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The map label for this gene is yegE [H]

Identifier: 71907293

GI number: 71907293

Start: 1785396

End: 1787858

Strand: Reverse

Name: yegE [H]

Synonym: Daro_1662

Alternate gene names: 71907293

Gene position: 1787858-1785396 (Counterclockwise)

Preceding gene: 71907296

Following gene: 71907292

Centisome position: 39.72

GC content: 52.21

Gene sequence:

>2463_bases
ATGACTATAAAAACAGAAATAATGACATCTGGGCAATCTGCCACCCAAAATTGCGCCACGCCCCACTGGACGATTCATAC
GTTGTTGGGATGGCTGGTCATCATCTGCCTTATTCCTGGCATCGTCGGGACCGTCATCTTCTTTTTCCTTGAATACAGCG
ATGGTCGTGACCGCTTGGAAAAAGACACAATCCAGACTGCTCGCGCGTTGGTCCAGGCTGTTGATGCCCATCTGCTCAAG
GCAGAAATTGCAGCCCAATCCTTGTCAACGGCTGGCTCTTTATCAAAGCGCAACTTCGCTGACTTCCACCGTCGAGCGAC
AGAATTGCTGGCCACGAACAAGCAAGGAAGGAACGTTGTATTGACCGACCCATCCGGACAGCAGATCGTCAACACGCTTA
AACCGTTCGGACAACTGTTGCCTAAGCACGGCAACTTCACCGCTGCTCGCCGTGTATTTGAAACGGGCAAGCCATTGATT
TCAGACTTGTTCATGGGTGAACTGACCCAACACCCTGTCATGAGCATTGATGTCCCTGTTCTGACCAATGAAAAAGTGAG
CTACGTGCTTAGCATCGGCATCGATCCAAATGATTTTAGCGGCATACTGCTGGCACAACGGCTTCCGGACGATTGGGTCG
CTGCTATTTTCGATACGACGGGGACAATTGTTTCCCGTACTCACAACGCCGAGCAGTTTGTAGGACAAAAAGGAACCGCG
GAATTCATTCAGCGTTTCCAAGAATCTCAGGAAGGGGGAATGGAGACAACAACCCGAGAGGGGATTCCTGTCTTCTCCGT
ATTCAGCCGTTCAGCAGTCACCGGCTGGACCGTCGGCATCGGTATTCCCCGTAAGTCCCTTGAGGCAGAGCTAAAGCACA
AACTCTTGATCATGGCTTTGGGCATGATGGCCGTATTTGGATTTGGGATCGTGCTAGCGTGGTTGATTGGCGGTCGGATT
GCCGTCTCTGTACGAGCATTGCAAGCCCCTGCGAAGGCCTTAGGGGCCGGGGAGCCACTGCCGGCAACAGTGGTCCATAT
CAAGGAAGCAGCCGAAGTGCTAGGAGCGATGAGCGAAGCAGCCATTTTGCTGGAACAGCGAACGGCCAGTCTTCAATCAA
CCTATCAAGCTCTTTTGGCAAGAGAGAAAGAACTGCTTGAGGCGCACCGGGTAGGTAAGTTCGGAATCTGGCAGTGGAAT
CCAAAGTCCCATGAAATTAACGTTTCCGAGGAAATTCGTCATATCTATGGGCGTGATGTCCCCCCCTTCCCGGAACAGCG
TGGAACGCTCCTCTCGATCGAGTCCTGGGAACGCGTGAATGCCGCGGCGCAAGAGGCAATAAAAACGGGGATTGGCTACG
ACCTCAAGTTGCAAGCCTACCGTAACGACGGTTCGCAAATTTGGATTCATGCAAGGTGCGAGGCCATTCGCGACGCAGAG
GGTGATATCTTGGCGCTGCGTGGAACGGTACAAGACATTACTGAACGCATTGAAGGGGAGAAGGCGTTACGCAACAGTGA
GATCCGCTTCCGTGCAACCTTTGAGCAGGCAGCGGTCGGCATGGCTCACGTTTCGCTGGATGGGAAGTGGCTACACGTCA
ATGACAAAACCTGCGAAATTGTTGGCTACTCGCGTGAAACACTGCTTGGCCTAACGTTTCAGGAAATCACCTACCCTCCC
GATCTAAATACGGATCTCGACAACCTCCAAAAATTGCTGGCAGGGAGTATTTCAAGCTACAGCATGGAGAAACGCTATGT
ACGTCGTGATGCCACGCTAACCTGGGTCAACCTCACAGTTGCGCTGGTCAGAACATCTGAAGGACAGCCGGACTATTTCG
TCTCTGTACTCGAGGACATTCAATCCCGAAAAGAGGCTGAAGCAGCGCTCGATGAAGCACGCAAGGTCTATCGGCAGCAC
CTGGAGCAACAAGTAGCGGAACGGACGGAAGCGCTATTGATGGCAAACCAGGAACTGGAGCGACTTGCCCATCAGGATGC
ATTGACCAAGCTACCGAATCGATTGGCAGCTAATGAACGACTTCGCCAAGAATTCCTGCGTCTAAAACGCACGGGAAGCC
CATATTGCGTATTCATGATGGACATTGATCATTTCAAAATGATCAATGACACCTACGGACATGAGACCGGCGACCATGTT
CTTGAACATTTTGCAGTGACGCTTACGGGAGCGCTCCGCGCCACTGATTTCGTTGCTCGCTTTGGGGGAGAAGAGTTTAT
AGCCCTTATGCCGGACACCGAAATCGAAGGTGCCATGGTTGCAGCCGAGAAAGTCCGAATTGCGATCCATCAAGAGAAAT
TCCCTGTGGTCGGATGTGTAACCGTTAGTATTGGCGTTGGAAATTCCCGGACAGAGGATGCCAATGAAGACGAGACGGTA
CGTCGGGCCGATGCTGCACTGTATCGTTCGAAGAAAGACGGGCGAAACCGGGTGAGTTCCTGA

Upstream 100 bases:

>100_bases
AACCCAATTGGGAATCAATTTGCGATAACTTCTGGCTAGTAACTCATAATGCTTCACTGATATAGTTTTCTTTTGCTTTA
GTAATACTTCTTGCCACCCG

Downstream 100 bases:

>100_bases
ATCAGCGCTCTAAGCGCCCAGCCAACCCGTATTGCTTTCTCGGTTTACGTGGCTTGGCTACCAAAGCGTAGCAAGCTGTA
ACGGCCGCCTGTTGTCGATT

Product: diguanylate cyclase with PAS/PAC sensor

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 820; Mature: 819

Protein sequence:

>820_residues
MTIKTEIMTSGQSATQNCATPHWTIHTLLGWLVIICLIPGIVGTVIFFFLEYSDGRDRLEKDTIQTARALVQAVDAHLLK
AEIAAQSLSTAGSLSKRNFADFHRRATELLATNKQGRNVVLTDPSGQQIVNTLKPFGQLLPKHGNFTAARRVFETGKPLI
SDLFMGELTQHPVMSIDVPVLTNEKVSYVLSIGIDPNDFSGILLAQRLPDDWVAAIFDTTGTIVSRTHNAEQFVGQKGTA
EFIQRFQESQEGGMETTTREGIPVFSVFSRSAVTGWTVGIGIPRKSLEAELKHKLLIMALGMMAVFGFGIVLAWLIGGRI
AVSVRALQAPAKALGAGEPLPATVVHIKEAAEVLGAMSEAAILLEQRTASLQSTYQALLAREKELLEAHRVGKFGIWQWN
PKSHEINVSEEIRHIYGRDVPPFPEQRGTLLSIESWERVNAAAQEAIKTGIGYDLKLQAYRNDGSQIWIHARCEAIRDAE
GDILALRGTVQDITERIEGEKALRNSEIRFRATFEQAAVGMAHVSLDGKWLHVNDKTCEIVGYSRETLLGLTFQEITYPP
DLNTDLDNLQKLLAGSISSYSMEKRYVRRDATLTWVNLTVALVRTSEGQPDYFVSVLEDIQSRKEAEAALDEARKVYRQH
LEQQVAERTEALLMANQELERLAHQDALTKLPNRLAANERLRQEFLRLKRTGSPYCVFMMDIDHFKMINDTYGHETGDHV
LEHFAVTLTGALRATDFVARFGGEEFIALMPDTEIEGAMVAAEKVRIAIHQEKFPVVGCVTVSIGVGNSRTEDANEDETV
RRADAALYRSKKDGRNRVSS

Sequences:

>Translated_820_residues
MTIKTEIMTSGQSATQNCATPHWTIHTLLGWLVIICLIPGIVGTVIFFFLEYSDGRDRLEKDTIQTARALVQAVDAHLLK
AEIAAQSLSTAGSLSKRNFADFHRRATELLATNKQGRNVVLTDPSGQQIVNTLKPFGQLLPKHGNFTAARRVFETGKPLI
SDLFMGELTQHPVMSIDVPVLTNEKVSYVLSIGIDPNDFSGILLAQRLPDDWVAAIFDTTGTIVSRTHNAEQFVGQKGTA
EFIQRFQESQEGGMETTTREGIPVFSVFSRSAVTGWTVGIGIPRKSLEAELKHKLLIMALGMMAVFGFGIVLAWLIGGRI
AVSVRALQAPAKALGAGEPLPATVVHIKEAAEVLGAMSEAAILLEQRTASLQSTYQALLAREKELLEAHRVGKFGIWQWN
PKSHEINVSEEIRHIYGRDVPPFPEQRGTLLSIESWERVNAAAQEAIKTGIGYDLKLQAYRNDGSQIWIHARCEAIRDAE
GDILALRGTVQDITERIEGEKALRNSEIRFRATFEQAAVGMAHVSLDGKWLHVNDKTCEIVGYSRETLLGLTFQEITYPP
DLNTDLDNLQKLLAGSISSYSMEKRYVRRDATLTWVNLTVALVRTSEGQPDYFVSVLEDIQSRKEAEAALDEARKVYRQH
LEQQVAERTEALLMANQELERLAHQDALTKLPNRLAANERLRQEFLRLKRTGSPYCVFMMDIDHFKMINDTYGHETGDHV
LEHFAVTLTGALRATDFVARFGGEEFIALMPDTEIEGAMVAAEKVRIAIHQEKFPVVGCVTVSIGVGNSRTEDANEDETV
RRADAALYRSKKDGRNRVSS
>Mature_819_residues
TIKTEIMTSGQSATQNCATPHWTIHTLLGWLVIICLIPGIVGTVIFFFLEYSDGRDRLEKDTIQTARALVQAVDAHLLKA
EIAAQSLSTAGSLSKRNFADFHRRATELLATNKQGRNVVLTDPSGQQIVNTLKPFGQLLPKHGNFTAARRVFETGKPLIS
DLFMGELTQHPVMSIDVPVLTNEKVSYVLSIGIDPNDFSGILLAQRLPDDWVAAIFDTTGTIVSRTHNAEQFVGQKGTAE
FIQRFQESQEGGMETTTREGIPVFSVFSRSAVTGWTVGIGIPRKSLEAELKHKLLIMALGMMAVFGFGIVLAWLIGGRIA
VSVRALQAPAKALGAGEPLPATVVHIKEAAEVLGAMSEAAILLEQRTASLQSTYQALLAREKELLEAHRVGKFGIWQWNP
KSHEINVSEEIRHIYGRDVPPFPEQRGTLLSIESWERVNAAAQEAIKTGIGYDLKLQAYRNDGSQIWIHARCEAIRDAEG
DILALRGTVQDITERIEGEKALRNSEIRFRATFEQAAVGMAHVSLDGKWLHVNDKTCEIVGYSRETLLGLTFQEITYPPD
LNTDLDNLQKLLAGSISSYSMEKRYVRRDATLTWVNLTVALVRTSEGQPDYFVSVLEDIQSRKEAEAALDEARKVYRQHL
EQQVAERTEALLMANQELERLAHQDALTKLPNRLAANERLRQEFLRLKRTGSPYCVFMMDIDHFKMINDTYGHETGDHVL
EHFAVTLTGALRATDFVARFGGEEFIALMPDTEIEGAMVAAEKVRIAIHQEKFPVVGCVTVSIGVGNSRTEDANEDETVR
RADAALYRSKKDGRNRVSS

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG3706

COG function: function code T; Response regulator containing a CheY-like receiver domain and a GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=127, Percent_Identity=47.244094488189, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87081881, Length=172, Percent_Identity=40.1162790697674, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1787262, Length=164, Percent_Identity=37.8048780487805, Blast_Score=113, Evalue=6e-26,
Organism=Escherichia coli, GI1786584, Length=163, Percent_Identity=35.5828220858896, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87082007, Length=165, Percent_Identity=36.969696969697, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1787802, Length=167, Percent_Identity=40.7185628742515, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI145693134, Length=156, Percent_Identity=33.974358974359, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787816, Length=162, Percent_Identity=35.1851851851852, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1787541, Length=166, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788085, Length=170, Percent_Identity=31.1764705882353, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI87081977, Length=168, Percent_Identity=29.7619047619048, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1787056, Length=162, Percent_Identity=33.9506172839506, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI87081974, Length=166, Percent_Identity=28.3132530120482, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 91069; Mature: 90938

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKTEIMTSGQSATQNCATPHWTIHTLLGWLVIICLIPGIVGTVIFFFLEYSDGRDRLE
CCEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KDTIQTARALVQAVDAHLLKAEIAAQSLSTAGSLSKRNFADFHRRATELLATNKQGRNVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
LTDPSGQQIVNTLKPFGQLLPKHGNFTAARRVFETGKPLISDLFMGELTQHPVMSIDVPV
EECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCE
LTNEKVSYVLSIGIDPNDFSGILLAQRLPDDWVAAIFDTTGTIVSRTHNAEQFVGQKGTA
ECCCCEEEEEEECCCCCCCCCEEEEHHCCHHHHHHHHHCCCHHHCCCCCHHHHHCCCCHH
EFIQRFQESQEGGMETTTREGIPVFSVFSRSAVTGWTVGIGIPRKSLEAELKHKLLIMAL
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
GMMAVFGFGIVLAWLIGGRIAVSVRALQAPAKALGAGEPLPATVVHIKEAAEVLGAMSEA
HHHHHHHHHHHHHHHHCCHHEEEHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AILLEQRTASLQSTYQALLAREKELLEAHRVGKFGIWQWNPKSHEINVSEEIRHIYGRDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCC
PPFPEQRGTLLSIESWERVNAAAQEAIKTGIGYDLKLQAYRNDGSQIWIHARCEAIRDAE
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEHHHHCCCC
GDILALRGTVQDITERIEGEKALRNSEIRFRATFEQAAVGMAHVSLDGKWLHVNDKTCEI
CCEEEECCCHHHHHHHHCHHHHHCCCCEEEEEEHHHHHHCEEEEEECCEEEEECCCEEEE
VGYSRETLLGLTFQEITYPPDLNTDLDNLQKLLAGSISSYSMEKRYVRRDATLTWVNLTV
ECCCHHHHEEEEHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEEEE
ALVRTSEGQPDYFVSVLEDIQSRKEAEAALDEARKVYRQHLEQQVAERTEALLMANQELE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAHQDALTKLPNRLAANERLRQEFLRLKRTGSPYCVFMMDIDHFKMINDTYGHETGDHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCCHHHH
LEHFAVTLTGALRATDFVARFGGEEFIALMPDTEIEGAMVAAEKVRIAIHQEKFPVVGCV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHEEEEEECCCCCEEEEE
TVSIGVGNSRTEDANEDETVRRADAALYRSKKDGRNRVSS
EEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TIKTEIMTSGQSATQNCATPHWTIHTLLGWLVIICLIPGIVGTVIFFFLEYSDGRDRLE
CEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KDTIQTARALVQAVDAHLLKAEIAAQSLSTAGSLSKRNFADFHRRATELLATNKQGRNVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
LTDPSGQQIVNTLKPFGQLLPKHGNFTAARRVFETGKPLISDLFMGELTQHPVMSIDVPV
EECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCE
LTNEKVSYVLSIGIDPNDFSGILLAQRLPDDWVAAIFDTTGTIVSRTHNAEQFVGQKGTA
ECCCCEEEEEEECCCCCCCCCEEEEHHCCHHHHHHHHHCCCHHHCCCCCHHHHHCCCCHH
EFIQRFQESQEGGMETTTREGIPVFSVFSRSAVTGWTVGIGIPRKSLEAELKHKLLIMAL
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
GMMAVFGFGIVLAWLIGGRIAVSVRALQAPAKALGAGEPLPATVVHIKEAAEVLGAMSEA
HHHHHHHHHHHHHHHHCCHHEEEHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
AILLEQRTASLQSTYQALLAREKELLEAHRVGKFGIWQWNPKSHEINVSEEIRHIYGRDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCC
PPFPEQRGTLLSIESWERVNAAAQEAIKTGIGYDLKLQAYRNDGSQIWIHARCEAIRDAE
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEHHHHCCCC
GDILALRGTVQDITERIEGEKALRNSEIRFRATFEQAAVGMAHVSLDGKWLHVNDKTCEI
CCEEEECCCHHHHHHHHCHHHHHCCCCEEEEEEHHHHHHCEEEEEECCEEEEECCCEEEE
VGYSRETLLGLTFQEITYPPDLNTDLDNLQKLLAGSISSYSMEKRYVRRDATLTWVNLTV
ECCCHHHHEEEEHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEEEE
ALVRTSEGQPDYFVSVLEDIQSRKEAEAALDEARKVYRQHLEQQVAERTEALLMANQELE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLAHQDALTKLPNRLAANERLRQEFLRLKRTGSPYCVFMMDIDHFKMINDTYGHETGDHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCCHHHH
LEHFAVTLTGALRATDFVARFGGEEFIALMPDTEIEGAMVAAEKVRIAIHQEKFPVVGCV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHEEEEEECCCCCEEEEE
TVSIGVGNSRTEDANEDETVRRADAALYRSKKDGRNRVSS
EEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]