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The map label for this gene is mmgC [H]

Identifier: 73538578

GI number: 73538578

Start: 1453069

End: 1454217

Strand: Reverse

Name: mmgC [H]

Synonym: Reut_B4753

Alternate gene names: 73538578

Gene position: 1454217-1453069 (Counterclockwise)

Preceding gene: 73538579

Following gene: 73538577

Centisome position: 53.34

GC content: 62.05

Gene sequence:

>1149_bases
ATGGCATTCAATCAACGTCCCTGGATTACTGACGACCTGGCGATGTTCCAGGACGGCATCCGCAAGTTCATCGAACGCGA
GCTGGTTCCGCACGAGGATCGCTGGTGGAAGCAGCAGCACGTCGACCGCGAGATCTGGCGCAAGGCTGGCGAGATGGGCA
TGTTGTGTGCGAGCATTCCCGAGGAATACGGCGGTGGCGGCGGCAACTTCGCGCATGAAGCAGTCATCACGCTCGAGCAG
TCCCGGGCGGGCGTCAGCAGCCTTGGCACTAACGTCCACAGCGGCATCGTCGCGCATTACATCCTGCGTTATGGCACCGA
GGCGCAGAAGCAGAACTGGCTGCCGAAGATGGCCAGCGGCGAAATAGTCGCGGCCATTGCCATGTCGGAGCCCGGTGCGG
GATCGGACCTCAAGAGCATCAAGGCGCGCGCCGTCCGCGACGGCGACCAGTATGTGCTGAACGGCTCGAAGACCTTCATC
ACCAATGGCTTTCTGGCCGACCTGATCCTGGTGGTCTGCAAGACCGATCCGGACAAGGGTGCAAAAGGCGTGTCGATCGT
CGTGGTCGAGACCGAGAACCTGCCGGGCTTCCGCCGCGGCCGCATCCTTGAAAAGATCGGCCAGAAGGGTCAGGACACAG
CCGAGCTGTTCTTCGACGACGTGCGCGTGCCCTGCACGAACCTGCTGGGCACGGAAGAAGGCAAAGGCTTCTACCAGCTC
ATGCAGCAGCTTCCGCAGGAGCGCATGATCATCGCGCTGGGCGCGTTGTCTGCGATGGAACGCGCGGTGGAACTGACCAC
CGACTACGTGCGCGAACGCAAAGTGTTTGGCGCGACGCTGCTCGACATGCAGAACACCCGCTTCAAGCTGGCGGAGTGCA
AGACCAAGGCTGTCATCGCGGGCGCATTTGTCGACGACTGCATGGCCAAGGTCCTGCGCGACGAGCTCGATCCCGAGACC
GCCGCCATGGCGAAGTGGTGGGGCACGCAGACGAGCTGCGAAATCATCGATGAATGCCTGCAGCTCCATGGCGGCTACGG
CTACATGATGGAGTACCCGATCGCGCGCATGTACGTGAACGCACGCGTGGGCAAGATCTACGGCGGCTCGAACGAGATCA
TGAAGGAGATCATCGCGCGCACGCTCTGA

Upstream 100 bases:

>100_bases
GGGTTCTGTGTACCTGCTGTGCATCCCCGAGTCGAACTACATCACCGGCCAGGTGCTGATCTGCGGCGGCGGCCGTCCCT
GATCGAAGCGGAGCAAGAGC

Downstream 100 bases:

>100_bases
CCTTAGCGGCACCGCAGGACCATGGCTGCATGACCAGGCCCGCCAGAGGCCGGCTGCAGCCGCGAATCGGTAGAACCAAT
GAAAAATGGAGACAGCAAGA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAFNQRPWITDDLAMFQDGIRKFIERELVPHEDRWWKQQHVDREIWRKAGEMGMLCASIPEEYGGGGGNFAHEAVITLEQ
SRAGVSSLGTNVHSGIVAHYILRYGTEAQKQNWLPKMASGEIVAAIAMSEPGAGSDLKSIKARAVRDGDQYVLNGSKTFI
TNGFLADLILVVCKTDPDKGAKGVSIVVVETENLPGFRRGRILEKIGQKGQDTAELFFDDVRVPCTNLLGTEEGKGFYQL
MQQLPQERMIIALGALSAMERAVELTTDYVRERKVFGATLLDMQNTRFKLAECKTKAVIAGAFVDDCMAKVLRDELDPET
AAMAKWWGTQTSCEIIDECLQLHGGYGYMMEYPIARMYVNARVGKIYGGSNEIMKEIIARTL

Sequences:

>Translated_382_residues
MAFNQRPWITDDLAMFQDGIRKFIERELVPHEDRWWKQQHVDREIWRKAGEMGMLCASIPEEYGGGGGNFAHEAVITLEQ
SRAGVSSLGTNVHSGIVAHYILRYGTEAQKQNWLPKMASGEIVAAIAMSEPGAGSDLKSIKARAVRDGDQYVLNGSKTFI
TNGFLADLILVVCKTDPDKGAKGVSIVVVETENLPGFRRGRILEKIGQKGQDTAELFFDDVRVPCTNLLGTEEGKGFYQL
MQQLPQERMIIALGALSAMERAVELTTDYVRERKVFGATLLDMQNTRFKLAECKTKAVIAGAFVDDCMAKVLRDELDPET
AAMAKWWGTQTSCEIIDECLQLHGGYGYMMEYPIARMYVNARVGKIYGGSNEIMKEIIARTL
>Mature_381_residues
AFNQRPWITDDLAMFQDGIRKFIERELVPHEDRWWKQQHVDREIWRKAGEMGMLCASIPEEYGGGGGNFAHEAVITLEQS
RAGVSSLGTNVHSGIVAHYILRYGTEAQKQNWLPKMASGEIVAAIAMSEPGAGSDLKSIKARAVRDGDQYVLNGSKTFIT
NGFLADLILVVCKTDPDKGAKGVSIVVVETENLPGFRRGRILEKIGQKGQDTAELFFDDVRVPCTNLLGTEEGKGFYQLM
QQLPQERMIIALGALSAMERAVELTTDYVRERKVFGATLLDMQNTRFKLAECKTKAVIAGAFVDDCMAKVLRDELDPETA
AMAKWWGTQTSCEIIDECLQLHGGYGYMMEYPIARMYVNARVGKIYGGSNEIMKEIIARTL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=48.3783783783784, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=31.9480519480519, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=33.5276967930029, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=35.230352303523, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI7656849, Length=371, Percent_Identity=34.2318059299191, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=31.5649867374005, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=31.5649867374005, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=28.5333333333333, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=32.9842931937173, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=32.9842931937173, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI21361497, Length=384, Percent_Identity=31.7708333333333, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=27.9683377308707, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=28.021978021978, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI48976061, Length=400, Percent_Identity=26, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI211971008, Length=400, Percent_Identity=26, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI38505218, Length=291, Percent_Identity=27.4914089347079, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=27.6762402088773, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=28.051948051948, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081702, Length=359, Percent_Identity=24.5125348189415, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=35.0132625994695, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=34.4262295081967, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=32.8042328042328, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17551932, Length=370, Percent_Identity=32.4324324324324, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=31.5649867374005, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=31.0991957104558, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=32.258064516129, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=380, Percent_Identity=30, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17508101, Length=363, Percent_Identity=30.5785123966942, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71985184, Length=377, Percent_Identity=32.3607427055703, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=33.9222614840989, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=35.3146853146853, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=33.0396475770925, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=265, Percent_Identity=29.0566037735849, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=27.0618556701031, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.2096219931272, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=27.1966527196653, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355753, Length=368, Percent_Identity=35.054347826087, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=33.3333333333333, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=29.5514511873351, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.1587301587302, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646207, Length=379, Percent_Identity=32.4538258575198, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=33.0459770114943, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=29.0155440414508, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42533; Mature: 42402

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNQRPWITDDLAMFQDGIRKFIERELVPHEDRWWKQQHVDREIWRKAGEMGMLCASIP
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHCHHHHHCC
EEYGGGGGNFAHEAVITLEQSRAGVSSLGTNVHSGIVAHYILRYGTEAQKQNWLPKMASG
HHHCCCCCCCHHHHHEEEHHHHCCHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
EIVAAIAMSEPGAGSDLKSIKARAVRDGDQYVLNGSKTFITNGFLADLILVVCKTDPDKG
CEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHHHCCCCCCC
AKGVSIVVVETENLPGFRRGRILEKIGQKGQDTAELFFDDVRVPCTNLLGTEEGKGFYQL
CCCEEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHCCCCCCCHHHHH
MQQLPQERMIIALGALSAMERAVELTTDYVRERKVFGATLLDMQNTRFKLAECKTKAVIA
HHHCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GAFVDDCMAKVLRDELDPETAAMAKWWGTQTSCEIIDECLQLHGGYGYMMEYPIARMYVN
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHH
ARVGKIYGGSNEIMKEIIARTL
HHHEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
AFNQRPWITDDLAMFQDGIRKFIERELVPHEDRWWKQQHVDREIWRKAGEMGMLCASIP
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHCHHHHHCC
EEYGGGGGNFAHEAVITLEQSRAGVSSLGTNVHSGIVAHYILRYGTEAQKQNWLPKMASG
HHHCCCCCCCHHHHHEEEHHHHCCHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
EIVAAIAMSEPGAGSDLKSIKARAVRDGDQYVLNGSKTFITNGFLADLILVVCKTDPDKG
CEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHHHCCCCCCC
AKGVSIVVVETENLPGFRRGRILEKIGQKGQDTAELFFDDVRVPCTNLLGTEEGKGFYQL
CCCEEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHCCCCCCCHHHHH
MQQLPQERMIIALGALSAMERAVELTTDYVRERKVFGATLLDMQNTRFKLAECKTKAVIA
HHHCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GAFVDDCMAKVLRDELDPETAAMAKWWGTQTSCEIIDECLQLHGGYGYMMEYPIARMYVN
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHH
ARVGKIYGGSNEIMKEIIARTL
HHHEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]