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The map label for this gene is ndh [H]

Identifier: 73538663

GI number: 73538663

Start: 1546071

End: 1547366

Strand: Direct

Name: ndh [H]

Synonym: Reut_B4838

Alternate gene names: 73538663

Gene position: 1546071-1547366 (Clockwise)

Preceding gene: 73538662

Following gene: 73538670

Centisome position: 56.71

GC content: 64.04

Gene sequence:

>1296_bases
ATGAAGACAATCGTCATTGCTGGCGGCGGAACCGCTGGCCTTCAACTCGCGGCCCGGCTGGGAAAGCAATTGGGCAAGCG
CGGCCTGGCGAAGATTGTCCTGGTGGACCGCTACAGGACACACCTCTGGAAGCCCCTGCTGCACGAAGTCGCCGCAGGAA
AGCTTGAGCCGTACATCCACCACACGTCATTCGCGCTCCAGGCGCGCCGCTACGGCTTTCGTTTCTTGCAGGGAGAGTTC
ACCTCACTGAATCGCGACAACCGCACACTGGCGATCACGACAGCCGGAAGCGATGGTGCCACGCACGTGACGGCGCTGGC
CTATGACACATTGGTGCTTGCGATTGGCGGCACCACCCAGTACTTCGGTGTCCCGGGGGCGAGGGAGCACGCGCTGGCGC
TGGATAGCGTACCCGGCGCCGAGTATGCGCGGACCCAGATCGTGGATGCGCTGCGCCGCGTGTCCTCGCAAGCGAAAGCA
GCCGACGGTCCCGCGCGAGCCAGCGTCGCCATTGTCGGCGCGGGCGCCACCGGCGTGCAACTGGCAGCCCAGGTGCGGCA
GATGTCGCGCGTGCTGAGCCAGTACGGCATTCATTCGCTCGATCCTGACCGCGGCACCGAGATACGCCTCGTCGAGGCTT
CCGGCAATATTCTTCCGGGCATGGATCATCGCCTCGCCGACAGGACGGCAGCTGAGTTGCAGGCGCAGGGTATCCAGATT
CTCCTTAACACGCGCGTCACCGAGGTCCGACCCGACTGCCTGCATATTGCAGGCGCGGACCCCGTTGCCGCGGACGTGAC
AATATGGACTGCCGGCGTTACCGTATCGCCGGTGTTGTCGAACATCGGCCTGCAGGTGACCCGCAACGGACGCGTTCGGG
TGGGAGACACGCTCCAGACCCTGGAAGACGAGCATATTTATGCCTTGGGCGATTGCGCGAGCTTCCGTCCGGCGGGCGAA
CTGGCAGAGCTTCCTACGCGAGCACAAGTCGCGCATCAGCAGGCCATTTACCTGGCCCGAGCCTTGCCCCGTGCGCTCGC
CGGAAAGCCCGTAGCCAGGTTCAAATTTCAAGATCGTGGCTCTGTCATCTCGTTGGCTGACGACATGGCGCTGTGCCATC
TGCTTGCGCCTGGCGCCAGCGATGGCTGGCAGGTACAAGGCGCGTTGGCGAAACTGGTGCACGCGGTCATCTATCGACGT
CACGTGCTGGCGATCCAGGGCTTTGCGCGAGCCGTCGCGATGACGCTGTCCCAGCGACTGGAGCGGTTGCTGGGTGCCGG
TTATCGGCTGGATTGA

Upstream 100 bases:

>100_bases
AAGGCGCACCGACCCAGCCGTCGCGCTACACGTCCCTAGGGACATTGGCCGCCCCGGCATGAGCCGTCGTGGGCACTACC
AACGCATAGAGGGGGATGGA

Downstream 100 bases:

>100_bases
AGCCCGGAACTTCGCGGCAAAGCGGAAAGCGCGTTGGAGACCAGCTTTTGGTGTTCTCCAACGCTACCTTGACTACCGCG
AGGTGTACGTCACTGTTCCA

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKTIVIAGGGTAGLQLAARLGKQLGKRGLAKIVLVDRYRTHLWKPLLHEVAAGKLEPYIHHTSFALQARRYGFRFLQGEF
TSLNRDNRTLAITTAGSDGATHVTALAYDTLVLAIGGTTQYFGVPGAREHALALDSVPGAEYARTQIVDALRRVSSQAKA
ADGPARASVAIVGAGATGVQLAAQVRQMSRVLSQYGIHSLDPDRGTEIRLVEASGNILPGMDHRLADRTAAELQAQGIQI
LLNTRVTEVRPDCLHIAGADPVAADVTIWTAGVTVSPVLSNIGLQVTRNGRVRVGDTLQTLEDEHIYALGDCASFRPAGE
LAELPTRAQVAHQQAIYLARALPRALAGKPVARFKFQDRGSVISLADDMALCHLLAPGASDGWQVQGALAKLVHAVIYRR
HVLAIQGFARAVAMTLSQRLERLLGAGYRLD

Sequences:

>Translated_431_residues
MKTIVIAGGGTAGLQLAARLGKQLGKRGLAKIVLVDRYRTHLWKPLLHEVAAGKLEPYIHHTSFALQARRYGFRFLQGEF
TSLNRDNRTLAITTAGSDGATHVTALAYDTLVLAIGGTTQYFGVPGAREHALALDSVPGAEYARTQIVDALRRVSSQAKA
ADGPARASVAIVGAGATGVQLAAQVRQMSRVLSQYGIHSLDPDRGTEIRLVEASGNILPGMDHRLADRTAAELQAQGIQI
LLNTRVTEVRPDCLHIAGADPVAADVTIWTAGVTVSPVLSNIGLQVTRNGRVRVGDTLQTLEDEHIYALGDCASFRPAGE
LAELPTRAQVAHQQAIYLARALPRALAGKPVARFKFQDRGSVISLADDMALCHLLAPGASDGWQVQGALAKLVHAVIYRR
HVLAIQGFARAVAMTLSQRLERLLGAGYRLD
>Mature_431_residues
MKTIVIAGGGTAGLQLAARLGKQLGKRGLAKIVLVDRYRTHLWKPLLHEVAAGKLEPYIHHTSFALQARRYGFRFLQGEF
TSLNRDNRTLAITTAGSDGATHVTALAYDTLVLAIGGTTQYFGVPGAREHALALDSVPGAEYARTQIVDALRRVSSQAKA
ADGPARASVAIVGAGATGVQLAAQVRQMSRVLSQYGIHSLDPDRGTEIRLVEASGNILPGMDHRLADRTAAELQAQGIQI
LLNTRVTEVRPDCLHIAGADPVAADVTIWTAGVTVSPVLSNIGLQVTRNGRVRVGDTLQTLEDEHIYALGDCASFRPAGE
LAELPTRAQVAHQQAIYLARALPRALAGKPVARFKFQDRGSVISLADDMALCHLLAPGASDGWQVQGALAKLVHAVIYRR
HVLAIQGFARAVAMTLSQRLERLLGAGYRLD

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=429, Percent_Identity=34.7319347319347, Blast_Score=250, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323794, Length=359, Percent_Identity=27.8551532033426, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320118, Length=359, Percent_Identity=26.1838440111421, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323515, Length=335, Percent_Identity=24.1791044776119, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 46087; Mature: 46087

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIVIAGGGTAGLQLAARLGKQLGKRGLAKIVLVDRYRTHLWKPLLHEVAAGKLEPYIH
CCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHH
HTSFALQARRYGFRFLQGEFTSLNRDNRTLAITTAGSDGATHVTALAYDTLVLAIGGTTQ
HHHHHHHHHHHCHHEECCHHHCCCCCCCEEEEEECCCCCCCEEHHEEEEEEEEEECCCEE
YFGVPGAREHALALDSVPGAEYARTQIVDALRRVSSQAKAADGPARASVAIVGAGATGVQ
ECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHH
LAAQVRQMSRVLSQYGIHSLDPDRGTEIRLVEASGNILPGMDHRLADRTAAELQAQGIQI
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEE
LLNTRVTEVRPDCLHIAGADPVAADVTIWTAGVTVSPVLSNIGLQVTRNGRVRVGDTLQT
EEECCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHCCEEEECCCCEEECCHHHH
LEDEHIYALGDCASFRPAGELAELPTRAQVAHQQAIYLARALPRALAGKPVARFKFQDRG
CCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
SVISLADDMALCHLLAPGASDGWQVQGALAKLVHAVIYRRHVLAIQGFARAVAMTLSQRL
CEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLLGAGYRLD
HHHHCCCCCCC
>Mature Secondary Structure
MKTIVIAGGGTAGLQLAARLGKQLGKRGLAKIVLVDRYRTHLWKPLLHEVAAGKLEPYIH
CCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHH
HTSFALQARRYGFRFLQGEFTSLNRDNRTLAITTAGSDGATHVTALAYDTLVLAIGGTTQ
HHHHHHHHHHHCHHEECCHHHCCCCCCCEEEEEECCCCCCCEEHHEEEEEEEEEECCCEE
YFGVPGAREHALALDSVPGAEYARTQIVDALRRVSSQAKAADGPARASVAIVGAGATGVQ
ECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHH
LAAQVRQMSRVLSQYGIHSLDPDRGTEIRLVEASGNILPGMDHRLADRTAAELQAQGIQI
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEE
LLNTRVTEVRPDCLHIAGADPVAADVTIWTAGVTVSPVLSNIGLQVTRNGRVRVGDTLQT
EEECCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHCCEEEECCCCEEECCHHHH
LEDEHIYALGDCASFRPAGELAELPTRAQVAHQQAIYLARALPRALAGKPVARFKFQDRG
CCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
SVISLADDMALCHLLAPGASDGWQVQGALAKLVHAVIYRRHVLAIQGFARAVAMTLSQRL
CEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLLGAGYRLD
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]