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The map label for this gene is iclR [H]

Identifier: 71906443

GI number: 71906443

Start: 868644

End: 869444

Strand: Reverse

Name: iclR [H]

Synonym: Daro_0804

Alternate gene names: 71906443

Gene position: 869444-868644 (Counterclockwise)

Preceding gene: 71906460

Following gene: 71906441

Centisome position: 19.32

GC content: 55.06

Gene sequence:

>801_bases
ATGGCCACTAAAGTTGCGAGCGATCGCCAGGGAATTCAGTCTGTCGAGGTAGGGTTTCGCCTGTTACGCGTACTGGCAGC
CACCAATCGTCCGATGATGCTGCGTGATATCGCCAAGGGAGCAGGAATGCCCGCAGCCAAAGCTCATCGTTACATGGTGA
GCTTTCTGCGTATCGGCATTGTTGAACAGGACGCCAGCAGCGGTCGCTACGACCTAGGCGCCTACGCATTGGAGCTTGGC
TTATCAGGGTTAGGGCGACTAGATCCAGTCCGCTTATCCGGCCCTATCCTTGAAGCCCTATGTGAAGAAATTCACGAGAC
CGTCGCACTTGCAGTTTGGGGGACCCATGGCGCAACCATTGTGCGAATTGTTGACCCCGGCGGCCCCATCACTATCACCT
TACGCCCAGGAACAACGCTGCCACTGTGTAACTCAGCCACTGGACGAGCGTTTGCCACCTTTTATCGCTCACCCTTTCTC
AAGAAAATGCTGGATGACGAACTGAAAGAAATATCAGAATCCAGCAAAACAGCCGTCACGACCATTCGCCGACAACTGGA
AAAAAACCTGACTGAAATTCGCTCCCACGGCATTGCGCGCGCCACCGGAAGCCTAACACCTGGCATCAACGGCTTTAGCG
CCCCTGTGTACGATCACACAGGAAGCATGGTCGCTGCGATTACCTCGCTCGGATCAATGGGGGAATTCGATGTGGAATGG
GAAAGCCCTGTAGCCAAGGCGATGCTGGCAGCTTCGATAAGCCTGTCACACCGCCTAGGCTACGGCAGCATGGCCGAATA
A

Upstream 100 bases:

>100_bases
TCGCATAGAACCCCCTATATATTTGCAGCGGCATTATATTCGCCACCGCAAAGGTGTCATAGATGCATAGAATGTGGTTT
TTTCACCCAACAAGATAACC

Downstream 100 bases:

>100_bases
CTACTGGTGCCCCCGAACGGCATAGGGAACTATACAGAACAGCCTGAAACACGCGCCAACTCGTGACCTGAGGCATGGCT
GGTTGATGAAAGTACCACAA

Product: regulatory proteins, IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MATKVASDRQGIQSVEVGFRLLRVLAATNRPMMLRDIAKGAGMPAAKAHRYMVSFLRIGIVEQDASSGRYDLGAYALELG
LSGLGRLDPVRLSGPILEALCEEIHETVALAVWGTHGATIVRIVDPGGPITITLRPGTTLPLCNSATGRAFATFYRSPFL
KKMLDDELKEISESSKTAVTTIRRQLEKNLTEIRSHGIARATGSLTPGINGFSAPVYDHTGSMVAAITSLGSMGEFDVEW
ESPVAKAMLAASISLSHRLGYGSMAE

Sequences:

>Translated_266_residues
MATKVASDRQGIQSVEVGFRLLRVLAATNRPMMLRDIAKGAGMPAAKAHRYMVSFLRIGIVEQDASSGRYDLGAYALELG
LSGLGRLDPVRLSGPILEALCEEIHETVALAVWGTHGATIVRIVDPGGPITITLRPGTTLPLCNSATGRAFATFYRSPFL
KKMLDDELKEISESSKTAVTTIRRQLEKNLTEIRSHGIARATGSLTPGINGFSAPVYDHTGSMVAAITSLGSMGEFDVEW
ESPVAKAMLAASISLSHRLGYGSMAE
>Mature_265_residues
ATKVASDRQGIQSVEVGFRLLRVLAATNRPMMLRDIAKGAGMPAAKAHRYMVSFLRIGIVEQDASSGRYDLGAYALELGL
SGLGRLDPVRLSGPILEALCEEIHETVALAVWGTHGATIVRIVDPGGPITITLRPGTTLPLCNSATGRAFATFYRSPFLK
KMLDDELKEISESSKTAVTTIRRQLEKNLTEIRSHGIARATGSLTPGINGFSAPVYDHTGSMVAAITSLGSMGEFDVEWE
SPVAKAMLAASISLSHRLGYGSMAE

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=255, Percent_Identity=25.8823529411765, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789999, Length=252, Percent_Identity=22.6190476190476, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28431; Mature: 28300

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKVASDRQGIQSVEVGFRLLRVLAATNRPMMLRDIAKGAGMPAAKAHRYMVSFLRIGI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VEQDASSGRYDLGAYALELGLSGLGRLDPVRLSGPILEALCEEIHETVALAVWGTHGATI
HCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCEEE
VRIVDPGGPITITLRPGTTLPLCNSATGRAFATFYRSPFLKKMLDDELKEISESSKTAVT
EEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TIRRQLEKNLTEIRSHGIARATGSLTPGINGFSAPVYDHTGSMVAAITSLGSMGEFDVEW
HHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
ESPVAKAMLAASISLSHRLGYGSMAE
CCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATKVASDRQGIQSVEVGFRLLRVLAATNRPMMLRDIAKGAGMPAAKAHRYMVSFLRIGI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VEQDASSGRYDLGAYALELGLSGLGRLDPVRLSGPILEALCEEIHETVALAVWGTHGATI
HCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCEEE
VRIVDPGGPITITLRPGTTLPLCNSATGRAFATFYRSPFLKKMLDDELKEISESSKTAVT
EEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TIRRQLEKNLTEIRSHGIARATGSLTPGINGFSAPVYDHTGSMVAAITSLGSMGEFDVEW
HHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
ESPVAKAMLAASISLSHRLGYGSMAE
CCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]