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The map label for this gene is dxs [C]

Identifier: 73538603

GI number: 73538603

Start: 1478172

End: 1479170

Strand: Direct

Name: dxs [C]

Synonym: Reut_B4778

Alternate gene names: 73538603

Gene position: 1478172-1479170 (Clockwise)

Preceding gene: 73538602

Following gene: 73538617

Centisome position: 54.22

GC content: 64.96

Gene sequence:

>999_bases
ATGAGCAGCAACAATGGCAAGCCGAAGCTGAAGACCTCGGCAATGATCGCCTCGATCGCCGGTGAAGGACAGGCGACACG
TTCGGCCCCGTTCGGCCACGCGCTGGTGGAACTCGCAAAGCAGAAGTCCAACGTGATCGGCATGACTGCCGACCTCGGCA
AATACACCGACCTGCATATCCTGGCGCAGGCATTCCCCGAGCGCTACTACCAGATGGGCATGGCCGAGCAGCTGCTGATG
GGCGCGGCCGCGGGCTTCGCGCATGAAGGCGCGCAACCGTTCGTGACCACGTACGCGGTGTTCGCCACGCGCCGTGCCTA
TGACTTCATGCACCAGACCATCGCCGAGGACAACCTCGACGTGAAGATCGTCTGCGCGCTGCCGGGCCTCACCACGGGCT
ACGGACCGAGCCATCAGGCCGCCGAAGACCTGGCGCTCATGCGCGCCATGCCCAACATGACGGTGATCGACCCGTGCGAC
GCCACCGACATCGAGCAGATGGTTCCCGCCATCGCGGCCCATGCGGGCCCGGTGTACGCGCGGTTGCTGCGCGGCAATGT
GCCGGTGGTACTCGACGAGTACGACTACAAGTTCGAGCTCGGCAAGGCAAAACTGCTGCGCGACGGCGCCGATGTGCTCG
TGATCTCGTCGGGCATCATGACCATGCGGGCGCTTGAAGTGGCCAAGGCACTCGAGAAGGATCGCGTCGGCGTGGCGGTG
CTGCATGTGCCGACGATCAAGCCGCTCGACACCGAGACCATCGTGCGCGAAGCCAGGCGTTCAGGCCGGCTGGTCGTGGT
CGCGGAGAACCATACCGTGATCGGCGGCCTCGGCGAAGCCGTCGCGACCGCGCTGATGCAAGCGGGCGTGCATCCGCCGT
TCCGTCAGGTGGCGCTGCCTGACCTGTTCCTCGATGCCGGCGCCCTGCCCACGCTGCATGACCGCTATGGCATCTCGACA
CAAGTCATGGCGGCAAACATCAAAGGCTGGCTGGTGTAA

Upstream 100 bases:

>100_bases
GCGTGCCGTTCCTCGAACAACGCGAAAAGAATCACTTCATCCGGGTCGATGCCCACGAATGGCAACTCGCCCTGCAGGCT
CTCGAAGCCGGGAGACAAGC

Downstream 100 bases:

>100_bases
CCGGCCGCGTGGTGGCGCGCCGCACTCACGCGCGGCGCGCCACCATGCATGTCGCCGTGGCCGTCGCCACCAGCTTGCCG
TCCTGGCTCAGTTCGCCCAC

Product: transketolase subunit B

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSSNNGKPKLKTSAMIASIAGEGQATRSAPFGHALVELAKQKSNVIGMTADLGKYTDLHILAQAFPERYYQMGMAEQLLM
GAAAGFAHEGAQPFVTTYAVFATRRAYDFMHQTIAEDNLDVKIVCALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCD
ATDIEQMVPAIAAHAGPVYARLLRGNVPVVLDEYDYKFELGKAKLLRDGADVLVISSGIMTMRALEVAKALEKDRVGVAV
LHVPTIKPLDTETIVREARRSGRLVVVAENHTVIGGLGEAVATALMQAGVHPPFRQVALPDLFLDAGALPTLHDRYGIST
QVMAANIKGWLV

Sequences:

