Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 71892055

GI number: 71892055

Start: 326982

End: 327707

Strand: Direct

Name: pyrH

Synonym: BPEN_281

Alternate gene names: 71892055

Gene position: 326982-327707 (Clockwise)

Preceding gene: 71892054

Following gene: 71892056

Centisome position: 41.3

GC content: 35.54

Gene sequence:

>726_bases
ATGGTAACTCACACGAAACCAATTTATCGGCGTATCGTACTTAAAATGAGTGGAGAAGCTCTACAAGGCGCCGAAGGTTT
TGGAATCGATACTACTATATTAAACCGAATGGTTACAGAAGTTAAAGAGTTAGTTAAAATAGGTATTCAAATAGGTATAG
TTATGGGAGGCGGCAACTTGTTCCGTGGCGCCGAATTAGTTAAATCCGGTATGAATCGTATAGTAGGAGACCATATAGGG
ATGTTAGCTACTATAATGAATGGATTAGCCATGAGAAGTGCATTAAATCATGCTTATGTTCATTCCCATTTAATGTCAGC
TATTCCATTAAATGGAGTATGCGATCATTATAATTGGATGAAAGCTATTAACTTACTGTCTAATAATTGGGTGGTAATTT
TTGCAGCTGGGACCGGAAACCCTTTATTTACTACCGATTCTGCTGCCTGTTTGCGTGGTATTGAAATTAAAGCAGATGTA
GTACTTAAAGCAACTAAAGTAGATGGTGTATTTTCTACTGATCCAATTCAACACCCTGATGCTACACTATATGAACAATT
GAGTTATCAGGACGTACTAGAGCGTGAATTAAAAGTTATGGATTTGACAGCATTTACATTGGCACGAGAACACAATTTAC
CAATACGCATATTTAATATAAATAAACTTGGAGCATTAAAAAGAATAATAATGGGATATAAAGAAGGGACTTTAATAACC
AAATAA

Upstream 100 bases:

>100_bases
AAATTGGTTAAAATCGGAATAATTGTTGACATGCATATTATACTTTAAATAAGTTAGTGTTTGCTTCTGTTTATGCCATT
TTTTGTGAGGAATATAATTA

Downstream 100 bases:

>100_bases
TTTAAAGATGTGCGACATTCAAATAAATACTTAAATTTATATAAATTGATTTTTAATTTAGAAATATAAATCAGAGGTAT
ATGATGTGATTAATAAAATT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MVTHTKPIYRRIVLKMSGEALQGAEGFGIDTTILNRMVTEVKELVKIGIQIGIVMGGGNLFRGAELVKSGMNRIVGDHIG
MLATIMNGLAMRSALNHAYVHSHLMSAIPLNGVCDHYNWMKAINLLSNNWVVIFAAGTGNPLFTTDSAACLRGIEIKADV
VLKATKVDGVFSTDPIQHPDATLYEQLSYQDVLERELKVMDLTAFTLAREHNLPIRIFNINKLGALKRIIMGYKEGTLIT
K

Sequences:

>Translated_241_residues
MVTHTKPIYRRIVLKMSGEALQGAEGFGIDTTILNRMVTEVKELVKIGIQIGIVMGGGNLFRGAELVKSGMNRIVGDHIG
MLATIMNGLAMRSALNHAYVHSHLMSAIPLNGVCDHYNWMKAINLLSNNWVVIFAAGTGNPLFTTDSAACLRGIEIKADV
VLKATKVDGVFSTDPIQHPDATLYEQLSYQDVLERELKVMDLTAFTLAREHNLPIRIFNINKLGALKRIIMGYKEGTLIT
K
>Mature_241_residues
MVTHTKPIYRRIVLKMSGEALQGAEGFGIDTTILNRMVTEVKELVKIGIQIGIVMGGGNLFRGAELVKSGMNRIVGDHIG
MLATIMNGLAMRSALNHAYVHSHLMSAIPLNGVCDHYNWMKAINLLSNNWVVIFAAGTGNPLFTTDSAACLRGIEIKADV
VLKATKVDGVFSTDPIQHPDATLYEQLSYQDVLERELKVMDLTAFTLAREHNLPIRIFNINKLGALKRIIMGYKEGTLIT
K

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=241, Percent_Identity=73.4439834024896, Blast_Score=389, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_BLOPB (Q493D0)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277785.1
- HSSP:   P65938
- ProteinModelPortal:   Q493D0
- SMR:   Q493D0
- STRING:   Q493D0
- GeneID:   3563218
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_281
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- BioCyc:   CBLO291272:BPEN_281-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26519; Mature: 26519

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: BINDING 57-57 BINDING 58-58 BINDING 62-62 BINDING 77-77 BINDING 165-165 BINDING 171-171 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTHTKPIYRRIVLKMSGEALQGAEGFGIDTTILNRMVTEVKELVKIGIQIGIVMGGGNL
CCCCCHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCH
FRGAELVKSGMNRIVGDHIGMLATIMNGLAMRSALNHAYVHSHLMSAIPLNGVCDHYNWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAINLLSNNWVVIFAAGTGNPLFTTDSAACLRGIEIKADVVLKATKVDGVFSTDPIQHPD
HHHHHHCCCEEEEEEECCCCCEEECCHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCCCC
ATLYEQLSYQDVLERELKVMDLTAFTLAREHNLPIRIFNINKLGALKRIIMGYKEGTLIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCEEC
K
C
>Mature Secondary Structure
MVTHTKPIYRRIVLKMSGEALQGAEGFGIDTTILNRMVTEVKELVKIGIQIGIVMGGGNL
CCCCCHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCH
FRGAELVKSGMNRIVGDHIGMLATIMNGLAMRSALNHAYVHSHLMSAIPLNGVCDHYNWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAINLLSNNWVVIFAAGTGNPLFTTDSAACLRGIEIKADVVLKATKVDGVFSTDPIQHPD
HHHHHHCCCEEEEEEECCCCCEEECCHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCCCC
ATLYEQLSYQDVLERELKVMDLTAFTLAREHNLPIRIFNINKLGALKRIIMGYKEGTLIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCEEC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA