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The map label for this gene is cysG

Identifier: 71891949

GI number: 71891949

Start: 213326

End: 214750

Strand: Direct

Name: cysG

Synonym: BPEN_166

Alternate gene names: 71891949

Gene position: 213326-214750 (Clockwise)

Preceding gene: 71891948

Following gene: 71891950

Centisome position: 26.95

GC content: 33.05

Gene sequence:

>1425_bases
GTGGAATATTTACCGATATTTATTGATCTCAAAAATAGGCCAGTGTTAGTAGTTGGGGGAGGTGCTGTTGCTGCACGAAA
AATACACATGCTACAAAGGGCCACTATTACAATAGTGGCCCCCGCCCTTTGTACAGAATTAAAAAAAGTTTTAATTAAAC
AAAATATCAGTTGGATTAGTAAAAATTTTCAACCTATTATGTTAAATAAAGTAATTTTAGTGATTGTAGCAACCAATGAT
TCTAAATTAAATACTTTTATATACCAAAATGCTGAAAAACACAATATATTGATAAATACTGTGGATGACAAAAATAAATG
TTCATTTATTTTCCCTGCTATTATTGATCGTAATCCTGTTTTAATAGGAATTTCTTCTTGCGGAAAAGCGCCTATTTTAG
TACGTATTTTACGTGAAAAACTTGAATTGTTATTACCAAAGTCTCTGGGATTTGTAGCAAAATTGGCGGGAGCATGGCGT
AATAAAGTAAAACAGCATATCGTAGATACAGTACTTAGGCGTCAGTTTTGGGAGAAAATATTTTATAATGGACACGTTGT
TACCTTAATGGAAAAAGGTCGCCCTAAAGAAGCCAATAAAGTTTTAAACTATGCGCTTAACAATTCTGTAAAAAATAAGA
ATAATAAAACAGGTCATGTCACGTTAGTAGGAGCGGGGCCCGGAGATATAGGATTGTTAACTATCAGAGGATTGCAAGTA
ATACAACAAGCAGATATCATCCTATATGATTATTTAGTAAATTCAGATATTTTAGATTTAGCCCGGCGCGATGCTGATAA
AATTTGTGTTGGAAAACATGTTGGGAATCATTCAATTTCTCAAAAAAAACTCAATCAATTTATAGTACAATTAGCGCAAA
AAGGAAATAAAGTCGTTAGACTGAAAGGAGGAGATCCATTTATTTTTGGACGGGGCGGAGAGGAATTACAAGCAATATCG
GAGGCAGGTATTGCTTTTCAAGTAGTTCCTGGTATTACAGCAGGAATCGGAGTTGCGGCTTATTCTGGTATTCCTTTAAC
TCATAGAAAATATGCTCATAGTGTTGTTTTTATTACAGGACATAATACAAATGGCGATAATCAATTTAATTGGAACAGTT
TATCGAACAACCAACAGACATTAGTCATTTACATGGGTAAGATTAATGCTATAAGTATTAGGAATAATCTAATCATTCAT
GGAAGAAATATGCATACGCCCGTAGCCGTAATTAGTCGAGGGACATATCAAGATCAAAAAATTTTAATTGGGACCTTAAT
TGAATTAGAAAAATTGACACAAATGGCTGATCATCCCGCTTTGTTAGTTATTGGCGATGTCGTGTCATTGCATAGTAAAA
TTAATTGGTTTGGTCAAAAAGCATTGCATTATTATCTTATTAATTCAATTATTAATTTGATATAA

Upstream 100 bases:

>100_bases
CTATTATTCATTAATTATAATTTTGTGATTGTATAATCATATTTAATGTACATTAAAAACTTTTAATATTTTATTATTAC
TTAAGCATCAACGTAATACC

Downstream 100 bases:

