACGGCGGCGCGCTCACCATCGATGGCGTCGAGTA
CAAGCTCGCGCAGTTCCACTTCCACACGCCGAGCGAAGAGAGAATCGACGGCAAGTCCTATCCGTTGGTAGCGCACCTCG
TGCACAAGAGCGCCGACGGCAAGCTTGCGGTGATCGCCGTGCTGTTCCGCACGGGCAAGACCAATGCCGCCTTGCAACCG
GTGTTCGCGGCGCTGCCGGGCAAGGCAGGTGCCAAGCACGCGGTCGATGGCACGATCGACGTCGGCGCGCTGCTGCCCGC
CAACCGCGACAACTACACGTTCATCGGCTCGCTGACCACGCCGCCTTGCAGCGAAGATGTCCGATGGGTCGTGATGAAGA
CGCCCGTGTCGATCTCGCAGAAGCAGCTTGCGGCGTTCAGGAAGCTGTACAGCATGAATGCGCGGCCGGTGCAGGCTGTG
AATGGGCGGGAGATTCAGGCCGGGAAGTAG

Upstream 100 bases:

>100_bases
GTCAACTGCAGTCTTCCGGCAGCGTTTCGGAGCCATGGGAACGGCCCGCCAATCGCGCGGCCTTCGCCTATCCCGCATAA
CCACAACGGTGACAATCAAG

Downstream 100 bases:

>100_bases
CCTCTGCGGTGGAGGCGGCGGGCGACGGCCCGCCGATTCTCCGCAAAACTATATCGTTGATCTATTTTCGCTGCGCGGGA
TACGCAAAACTATATTTATC

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKTRIAFAALGTLFCTTLASAAEAPHWTYQGKTGASHWAGLESDYAVCGTGQRQSPINIETRKVTGTTAQPVSLAYAPAS
AEVINNGHTIQVEPANGGALTIDGVEYKLAQFHFHTPSEERIDGKSYPLVAHLVHKSADGKLAVIAVLFRTGKTNAALQP
VFAALPGKAGAKHAVDGTIDVGALLPANRDNYTFIGSLTTPPCSEDVRWVVMKTPVSISQKQLAAFRKLYSMNARPVQAV
NGREIQAGK

Sequences:

>Translated_249_residues
MKTRIAFAALGTLFCTTLASAAEAPHWTYQGKTGASHWAGLESDYAVCGTGQRQSPINIETRKVTGTTAQPVSLAYAPAS
AEVINNGHTIQVEPANGGALTIDGVEYKLAQFHFHTPSEERIDGKSYPLVAHLVHKSADGKLAVIAVLFRTGKTNAALQP
VFAALPGKAGAKHAVDGTIDVGALLPANRDNYTFIGSLTTPPCSEDVRWVVMKTPVSISQKQLAAFRKLYSMNARPVQAV
NGREIQAGK
>Mature_249_residues
MKTRIAFAALGTLFCTTLASAAEAPHWTYQGKTGASHWAGLESDYAVCGTGQRQSPINIETRKVTGTTAQPVSLAYAPAS
AEVINNGHTIQVEPANGGALTIDGVEYKLAQFHFHTPSEERIDGKSYPLVAHLVHKSADGKLAVIAVLFRTGKTNAALQP
VFAALPGKAGAKHAVDGTIDVGALLPANRDNYTFIGSLTTPPCSEDVRWVVMKTPVSISQKQLAAFRKLYSMNARPVQAV
NGREIQAGK

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=262, Percent_Identity=35.8778625954198, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI192447434, Length=262, Percent_Identity=35.8778625954198, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI192447432, Length=262, Percent_Identity=35.8778625954198, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI192447430, Length=262, Percent_Identity=35.8778625954198, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI4502517, Length=262, Percent_Identity=35.8778625954198, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI4885101, Length=259, Percent_Identity=35.5212355212355, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557395, Length=262, Percent_Identity=35.1145038167939, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI38348436, Length=261, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI6005723, Length=263, Percent_Identity=33.0798479087452, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4885099, Length=264, Percent_Identity=32.5757575757576, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI4502521, Length=237, Percent_Identity=35.0210970464135, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI62240989, Length=205, Percent_Identity=34.6341463414634, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI22027500, Length=245, Percent_Identity=30.6122448979592, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI45935383, Length=283, Percent_Identity=28.9752650176678, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4502515, Length=283, Percent_Identity=28.9752650176678, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4502519, Length=269, Percent_Identity=28.996282527881, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI6912284, Length=292, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI169636420, Length=257, Percent_Identity=30.3501945525292, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI194097398, Length=268, Percent_Identity=27.6119402985075, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI91208428, Length=238, Percent_Identity=27.7310924369748, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI130979954, Length=269, Percent_Identity=25.2788104089219, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI130979679, Length=269, Percent_Identity=25.2788104089219, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI9910366, Length=269, Percent_Identity=25.2788104089219, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568715, Length=244, Percent_Identity=36.4754098360656, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71995280, Length=262, Percent_Identity=30.9160305343511, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17569163, Length=228, Percent_Identity=29.8245614035088, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17569165, Length=228, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358169, Length=275, Percent_Identity=30.9090909090909, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737413, Length=253, Percent_Identity=32.8063241106719, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI18858185, Length=265, Percent_Identity=26.0377358490566, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24645604, Length=282, Percent_Identity=26.9503546099291, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI161079350, Length=268, Percent_Identity=30.2238805970149, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI116008410, Length=241, Percent_Identity=31.1203319502075, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24650523, Length=243, Percent_Identity=29.2181069958848, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161079354, Length=261, Percent_Identity=25.6704980842912, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28573346, Length=268, Percent_Identity=26.4925373134328, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 26438; Mature: 26438

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRIAFAALGTLFCTTLASAAEAPHWTYQGKTGASHWAGLESDYAVCGTGQRQSPINIE
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHCCCCCCCEEEECCCCCCCCCCEE
TRKVTGTTAQPVSLAYAPASAEVINNGHTIQVEPANGGALTIDGVEYKLAQFHFHTPSEE
EEEEECCCCCCEEEEECCCCHHEECCCCEEEEEECCCCEEEECCCEEEEEEEEECCCCHH
RIDGKSYPLVAHLVHKSADGKLAVIAVLFRTGKTNAALQPVFAALPGKAGAKHAVDGTID
HCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
VGALLPANRDNYTFIGSLTTPPCSEDVRWVVMKTPVSISQKQLAAFRKLYSMNARPVQAV
EEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEC
NGREIQAGK
CCCEEECCC
>Mature Secondary Structure
MKTRIAFAALGTLFCTTLASAAEAPHWTYQGKTGASHWAGLESDYAVCGTGQRQSPINIE
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHCCCCCCCEEEECCCCCCCCCCEE
TRKVTGTTAQPVSLAYAPASAEVINNGHTIQVEPANGGALTIDGVEYKLAQFHFHTPSEE
EEEEECCCCCCEEEEECCCCHHEECCCCEEEEEECCCCEEEECCCEEEEEEEEECCCCHH
RIDGKSYPLVAHLVHKSADGKLAVIAVLFRTGKTNAALQPVFAALPGKAGAKHAVDGTID
HCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCEE
VGALLPANRDNYTFIGSLTTPPCSEDVRWVVMKTPVSISQKQLAAFRKLYSMNARPVQAV
EEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEC
NGREIQAGK
CCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]