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The map label for this gene is lon [H]

Identifier: 71907346

GI number: 71907346

Start: 1842675

End: 1845089

Strand: Reverse

Name: lon [H]

Synonym: Daro_1716

Alternate gene names: 71907346

Gene position: 1845089-1842675 (Counterclockwise)

Preceding gene: 71907347

Following gene: 71907345

Centisome position: 40.99

GC content: 60.0

Gene sequence:

>2415_bases
ATGTCGAACCCCAACACGCTCCCGGAAACCGTCGAACTGCCGCTGCTGCCGCTGCGCGACGTCGTCGTTTTCCCGCACAT
GGTCATCCCGCTGTTCGTCGGCCGCCCAAAATCCATCAAGGCGCTCGAAATGGCCATGGAATCCGGCAAGAACATCCTGC
TGGTCGCCCAGAAATCGGCCGCCAAGGATGAACCGGAACCGGAAGACCTGTATCGTATCGGCTGCCTGGCCAACATCCTG
CAAATGCTCAAGCTGCCGGACGGCACCGTCAAGGTGCTGGTCGAAGGGACGCAGCGCGCCCGCGTCGAAGCCATCGAGGT
GCAATCCTCGGTCTTCATGGCCACTGCCGTTCCGCTGGTTCAGCCGGGTATTGAAGATCACGAAATCGAGGCGATGCGCC
GCGCCGTGGTTGCCCAGTTTGACCAATTCGTCAAACTGAACAAGAAGATTCCGCCGGAAGTGTTGTCCTCCATCGCCGGC
ATCGAGGATGCCGGTCGCCTGGCCGACACCATCGCCGCTCACCTGCCACTCAAGCTTGAGCAGAAGCAGGAAGTGCTGGA
AATGGAAAGCATTCGCGAGCGTATCGACCGCCTGCTCTCCCAACTCGAAGCCGAAATCGACATCCTGCAGGTCGAAAAGC
GCATCCGTGGACGCGTCAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAACAGGTTAAAGCGATCCAG
AAGGAACTCGGCGAAGGCGAAGAAGGTGCCGACCTCGAAGAGCTGGACAAGAAGATCAAAGCCGCCGGCATGAGCAAGGA
AGGCCTGGCCAAGGCCGAGGGCGAGTTGAAGAAGCTGCGCCTGATGTCGCCGATGTCGGCTGAAGCCACTGTCGTCCGCA
ACTTCATTGAGACGCTGATCGGCTTGCCGTGGCGCAAGAAAACGCGCATCAGCAAGGATCTGCGTGAAGCCGAGAAGGTG
CTCGATCAGGATCATTACGGCCTGGACAAGGTCAAGGAACGCATTGTCGAGTACCTTGCAGTGCAGCAACGTGTCGACAA
GGTCAAGGCGCCGATTCTCTGCCTCGTAGGCCCCCCTGGCGTCGGCAAGACCTCGCTCGGCCAGTCCATCGCCAAGGCGA
CGAACCGCAAGTTCGTGCGCATGGCTTTGGGTGGCGTGCGCGATGAAGCCGAGATTCGCGGCCACCGTCGTACTTACATC
GGCTCGATGCCGGGCAAGATCCTGAGCAGCCTGACCAAGGTCGGCGTGCGCAATCCACTGTTCCTGCTCGACGAAGTGGA
CAAGCTCGGCCAGGATTTCCGCGGCGACCCCTCCTCCGCCCTGCTCGAAGTGCTCGACCCGGAACAGAACCACACCTTCC
AGGACCATTATGTCGAGGTCGACTTCGACCTTTCCGACGTGATGTTCGTGGCCACGGCGAACACGCTGAACATTCCCGCC
CCGCTGCTTGACCGGATGGAAGTGATTCGCCTGTCGGGTTACACGGAGGACGAGAAGGTCAATATCGCCATGCGCTATCT
GCTGCCCAAGCAGATCAAGAACAATGGCCTGAAGAAGACCGAAATTGCCGTCGCCGACAGCGCCGTTCGTGACATCGTCC
GTTACTACACCCGTGAAGCCGGCGTTCGCGCCCTGGAACGCGAGATCTCGAAGATTTGCCGCAAGGTGGTCAAGACCCTG
GTGCTGAAGAAGCGTGATTCGAAGATCCTGGTCAACGCCAAGAACCTCGACAAATTCCTCGGCGTCCAGCGCTACAGCTA
TGGCATGGCGGAAAAGGAAAACCAGGTCGGCCAGGTGACCGGTCTGGCCTGGACCGAAGTCGGCGGCGAACTGCTGACCA
TCGAATGCGCCAACATGCCGGGCAAGGGCAATATCCTGCGCACCGGCTCGCTGGGTGACGTGATGAAGGAATCGGTCGAA
GCGGCCCGTTCCGTTGTCCGCGCCCGCTCGCGTCGCCTGGGCATCAAGGATGAGGCCTTCGAGAAGACCGATATCCACAT
CCACGTTCCGGAAGGCGCCACGCCCAAGGACGGCCCGTCCGCGGGCATCGCCATGACGACGGCACTGGTTTCTTCTTACA
CCGGCATTCCGGTTCGTTGCGACGTCTGCATGACTGGCGAAATCACCCTGCGTGGTGAGGTGCTGGCCATCGGTGGTCTG
AAGGAAAAACTCCTGGCCGCCGTGCGTGGCGGACTGAAGATTGCCTTGATCCCGGAAGAGAACGTCAAGGACCTCACCGA
GATCCCTGACAACATCAAAAACAAGATCGAAATCATCCCGGTCAAGTGGATCGATCAGGTGCTGGAACGTGCACTGGAAC
GCAAGCCAGAGGCGCTTCCGGAGCTGGCGGATGCCAATTCCGGGACACCAGCGTCAGCCGAGGCCGCTGCAGCAACAACC
CTGCTTACTCATTGA

Upstream 100 bases:

>100_bases
GCTGACCAGCCCAAGGTTTCCGGCTCGAACTGAGCCGGGACTTGAATTGCGGTTCCCCGCCCCCACGTAGGGGGCACATA
CCTATTTCAAAGGCATCGTA

Downstream 100 bases:

>100_bases
TTTTGAAGGAAAGGATGCCGACGTATTAAGTCCGGCAGCCTTTCCTCCAGATCAAAGCCCGGCGATTCCCCGAAAATCCG
CTTGACACAAGGATTTCGGC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MSNPNTLPETVELPLLPLRDVVVFPHMVIPLFVGRPKSIKALEMAMESGKNILLVAQKSAAKDEPEPEDLYRIGCLANIL
QMLKLPDGTVKVLVEGTQRARVEAIEVQSSVFMATAVPLVQPGIEDHEIEAMRRAVVAQFDQFVKLNKKIPPEVLSSIAG
IEDAGRLADTIAAHLPLKLEQKQEVLEMESIRERIDRLLSQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELDKKIKAAGMSKEGLAKAEGELKKLRLMSPMSAEATVVRNFIETLIGLPWRKKTRISKDLREAEKV
LDQDHYGLDKVKERIVEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILSSLTKVGVRNPLFLLDEVDKLGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVDFDLSDVMFVATANTLNIPA
PLLDRMEVIRLSGYTEDEKVNIAMRYLLPKQIKNNGLKKTEIAVADSAVRDIVRYYTREAGVRALEREISKICRKVVKTL
VLKKRDSKILVNAKNLDKFLGVQRYSYGMAEKENQVGQVTGLAWTEVGGELLTIECANMPGKGNILRTGSLGDVMKESVE
AARSVVRARSRRLGIKDEAFEKTDIHIHVPEGATPKDGPSAGIAMTTALVSSYTGIPVRCDVCMTGEITLRGEVLAIGGL
KEKLLAAVRGGLKIALIPEENVKDLTEIPDNIKNKIEIIPVKWIDQVLERALERKPEALPELADANSGTPASAEAAAATT
LLTH

