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The map label for this gene is phnW2

Identifier: 73539691

GI number: 73539691

Start: 2711145

End: 2712272

Strand: Reverse

Name: phnW2

Synonym: Reut_B5871

Alternate gene names: 73539691

Gene position: 2712272-2711145 (Counterclockwise)

Preceding gene: 73539692

Following gene: 73539684

Centisome position: 99.49

GC content: 66.05

Gene sequence:

>1128_bases
ATGACCGCCACGCCCTACCCCATCCTGCTCACTCCCGGCCCCCTCACTACCTCGGACCGCACCCGCGCTGCCATGCTACG
CGACTGGGGCTCGTGGGACACTGACTTCAACGCCATTACCGCCCGCATTCGCCAGCAGGTGCTGGCGATCGTCCACGGCG
ACGACACGCATGAATGCGTGCCCCTGCAGGGCAGCGGCACCTTCTCCGTGGAGGCCGCCATCGGCACGCTGGTGCCGCGC
GACGGCCATGTGCTGGTGCCTGTGAACGGCGCCTATTGCCAGCGCATCGCGAAAATCTGCAAGACCCTTGGCCGGCGCCT
GTCCACCATCGACTATGCCGAGGACCGCCCCATGCGGGCAGCGGACATCGACCGCCAACTGGCTGCGGACAGCACCATCA
CCCACGTCGCGGTCGTCCATTGCGAAACCGGCACCGGCGTGCTCAACCCGCTGGACGAGATCGCCCAGGTCGTAGCCCGG
CATGGGCGCGGCCTGATCGTCGATGCGATGAGCTCCTTCGGCGCCATCGACATCGACGCCCGCACGACCCCGTTCGATGC
CGTCATTGCGGCCTCCGGCAAATGCCTGGAAGGCGTGCCCGGCATGGGCTTCGTAATCGCGCGGCGCACGGCGCTGGAGC
GCTGTGAAGGTAACAGCCATTCCCTTTCGCTTGACCTCTATGACCAGTGGAAATACATGGAACGGACCACGCAGTGGCGC
TTCACGCCGCCGACGCATGTGGTCGCGGCGCTTGACCAGGCGCTCCAGCAGTATGTGGAAGAAGGCGGACTTCCGGCACG
CGGCGCGCGCTACGCCAGCAACTGCCAGTTGCTGGTGGACGGCATGGAGACGCTCGGCCTGAAGCCTTACCTCGAGCGCA
AGGTACAGGCCCCGATCATCGTCACGTTTCATGCGCCGGCCGACCCGCGCTATGACTTCAAGACCTTCTATCAGGCCGTC
AAGCAGCGCGGCTACATCCTGTATCCGGGCAAGCTCACCGAAATCGAGACCTTCCGCGTGGGATGCATCGGCCATTTCGG
CGACGCGGGCATCCCCGGCGCGGTGAAGGCCATCGGCGAAGTCCTGGCGGGGATGGGCGTCGAGATCGGGATGACCGTTG
CCGCGTGA

Upstream 100 bases:

>100_bases
GCAGGGCTGGCGCGACCTGGCCCGCCACTGAGCGCCGCGATCCCGGAATACCGAGATACCGACAAGCCGACAGACCAGAA
CCCAACGTCAGGAGACACCC

Downstream 100 bases:

>100_bases
CGGTCGGCGCCTGCGCCATTGATTTGAGCTTGACTGACATGGCCAGGACACACCGGCGAAGCAGCCGATGCGATCCTGGC
CATTTTTTATTGGCACTGCG

Product: 2-aminoethylphosphonate--pyruvate transaminase

Products: NA

Alternate protein names: 2-aminoethylphosphonate aminotransferase 2; AEP transaminase 2; AEPT 2

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTATPYPILLTPGPLTTSDRTRAAMLRDWGSWDTDFNAITARIRQQVLAIVHGDDTHECVPLQGSGTFSVEAAIGTLVPR
DGHVLVPVNGAYCQRIAKICKTLGRRLSTIDYAEDRPMRAADIDRQLAADSTITHVAVVHCETGTGVLNPLDEIAQVVAR
HGRGLIVDAMSSFGAIDIDARTTPFDAVIAASGKCLEGVPGMGFVIARRTALERCEGNSHSLSLDLYDQWKYMERTTQWR
FTPPTHVVAALDQALQQYVEEGGLPARGARYASNCQLLVDGMETLGLKPYLERKVQAPIIVTFHAPADPRYDFKTFYQAV
KQRGYILYPGKLTEIETFRVGCIGHFGDAGIPGAVKAIGEVLAGMGVEIGMTVAA

Sequences:

