BacMap

Definition	Ralstonia eutropha JMP134 chromosome chromosome 2, complete sequence.
Accession	NC_007348
Length	2,726,152

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The map label for this gene is ccmA

Identifier: 73538591

GI number: 73538591

Start: 1466934

End: 1467614

Strand: Direct

Name: ccmA

Synonym: Reut_B4766

Alternate gene names: 73538591

Gene position: 1466934-1467614 (Clockwise)

Preceding gene: 73538590

Following gene: 73538592

Centisome position: 53.81

GC content: 68.14

Gene sequence:

>681_bases
GTGCCGACTCCCTCTTCCGGGCTCTCCTGTAATGGCGTTGCCGTTGGCCCGGTGCTGCGGGCCAACGATCTTGCGTTTTC
TCGTGGGGGGCGCCCTGTCTTTACCGGCATCGACTTCAGCGTCAGCGCAGGCGGCGTGATACAGGTCGTGGGCCCGAACG
GCAGCGGCAAGTCGTCGCTGCTGCGCGTGCTGAGCGGACTGCTGCAACCGGCTAGCGGCAGCGTGAGCTGGCTCGGCAAA
TGCGTTCGCGCAGGCGATCCGGCCTACCTGCAGTCGCTCGCCTACGTCGGCCATGCTGACGGCATCGATACCGACCTGAC
TGCGGACGAACACCTGCGCTACGCTGCGCGGCTCACTGGCCTGCACGCGACGAACGAGACCGTGCGCGTGGCGCTCGCGC
GGCTTGGCATCGCAAAGACCATGCATGTCCCAATACGGACGCTTTCGCAAGGCCAGCGCCGCCGCGTCGCGCTGGCGCGG
CTGGCGTTGGTCTGGCGTGCGTTGTGGCTGCTCGACGAACCGCTCACCTCGCTCGATGACGAATCGGCCGCCTGCTTTCA
CGACCTGCTTGACGAGCACCTCCGCGACGGCGGCATGGCGGTGATCGCCACGCACCGGCTGTTGCCCGGCGGCGGGGAAG
TACTGCAACTTGGCGGCGCGCATGCGCTGCCCCCCGCCTGA

Upstream 100 bases:

>100_bases
TTCGACCTATCTGGAAAACAAGGAAAAGACCTGCATCGATTGCCACAAGGGCATTGCCCACCACCTGCCCGACGTGTCGA
AAGCCGGGGAACAGTAGCGC

Downstream 100 bases:

>100_bases
TCGCGCCATGCTCGCAACCCTTGGCGCCATCGTCATGCACGACCTGTCGCTCGCCTGGCGGCGGCGCGGCAGCCTGCTCG
GCAGCGTGGTGTTCTTCGTC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPTPSSGLSCNGVAVGPVLRANDLAFSRGGRPVFTGIDFSVSAGGVIQVVGPNGSGKSSLLRVLSGLLQPASGSVSWLGK
CVRAGDPAYLQSLAYVGHADGIDTDLTADEHLRYAARLTGLHATNETVRVALARLGIAKTMHVPIRTLSQGQRRRVALAR
LALVWRALWLLDEPLTSLDDESAACFHDLLDEHLRDGGMAVIATHRLLPGGGEVLQLGGAHALPPA

Sequences:

>Translated_226_residues
MPTPSSGLSCNGVAVGPVLRANDLAFSRGGRPVFTGIDFSVSAGGVIQVVGPNGSGKSSLLRVLSGLLQPASGSVSWLGK
CVRAGDPAYLQSLAYVGHADGIDTDLTADEHLRYAARLTGLHATNETVRVALARLGIAKTMHVPIRTLSQGQRRRVALAR
LALVWRALWLLDEPLTSLDDESAACFHDLLDEHLRDGGMAVIATHRLLPGGGEVLQLGGAHALPPA
>Mature_225_residues
PTPSSGLSCNGVAVGPVLRANDLAFSRGGRPVFTGIDFSVSAGGVIQVVGPNGSGKSSLLRVLSGLLQPASGSVSWLGKC
VRAGDPAYLQSLAYVGHADGIDTDLTADEHLRYAARLTGLHATNETVRVALARLGIAKTMHVPIRTLSQGQRRRVALARL
ALVWRALWLLDEPLTSLDDESAACFHDLLDEHLRDGGMAVIATHRLLPGGGEVLQLGGAHALPPA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI171184400, Length=216, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI150417984, Length=199, Percent_Identity=30.1507537688442, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI27436953, Length=147, Percent_Identity=34.6938775510204, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI47078218, Length=169, Percent_Identity=29.585798816568, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI153792144, Length=159, Percent_Identity=28.3018867924528, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI45446740, Length=169, Percent_Identity=29.585798816568, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI42741659, Length=188, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21536376, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI27477115, Length=186, Percent_Identity=27.4193548387097, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI105990541, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI27881501, Length=175, Percent_Identity=28, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI30795238, Length=175, Percent_Identity=28, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI9961250, Length=202, Percent_Identity=27.7227722772277, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4505771, Length=202, Percent_Identity=27.7227722772277, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI89111135, Length=201, Percent_Identity=31.3432835820896, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI9961252, Length=202, Percent_Identity=27.7227722772277, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI10947137, Length=190, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI27881506, Length=190, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI6005701, Length=159, Percent_Identity=30.8176100628931, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI27262624, Length=165, Percent_Identity=28.4848484848485, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27262626, Length=165, Percent_Identity=28.4848484848485, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI116734710, Length=173, Percent_Identity=28.3236994219653, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=191, Percent_Identity=38.7434554973822, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1788165, Length=203, Percent_Identity=31.5270935960591, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787029, Length=187, Percent_Identity=30.4812834224599, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786698, Length=193, Percent_Identity=25.3886010362694, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI2367384, Length=190, Percent_Identity=31.0526315789474, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87081782, Length=192, Percent_Identity=26.0416666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081791, Length=196, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790467, Length=149, Percent_Identity=30.2013422818792, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI48994943, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787041, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787105, Length=185, Percent_Identity=31.3513513513514, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=184, Percent_Identity=33.1521739130435, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790739, Length=199, Percent_Identity=30.6532663316583, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786563, Length=191, Percent_Identity=27.2251308900524, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786803, Length=192, Percent_Identity=30.2083333333333, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI48995001, Length=199, Percent_Identity=27.1356783919598, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=26.5060240963855, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87081834, Length=185, Percent_Identity=34.5945945945946, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI87082267, Length=153, Percent_Identity=30.0653594771242, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789873, Length=184, Percent_Identity=28.2608695652174, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786319, Length=181, Percent_Identity=27.6243093922652, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=192, Percent_Identity=34.8958333333333, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17511077, Length=201, Percent_Identity=29.3532338308458, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=177, Percent_Identity=25.4237288135593, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533592, Length=205, Percent_Identity=28.780487804878, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=191, Percent_Identity=28.7958115183246, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992290, Length=192, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567265, Length=188, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=213, Percent_Identity=30.5164319248826, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320874, Length=198, Percent_Identity=33.8383838383838, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324498, Length=197, Percent_Identity=27.9187817258883, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641342, Length=191, Percent_Identity=31.413612565445, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24642252, Length=198, Percent_Identity=32.3232323232323, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI18859989, Length=198, Percent_Identity=32.3232323232323, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221500365, Length=201, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI116007184, Length=201, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574744, Length=219, Percent_Identity=29.2237442922374, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19920532, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24580930, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574150, Length=159, Percent_Identity=27.6729559748428, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007328, Length=159, Percent_Identity=27.6729559748428, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077321, Length=208, Percent_Identity=29.8076923076923, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574533, Length=189, Percent_Identity=26.4550264550265, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_CUPPJ (Q46RX0)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_298958.1
- ProteinModelPortal:   Q46RX0
- SMR:   Q46RX0
- GeneID:   3613322
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B4766
- NMPDR:   fig|264198.3.peg.5699
- HOGENOM:   HBG758042
- OMA:   ACDEERT
- ProtClustDB:   PRK13538
- BioCyc:   REUT264198:REUT_B4766-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23618; Mature: 23487

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPSSGLSCNGVAVGPVLRANDLAFSRGGRPVFTGIDFSVSAGGVIQVVGPNGSGKSSL
CCCCCCCCCCCCEEECCEEECCCCEECCCCCEEEECCCEEECCCCEEEEECCCCCCHHHH
LRVLSGLLQPASGSVSWLGKCVRAGDPAYLQSLAYVGHADGIDTDLTADEHLRYAARLTG
HHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
LHATNETVRVALARLGIAKTMHVPIRTLSQGQRRRVALARLALVWRALWLLDEPLTSLDD
CCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ESAACFHDLLDEHLRDGGMAVIATHRLLPGGGEVLQLGGAHALPPA
CHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
PTPSSGLSCNGVAVGPVLRANDLAFSRGGRPVFTGIDFSVSAGGVIQVVGPNGSGKSSL
CCCCCCCCCCCEEECCEEECCCCEECCCCCEEEECCCEEECCCCEEEEECCCCCCHHHH
LRVLSGLLQPASGSVSWLGKCVRAGDPAYLQSLAYVGHADGIDTDLTADEHLRYAARLTG
HHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHC
LHATNETVRVALARLGIAKTMHVPIRTLSQGQRRRVALARLALVWRALWLLDEPLTSLDD
CCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ESAACFHDLLDEHLRDGGMAVIATHRLLPGGGEVLQLGGAHALPPA
CHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA