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The map label for this gene is copR [H]

Identifier: 71907879

GI number: 71907879

Start: 2446519

End: 2447196

Strand: Reverse

Name: copR [H]

Synonym: Daro_2259

Alternate gene names: 71907879

Gene position: 2447196-2446519 (Counterclockwise)

Preceding gene: 71907898

Following gene: 71907878

Centisome position: 54.37

GC content: 61.06

Gene sequence:

>678_bases
ATGAAAATCCTGGTCGTGGAAGACGAACAGAAAACCGGCGATTACCTGCGGCAGGGGCTAATGGAAGCGGGCTTCATCGT
CGATCTGGCGCGTGACGGATTCGACGGGTTGCACCTGGCGCTGACCGAGGCCTACGATCTGGCAGTCCTCGACGTGATGC
TGCCCGGCATCGACGGCTGGCAAGTGCTGCAAGGCATTCGCCGGGCCGGCAAGGACATGCCGGTGCTCTTTCTGACGGCT
CGCGATGACGTCGAGGACCGAGTCAAGGGGCTGGAACTTGGGGCCGATGACTACCTGGTGAAACCTTTCGCCTTTTCTGA
ACTGCTGGCCCGTGTCCGAACCCTGCTTCGGCGCGGCGGCAAAGCAAAGGAATCCGATCTCCTGAACGCGGCCGACCTCG
AACTCGACCTGATGCGTCGTCGGGTTACCCGATCCGGCAAGAAAATCGACCTGACCTCGAAAGAGTTCGCGCTGCTGGAA
GTTCTTTTGCGGCGTCAGGGCGAGGTGCTGCCGCGCTCGCTGATTGCCTCCCAGGTGTGGGACATGAACTTCGACAGCGA
TACAAACGTCATCGAGGTCGCCATCCGGCGGCTGCGGGCCAAGGTGGACGACGGTTTCGAGCCGAAACTAATCCGGACGG
TTCGAGGCATGGGCTATGTGCTGGAGACAGCCGAGTGA

Upstream 100 bases:

>100_bases
CGGGAAACTGACTGGCGTATTACATTTCCGTAATCTACGAGTCCAGCCCTCCGTGCCGGCGCAGAATGGCATCGATATCT
GGTGGCAAGGGAGAGTGAAC

Downstream 100 bases:

>100_bases
ATCTGATCGGGAAAAAATCCGTCACCTTTCGGCTGACCATGCTTTTTGCATCGGTCTCGACCACGGTGCTTCTTATGCTG
GGACTGCTGATCGGCTCGCT

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILVVEDEQKTGDYLRQGLMEAGFIVDLARDGFDGLHLALTEAYDLAVLDVMLPGIDGWQVLQGIRRAGKDMPVLFLTA
RDDVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGGKAKESDLLNAADLELDLMRRRVTRSGKKIDLTSKEFALLE
VLLRRQGEVLPRSLIASQVWDMNFDSDTNVIEVAIRRLRAKVDDGFEPKLIRTVRGMGYVLETAE

Sequences:

>Translated_225_residues
MKILVVEDEQKTGDYLRQGLMEAGFIVDLARDGFDGLHLALTEAYDLAVLDVMLPGIDGWQVLQGIRRAGKDMPVLFLTA
RDDVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGGKAKESDLLNAADLELDLMRRRVTRSGKKIDLTSKEFALLE
VLLRRQGEVLPRSLIASQVWDMNFDSDTNVIEVAIRRLRAKVDDGFEPKLIRTVRGMGYVLETAE
>Mature_225_residues
MKILVVEDEQKTGDYLRQGLMEAGFIVDLARDGFDGLHLALTEAYDLAVLDVMLPGIDGWQVLQGIRRAGKDMPVLFLTA
RDDVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGGKAKESDLLNAADLELDLMRRRVTRSGKKIDLTSKEFALLE
VLLRRQGEVLPRSLIASQVWDMNFDSDTNVIEVAIRRLRAKVDDGFEPKLIRTVRGMGYVLETAE

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=66.2222222222222, Blast_Score=308, Evalue=2e-85,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=57.0776255707763, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=42.5339366515837, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=41.9213973799127, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.4444444444444, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.0044052863436, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=38.7387387387387, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.8828828828829, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=37.219730941704, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.8181818181818, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.4978354978355, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.8695652173913, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=32.034632034632, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=33.0769230769231, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=37.6237623762376, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=31.304347826087, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25348; Mature: 25348

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDEQKTGDYLRQGLMEAGFIVDLARDGFDGLHLALTEAYDLAVLDVMLPGIDGW
CEEEEECCCHHHHHHHHHHHHHCCHHEEEHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
QVLQGIRRAGKDMPVLFLTARDDVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGG
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHCCC
KAKESDLLNAADLELDLMRRRVTRSGKKIDLTSKEFALLEVLLRRQGEVLPRSLIASQVW
CCCHHHCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNVIEVAIRRLRAKVDDGFEPKLIRTVRGMGYVLETAE
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MKILVVEDEQKTGDYLRQGLMEAGFIVDLARDGFDGLHLALTEAYDLAVLDVMLPGIDGW
CEEEEECCCHHHHHHHHHHHHHCCHHEEEHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
QVLQGIRRAGKDMPVLFLTARDDVEDRVKGLELGADDYLVKPFAFSELLARVRTLLRRGG
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHCCC
KAKESDLLNAADLELDLMRRRVTRSGKKIDLTSKEFALLEVLLRRQGEVLPRSLIASQVW
CCCHHHCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNVIEVAIRRLRAKVDDGFEPKLIRTVRGMGYVLETAE
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]