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The map label for this gene is czcR [H]

Identifier: 73537794

GI number: 73537794

Start: 594724

End: 595413

Strand: Direct

Name: czcR [H]

Synonym: Reut_B3961

Alternate gene names: 73537794

Gene position: 594724-595413 (Clockwise)

Preceding gene: 73537792

Following gene: 73537795

Centisome position: 21.82

GC content: 64.93

Gene sequence:

>690_bases
ATGCGCATCCTGATTGTCGAAGACGAGCCCAAGGCGGGCGATTACCTGCTCAAGGGGCTGACCGAATCCGGCTTTGTGGT
CGACCTTGCGCGCGACGGTGTCGACGGTCTGGCCCACGCGCGCGAGCAGCCTTATGACCTCATCGTGCTCGACGTGATGC
TGCCCGGCATGGACGGCTGGAGCGTGCTGCGTGAACTGCGCCGCGAACGCGATACGCCGGTGCTGTTCCTGACCGCGCGC
GATGAACTGCAGGACCGGTTGAAGGGACTGGAGCTTGGCGCCGACGACTACATGGTCAAGCCATTCGCGTTTGCCGAGCT
GGTCATGCGCATCCGCACCATCCTGCGCCGCGGGCCGCTGCGCGAGAGCGAGTTCATCGAAGTCGCCGATTTGCAGATCG
ACGCAATCCGCCGACGCGTGTCGCGCTCGGGCCAGAAGATCGACCTCACATCGAAGGAATTCGCGCTGCTCTACCTGCTC
GCGCGGCGCCGCGGCGAGGTGCTGTCGCGCTCGCTGATCGCCTCGCAGGTGTGGGACGTGAACTTCGACAGCAACACCAA
TGTGGTCGATGTCTCCATCCGGAGGCTACGCGCGAAGGTCGACGATCCGTTCGACCACAAGCTGATCCACACGCGGCGCG
GCATGGGCTACGTGCTCGATGATGGCGAGCCCGGACTGGGCGACGCGTGA

Upstream 100 bases:

>100_bases
CACCTGTAGATGACATTTTTGACATCTTTCGCCACACGTCGCCAGACTCCGCTAGCGTTATGCCCTGGCGGCGCAATGGG
GCCCGCCTGAGAGGTCCTGA

Downstream 100 bases:

>100_bases
TGCGGTTGCCATCGTCGCTTACCGCGCGCCTGACGCTCGCATATGGACTGGCGACTGCCGCGATCCTGGCGGGCGTCGCC
GCATACCTGTCGAGCGCACT

Product: heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRILIVEDEPKAGDYLLKGLTESGFVVDLARDGVDGLAHAREQPYDLIVLDVMLPGMDGWSVLRELRRERDTPVLFLTAR
DELQDRLKGLELGADDYMVKPFAFAELVMRIRTILRRGPLRESEFIEVADLQIDAIRRRVSRSGQKIDLTSKEFALLYLL
ARRRGEVLSRSLIASQVWDVNFDSNTNVVDVSIRRLRAKVDDPFDHKLIHTRRGMGYVLDDGEPGLGDA

Sequences:

>Translated_229_residues
MRILIVEDEPKAGDYLLKGLTESGFVVDLARDGVDGLAHAREQPYDLIVLDVMLPGMDGWSVLRELRRERDTPVLFLTAR
DELQDRLKGLELGADDYMVKPFAFAELVMRIRTILRRGPLRESEFIEVADLQIDAIRRRVSRSGQKIDLTSKEFALLYLL
ARRRGEVLSRSLIASQVWDVNFDSNTNVVDVSIRRLRAKVDDPFDHKLIHTRRGMGYVLDDGEPGLGDA
>Mature_229_residues
MRILIVEDEPKAGDYLLKGLTESGFVVDLARDGVDGLAHAREQPYDLIVLDVMLPGMDGWSVLRELRRERDTPVLFLTAR
DELQDRLKGLELGADDYMVKPFAFAELVMRIRTILRRGPLRESEFIEVADLQIDAIRRRVSRSGQKIDLTSKEFALLYLL
ARRRGEVLSRSLIASQVWDVNFDSNTNVVDVSIRRLRAKVDDPFDHKLIHTRRGMGYVLDDGEPGLGDA

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=58.7719298245614, Blast_Score=264, Evalue=3e-72,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=53.4562211981567, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=40.990990990991, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=41.0958904109589, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=39.0909090909091, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=40.6113537117904, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=39.6396396396396, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=40.5286343612335, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=32.579185520362, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.1233480176211, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=34.8623853211009, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=33.6244541484716, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.858407079646, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.4655172413793, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=34.4827586206897, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=37.1428571428571, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790437, Length=106, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26062; Mature: 26062

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVEDEPKAGDYLLKGLTESGFVVDLARDGVDGLAHAREQPYDLIVLDVMLPGMDGW
CEEEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCHH
SVLRELRRERDTPVLFLTARDELQDRLKGLELGADDYMVKPFAFAELVMRIRTILRRGPL
HHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHCCC
RESEFIEVADLQIDAIRRRVSRSGQKIDLTSKEFALLYLLARRRGEVLSRSLIASQVWDV
CCCCCEEHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
NFDSNTNVVDVSIRRLRAKVDDPFDHKLIHTRRGMGYVLDDGEPGLGDA
CCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MRILIVEDEPKAGDYLLKGLTESGFVVDLARDGVDGLAHAREQPYDLIVLDVMLPGMDGW
CEEEEEECCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCHH
SVLRELRRERDTPVLFLTARDELQDRLKGLELGADDYMVKPFAFAELVMRIRTILRRGPL
HHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHCCC
RESEFIEVADLQIDAIRRRVSRSGQKIDLTSKEFALLYLLARRRGEVLSRSLIASQVWDV
CCCCCEEHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
NFDSNTNVVDVSIRRLRAKVDDPFDHKLIHTRRGMGYVLDDGEPGLGDA
CCCCCCCEEEHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]