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The map label for this gene is mprA [H]

Identifier: 71905654

GI number: 71905654

Start: 16355

End: 17488

Strand: Reverse

Name: mprA [H]

Synonym: Daro_0012

Alternate gene names: 71905654

Gene position: 17488-16355 (Counterclockwise)

Preceding gene: 71905656

Following gene: 71905653

Centisome position: 0.39

GC content: 60.14

Gene sequence:

>1134_bases
ATGCCCCACCGTTTTCGCGTTGCCATTGTCGAGGACAATCCGCCCCAGCGCATGATACTGACCCGCCTGCTGGAGAAGGA
TTACCAGATCGAATCGTTCGAAAGTGGCCCGATTTTCCTGGCGAGTGATGGTCTTTTCGACGCCGTACTGCTCGACATCG
AAATGCCTGAACTCAGCGGCTATGACACCTGCCGGCGCTTCCGGGAACAGACGCGCGGCGCCGATGTGCCGGTCATTTTC
GTTTCTGCCCACGACACCACACCGGAGCGTGTCGCCTCCTACGACGCGGGTGGCGACGATTTCCTGACCAAACCGATCGC
CGCGCACGAATTGCGTCACAAATTGGGCAACGCCATCGAGTTGCGGGAAAAGGTCCGCACCCTGTCCAGCCAGACGACCG
ATGCGCAACGCGTTGCCTTCACCGCCATGACCAGCATGGGCGACCTCGGAGTGGTCATCGAATTCCTGCGCAAATCGGCC
CAGGCCACCACCTATTCGGCCATTGCCGCCCGCCTGGTCGCAGCGATGAAAGCCTGGGGCCTGCAAGGCGCTGTTCAAGT
CCGTGGCCGGCATGAACAGGTAGCGCTAAATGCCGAGGGACCCATGACGGCCATGCAGGCGGCCGTGTTGGAAAAACTGC
GCGATATCGGACGTATTTTCGAAATGGGTTCGCGTGCCGTGATCAATTTCGACCACGTTTCCCTGCTGGTTGAAAACCTG
CCGGTAGACGACCCGAACAAGGTCGGCCGCCTGCGTGATCATCTCGCCGTCCTGGCCGAAAGCGCCGACATGCGTATGGC
CGCGCTGGATTCCGCCATCGAACGCGACCTGCAGAAACAGGGCATCGAAGCTGCTCTGGACGAACTCCGGGCAGCCATGC
AGCAGGCAACGCATCATTCCGCCACCAGTCACCCGAGACAGCAGGCAACCATGCTCGAATCCATCGAACAACTGGGCAGG
ACCACTCATACCCTCGGGCTGACCGCCGTTCAAGTGGAGTATCTCGATGATCTGATCCGCCACATTCTGGAGGAATCCCA
GCATTACTTCGACGACGTCGCGCAAAGCGAAAGCGACTTCGCCGATGTGTTCAGCCGCCTGGAACGCCTCGCACAAGCCG
ACTACCGGCTATAG

Upstream 100 bases:

>100_bases
ACAAGGGGTCGAATTCTACCTTTTTTCAAGCACTTGCGGTGACAACGGCTGCTCGTTGTGATACTTTTGCCACAATTGTC
ATTCGCTCAGGAGTGCCGGT

Downstream 100 bases:

>100_bases
TCCCTTTTGTTGCACCGCAGTGTAAGATTTGCGGCGATAACAAAAACCTCGGATTGAGACACAGCATATGGTTCCACACC
TCACCACAGCCCTCACCGGC

Product: response regulator receiver

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPHRFRVAIVEDNPPQRMILTRLLEKDYQIESFESGPIFLASDGLFDAVLLDIEMPELSGYDTCRRFREQTRGADVPVIF
VSAHDTTPERVASYDAGGDDFLTKPIAAHELRHKLGNAIELREKVRTLSSQTTDAQRVAFTAMTSMGDLGVVIEFLRKSA
QATTYSAIAARLVAAMKAWGLQGAVQVRGRHEQVALNAEGPMTAMQAAVLEKLRDIGRIFEMGSRAVINFDHVSLLVENL
PVDDPNKVGRLRDHLAVLAESADMRMAALDSAIERDLQKQGIEAALDELRAAMQQATHHSATSHPRQQATMLESIEQLGR
TTHTLGLTAVQVEYLDDLIRHILEESQHYFDDVAQSESDFADVFSRLERLAQADYRL

Sequences:

>Translated_377_residues
MPHRFRVAIVEDNPPQRMILTRLLEKDYQIESFESGPIFLASDGLFDAVLLDIEMPELSGYDTCRRFREQTRGADVPVIF
VSAHDTTPERVASYDAGGDDFLTKPIAAHELRHKLGNAIELREKVRTLSSQTTDAQRVAFTAMTSMGDLGVVIEFLRKSA
QATTYSAIAARLVAAMKAWGLQGAVQVRGRHEQVALNAEGPMTAMQAAVLEKLRDIGRIFEMGSRAVINFDHVSLLVENL
PVDDPNKVGRLRDHLAVLAESADMRMAALDSAIERDLQKQGIEAALDELRAAMQQATHHSATSHPRQQATMLESIEQLGR
TTHTLGLTAVQVEYLDDLIRHILEESQHYFDDVAQSESDFADVFSRLERLAQADYRL
>Mature_376_residues
PHRFRVAIVEDNPPQRMILTRLLEKDYQIESFESGPIFLASDGLFDAVLLDIEMPELSGYDTCRRFREQTRGADVPVIFV
SAHDTTPERVASYDAGGDDFLTKPIAAHELRHKLGNAIELREKVRTLSSQTTDAQRVAFTAMTSMGDLGVVIEFLRKSAQ
ATTYSAIAARLVAAMKAWGLQGAVQVRGRHEQVALNAEGPMTAMQAAVLEKLRDIGRIFEMGSRAVINFDHVSLLVENLP
VDDPNKVGRLRDHLAVLAESADMRMAALDSAIERDLQKQGIEAALDELRAAMQQATHHSATSHPRQQATMLESIEQLGRT
THTLGLTAVQVEYLDDLIRHILEESQHYFDDVAQSESDFADVFSRLERLAQADYRL

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 42021; Mature: 41890

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHRFRVAIVEDNPPQRMILTRLLEKDYQIESFESGPIFLASDGLFDAVLLDIEMPELSG
CCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEEEECCCCCC
YDTCRRFREQTRGADVPVIFVSAHDTTPERVASYDAGGDDFLTKPIAAHELRHKLGNAIE
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHCCHHH
LREKVRTLSSQTTDAQRVAFTAMTSMGDLGVVIEFLRKSAQATTYSAIAARLVAAMKAWG
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQGAVQVRGRHEQVALNAEGPMTAMQAAVLEKLRDIGRIFEMGSRAVINFDHVSLLVENL
CCCHHEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHC
PVDDPNKVGRLRDHLAVLAESADMRMAALDSAIERDLQKQGIEAALDELRAAMQQATHHS
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATSHPRQQATMLESIEQLGRTTHTLGLTAVQVEYLDDLIRHILEESQHYFDDVAQSESDF
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ADVFSRLERLAQADYRL
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PHRFRVAIVEDNPPQRMILTRLLEKDYQIESFESGPIFLASDGLFDAVLLDIEMPELSG
CCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEEEECCCCCC
YDTCRRFREQTRGADVPVIFVSAHDTTPERVASYDAGGDDFLTKPIAAHELRHKLGNAIE
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHCCHHH
LREKVRTLSSQTTDAQRVAFTAMTSMGDLGVVIEFLRKSAQATTYSAIAARLVAAMKAWG
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQGAVQVRGRHEQVALNAEGPMTAMQAAVLEKLRDIGRIFEMGSRAVINFDHVSLLVENL
CCCHHEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHC
PVDDPNKVGRLRDHLAVLAESADMRMAALDSAIERDLQKQGIEAALDELRAAMQQATHHS
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATSHPRQQATMLESIEQLGRTTHTLGLTAVQVEYLDDLIRHILEESQHYFDDVAQSESDF
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ADVFSRLERLAQADYRL
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA