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The map label for this gene is pdhD-1 [H]

Identifier: 71893921

GI number: 71893921

Start: 739135

End: 740499

Strand: Reverse

Name: pdhD-1 [H]

Synonym: MHJ_0572

Alternate gene names: 71893921

Gene position: 740499-739135 (Counterclockwise)

Preceding gene: 71893923

Following gene: 71893920

Centisome position: 82.52

GC content: 31.14

Gene sequence:

>1365_bases
ATGCAAAAATACGATGTAATTATTATTGGTGGTGGCCCTGGGGGTCATTCTCTAGCTGCTATTTTGGGTAAAAATGGTAA
AAAAGTTGCGCTTTTTGAGCAAGAATTTCTCGGAGGAACTTGTGTAAATTGAGGATGTGTTCCTACAAAAACAATTCTTA
AATCAGCAAAAATTAAATCTTATTTTGATAATGCAGAAAAATTTGGATTAAATTCAGTAGCGAAATTTAATTTTAAGCAA
ATTTTTCAAAGAGCAAAAAATAATTCACTAAAATTACAAGGCTCAATTTTAGAAACATTAAAAAATTCTGGTGTTGATTT
TTATAATAAAAAAGCAAAAGTTACATCAAATCATACAGTTTTAGCAGAAAATGAAGAATTTTTCTTTGAAAAATTAGTTA
TAGCAACAGGCTCTAAACCAAGAAAAATTAAAATTGAAGGTGCTGAAAAAGCAAATTTAATTACTTCTGATGATTTTTTT
AAAGGCAAAATTGAATTTGATGAACTAACAATCATTGGCGGTGGGGCAATTTCGCTTGAATTTGCAGTTTTTTATGCTAG
TTTTGGGGCAAAAATTACAATAATTGAAGGAAATGATCGTGTTTTTGCCAATTTTGATAATTCAATTGCCGAGGCGGCAA
ATTTTGTTTTAGACAGAAACAAAGTGAAAATTTTTACTAAAACAAAAGTCAAAAAATATGAAAATGGGCAACTTTTACTT
GAAAAAGAAGACAAAATTTTTGCTCATACAACCAAAAATATTCTTTTGGCAATCGGTCGTCAGCCCCAAAATGAGGCATT
CTCTGGTTTAAAAATTGATCTAGATAACCGTGGATTTCTAAAAATCAATAAATTTATGCAAACTTCAGTTCCAAATATTT
ATGCAATCGGTGACATTACGGGTCAAATGATGCTTTCATCAACTGCCTACAAACATGCTGATATTGTTGCAAAGCACATA
TTATTCGGTAGTTCTGATGAAGAATTTAGCGCAGAATTGATTCCTTGGGCAATTTATTCAATTCCGGAAATTGCTTCTGT
AGGGAAGACAGAAAAACAATTATTAAATTTGGATGTTGATTTTCAAAAAGCAAAAATTTTTGCAAAAAATTTGCCCCGTG
CCCACGCTAATGGCGAAATTGAGGCCGGTTTTATTGAGTTATTCTTCCATTCTAAAACTTTTGAAATTCTTGGATGTAAC
ATTTTCCTTGAAGAGGCTTCGCTTCTAGTCAATCAAATTGCCCTTGCACTTTCACAAAAATTAACAATTTTTGACTTGCA
AAAAATGGCTTATACCCATCCGAGCCTTAGCGAGGCATTTTATTATCTTTGTCGAAATATTACCTTTTCAAATCTTAAAA
AATAA

Upstream 100 bases:

>100_bases
TTTATATAATAAAATTCAAAAATTAGTTATAATTAGTAGTAATACTAAAAATAAAAAAGTCAAAAAAAAAAAAAAAAAAA
AACAGAAAAAGCTGGAAAAA

Downstream 100 bases:

>100_bases
AGAGGATTTAAAAATTTATTTTTTAAATTTTTCTTGTTTTGCTTGCTAATAAAAAAATATCCATTAATAAAAGGATATTT
TTTTATTAGTTTTAAAAAAT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVNWGCVPTKTILKSAKIKSYFDNAEKFGLNSVAKFNFKQ
IFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVTSNHTVLAENEEFFFEKLVIATGSKPRKIKIEGAEKANLITSDDFF
KGKIEFDELTIIGGGAISLEFAVFYASFGAKITIIEGNDRVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLL
EKEDKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPNIYAIGDITGQMMLSSTAYKHADIVAKHI
LFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDFQKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCN
IFLEEASLLVNQIALALSQKLTIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK

Sequences:

>Translated_454_residues
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVN*GCVPTKTILKSAKIKSYFDNAEKFGLNSVAKFNFKQ
IFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVTSNHTVLAENEEFFFEKLVIATGSKPRKIKIEGAEKANLITSDDFF
KGKIEFDELTIIGGGAISLEFAVFYASFGAKITIIEGNDRVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLL
EKEDKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPNIYAIGDITGQMMLSSTAYKHADIVAKHI
LFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDFQKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCN
IFLEEASLLVNQIALALSQKLTIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK
>Mature_454_residues
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVN*GCVPTKTILKSAKIKSYFDNAEKFGLNSVAKFNFKQ
IFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVTSNHTVLAENEEFFFEKLVIATGSKPRKIKIEGAEKANLITSDDFF
KGKIEFDELTIIGGGAISLEFAVFYASFGAKITIIEGNDRVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLL
EKEDKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPNIYAIGDITGQMMLSSTAYKHADIVAKHI
LFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDFQKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCN
IFLEEASLLVNQIALALSQKLTIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=29.4117647058824, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50301238, Length=438, Percent_Identity=26.027397260274, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI291045266, Length=467, Percent_Identity=26.7665952890792, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI291045268, Length=354, Percent_Identity=28.8135593220339, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI22035672, Length=357, Percent_Identity=26.3305322128852, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=23.9035087719298, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=23.9035087719298, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=23.9035087719298, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=23.9035087719298, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=23.9035087719298, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI21389617, Length=199, Percent_Identity=25.1256281407035, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI226437568, Length=199, Percent_Identity=25.1256281407035, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI65787454, Length=199, Percent_Identity=25.1256281407035, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082354, Length=453, Percent_Identity=28.6975717439294, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=29.0598290598291, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=27.5711159737418, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789915, Length=426, Percent_Identity=26.5258215962441, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=29.2841648590022, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71983429, Length=336, Percent_Identity=26.7857142857143, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=336, Percent_Identity=26.7857142857143, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17557007, Length=483, Percent_Identity=23.8095238095238, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=394, Percent_Identity=25.1269035532995, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=30.3225806451613, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=30.9012875536481, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=377, Percent_Identity=25.1989389920424, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=28.2327586206897, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24640549, Length=381, Percent_Identity=27.0341207349081, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640553, Length=381, Percent_Identity=27.0341207349081, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640551, Length=492, Percent_Identity=25.609756097561, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737741, Length=488, Percent_Identity=23.9754098360656, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50363; Mature: 50363

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVNGCVPTKTILKSAKIKSY
CCCEEEEEEECCCCCCHHHEEECCCCCEEEEEEHHHCCCEEECCCCCHHHHHHHHHHHHH
FDNAEKFGLNSVAKFNFKQIFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVTSNHTVL
HCCHHHCCCCHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCEECCCEEEECCCEEE
AENEEFFFEKLVIATGSKPRKIKIEGAEKANLITSDDFFKGKIEFDELTIIGGGAISLEF
ECCCHHHHHEEEEECCCCCCEEEEECCCCCCEEECCCCEECEEEEEEEEEEECCEEEEEE
AVFYASFGAKITIIEGNDRVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLLE
EEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHEECCEEEEEEEEEEEEECCCEEEEE
KEDKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPNIYAIGDITG
ECCCEEEEECCEEEEEECCCCCCCCCCCCEEEECCCCEEEEEHHHHCCCCCEEEEECCCH
QMMLSSTAYKHADIVAKHILFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDF
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCEECCCHHHCCHHHHHCCCCCHHHEECCCCH
QKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCNIFLEEASLLVNQIALALSQKL
HHHHHHHHCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEEEEHHHHHHHHHHHHHHHCCC
TIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK
EEEEHHHHHCCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MQKYDVIIIGGGPGGHSLAAILGKNGKKVALFEQEFLGGTCVNGCVPTKTILKSAKIKSY
CCCEEEEEEECCCCCCHHHEEECCCCCEEEEEEHHHCCCEEECCCCCHHHHHHHHHHHHH
FDNAEKFGLNSVAKFNFKQIFQRAKNNSLKLQGSILETLKNSGVDFYNKKAKVTSNHTVL
HCCHHHCCCCHHHHCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCEECCCEEEECCCEEE
AENEEFFFEKLVIATGSKPRKIKIEGAEKANLITSDDFFKGKIEFDELTIIGGGAISLEF
ECCCHHHHHEEEEECCCCCCEEEEECCCCCCEEECCCCEECEEEEEEEEEEECCEEEEEE
AVFYASFGAKITIIEGNDRVFANFDNSIAEAANFVLDRNKVKIFTKTKVKKYENGQLLLE
EEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHEECCEEEEEEEEEEEEECCCEEEEE
KEDKIFAHTTKNILLAIGRQPQNEAFSGLKIDLDNRGFLKINKFMQTSVPNIYAIGDITG
ECCCEEEEECCEEEEEECCCCCCCCCCCCEEEECCCCEEEEEHHHHCCCCCEEEEECCCH
QMMLSSTAYKHADIVAKHILFGSSDEEFSAELIPWAIYSIPEIASVGKTEKQLLNLDVDF
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCEECCCHHHCCHHHHHCCCCCHHHEECCCCH
QKAKIFAKNLPRAHANGEIEAGFIELFFHSKTFEILGCNIFLEEASLLVNQIALALSQKL
HHHHHHHHCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEEEEHHHHHHHHHHHHHHHCCC
TIFDLQKMAYTHPSLSEAFYYLCRNITFSNLKK
EEEEHHHHHCCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]