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The map label for this gene is copR [H]

Identifier: 71908092

GI number: 71908092

Start: 2673168

End: 2673839

Strand: Reverse

Name: copR [H]

Synonym: Daro_2474

Alternate gene names: 71908092

Gene position: 2673839-2673168 (Counterclockwise)

Preceding gene: 71908093

Following gene: 71908091

Centisome position: 59.4

GC content: 59.82

Gene sequence:

>672_bases
ATGAAGATCCTCATTGTTGAAGACGAAGCGAAGACTGGCGATTACCTCAAACAGGGGCTTTCCGAAGCTGGCTTTGGCGC
CGATCTCGCCCGCAATGGGCTGGATGGGATGCATGAAGGTCTGGCCGGTGAATACGACCTGCTGATTCTCGACGTTAACC
TTCCGGGGCTGGATGGCTGGCAGGTACTGAAAGCCTTGCGTGCTGCCGGGCGCGATCTGCCAGTGCTGTTCCTGACGGCG
CGCGACCAGGTTGAGGATAGGGTCAAGGGGCTGGAACTCGGTGCCGATGATTACCTGGTCAAACCCTTCGCTTTCTCGGA
GCTGCTCGCTCGCGTCCGAACACTGCTGCGTCGCGGTCGTGCCAAGGAGACGGGGAATCTGAGCATTGCTGATCTTGAAC
TCGATGTGCTGAAGCGGCGGGCGATCCGGGCCGGTCAGCGCATCGACCTGACGGCCAAGGAATTCGCGCTGCTTGAACTG
TTCCTGCGCCGGCAGGGCGAGGTGCTGGCACGCAGTTTCATCGCCTCGCAGGTCTGGGACATGAATTTCGATTCCGACAC
CAATGTGGTCGAAGTTGCCATCCGCCGCCTGCGGGCCAAGGTCGATGAGGAGTTCACGCCCAAACTGATCCATACCCTGC
GCGGCATGGGCTATGTGATGGAGATTCGCTGA

Upstream 100 bases:

>100_bases
GGCGGTGTATCGGCTATCCCGGCGGCGTGGCCGGCTGACCTGTTTCTAGCGTCGGGCGGCTAATCACACAAGGTGACTGG
TTGTCGGGCAAAATGCGGTC

Downstream 100 bases:

>100_bases
TCGTGCCGGGCTGGCGGTATTCGATCACGCTGCGCCTGTCGCTGGCCTTCGCGCTGCTGGCGACGCTCGTGTTCGCAGCG
CTCGGTCTGTATTTCAGCCG

Product: heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKILIVEDEAKTGDYLKQGLSEAGFGADLARNGLDGMHEGLAGEYDLLILDVNLPGLDGWQVLKALRAAGRDLPVLFLTA
RDQVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGRAKETGNLSIADLELDVLKRRAIRAGQRIDLTAKEFALLEL
FLRRQGEVLARSFIASQVWDMNFDSDTNVVEVAIRRLRAKVDEEFTPKLIHTLRGMGYVMEIR

Sequences:

>Translated_223_residues
MKILIVEDEAKTGDYLKQGLSEAGFGADLARNGLDGMHEGLAGEYDLLILDVNLPGLDGWQVLKALRAAGRDLPVLFLTA
RDQVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGRAKETGNLSIADLELDVLKRRAIRAGQRIDLTAKEFALLEL
FLRRQGEVLARSFIASQVWDMNFDSDTNVVEVAIRRLRAKVDEEFTPKLIHTLRGMGYVMEIR
>Mature_223_residues
MKILIVEDEAKTGDYLKQGLSEAGFGADLARNGLDGMHEGLAGEYDLLILDVNLPGLDGWQVLKALRAAGRDLPVLFLTA
RDQVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGRAKETGNLSIADLELDVLKRRAIRAGQRIDLTAKEFALLEL
FLRRQGEVLARSFIASQVWDMNFDSDTNVVEVAIRRLRAKVDEEFTPKLIHTLRGMGYVMEIR

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=62.780269058296, Blast_Score=294, Evalue=4e-81,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=55.045871559633, Blast_Score=237, Evalue=5e-64,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=42.7272727272727, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=39.2857142857143, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.6681614349776, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=34.6666666666667, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.390134529148, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.6363636363636, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=32.7354260089686, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=34.9344978165939, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=37.719298245614, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.4561403508772, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=35.5140186915888, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=35.6521739130435, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.0578512396694, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=33.6206896551724, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=27.2058823529412, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=38.2352941176471, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25024; Mature: 25024

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEAKTGDYLKQGLSEAGFGADLARNGLDGMHEGLAGEYDLLILDVNLPGLDGW
CEEEEEECCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCCHH
QVLKALRAAGRDLPVLFLTARDQVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGR
HHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHCCC
AKETGNLSIADLELDVLKRRAIRAGQRIDLTAKEFALLELFLRRQGEVLARSFIASQVWD
CCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MNFDSDTNVVEVAIRRLRAKVDEEFTPKLIHTLRGMGYVMEIR
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MKILIVEDEAKTGDYLKQGLSEAGFGADLARNGLDGMHEGLAGEYDLLILDVNLPGLDGW
CEEEEEECCCCCHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCCHH
QVLKALRAAGRDLPVLFLTARDQVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGR
HHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHCCC
AKETGNLSIADLELDVLKRRAIRAGQRIDLTAKEFALLELFLRRQGEVLARSFIASQVWD
CCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MNFDSDTNVVEVAIRRLRAKVDEEFTPKLIHTLRGMGYVMEIR
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]