>100_bases
GTTAAAAGGACAATGTATGATCCACAATAGAAAGCATATTACTTATTTTCATAGATTAGAGTCAGAAAGTATCTATATTA
TTCGTGAAGTAGTTGCTGAG

Product: 1,3-dimethyluroporphyriongen III dehydrogenase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MEYLPIFIDLKNRPVLVVGGGAVAARKIHMLQRATITIVAPALCTELKKVLIKQNISWISKNFQPIMLNKVILVIVATND
SKLNTFIYQNAEKHNILINTVDDKNKCSFIFPAIIDRNPVLIGISSCGKAPILVRILREKLELLLPKSLGFVAKLAGAWR
NKVKQHIVDTVLRRQFWEKIFYNGHVVTLMEKGRPKEANKVLNYALNNSVKNKNNKTGHVTLVGAGPGDIGLLTIRGLQV
IQQADIILYDYLVNSDILDLARRDADKICVGKHVGNHSISQKKLNQFIVQLAQKGNKVVRLKGGDPFIFGRGGEELQAIS
EAGIAFQVVPGITAGIGVAAYSGIPLTHRKYAHSVVFITGHNTNGDNQFNWNSLSNNQQTLVIYMGKINAISIRNNLIIH
GRNMHTPVAVISRGTYQDQKILIGTLIELEKLTQMADHPALLVIGDVVSLHSKINWFGQKALHYYLINSIINLI

Sequences:

>Translated_474_residues
MEYLPIFIDLKNRPVLVVGGGAVAARKIHMLQRATITIVAPALCTELKKVLIKQNISWISKNFQPIMLNKVILVIVATND
SKLNTFIYQNAEKHNILINTVDDKNKCSFIFPAIIDRNPVLIGISSCGKAPILVRILREKLELLLPKSLGFVAKLAGAWR
NKVKQHIVDTVLRRQFWEKIFYNGHVVTLMEKGRPKEANKVLNYALNNSVKNKNNKTGHVTLVGAGPGDIGLLTIRGLQV
IQQADIILYDYLVNSDILDLARRDADKICVGKHVGNHSISQKKLNQFIVQLAQKGNKVVRLKGGDPFIFGRGGEELQAIS
EAGIAFQVVPGITAGIGVAAYSGIPLTHRKYAHSVVFITGHNTNGDNQFNWNSLSNNQQTLVIYMGKINAISIRNNLIIH
GRNMHTPVAVISRGTYQDQKILIGTLIELEKLTQMADHPALLVIGDVVSLHSKINWFGQKALHYYLINSIINLI
>Mature_474_residues
MEYLPIFIDLKNRPVLVVGGGAVAARKIHMLQRATITIVAPALCTELKKVLIKQNISWISKNFQPIMLNKVILVIVATND
SKLNTFIYQNAEKHNILINTVDDKNKCSFIFPAIIDRNPVLIGISSCGKAPILVRILREKLELLLPKSLGFVAKLAGAWR
NKVKQHIVDTVLRRQFWEKIFYNGHVVTLMEKGRPKEANKVLNYALNNSVKNKNNKTGHVTLVGAGPGDIGLLTIRGLQV
IQQADIILYDYLVNSDILDLARRDADKICVGKHVGNHSISQKKLNQFIVQLAQKGNKVVRLKGGDPFIFGRGGEELQAIS
EAGIAFQVVPGITAGIGVAAYSGIPLTHRKYAHSVVFITGHNTNGDNQFNWNSLSNNQQTLVIYMGKINAISIRNNLIIH
GRNMHTPVAVISRGTYQDQKILIGTLIELEKLTQMADHPALLVIGDVVSLHSKINWFGQKALHYYLINSIINLI

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family

Homologues:

Organism=Escherichia coli, GI1789768, Length=459, Percent_Identity=46.8409586056645, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322922, Length=235, Percent_Identity=33.6170212765957, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSG_BLOPB (Q493N1)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277679.1
- ProteinModelPortal:   Q493N1
- SMR:   Q493N1
- STRING:   Q493N1
- GeneID:   3563112
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_166
- eggNOG:   COG0007
- HOGENOM:   HBG730212
- OMA:   PVLAQMI
- ProtClustDB:   CLSK280718
- BioCyc:   CBLO291272:BPEN_166-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01646
- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043
- Gene3D:   G3DSA:3.40.1010.10
- Gene3D:   G3DSA:3.30.950.10
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.8.210
- TIGRFAMs:   TIGR01469
- TIGRFAMs:   TIGR01470

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase; SSF53790 Cor/por_Metransf

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4

Molecular weight: Translated: 52602; Mature: 52602

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS00839 SUMT_1; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYLPIFIDLKNRPVLVVGGGAVAARKIHMLQRATITIVAPALCTELKKVLIKQNISWIS
CCEEEEEEEECCCCEEEECCCHHHHHHHHHHHHCEEEEECHHHHHHHHHHHHHHCHHHHH
KNFQPIMLNKVILVIVATNDSKLNTFIYQNAEKHNILINTVDDKNKCSFIFPAIIDRNPV
CCCCEEEECEEEEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEHHHCCCCCE
LIGISSCGKAPILVRILREKLELLLPKSLGFVAKLAGAWRNKVKQHIVDTVLRRQFWEKI
EEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYNGHVVTLMEKGRPKEANKVLNYALNNSVKNKNNKTGHVTLVGAGPGDIGLLTIRGLQV
HHCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHH
IQQADIILYDYLVNSDILDLARRDADKICVGKHVGNHSISQKKLNQFIVQLAQKGNKVVR
HHHCCEEEEEEHHCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEE
LKGGDPFIFGRGGEELQAISEAGIAFQVVPGITAGIGVAAYSGIPLTHRKYAHSVVFITG
EECCCEEEECCCCHHHHHHHHCCCEEEECCCCCCCCCHHHCCCCCCCCCCCCCEEEEEEE
HNTNGDNQFNWNSLSNNQQTLVIYMGKINAISIRNNLIIHGRNMHTPVAVISRGTYQDQK
CCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECEEEEECCCCCCCEEEEECCCCCCCH
ILIGTLIELEKLTQMADHPALLVIGDVVSLHSKINWFGQKALHYYLINSIINLI
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEYLPIFIDLKNRPVLVVGGGAVAARKIHMLQRATITIVAPALCTELKKVLIKQNISWIS
CCEEEEEEEECCCCEEEECCCHHHHHHHHHHHHCEEEEECHHHHHHHHHHHHHHCHHHHH
KNFQPIMLNKVILVIVATNDSKLNTFIYQNAEKHNILINTVDDKNKCSFIFPAIIDRNPV
CCCCEEEECEEEEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEHHHCCCCCE
LIGISSCGKAPILVRILREKLELLLPKSLGFVAKLAGAWRNKVKQHIVDTVLRRQFWEKI
EEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYNGHVVTLMEKGRPKEANKVLNYALNNSVKNKNNKTGHVTLVGAGPGDIGLLTIRGLQV
HHCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHH
IQQADIILYDYLVNSDILDLARRDADKICVGKHVGNHSISQKKLNQFIVQLAQKGNKVVR
HHHCCEEEEEEHHCCHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEE
LKGGDPFIFGRGGEELQAISEAGIAFQVVPGITAGIGVAAYSGIPLTHRKYAHSVVFITG
EECCCEEEECCCCHHHHHHHHCCCEEEECCCCCCCCCHHHCCCCCCCCCCCCCEEEEEEE
HNTNGDNQFNWNSLSNNQQTLVIYMGKINAISIRNNLIIHGRNMHTPVAVISRGTYQDQK
CCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECEEEEECCCCCCCEEEEECCCCCCCH
ILIGTLIELEKLTQMADHPALLVIGDVVSLHSKINWFGQKALHYYLINSIINLI
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA