Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 71891938

GI number: 71891938

Start: 191738

End: 192232

Strand: Direct

Name: folK [H]

Synonym: BPEN_155

Alternate gene names: 71891938

Gene position: 191738-192232 (Clockwise)

Preceding gene: 71891937

Following gene: 71891942

Centisome position: 24.22

GC content: 34.14

Gene sequence:

>495_bases
ATGGAACGAGTTTGGGTCAGCATTGGTAGTAATCTGTTAAATCCAAAACAACAAGCGGATCGTGCTATCTGGTCTCTTTC
TAAGCTTCCAATGACTAGACTTATAGATTTTTCTTCCTATTATCGTAGTCTGCCATTAGGAGATAAAAATCAGCCCGATT
TTCTAAATGCGATAATAATTCTAGATACTAATTTATCTCCAAAAGGATTATTAAGTCATATGCAATATATCGAACGAAAA
CAAGGACGTGCACGACGATCACGGGATTCTCTTATATGGCAGCCACGTACTTTAGATTTAGATATCTTACTATTTGGAAA
ATACTTTACATATAGTACTGAATTGACAATACCGCATCATGGTTTGCTTAATCGAGAGTTCGTACTTTATCCATTGATGG
CATTAGATAATAATTTCATTTTTCCTAATGGGAGCGTTATAACAGATATCGTTAAAACTGTACCTAAAAATGATTTAGAT
TTTTGGCAGGAATAA

Upstream 100 bases:

>100_bases
CTAAATATTTATGTGATGTTTTAATTTTGATATTATTTAAAGTTTTTTCATGAAAATGAAGGGGTCGGTAATTTGATAAT
TTATTGGAATATATAATAAA

Downstream 100 bases:

>100_bases
TAAAAATGAAAATATATATATTATATATAGACTGTTGTATGTGTTGTTTTTAAAAATAAATTAGACGATATATATTCAAC
TAAAGATCTAATGATATTGA

Product: 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MERVWVSIGSNLLNPKQQADRAIWSLSKLPMTRLIDFSSYYRSLPLGDKNQPDFLNAIIILDTNLSPKGLLSHMQYIERK
QGRARRSRDSLIWQPRTLDLDILLFGKYFTYSTELTIPHHGLLNREFVLYPLMALDNNFIFPNGSVITDIVKTVPKNDLD
FWQE

Sequences:

>Translated_164_residues
MERVWVSIGSNLLNPKQQADRAIWSLSKLPMTRLIDFSSYYRSLPLGDKNQPDFLNAIIILDTNLSPKGLLSHMQYIERK
QGRARRSRDSLIWQPRTLDLDILLFGKYFTYSTELTIPHHGLLNREFVLYPLMALDNNFIFPNGSVITDIVKTVPKNDLD
FWQE
>Mature_164_residues
MERVWVSIGSNLLNPKQQADRAIWSLSKLPMTRLIDFSSYYRSLPLGDKNQPDFLNAIIILDTNLSPKGLLSHMQYIERK
QGRARRSRDSLIWQPRTLDLDILLFGKYFTYSTELTIPHHGLLNREFVLYPLMALDNNFIFPNGSVITDIVKTVPKNDLD
FWQE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=162, Percent_Identity=41.358024691358, Blast_Score=143, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324073, Length=139, Percent_Identity=31.6546762589928, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19112; Mature: 19112

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERVWVSIGSNLLNPKQQADRAIWSLSKLPMTRLIDFSSYYRSLPLGDKNQPDFLNAIII
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LDTNLSPKGLLSHMQYIERKQGRARRSRDSLIWQPRTLDLDILLFGKYFTYSTELTIPHH
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECEEEEEEEEECCCC
GLLNREFVLYPLMALDNNFIFPNGSVITDIVKTVPKNDLDFWQE
CCCCCCHHEEEHHHCCCCEECCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MERVWVSIGSNLLNPKQQADRAIWSLSKLPMTRLIDFSSYYRSLPLGDKNQPDFLNAIII
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LDTNLSPKGLLSHMQYIERKQGRARRSRDSLIWQPRTLDLDILLFGKYFTYSTELTIPHH
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECEEEEEEEEECCCC
GLLNREFVLYPLMALDNNFIFPNGSVITDIVKTVPKNDLDFWQE
CCCCCCHHEEEHHHCCCCEECCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]