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The map label for this gene is ccrA [H]

Identifier: 73538047

GI number: 73538047

Start: 857260

End: 858219

Strand: Direct

Name: ccrA [H]

Synonym: Reut_B4217

Alternate gene names: 73538047

Gene position: 857260-858219 (Clockwise)

Preceding gene: 73538044

Following gene: 73538048

Centisome position: 31.45

GC content: 65.0

Gene sequence:

>960_bases
ATGAGCAAGGCATTCGCATCCCAGGCCGACCTGGAAGCCAAGCAGATCACCTTCACCCAGTTGTCCGAGAACGCCTATGC
CTACACGGCCGAAGGCGACCCCAACTCGGGCGTGATCATCGGCGACGACGGCGTGCTGATCGTCGACACCACCGCCACGC
CGGCCATGGCGCAAGACCTGATCACCAGGATCCGGTCGGTCACCGACAAGCCGATCAAGTACGTGGTGCTGTCGCACTAC
CATGCGGTGCGCGTACTGGGCGCATCGGCGTACTTTGCCGAGGGCGCGCAGCAGGTCATCGCCAGCCGCGGTACCTATGA
AATGATCGTCGAGCGTGGCGAGGCCGACATGAAGTCGGAAATCGAACGCTTCCCACGTCTGTTTGCCGGCGTGGAGACCG
TGCCGGGCCTGACCTGGCCGACGCTGGTGTTCGAGAAGGAAATCACCCTGTACCTCGGCAAGCTGGAAGTCCGCATCGCC
CACCTGGGCTCTGGTCACACCAAGGGCGACACGGTGGTATGGCTGCCGTCGCAGAAGGTGCTGTTCTCGGGCGACCTGGT
CGAATACGACGCGGCTTGCTACTGCGGCGACGCCCAGCTCGCCGAGTGGCCCGCCACGCTCGATGCGCTGGCCGCGCTGC
AGCCCGAAAAACTCGTGCCCGGCCGCGGCCCGGCGCTGACCACGCCCGAAGAGGTCAGCAAGGGCATCGCCTACACCAAG
GACTTCGTCACCACGCTGTTCCAGGCCGGCAAGGAAGCCGTAGCCGACAAGCTCGACCTGAAGGCCGCCATGGCACATAC
GCGGCTGGCGATGGACCCGAAGTTCGGCCAGGTCTTCATCTACGAGCATTGCCTGCCGTTCGACGTCTCGCGCGCATTTG
ACGAGGCCAGCGGCATCGGCCACCCGCGCATCTGGACGGCCCAGCGCGACAAGGAAATGTGGGCGGCTCTGCAGGACTGA

Upstream 100 bases:

>100_bases
CGACAGAACCAAGATCCATGAAAACGGGGCGAGACAGCTGCAGTACCGCATACGGCTTATGCGGCTGCCTCGCCCTGCCC
CCACCAAAAGGACCGACAGC

Downstream 100 bases:

>100_bases
CGCGCAGACGATACATACAAGAGACTGAACGAGAGTGGACGGAGACATAGGCATGACCATCGCCAGCGCCATTGATTACC
AGCGCCTGTCATTCGAGTAC

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: Cephalosporinase; Imipenem-cefoxitin hydrolyzing enzyme; Penicillinase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSKAFASQADLEAKQITFTQLSENAYAYTAEGDPNSGVIIGDDGVLIVDTTATPAMAQDLITRIRSVTDKPIKYVVLSHY
HAVRVLGASAYFAEGAQQVIASRGTYEMIVERGEADMKSEIERFPRLFAGVETVPGLTWPTLVFEKEITLYLGKLEVRIA
HLGSGHTKGDTVVWLPSQKVLFSGDLVEYDAACYCGDAQLAEWPATLDALAALQPEKLVPGRGPALTTPEEVSKGIAYTK
DFVTTLFQAGKEAVADKLDLKAAMAHTRLAMDPKFGQVFIYEHCLPFDVSRAFDEASGIGHPRIWTAQRDKEMWAALQD

Sequences:

>Translated_319_residues
MSKAFASQADLEAKQITFTQLSENAYAYTAEGDPNSGVIIGDDGVLIVDTTATPAMAQDLITRIRSVTDKPIKYVVLSHY
HAVRVLGASAYFAEGAQQVIASRGTYEMIVERGEADMKSEIERFPRLFAGVETVPGLTWPTLVFEKEITLYLGKLEVRIA
HLGSGHTKGDTVVWLPSQKVLFSGDLVEYDAACYCGDAQLAEWPATLDALAALQPEKLVPGRGPALTTPEEVSKGIAYTK
DFVTTLFQAGKEAVADKLDLKAAMAHTRLAMDPKFGQVFIYEHCLPFDVSRAFDEASGIGHPRIWTAQRDKEMWAALQD
>Mature_318_residues
SKAFASQADLEAKQITFTQLSENAYAYTAEGDPNSGVIIGDDGVLIVDTTATPAMAQDLITRIRSVTDKPIKYVVLSHYH
AVRVLGASAYFAEGAQQVIASRGTYEMIVERGEADMKSEIERFPRLFAGVETVPGLTWPTLVFEKEITLYLGKLEVRIAH
LGSGHTKGDTVVWLPSQKVLFSGDLVEYDAACYCGDAQLAEWPATLDALAALQPEKLVPGRGPALTTPEEVSKGIAYTKD
FVTTLFQAGKEAVADKLDLKAAMAHTRLAMDPKFGQVFIYEHCLPFDVSRAFDEASGIGHPRIWTAQRDKEMWAALQD

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 34879; Mature: 34748

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAFASQADLEAKQITFTQLSENAYAYTAEGDPNSGVIIGDDGVLIVDTTATPAMAQDL
CCCCCCCCCCCCHHEEEEEEECCCCEEEEECCCCCCCEEECCCCEEEEECCCCHHHHHHH
ITRIRSVTDKPIKYVVLSHYHAVRVLGASAYFAEGAQQVIASRGTYEMIVERGEADMKSE
HHHHHHCCCCCCEEEEHHHHHEEHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHH
IERFPRLFAGVETVPGLTWPTLVFEKEITLYLGKLEVRIAHLGSGHTKGDTVVWLPSQKV
HHHHHHHHHCHHHCCCCCCCHHEEECEEEEEEEEEEEEEEECCCCCCCCCEEEEECCCCE
LFSGDLVEYDAACYCGDAQLAEWPATLDALAALQPEKLVPGRGPALTTPEEVSKGIAYTK
EEECCEEEECCEEEECCCHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHH
DFVTTLFQAGKEAVADKLDLKAAMAHTRLAMDPKFGQVFIYEHCLPFDVSRAFDEASGIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
HPRIWTAQRDKEMWAALQD
CCCEECCCCHHHHHHHCCC
>Mature Secondary Structure 
SKAFASQADLEAKQITFTQLSENAYAYTAEGDPNSGVIIGDDGVLIVDTTATPAMAQDL
CCCCCCCCCCCHHEEEEEEECCCCEEEEECCCCCCCEEECCCCEEEEECCCCHHHHHHH
ITRIRSVTDKPIKYVVLSHYHAVRVLGASAYFAEGAQQVIASRGTYEMIVERGEADMKSE
HHHHHHCCCCCCEEEEHHHHHEEHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHH
IERFPRLFAGVETVPGLTWPTLVFEKEITLYLGKLEVRIAHLGSGHTKGDTVVWLPSQKV
HHHHHHHHHCHHHCCCCCCCHHEEECEEEEEEEEEEEEEEECCCCCCCCCEEEEECCCCE
LFSGDLVEYDAACYCGDAQLAEWPATLDALAALQPEKLVPGRGPALTTPEEVSKGIAYTK
EEECCEEEECCEEEECCCHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCHHHHH
DFVTTLFQAGKEAVADKLDLKAAMAHTRLAMDPKFGQVFIYEHCLPFDVSRAFDEASGIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
HPRIWTAQRDKEMWAALQD
CCCEECCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2121094; 1956298; 2110145; 8805566; 9416622; 9578564; 10210203 [H]