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The map label for this gene is ubiH [H]

Identifier: 71892040

GI number: 71892040

Start: 302617

End: 303807

Strand: Direct

Name: ubiH [H]

Synonym: BPEN_266

Alternate gene names: 71892040

Gene position: 302617-303807 (Clockwise)

Preceding gene: 71892037

Following gene: 71892041

Centisome position: 38.23

GC content: 30.73

Gene sequence:

>1191_bases
ATGTCTATTGTTATAAATGGCGGAGGGATGACGGGCGCAATACTAGCCTTAATGTTATCTAAATTGACAAAAGGAGATTT
AGAAATTTCCTTAATAGAGCAACATTCTCCTTATTGTTATAATACAAAATTATCCTCAAATGCATACCCACCTCATGTAA
TAGCTTTATCGCGAGGCGCTTATTTTGAATTAATACGAATTAATATGGCTCCAATTTTATCTTCTTGCTCCACCATTATA
AAACAAGTAGAGGTTAGTGAATATCATCGGTTGAATAAAATATTTATTGATGCTCAAGACTATCAATTACCAGAATTAGG
TTATGTTATCGAATTAGATATATTTAGAAAGAAATTGTTTGATTTTTTACATAATAAATCTACTGTAACTGTATATTGCC
CAGCAACTTTAAAAAAAATTAAACGTGAAAAAAAAAATAACATAATTGTTTTAAATAATGATCATCAAATAGTTTCAAAA
TTAATGGTCGCGGCAGATGGTGCAGATTCAACACTAGCTGCCAATTGTGGTATGCAATGGTTCAGATGGAATTATCAACA
AATTGCTGTAGTTTCTAAAATTACTACTGAAATACCTCATTTTGGAAGAGCTTTTGAAAAATTTACAGAGTATGGACCAT
TAGCCATATTGCCTATGGCTAACGATTCTAGTTTTTTAATTTGGTGTATTTCTGATAAACAAAAAAAAGAGGTATCTACA
TGGAATAGAGATAAATTTGCTCAAGAATTACAAAATGTATTCGGATGGAAATTAGGAAAAATTTTGAATATAGGAAAGAG
ATATTTTTATGATCTTTGGTTAACGCGGGCTAATAGCCATATTAGTCATAGATTAGCATTAGTCGGAAATGCGGCACAAA
ATTTACACCCTATTGCTGGACAAGGATTCAATCTTGGATTGCGTGACATTGTAGTGTTATCAAAAATAGTAACACAAGCA
TTATATCAGAATCTAGATATTGGAGACTATTCTGTGTTAAATAGATACCAAAAACATAGGCATTTAGATCAATGTAGGAC
CATTAAAATTACCGATGGATTAGTGCGTCTATTTAGCAATCATTACTTGCCCTTGATTATTGCTCGAAATATGGGTTTAT
TTTTTGTTAACTATAATGTCTTTCTAAGACGTCTTTTAGTAAGTTCAATATTAAATTGGAAAACAGATTAA

Upstream 100 bases:

>100_bases
TACTGATATTTGAAAAAATATAGTCTGATTATATATAATTCATATACTATATTTTTGTTTGATATTAAAATTTTTATATT
CATACGTTAGATAATAATCG

Downstream 100 bases:

>100_bases
TTTTTATTTAAATAAACAATAATGTGGACAGTTTCGATCTATTAATTGTAAATCAAGGAATTGCCGGATTGGCATTAGCC
TGCGGTTTAGGTGATTGTTT

Product: 2-octaprenyl-6-methoxyphenol hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSIVINGGGMTGAILALMLSKLTKGDLEISLIEQHSPYCYNTKLSSNAYPPHVIALSRGAYFELIRINMAPILSSCSTII
KQVEVSEYHRLNKIFIDAQDYQLPELGYVIELDIFRKKLFDFLHNKSTVTVYCPATLKKIKREKKNNIIVLNNDHQIVSK
LMVAADGADSTLAANCGMQWFRWNYQQIAVVSKITTEIPHFGRAFEKFTEYGPLAILPMANDSSFLIWCISDKQKKEVST
WNRDKFAQELQNVFGWKLGKILNIGKRYFYDLWLTRANSHISHRLALVGNAAQNLHPIAGQGFNLGLRDIVVLSKIVTQA
LYQNLDIGDYSVLNRYQKHRHLDQCRTIKITDGLVRLFSNHYLPLIIARNMGLFFVNYNVFLRRLLVSSILNWKTD

Sequences:

>Translated_396_residues
MSIVINGGGMTGAILALMLSKLTKGDLEISLIEQHSPYCYNTKLSSNAYPPHVIALSRGAYFELIRINMAPILSSCSTII
KQVEVSEYHRLNKIFIDAQDYQLPELGYVIELDIFRKKLFDFLHNKSTVTVYCPATLKKIKREKKNNIIVLNNDHQIVSK
LMVAADGADSTLAANCGMQWFRWNYQQIAVVSKITTEIPHFGRAFEKFTEYGPLAILPMANDSSFLIWCISDKQKKEVST
WNRDKFAQELQNVFGWKLGKILNIGKRYFYDLWLTRANSHISHRLALVGNAAQNLHPIAGQGFNLGLRDIVVLSKIVTQA
LYQNLDIGDYSVLNRYQKHRHLDQCRTIKITDGLVRLFSNHYLPLIIARNMGLFFVNYNVFLRRLLVSSILNWKTD
>Mature_395_residues
SIVINGGGMTGAILALMLSKLTKGDLEISLIEQHSPYCYNTKLSSNAYPPHVIALSRGAYFELIRINMAPILSSCSTIIK
QVEVSEYHRLNKIFIDAQDYQLPELGYVIELDIFRKKLFDFLHNKSTVTVYCPATLKKIKREKKNNIIVLNNDHQIVSKL
MVAADGADSTLAANCGMQWFRWNYQQIAVVSKITTEIPHFGRAFEKFTEYGPLAILPMANDSSFLIWCISDKQKKEVSTW
NRDKFAQELQNVFGWKLGKILNIGKRYFYDLWLTRANSHISHRLALVGNAAQNLHPIAGQGFNLGLRDIVVLSKIVTQAL
YQNLDIGDYSVLNRYQKHRHLDQCRTIKITDGLVRLFSNHYLPLIIARNMGLFFVNYNVFLRRLLVSSILNWKTD

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=322, Percent_Identity=27.0186335403727, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI32967307, Length=322, Percent_Identity=27.0186335403727, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1789274, Length=396, Percent_Identity=43.1818181818182, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1789273, Length=380, Percent_Identity=28.9473684210526, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786883, Length=388, Percent_Identity=28.8659793814433, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI25146631, Length=425, Percent_Identity=25.1764705882353, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321694, Length=293, Percent_Identity=22.8668941979522, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920760, Length=322, Percent_Identity=22.9813664596273, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 45308; Mature: 45177

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVINGGGMTGAILALMLSKLTKGDLEISLIEQHSPYCYNTKLSSNAYPPHVIALSRGA
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCC
YFELIRINMAPILSSCSTIIKQVEVSEYHRLNKIFIDAQDYQLPELGYVIELDIFRKKLF
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEHHHHHHHHH
DFLHNKSTVTVYCPATLKKIKREKKNNIIVLNNDHQIVSKLMVAADGADSTLAANCGMQW
HHHCCCCEEEEECCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHCCCHH
FRWNYQQIAVVSKITTEIPHFGRAFEKFTEYGPLAILPMANDSSFLIWCISDKQKKEVST
HHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHC
WNRDKFAQELQNVFGWKLGKILNIGKRYFYDLWLTRANSHISHRLALVGNAAQNLHPIAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCHHCCCCCCC
QGFNLGLRDIVVLSKIVTQALYQNLDIGDYSVLNRYQKHRHLDQCRTIKITDGLVRLFSN
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHC
HYLPLIIARNMGLFFVNYNVFLRRLLVSSILNWKTD
CCEEEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SIVINGGGMTGAILALMLSKLTKGDLEISLIEQHSPYCYNTKLSSNAYPPHVIALSRGA
EEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCC
YFELIRINMAPILSSCSTIIKQVEVSEYHRLNKIFIDAQDYQLPELGYVIELDIFRKKLF
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEHHHHHHHHH
DFLHNKSTVTVYCPATLKKIKREKKNNIIVLNNDHQIVSKLMVAADGADSTLAANCGMQW
HHHCCCCEEEEECCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHCCCHH
FRWNYQQIAVVSKITTEIPHFGRAFEKFTEYGPLAILPMANDSSFLIWCISDKQKKEVST
HHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHHC
WNRDKFAQELQNVFGWKLGKILNIGKRYFYDLWLTRANSHISHRLALVGNAAQNLHPIAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCHHCCCCCCC
QGFNLGLRDIVVLSKIVTQALYQNLDIGDYSVLNRYQKHRHLDQCRTIKITDGLVRLFSN
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHC
HYLPLIIARNMGLFFVNYNVFLRRLLVSSILNWKTD
CCEEEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]