Click here to switch to the map view.

The map label for this gene is ykpB [H]

Identifier: 73538562

GI number: 73538562

Start: 1436326

End: 1437258

Strand: Reverse

Name: ykpB [H]

Synonym: Reut_B4737

Alternate gene names: 73538562

Gene position: 1437258-1436326 (Counterclockwise)

Preceding gene: 73538563

Following gene: 73538556

Centisome position: 52.72

GC content: 66.02

Gene sequence:

>933_bases
ATGAAGATACTTGTGCTGGGCGCGGGCGCCATGGGCGGTTACTATGGCGCGCGCCTGATCGAGGCCGGCGCGGACGTCAC
GTTCCTTGTGCGCGCGGGACGTGCCCGGGCGCTGGCGGAACACGGGCTGGTCGTGCGCAGCGCGCTTGGTGATTTCAGGC
GCGCCGTGAAGACCGTGCAGGCGGGCGCAGTCAGGCCCGAGTACAACCTCGTGCTCATGGCGTGCAAGGCCTATGACCTC
GAAGACGCCATGCTCGCAATCGCGCCGGCCGTCGGCAGCGACACGGCCATCCTGCCGCTGCTCAATGGAATGTCCGCCTA
TGACCAGCTCGACGCGCGCTTCGGCGGGAAGCGCGTGCTTGGTGGTGTGTCATACATTGCGACGACGCTTGCGGATGACG
GAACCATCGCTCACGCCGGCAGCAACGACCGGCTGATGGTGGGCGCGCGCGCACCCGAAACGCATGATATTGCCAGGGCG
CTCCACGAGCAGTTTTCCCGCTCGGCGGGCACGCGCGAACTGTCATCCGATATCGTCCAGGAGCTCTGGAACAAATGGGC
GATGATCGCCGCCGGCGCGTTGATGACCTGCCTGATGCGCGGCAACGTCGGACAGATCATGCGGACGCGCGACGGCCGGA
GCCTGACGTTGCAGGCGATTGCGGAGTGCGGGGCTGTCGCGGCACTGAGCGGCTTTCCGCTTCCAGAGGCGGTCGCCAAT
GCCGTGAAGAGCCGCCTGCTCGATGAATCGTCGACCTGGGCCGCCTCGATGATGCGCGATATCGCACAAGGCAGGCGCCA
GATTGAGGCCGATGCGATTGTTGGGGATCTCGTCGCGCGTGCGGCCGTGCTCGGGCATGAGGTGCCGTTGAGCCGCATGG
CTTATTGCCACCTTCAGGTCTATCAAGGCCAGCGCGCTGCGGAACGGGTCTGA

Upstream 100 bases:

>100_bases
TGCAGTCGGACGGCATCCGGCGCGGCATTGTCACGCTCTGCATTGGCGGCGGGCAGGGCATTGCGCTTGCCATCGAATCT
CTCTGAACAGACGAGACCTT

Downstream 100 bases:

>100_bases
GCCACGTGTGACGACGGCGGGTACGACCTGGCACTTGCCAGCGGCTCGTCCCCCCGTATCGCACTAATCTTCCTTCTTTT
CCTCGCGCATTGCCCGCGGC

Product: ketopantoate reductase ApbA/PanE

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKILVLGAGAMGGYYGARLIEAGADVTFLVRAGRARALAEHGLVVRSALGDFRRAVKTVQAGAVRPEYNLVLMACKAYDL
EDAMLAIAPAVGSDTAILPLLNGMSAYDQLDARFGGKRVLGGVSYIATTLADDGTIAHAGSNDRLMVGARAPETHDIARA
LHEQFSRSAGTRELSSDIVQELWNKWAMIAAGALMTCLMRGNVGQIMRTRDGRSLTLQAIAECGAVAALSGFPLPEAVAN
AVKSRLLDESSTWAASMMRDIAQGRRQIEADAIVGDLVARAAVLGHEVPLSRMAYCHLQVYQGQRAAERV

Sequences:

>Translated_310_residues
MKILVLGAGAMGGYYGARLIEAGADVTFLVRAGRARALAEHGLVVRSALGDFRRAVKTVQAGAVRPEYNLVLMACKAYDL
EDAMLAIAPAVGSDTAILPLLNGMSAYDQLDARFGGKRVLGGVSYIATTLADDGTIAHAGSNDRLMVGARAPETHDIARA
LHEQFSRSAGTRELSSDIVQELWNKWAMIAAGALMTCLMRGNVGQIMRTRDGRSLTLQAIAECGAVAALSGFPLPEAVAN
AVKSRLLDESSTWAASMMRDIAQGRRQIEADAIVGDLVARAAVLGHEVPLSRMAYCHLQVYQGQRAAERV
>Mature_310_residues
MKILVLGAGAMGGYYGARLIEAGADVTFLVRAGRARALAEHGLVVRSALGDFRRAVKTVQAGAVRPEYNLVLMACKAYDL
EDAMLAIAPAVGSDTAILPLLNGMSAYDQLDARFGGKRVLGGVSYIATTLADDGTIAHAGSNDRLMVGARAPETHDIARA
LHEQFSRSAGTRELSSDIVQELWNKWAMIAAGALMTCLMRGNVGQIMRTRDGRSLTLQAIAECGAVAALSGFPLPEAVAN
AVKSRLLDESSTWAASMMRDIAQGRRQIEADAIVGDLVARAAVLGHEVPLSRMAYCHLQVYQGQRAAERV

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 32937; Mature: 32937

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVLGAGAMGGYYGARLIEAGADVTFLVRAGRARALAEHGLVVRSALGDFRRAVKTVQ
CEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGAVRPEYNLVLMACKAYDLEDAMLAIAPAVGSDTAILPLLNGMSAYDQLDARFGGKRVL
HCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHCCCHHHH
GGVSYIATTLADDGTIAHAGSNDRLMVGARAPETHDIARALHEQFSRSAGTRELSSDIVQ
HHHHHHHHHHCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELWNKWAMIAAGALMTCLMRGNVGQIMRTRDGRSLTLQAIAECGAVAALSGFPLPEAVAN
HHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEHHHHHHHCCHHHHHCCCCCHHHHHH
AVKSRLLDESSTWAASMMRDIAQGRRQIEADAIVGDLVARAAVLGHEVPLSRMAYCHLQV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YQGQRAAERV
HCCCHHHHCC
>Mature Secondary Structure
MKILVLGAGAMGGYYGARLIEAGADVTFLVRAGRARALAEHGLVVRSALGDFRRAVKTVQ
CEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGAVRPEYNLVLMACKAYDLEDAMLAIAPAVGSDTAILPLLNGMSAYDQLDARFGGKRVL
HCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHCCCHHHH
GGVSYIATTLADDGTIAHAGSNDRLMVGARAPETHDIARALHEQFSRSAGTRELSSDIVQ
HHHHHHHHHHCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELWNKWAMIAAGALMTCLMRGNVGQIMRTRDGRSLTLQAIAECGAVAALSGFPLPEAVAN
HHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEHHHHHHHCCHHHHHCCCCCHHHHHH
AVKSRLLDESSTWAASMMRDIAQGRRQIEADAIVGDLVARAAVLGHEVPLSRMAYCHLQV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YQGQRAAERV
HCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]