>Translated_332_residues
MSSNNGKPKLKTSAMIASIAGEGQATRSAPFGHALVELAKQKSNVIGMTADLGKYTDLHILAQAFPERYYQMGMAEQLLM
GAAAGFAHEGAQPFVTTYAVFATRRAYDFMHQTIAEDNLDVKIVCALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCD
ATDIEQMVPAIAAHAGPVYARLLRGNVPVVLDEYDYKFELGKAKLLRDGADVLVISSGIMTMRALEVAKALEKDRVGVAV
LHVPTIKPLDTETIVREARRSGRLVVVAENHTVIGGLGEAVATALMQAGVHPPFRQVALPDLFLDAGALPTLHDRYGIST
QVMAANIKGWLV
>Mature_331_residues
SSNNGKPKLKTSAMIASIAGEGQATRSAPFGHALVELAKQKSNVIGMTADLGKYTDLHILAQAFPERYYQMGMAEQLLMG
AAAGFAHEGAQPFVTTYAVFATRRAYDFMHQTIAEDNLDVKIVCALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCDA
TDIEQMVPAIAAHAGPVYARLLRGNVPVVLDEYDYKFELGKAKLLRDGADVLVISSGIMTMRALEVAKALEKDRVGVAVL
HVPTIKPLDTETIVREARRSGRLVVVAENHTVIGGLGEAVATALMQAGVHPPFRQVALPDLFLDAGALPTLHDRYGISTQ
VMAANIKGWLV

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=270, Percent_Identity=32.2222222222222, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4507521, Length=270, Percent_Identity=32.2222222222222, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI225637459, Length=318, Percent_Identity=33.0188679245283, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI225637461, Length=318, Percent_Identity=33.0188679245283, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI225637463, Length=318, Percent_Identity=33.0188679245283, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI133778974, Length=331, Percent_Identity=30.2114803625378, Blast_Score=118, Evalue=8e-27,
Organism=Escherichia coli, GI1786622, Length=326, Percent_Identity=30.0613496932515, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17539652, Length=315, Percent_Identity=33.968253968254, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24645119, Length=281, Percent_Identity=34.8754448398576, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45551847, Length=281, Percent_Identity=34.8754448398576, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45550715, Length=281, Percent_Identity=34.8754448398576, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24666278, Length=309, Percent_Identity=32.0388349514563, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 35591; Mature: 35460

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNGKPKLKTSAMIASIAGEGQATRSAPFGHALVELAKQKSNVIGMTADLGKYTDLHI
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
LAQAFPERYYQMGMAEQLLMGAAAGFAHEGAQPFVTTYAVFATRRAYDFMHQTIAEDNLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VKIVCALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCDATDIEQMVPAIAAHAGPVYA
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCHHHH
RLLRGNVPVVLDEYDYKFELGKAKLLRDGADVLVISSGIMTMRALEVAKALEKDRVGVAV
HHHCCCCCEEECCCCCEEECCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEE
LHVPTIKPLDTETIVREARRSGRLVVVAENHTVIGGLGEAVATALMQAGVHPPFRQVALP
EEECCCCCCCHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHHHCCCCCHHHHCCC
DLFLDAGALPTLHDRYGISTQVMAANIKGWLV
HHHHCCCCCCCCHHHCCCCCEEEEECCCEECC
>Mature Secondary Structure 
SSNNGKPKLKTSAMIASIAGEGQATRSAPFGHALVELAKQKSNVIGMTADLGKYTDLHI
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
LAQAFPERYYQMGMAEQLLMGAAAGFAHEGAQPFVTTYAVFATRRAYDFMHQTIAEDNLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VKIVCALPGLTTGYGPSHQAAEDLALMRAMPNMTVIDPCDATDIEQMVPAIAAHAGPVYA
EEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCHHHH
RLLRGNVPVVLDEYDYKFELGKAKLLRDGADVLVISSGIMTMRALEVAKALEKDRVGVAV
HHHCCCCCEEECCCCCEEECCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEE
LHVPTIKPLDTETIVREARRSGRLVVVAENHTVIGGLGEAVATALMQAGVHPPFRQVALP
EEECCCCCCCHHHHHHHHHHCCCEEEEECCCEEECCHHHHHHHHHHHHCCCCCHHHHCCC
DLFLDAGALPTLHDRYGISTQVMAANIKGWLV
HHHHCCCCCCCCHHHCCCCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]