Sequences:

>Translated_804_residues
MSNPNTLPETVELPLLPLRDVVVFPHMVIPLFVGRPKSIKALEMAMESGKNILLVAQKSAAKDEPEPEDLYRIGCLANIL
QMLKLPDGTVKVLVEGTQRARVEAIEVQSSVFMATAVPLVQPGIEDHEIEAMRRAVVAQFDQFVKLNKKIPPEVLSSIAG
IEDAGRLADTIAAHLPLKLEQKQEVLEMESIRERIDRLLSQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELDKKIKAAGMSKEGLAKAEGELKKLRLMSPMSAEATVVRNFIETLIGLPWRKKTRISKDLREAEKV
LDQDHYGLDKVKERIVEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILSSLTKVGVRNPLFLLDEVDKLGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVDFDLSDVMFVATANTLNIPA
PLLDRMEVIRLSGYTEDEKVNIAMRYLLPKQIKNNGLKKTEIAVADSAVRDIVRYYTREAGVRALEREISKICRKVVKTL
VLKKRDSKILVNAKNLDKFLGVQRYSYGMAEKENQVGQVTGLAWTEVGGELLTIECANMPGKGNILRTGSLGDVMKESVE
AARSVVRARSRRLGIKDEAFEKTDIHIHVPEGATPKDGPSAGIAMTTALVSSYTGIPVRCDVCMTGEITLRGEVLAIGGL
KEKLLAAVRGGLKIALIPEENVKDLTEIPDNIKNKIEIIPVKWIDQVLERALERKPEALPELADANSGTPASAEAAAATT
LLTH
>Mature_803_residues
SNPNTLPETVELPLLPLRDVVVFPHMVIPLFVGRPKSIKALEMAMESGKNILLVAQKSAAKDEPEPEDLYRIGCLANILQ
MLKLPDGTVKVLVEGTQRARVEAIEVQSSVFMATAVPLVQPGIEDHEIEAMRRAVVAQFDQFVKLNKKIPPEVLSSIAGI
EDAGRLADTIAAHLPLKLEQKQEVLEMESIRERIDRLLSQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQK
ELGEGEEGADLEELDKKIKAAGMSKEGLAKAEGELKKLRLMSPMSAEATVVRNFIETLIGLPWRKKTRISKDLREAEKVL
DQDHYGLDKVKERIVEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATNRKFVRMALGGVRDEAEIRGHRRTYIG
SMPGKILSSLTKVGVRNPLFLLDEVDKLGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVDFDLSDVMFVATANTLNIPAP
LLDRMEVIRLSGYTEDEKVNIAMRYLLPKQIKNNGLKKTEIAVADSAVRDIVRYYTREAGVRALEREISKICRKVVKTLV
LKKRDSKILVNAKNLDKFLGVQRYSYGMAEKENQVGQVTGLAWTEVGGELLTIECANMPGKGNILRTGSLGDVMKESVEA
ARSVVRARSRRLGIKDEAFEKTDIHIHVPEGATPKDGPSAGIAMTTALVSSYTGIPVRCDVCMTGEITLRGEVLAIGGLK
EKLLAAVRGGLKIALIPEENVKDLTEIPDNIKNKIEIIPVKWIDQVLERALERKPEALPELADANSGTPASAEAAAATTL
LTH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=45.9219858156028, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=669, Percent_Identity=39.7608370702541, Blast_Score=471, Evalue=1e-133,
Organism=Escherichia coli, GI1786643, Length=772, Percent_Identity=67.4870466321243, Blast_Score=1058, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=706, Percent_Identity=37.9603399433428, Blast_Score=464, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17556486, Length=789, Percent_Identity=33.3333333333333, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=712, Percent_Identity=38.3426966292135, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI221513036, Length=606, Percent_Identity=43.8943894389439, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24666867, Length=606, Percent_Identity=43.8943894389439, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88983; Mature: 88851

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPNTLPETVELPLLPLRDVVVFPHMVIPLFVGRPKSIKALEMAMESGKNILLVAQKSA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCC
AKDEPEPEDLYRIGCLANILQMLKLPDGTVKVLVEGTQRARVEAIEVQSSVFMATAVPLV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
QPGIEDHEIEAMRRAVVAQFDQFVKLNKKIPPEVLSSIAGIEDAGRLADTIAAHLPLKLE
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QKQEVLEMESIRERIDRLLSQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGEGEEGADLEELDKKIKAAGMSKEGLAKAEGELKKLRLMSPMSAEATVVRNFIETLI
HHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GLPWRKKTRISKDLREAEKVLDQDHYGLDKVKERIVEYLAVQQRVDKVKAPILCLVGPPG
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIAKATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILSSLTKVGVRNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCH
FLLDEVDKLGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVDFDLSDVMFVATANTLNIPA
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCH
PLLDRMEVIRLSGYTEDEKVNIAMRYLLPKQIKNNGLKKTEIAVADSAVRDIVRYYTREA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVRALEREISKICRKVVKTLVLKKRDSKILVNAKNLDKFLGVQRYSYGMAEKENQVGQVT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHC
GLAWTEVGGELLTIECANMPGKGNILRTGSLGDVMKESVEAARSVVRARSRRLGIKDEAF
CEEHHHCCCEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EKTDIHIHVPEGATPKDGPSAGIAMTTALVSSYTGIPVRCDVCMTGEITLRGEVLAIGGL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEECCCEEEECCH
KEKLLAAVRGGLKIALIPEENVKDLTEIPDNIKNKIEIIPVKWIDQVLERALERKPEALP
HHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHCCCEEEEEHHHHHHHHHHHHHCCCHHHH
ELADANSGTPASAEAAAATTLLTH
HHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SNPNTLPETVELPLLPLRDVVVFPHMVIPLFVGRPKSIKALEMAMESGKNILLVAQKSA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCC
AKDEPEPEDLYRIGCLANILQMLKLPDGTVKVLVEGTQRARVEAIEVQSSVFMATAVPLV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
QPGIEDHEIEAMRRAVVAQFDQFVKLNKKIPPEVLSSIAGIEDAGRLADTIAAHLPLKLE
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHH
QKQEVLEMESIRERIDRLLSQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGEGEEGADLEELDKKIKAAGMSKEGLAKAEGELKKLRLMSPMSAEATVVRNFIETLI
HHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GLPWRKKTRISKDLREAEKVLDQDHYGLDKVKERIVEYLAVQQRVDKVKAPILCLVGPPG
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIAKATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILSSLTKVGVRNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCH
FLLDEVDKLGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVDFDLSDVMFVATANTLNIPA
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCH
PLLDRMEVIRLSGYTEDEKVNIAMRYLLPKQIKNNGLKKTEIAVADSAVRDIVRYYTREA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
GVRALEREISKICRKVVKTLVLKKRDSKILVNAKNLDKFLGVQRYSYGMAEKENQVGQVT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHC
GLAWTEVGGELLTIECANMPGKGNILRTGSLGDVMKESVEAARSVVRARSRRLGIKDEAF
CEEHHHCCCEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EKTDIHIHVPEGATPKDGPSAGIAMTTALVSSYTGIPVRCDVCMTGEITLRGEVLAIGGL
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEECCCEEEECCH
KEKLLAAVRGGLKIALIPEENVKDLTEIPDNIKNKIEIIPVKWIDQVLERALERKPEALP
HHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHCCCEEEEEHHHHHHHHHHHHHCCCHHHH
ELADANSGTPASAEAAAATTLLTH
HHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]