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The map label for this gene is cvrA [H]

Identifier: 71907699

GI number: 71907699

Start: 2230509

End: 2231858

Strand: Reverse

Name: cvrA [H]

Synonym: Daro_2072

Alternate gene names: 71907699

Gene position: 2231858-2230509 (Counterclockwise)

Preceding gene: 71907702

Following gene: 71907692

Centisome position: 49.58

GC content: 61.7

Gene sequence:

>1350_bases
ATGTCTTTTTCCGTCTGGGCGCTGATCGTCGGCGCCTTGCTGATCACCATGGCTTTGGCCGGTACGCTGATGAAGCGATT
GCCGGTCAGTGCTTCGATGTTTTATCTGGCGGTCGGCTACGGGCTGGGCAGTGCCGGATGGGGGCTGATGGCGCCTGATC
CACGGCAGGTATCGGTCATTCTCGAGCGGGTCGCCGAAGTGGCCTTGCTGATTTCACTGTTTTCGGTCGGCCTGAAACTG
GGACTGCCGTTTTCCAGCCGACACTGGCGCTTGCCCTTGCGTCTGGCTTTTGTCTCGATGGCGCTGACCATCGGCCTCAT
TACGTTGGCCGGCATCTTCCTGCTGGGTATGCCGCTGGGGGCTGCGATCCTGCTCGGCGGGATTCTGGCCCCGACTGACC
CGGTCCTCGCTGCGGATGTCCAGGTCGATGAACCTAGTGACCGTGATCGTCTGCGCTTCAGCCTGACCGGCGAGGGCGGT
TTCAACGACGGCGCCGCTTTCCCCTTCGTGATGCTGGGCCTGGGACTGCTGGGCATGCACGAACTTGGCAGCTGGGGCTG
GCGATGGATCGCGATCGATGTCCTCTGGGCCTTGGCCGGTGGCTTGCTCATCGGGAGCCTGCTGGGGGCATTGATCGGCA
AACTGGTGGTCTATCTGAGAACGCGCCATCAGGAAGCGGTCGGGCTGGATGAATTTCTGGCACTTGGGCTGGTTGCCCTG
GCTTTCGGTGTGGCGCAATTGCTTCAGGCTTCGGGATTTCTCGCGGTCTTCGCCGCCGGGCTTGCCTTGCAGCGAGTCAA
GGAACGCTCGCGCCACCAGAAGGCGCCAGACGAAGGGCCGGCCGGTTTGCAAGGCAAGGATGCGCACCTGGCTGTCGCCA
CCCATCCCAATCTCGCCAGCGCCTACATGATGCAGGCGGTACGTGGCTTCAACGAACAACTCGAGCGGATCGCCGAACTG
GTGATTGTCCTTGCCGTTGGCGCCATGCTGGCCTATGTCCGGATCGATGCATGGGCAATTGCCTTCCTTGCCCTCCTGTT
TTTCGTCCTGCGCCCGGTGTCGGTCTGGCTGGGATTGCTTGGCGCCTCAGTGTCCGGTGATCAGCGTTTCCTGATTGCCT
GGTTCGGCATCCGCGGTATTGGCTCTGTCTATTACCTGATGTTCGCCCTGAATCATGGCCTCTCAGGTTCGCTGGCCGAT
CAGGCGATCAATATCACCCTGCTGGCGGTGGCTGCTTCCATCATCCTGCACGGGGTTTCGGTGACCCCTTTGATGGCGCT
CTATGGCAGGCGGCAGGCCGGCAGGAGCAGGCGTTCGCTATCAGAGAACCGTCGCCACGACATTCGCTGA

Upstream 100 bases:

>100_bases
CTGCCGAACGGAGAACCTGCAGATGGAAAGAGATACTGATTGCAGGCTCCTGATATTTGAGCGCTTGGTGTGATTTCCAG
TTCAAAAGGAGCCGGTTGTA

Downstream 100 bases:

>100_bases
TCGCCCCGCTTCGGCATCGGCCAGCAGGCAGGCATCGTTGCGCACGGCATGCGCAATCGGTAGCTTGGCGTCTTGCTGCC
AGGCGAACAAAGCGGGGGAC

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSFSVWALIVGALLITMALAGTLMKRLPVSASMFYLAVGYGLGSAGWGLMAPDPRQVSVILERVAEVALLISLFSVGLKL
GLPFSSRHWRLPLRLAFVSMALTIGLITLAGIFLLGMPLGAAILLGGILAPTDPVLAADVQVDEPSDRDRLRFSLTGEGG
FNDGAAFPFVMLGLGLLGMHELGSWGWRWIAIDVLWALAGGLLIGSLLGALIGKLVVYLRTRHQEAVGLDEFLALGLVAL
AFGVAQLLQASGFLAVFAAGLALQRVKERSRHQKAPDEGPAGLQGKDAHLAVATHPNLASAYMMQAVRGFNEQLERIAEL
VIVLAVGAMLAYVRIDAWAIAFLALLFFVLRPVSVWLGLLGASVSGDQRFLIAWFGIRGIGSVYYLMFALNHGLSGSLAD
QAINITLLAVAASIILHGVSVTPLMALYGRRQAGRSRRSLSENRRHDIR

Sequences:

>Translated_449_residues
MSFSVWALIVGALLITMALAGTLMKRLPVSASMFYLAVGYGLGSAGWGLMAPDPRQVSVILERVAEVALLISLFSVGLKL
GLPFSSRHWRLPLRLAFVSMALTIGLITLAGIFLLGMPLGAAILLGGILAPTDPVLAADVQVDEPSDRDRLRFSLTGEGG
FNDGAAFPFVMLGLGLLGMHELGSWGWRWIAIDVLWALAGGLLIGSLLGALIGKLVVYLRTRHQEAVGLDEFLALGLVAL
AFGVAQLLQASGFLAVFAAGLALQRVKERSRHQKAPDEGPAGLQGKDAHLAVATHPNLASAYMMQAVRGFNEQLERIAEL
VIVLAVGAMLAYVRIDAWAIAFLALLFFVLRPVSVWLGLLGASVSGDQRFLIAWFGIRGIGSVYYLMFALNHGLSGSLAD
QAINITLLAVAASIILHGVSVTPLMALYGRRQAGRSRRSLSENRRHDIR
>Mature_448_residues
SFSVWALIVGALLITMALAGTLMKRLPVSASMFYLAVGYGLGSAGWGLMAPDPRQVSVILERVAEVALLISLFSVGLKLG
LPFSSRHWRLPLRLAFVSMALTIGLITLAGIFLLGMPLGAAILLGGILAPTDPVLAADVQVDEPSDRDRLRFSLTGEGGF
NDGAAFPFVMLGLGLLGMHELGSWGWRWIAIDVLWALAGGLLIGSLLGALIGKLVVYLRTRHQEAVGLDEFLALGLVALA
FGVAQLLQASGFLAVFAAGLALQRVKERSRHQKAPDEGPAGLQGKDAHLAVATHPNLASAYMMQAVRGFNEQLERIAELV
IVLAVGAMLAYVRIDAWAIAFLALLFFVLRPVSVWLGLLGASVSGDQRFLIAWFGIRGIGSVYYLMFALNHGLSGSLADQ
AINITLLAVAASIILHGVSVTPLMALYGRRQAGRSRRSLSENRRHDIR

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323167, Length=213, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 47963; Mature: 47831

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSVWALIVGALLITMALAGTLMKRLPVSASMFYLAVGYGLGSAGWGLMAPDPRQVSVI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LERVAEVALLISLFSVGLKLGLPFSSRHWRLPLRLAFVSMALTIGLITLAGIFLLGMPLG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAILLGGILAPTDPVLAADVQVDEPSDRDRLRFSLTGEGGFNDGAAFPFVMLGLGLLGMH
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
ELGSWGWRWIAIDVLWALAGGLLIGSLLGALIGKLVVYLRTRHQEAVGLDEFLALGLVAL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AFGVAQLLQASGFLAVFAAGLALQRVKERSRHQKAPDEGPAGLQGKDAHLAVATHPNLAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHH
AYMMQAVRGFNEQLERIAELVIVLAVGAMLAYVRIDAWAIAFLALLFFVLRPVSVWLGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GASVSGDQRFLIAWFGIRGIGSVYYLMFALNHGLSGSLADQAINITLLAVAASIILHGVS
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
VTPLMALYGRRQAGRSRRSLSENRRHDIR
HHHHHHHHHHHHHCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFSVWALIVGALLITMALAGTLMKRLPVSASMFYLAVGYGLGSAGWGLMAPDPRQVSVI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LERVAEVALLISLFSVGLKLGLPFSSRHWRLPLRLAFVSMALTIGLITLAGIFLLGMPLG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAILLGGILAPTDPVLAADVQVDEPSDRDRLRFSLTGEGGFNDGAAFPFVMLGLGLLGMH
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
ELGSWGWRWIAIDVLWALAGGLLIGSLLGALIGKLVVYLRTRHQEAVGLDEFLALGLVAL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AFGVAQLLQASGFLAVFAAGLALQRVKERSRHQKAPDEGPAGLQGKDAHLAVATHPNLAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHH
AYMMQAVRGFNEQLERIAELVIVLAVGAMLAYVRIDAWAIAFLALLFFVLRPVSVWLGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GASVSGDQRFLIAWFGIRGIGSVYYLMFALNHGLSGSLADQAINITLLAVAASIILHGVS
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
VTPLMALYGRRQAGRSRRSLSENRRHDIR
HHHHHHHHHHHHHCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]