>Translated_375_residues
MTATPYPILLTPGPLTTSDRTRAAMLRDWGSWDTDFNAITARIRQQVLAIVHGDDTHECVPLQGSGTFSVEAAIGTLVPR
DGHVLVPVNGAYCQRIAKICKTLGRRLSTIDYAEDRPMRAADIDRQLAADSTITHVAVVHCETGTGVLNPLDEIAQVVAR
HGRGLIVDAMSSFGAIDIDARTTPFDAVIAASGKCLEGVPGMGFVIARRTALERCEGNSHSLSLDLYDQWKYMERTTQWR
FTPPTHVVAALDQALQQYVEEGGLPARGARYASNCQLLVDGMETLGLKPYLERKVQAPIIVTFHAPADPRYDFKTFYQAV
KQRGYILYPGKLTEIETFRVGCIGHFGDAGIPGAVKAIGEVLAGMGVEIGMTVAA
>Mature_374_residues
TATPYPILLTPGPLTTSDRTRAAMLRDWGSWDTDFNAITARIRQQVLAIVHGDDTHECVPLQGSGTFSVEAAIGTLVPRD
GHVLVPVNGAYCQRIAKICKTLGRRLSTIDYAEDRPMRAADIDRQLAADSTITHVAVVHCETGTGVLNPLDEIAQVVARH
GRGLIVDAMSSFGAIDIDARTTPFDAVIAASGKCLEGVPGMGFVIARRTALERCEGNSHSLSLDLYDQWKYMERTTQWRF
TPPTHVVAALDQALQQYVEEGGLPARGARYASNCQLLVDGMETLGLKPYLERKVQAPIIVTFHAPADPRYDFKTFYQAVK
QRGYILYPGKLTEIETFRVGCIGHFGDAGIPGAVKAIGEVLAGMGVEIGMTVAA

Specific function: Involved in phosphonate degradation

COG id: COG0075

COG function: function code E; Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily

Homologues:

Organism=Homo sapiens, GI4557289, Length=352, Percent_Identity=23.8636363636364, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536281, Length=306, Percent_Identity=25.4901960784314, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHNW2_CUPPJ (Q46NS0)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_300058.1
- ProteinModelPortal:   Q46NS0
- SMR:   Q46NS0
- GeneID:   3614524
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B5871
- NMPDR:   fig|264198.3.peg.6519
- HOGENOM:   HBG423997
- OMA:   HSLAMDL
- ProtClustDB:   PRK13479
- BioCyc:   REUT264198:REUT_B5871-MONOMER
- HAMAP:   MF_01376
- InterPro:   IPR017688
- InterPro:   IPR000192
- InterPro:   IPR012703
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03301
- TIGRFAMs:   TIGR02326

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.37

Molecular weight: Translated: 40684; Mature: 40553

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATPYPILLTPGPLTTSDRTRAAMLRDWGSWDTDFNAITARIRQQVLAIVHGDDTHECV
CCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCEE
PLQGSGTFSVEAAIGTLVPRDGHVLVPVNGAYCQRIAKICKTLGRRLSTIDYAEDRPMRA
EECCCCCEEEEEHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
ADIDRQLAADSTITHVAVVHCETGTGVLNPLDEIAQVVARHGRGLIVDAMSSFGAIDIDA
HHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEHHHHCCEEEECC
RTTPFDAVIAASGKCLEGVPGMGFVIARRTALERCEGNSHSLSLDLYDQWKYMERTTQWR
CCCCCHHHEECCCCHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCEE
FTPPTHVVAALDQALQQYVEEGGLPARGARYASNCQLLVDGMETLGLKPYLERKVQAPII
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHCCCCHHHHHHCCCCEE
VTFHAPADPRYDFKTFYQAVKQRGYILYPGKLTEIETFRVGCIGHFGDAGIPGAVKAIGE
EEEECCCCCCCCHHHHHHHHHHCCEEEECCCCCEEEEEEEEEEECCCCCCCCHHHHHHHH
VLAGMGVEIGMTVAA
HHHCCCCEEEEEECC
>Mature Secondary Structure 
TATPYPILLTPGPLTTSDRTRAAMLRDWGSWDTDFNAITARIRQQVLAIVHGDDTHECV
CCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEECCCCCCEE
PLQGSGTFSVEAAIGTLVPRDGHVLVPVNGAYCQRIAKICKTLGRRLSTIDYAEDRPMRA
EECCCCCEEEEEHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
ADIDRQLAADSTITHVAVVHCETGTGVLNPLDEIAQVVARHGRGLIVDAMSSFGAIDIDA
HHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEHHHHCCEEEECC
RTTPFDAVIAASGKCLEGVPGMGFVIARRTALERCEGNSHSLSLDLYDQWKYMERTTQWR
CCCCCHHHEECCCCHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCEE
FTPPTHVVAALDQALQQYVEEGGLPARGARYASNCQLLVDGMETLGLKPYLERKVQAPII
ECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECHHHCCCCHHHHHHCCCCEE
VTFHAPADPRYDFKTFYQAVKQRGYILYPGKLTEIETFRVGCIGHFGDAGIPGAVKAIGE
EEEECCCCCCCCHHHHHHHHHHCCEEEECCCCCEEEEEEEEEEECCCCCCCCHHHHHHHH
VLAGMGVEIGMTVAA
HHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA