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The map label for this gene is uvrC [H]

Identifier: 71893421

GI number: 71893421

Start: 78940

End: 80457

Strand: Reverse

Name: uvrC [H]

Synonym: MHJ_0062

Alternate gene names: 71893421

Gene position: 80457-78940 (Counterclockwise)

Preceding gene: 71893430

Following gene: 71893394

Centisome position: 8.97

GC content: 23.65

Gene sequence:

>1518_bases
ATGCTGCCAAACCAGGTAGGAGTTTACCGTTTTTATGATGAAAAAAACACCCTTTTATATGTTGGGAAAGCTAAGAATCT
AAAATCACGAATGAATCAGTATGCAAAAGGAGCAACTAATTCTTATAAAACCGAAGTTTTAATTAGAAAAACTAAAGAAA
TTAAATATGATATTCTCCAAAACGAAACCGAAGCACTAATTTTAGAAAAAAAAATCATAAGCAAATTCCAACCAATTTAT
AATATTAAACTTAAAGATGACCAAAATTATCCCTATATAAAATTAGAATTAGAAAAAAAACTGAATATTGAACTAGTTTA
TAAAATTTCACGCAGCAAAAAGTCAAAAAATATCTTTTTTTATGGGCCTTTTCTTAATAAAAGCAGCGCTTTGGTCCTAA
AAAAAATATTAGAAAATATTGTCTTATACAAAAAAGGACAACAAATTGTACAATCAGAACCAGAAATTTTAAATCAAAAA
TTTTTTTTATGTAAAAAAATACTACAGGAACAAAAATTAATTAGTTTTTGCGAACAAAAATTAGAAAAAGCAAAGAAAAA
TAACCAATTTGAACTCGCCAACGAATATCACAAAGCGCTTATTGCACTGAAAAAAACTAAAATTGAACAACAAAATATTG
AGCTTAACAACCTAAAAAATATTGATTTTCTTTATTATAGTGAAATTGGCGAGAATAATTTAGTAATTAGTTTTGCTTTT
TATCGCAATGGTGTTTTTTTATCTAATAAAAATTTTATTATTGATATTATACTTAATTATACAGAAGTTTTAATTAATTT
TTTAAATAATTATTATAAAATTAATATTTATCCCGATGAGTTAGTAGTTAAAAATTTTTGGCCTAAAAATGCTGAATTTT
TAGACCCAAAAATTAATATCAAAATTGGAAAAAGCTTAAAATATAAGCATATTTTAAACACTTTAGCAAAAAATCACCAA
GATTTTATCAGCCATAATTTTGACCAAGAAATTAAGAAAAAAATTAAAAATCAGAAAATTTTAGAACTAGTTAAAACCAG
TTTAAAAATTGAAAATGTTGAAAAAATTATGGCAATTGACTGCTCAAATTTAGAGTCAAACTACCCCACAACTGGAATTA
TTTTCTATATAAACGGAATATATGAGCGAAATTACAATAGATTTTTCAATTATAGGGGAACAAAAAAAGGTGATACAAAT
TATATGAGACAGGGTTTTGAAAAATATATTAAAAATCCAAAATTTCTAAAACCTGATTTGATTTTAGTAGATGGAGGAAT
TCAACAAATTAATTTAATTATAGAAATTTTAAGAAAAAATCACTTTGAAATTCCGATTTTTGGAATGGTAAAAAATAAAA
GGCATAAAACTGAAAAAATTATTGACTTAAATGGTAAAAAAATTAACCTAGCTCAAGAAGTTCTTAATTTCTTTGCTTTA
ATTCAAGAAAATGTCGATTTATTTGTTAAGGAAAAAATGAAGAAAAAACAAATAAAAAGTTTATTTTCTAAGGAATAA

Upstream 100 bases:

>100_bases
AATTTTTTGTTAAAATTATAATAATTATCAAAAATTTGTTTATATTTTAAGAACTTAAAATTTTTATATGGAAAAATTTC
AGGAATTAGTTAAAAAATTG

Downstream 100 bases:

>100_bases
TTCAAATTTCAGCATTTAAATTTTGTTATCTTTTTGAAAAAAATAAGTTAACAAAATTTAATTTTTAAGCTTATTAATAT
TTAAAAAGGTCTTTAAATTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQNETEALILEKKIISKFQPIY
NIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQK
FFLCKKILQEQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEIGENNLVISFAF
YRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINIKIGKSLKYKHILNTLAKNHQ
DFISHNFDQEIKKKIKNQKILELVKTSLKIENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTN
YMRQGFEKYIKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKINLAQEVLNFFAL
IQENVDLFVKEKMKKKQIKSLFSKE

Sequences:

>Translated_505_residues
MLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQNETEALILEKKIISKFQPIY
NIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQK
FFLCKKILQEQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEIGENNLVISFAF
YRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINIKIGKSLKYKHILNTLAKNHQ
DFISHNFDQEIKKKIKNQKILELVKTSLKIENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTN
YMRQGFEKYIKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKINLAQEVLNFFAL
IQENVDLFVKEKMKKKQIKSLFSKE
>Mature_505_residues
MLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQNETEALILEKKIISKFQPIY
NIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQK
FFLCKKILQEQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEIGENNLVISFAF
YRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINIKIGKSLKYKHILNTLAKNHQ
DFISHNFDQEIKKKIKNQKILELVKTSLKIENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTN
YMRQGFEKYIKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKINLAQEVLNFFAL
IQENVDLFVKEKMKKKQIKSLFSKE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=477, Percent_Identity=25.7861635220126, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 59808; Mature: 59808

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQ
CCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHEEEHHHHHHHHHHC
NETEALILEKKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFF
CCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEE
YGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQKFFLCKKILQEQKLISFCEQK
EECCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEIGENNLVISFAF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEE
YRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINI
EECCEEEECCCEEEEEHHHHHHHHHHHHCCEEEEEEECCHHHHCCCCCCCCCCCCCEEEE
KIGKSLKYKHILNTLAKNHQDFISHNFDQEIKKKIKNQKILELVKTSLKIENVEKIMAID
EECCCCCHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
CSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTNYMRQGFEKYIKNPKFLKPDL
CCCCCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCE
ILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKINLAQEVLNFFAL
EEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEEECCCCEEHHHHHHHHHHHH
IQENVDLFVKEKMKKKQIKSLFSKE
HHHCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQ
CCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHEEEHHHHHHHHHHC
NETEALILEKKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFF
CCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEE
YGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQKFFLCKKILQEQKLISFCEQK
EECCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEIGENNLVISFAF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEE
YRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINI
EECCEEEECCCEEEEEHHHHHHHHHHHHCCEEEEEEECCHHHHCCCCCCCCCCCCCEEEE
KIGKSLKYKHILNTLAKNHQDFISHNFDQEIKKKIKNQKILELVKTSLKIENVEKIMAID
EECCCCCHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
CSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTNYMRQGFEKYIKNPKFLKPDL
CCCCCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCE
ILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKINLAQEVLNFFAL
EEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEEECCCCEEHHHHHHHHHHHH
IQENVDLFVKEKMKKKQIKSLFSKE
HHHCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9664578 [H]