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The map label for this gene is metC [H]

Identifier: 73537416

GI number: 73537416

Start: 138234

End: 139490

Strand: Reverse

Name: metC [H]

Synonym: Reut_B3581

Alternate gene names: 73537416

Gene position: 139490-138234 (Counterclockwise)

Preceding gene: 73537417

Following gene: 73537402

Centisome position: 5.12

GC content: 61.34

Gene sequence:

>1257_bases
ATGCCGCATCGTTTAACCATGAGAATTGCTATGAATGAAAACACCCACCTCGTTTGTGCCGGCCGCCACCCGGAGCGCTT
CGGCGGCGTCGTCAACACGCCGATCTTCAGGGCGTCGACCATCCTCGCAGGTTCGATGGCCGAATGGGAAGAGATGAAGC
GCGCGCGCGCTGCGGAAGAGCCCGGGGCAACGACTTATGGCCGCTATGGCACGCCTACTACGCAAGCGCTCGAAGAAGCC
GTAGCTGGTCTTGAGGGCGGATATCGATCGCTAGTCTTTCCTTCCGGCCTTGCCGCGGTCAGTACTGCGCTGACAGCTTT
ACTTTCGGCAGGTGACCACGTCCTCGTGACCGACAGCGCTTATTCCCCGACACGCGCCTTTCTGGAGCGGGTCCTGGCGC
GCTTCGGCGTTGAAGTCGAGACCTATGATCCGGTAGGCGGCACGCCGATCGAGGCCCTGTTGCGGGCGAATACGCGCGTG
GTCTATGTAGAATCGCCCGGTTCCGAGACCTTCGACATCCAGGACATTCCTGCCATTGCTGCAGCGGCGCATCGACACGG
TGCCTATGTCGTAATGGACAACACCTGGGGGACGCCGCTCTACTTCAAGCCGTTCGCACATGGGGTCGACGTGTCGGTCC
AGGCCGCCACGAAGTACATCGTGGGTCATTCCGACGCAATGCTTGGCGTAGTGACGTGCAATCGAGAGACCTGGCCTCTG
ATCAAGCAGACCACTCATGACATGGGTCAAACGGCAGGCCCGGATGATATCTATCTGGCTCTGCGCGGCCTGCGTACATT
GGCCGTCAGATTGCAGCGTCACTGGCAATCTGGGCTGCGTGTCGCCCAATGGCTGGAGCTGCAGCCGCAGGTCGAAGCGG
TCCTGCATCCCGCCTTACCATCCCATCCGGGACACGCACTGTGGAAGCGCGACTTTACCGGCGCATGCGGCCTCTTTTCG
GTGGTGCTGCGCACAAACTCTAAAGCCTCGCTCGCGGCGTTCATTGACGCTCTCGAGCATTTCGGCCTGGGTGTTTCGTG
GGGCGGCTATGAAAGCCTCGTGATCCCGTTCACGCCGGGAATGGGACGCACCGGCCATCGGTGGCCGCACCAGGGACAAG
CAGTACGTCTGCATGTGGGCCTGGAGGACACGGAGGATCTGATCGACGATCTGCGGCGGGGTTTGCTGGCCCTTTCGGCG
TGCGACTCCGAAGCAGAGAACGAGAAGTCTGGCTCCGGCGAGATCTGCCATAGCTGA

Upstream 100 bases:

>100_bases
CACCGGCGCTATTTGCCTATCGCGACGCGCTCCCGGCAGTCCTCATTTAATCATCTGCCTGCATATCAAACGTCCCGGCG
GCACTCGACCACGAATAACG

Downstream 100 bases:

>100_bases
AGCACCGCACTGCTTGCTACCACGATGACTGGCGAAGCTTTCGCGCTCCTAAAATGGCGAGAAGGCTTGCCGCAACTCAG
TCACGCCGATTCCCTCAATG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPHRLTMRIAMNENTHLVCAGRHPERFGGVVNTPIFRASTILAGSMAEWEEMKRARAAEEPGATTYGRYGTPTTQALEEA
VAGLEGGYRSLVFPSGLAAVSTALTALLSAGDHVLVTDSAYSPTRAFLERVLARFGVEVETYDPVGGTPIEALLRANTRV
VYVESPGSETFDIQDIPAIAAAAHRHGAYVVMDNTWGTPLYFKPFAHGVDVSVQAATKYIVGHSDAMLGVVTCNRETWPL
IKQTTHDMGQTAGPDDIYLALRGLRTLAVRLQRHWQSGLRVAQWLELQPQVEAVLHPALPSHPGHALWKRDFTGACGLFS
VVLRTNSKASLAAFIDALEHFGLGVSWGGYESLVIPFTPGMGRTGHRWPHQGQAVRLHVGLEDTEDLIDDLRRGLLALSA
CDSEAENEKSGSGEICHS

Sequences:

>Translated_418_residues
MPHRLTMRIAMNENTHLVCAGRHPERFGGVVNTPIFRASTILAGSMAEWEEMKRARAAEEPGATTYGRYGTPTTQALEEA
VAGLEGGYRSLVFPSGLAAVSTALTALLSAGDHVLVTDSAYSPTRAFLERVLARFGVEVETYDPVGGTPIEALLRANTRV
VYVESPGSETFDIQDIPAIAAAAHRHGAYVVMDNTWGTPLYFKPFAHGVDVSVQAATKYIVGHSDAMLGVVTCNRETWPL
IKQTTHDMGQTAGPDDIYLALRGLRTLAVRLQRHWQSGLRVAQWLELQPQVEAVLHPALPSHPGHALWKRDFTGACGLFS
VVLRTNSKASLAAFIDALEHFGLGVSWGGYESLVIPFTPGMGRTGHRWPHQGQAVRLHVGLEDTEDLIDDLRRGLLALSA
CDSEAENEKSGSGEICHS
>Mature_417_residues
PHRLTMRIAMNENTHLVCAGRHPERFGGVVNTPIFRASTILAGSMAEWEEMKRARAAEEPGATTYGRYGTPTTQALEEAV
AGLEGGYRSLVFPSGLAAVSTALTALLSAGDHVLVTDSAYSPTRAFLERVLARFGVEVETYDPVGGTPIEALLRANTRVV
YVESPGSETFDIQDIPAIAAAAHRHGAYVVMDNTWGTPLYFKPFAHGVDVSVQAATKYIVGHSDAMLGVVTCNRETWPLI
KQTTHDMGQTAGPDDIYLALRGLRTLAVRLQRHWQSGLRVAQWLELQPQVEAVLHPALPSHPGHALWKRDFTGACGLFSV
VLRTNSKASLAAFIDALEHFGLGVSWGGYESLVIPFTPGMGRTGHRWPHQGQAVRLHVGLEDTEDLIDDLRRGLLALSAC
DSEAENEKSGSGEICHS

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=290, Percent_Identity=39.3103448275862, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI299473759, Length=290, Percent_Identity=34.4827586206897, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI25453487, Length=289, Percent_Identity=34.2560553633218, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1789383, Length=388, Percent_Identity=44.0721649484536, Blast_Score=330, Evalue=7e-92,
Organism=Escherichia coli, GI1790375, Length=346, Percent_Identity=32.0809248554913, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=298, Percent_Identity=38.255033557047, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71980708, Length=381, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17560056, Length=301, Percent_Identity=37.2093023255814, Blast_Score=197, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=44.3452380952381, Blast_Score=306, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6319307, Length=398, Percent_Identity=31.1557788944724, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323333, Length=417, Percent_Identity=28.537170263789, Blast_Score=122, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321904, Length=348, Percent_Identity=25.5747126436782, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=369, Percent_Identity=27.10027100271, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922554, Length=341, Percent_Identity=36.6568914956012, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45323; Mature: 45192

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHRLTMRIAMNENTHLVCAGRHPERFGGVVNTPIFRASTILAGSMAEWEEMKRARAAEE
CCCEEEEEEEECCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCC
PGATTYGRYGTPTTQALEEAVAGLEGGYRSLVFPSGLAAVSTALTALLSAGDHVLVTDSA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCC
YSPTRAFLERVLARFGVEVETYDPVGGTPIEALLRANTRVVYVESPGSETFDIQDIPAIA
CCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCEECCCCCCHHH
AAAHRHGAYVVMDNTWGTPLYFKPFAHGVDVSVQAATKYIVGHSDAMLGVVTCNRETWPL
HHHHCCCCEEEEECCCCCCEEECCCCCCCCEEHHHHHEEEEECCCCEEEEEEECCCCCCH
IKQTTHDMGQTAGPDDIYLALRGLRTLAVRLQRHWQSGLRVAQWLELQPQVEAVLHPALP
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
SHPGHALWKRDFTGACGLFSVVLRTNSKASLAAFIDALEHFGLGVSWGGYESLVIPFTPG
CCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
MGRTGHRWPHQGQAVRLHVGLEDTEDLIDDLRRGLLALSACDSEAENEKSGSGEICHS
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PHRLTMRIAMNENTHLVCAGRHPERFGGVVNTPIFRASTILAGSMAEWEEMKRARAAEE
CCEEEEEEEECCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCC
PGATTYGRYGTPTTQALEEAVAGLEGGYRSLVFPSGLAAVSTALTALLSAGDHVLVTDSA
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEECCC
YSPTRAFLERVLARFGVEVETYDPVGGTPIEALLRANTRVVYVESPGSETFDIQDIPAIA
CCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCEECCCCCCHHH
AAAHRHGAYVVMDNTWGTPLYFKPFAHGVDVSVQAATKYIVGHSDAMLGVVTCNRETWPL
HHHHCCCCEEEEECCCCCCEEECCCCCCCCEEHHHHHEEEEECCCCEEEEEEECCCCCCH
IKQTTHDMGQTAGPDDIYLALRGLRTLAVRLQRHWQSGLRVAQWLELQPQVEAVLHPALP
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
SHPGHALWKRDFTGACGLFSVVLRTNSKASLAAFIDALEHFGLGVSWGGYESLVIPFTPG
CCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
MGRTGHRWPHQGQAVRLHVGLEDTEDLIDDLRRGLLALSACDSEAENEKSGSGEICHS
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]