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The map label for this gene is lpxC

Identifier: 71891934

GI number: 71891934

Start: 185108

End: 186001

Strand: Direct

Name: lpxC

Synonym: BPEN_151

Alternate gene names: 71891934

Gene position: 185108-186001 (Clockwise)

Preceding gene: 71891933

Following gene: 71891935

Centisome position: 23.38

GC content: 32.89

Gene sequence:

>894_bases
ATGATAAAACAACGAACATTGAAACGCGTTGTGCAAACTACTGGTGTAGGTTTACACACCGGTAAAAAAGTTACGTTAAC
TTTACGTCCTACTTCAGCAAATACTGGAATTATTTATCGTCGTACTGACTTATATCCTCCTGTAGATCTTCAAGTTAATG
TGAAATCAGTAGGAAACACCGTGTTATGTACATGTTTGATTAATGAATATGGTGTTCAGATTTTTACTGTTGAACATTTA
AGTGCTGCTCAAGCAGGATTGGGTATTGACAATATTATTATAGAACTCAATGCTCCTGAGGTTCCAATAATGGATGGTAG
CGCTAGTCCTTTTGTGTGTTTGTTATTGGATGCTGGTATAGAAGAACTTAATAGTGCAAAAAAATTTCTTCGATTAAAAC
AAACAGTACGTGTTGAAGATGGAGAAAAATGGGCTGAATTAAGGCCGTTTAATGGTTTTACGCTTGATTTTACTATTGAT
TTCAATCATCCAGCTATCAATGTGGATACACAACATTGTTTTTTTAATTTTTCTTCAGCATCTTTTGTTCATAATATTAG
TAGAGCACGTACTTTTGGTTTTATGCGCGATATTAAAGATTTACAATCTCGTGGATTTGCTTTAGGAGGAAGTTTTAATT
CTGCTATAATAATTGATGATTATCGTGTACTTAATGAAGATGGTTTACGTTTTGATGATGAATTTGTCCGTCATAAAATG
CTTGATGCTATTGGGGATTTATTTATGTGTGGACATAATCTTATTGGTTCTTTTATTGCTTTTAAATCGGGACATACCTT
AAATAATAAATTATTAAAAACTGTTTTGTCATGCCAAGAAGCATGGGAACTTGCTACTTTTTCTAACGCATCTGACTTAC
CTTTAGTATTTTAA

Upstream 100 bases:

>100_bases
GAGATAATAGTGTAAATGAGTAATTTGTATAACAAATGCAATATACATATAGTGATTTACTAATAAAGTAAATATTACAA
TAATTGCATGAGATGATATA

Downstream 100 bases:

>100_bases
GATTTAATCGTATCTTTGAATATAGAATATAATAATAATCATTCTAAATTTTAGCATACAAATTTACCTAGATTTATTTA
TAGATATTATGTATTTTGAT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIKQRTLKRVVQTTGVGLHTGKKVTLTLRPTSANTGIIYRRTDLYPPVDLQVNVKSVGNTVLCTCLINEYGVQIFTVEHL
SAAQAGLGIDNIIIELNAPEVPIMDGSASPFVCLLLDAGIEELNSAKKFLRLKQTVRVEDGEKWAELRPFNGFTLDFTID
FNHPAINVDTQHCFFNFSSASFVHNISRARTFGFMRDIKDLQSRGFALGGSFNSAIIIDDYRVLNEDGLRFDDEFVRHKM
LDAIGDLFMCGHNLIGSFIAFKSGHTLNNKLLKTVLSCQEAWELATFSNASDLPLVF

Sequences:

>Translated_297_residues
MIKQRTLKRVVQTTGVGLHTGKKVTLTLRPTSANTGIIYRRTDLYPPVDLQVNVKSVGNTVLCTCLINEYGVQIFTVEHL
SAAQAGLGIDNIIIELNAPEVPIMDGSASPFVCLLLDAGIEELNSAKKFLRLKQTVRVEDGEKWAELRPFNGFTLDFTID
FNHPAINVDTQHCFFNFSSASFVHNISRARTFGFMRDIKDLQSRGFALGGSFNSAIIIDDYRVLNEDGLRFDDEFVRHKM
LDAIGDLFMCGHNLIGSFIAFKSGHTLNNKLLKTVLSCQEAWELATFSNASDLPLVF
>Mature_297_residues
MIKQRTLKRVVQTTGVGLHTGKKVTLTLRPTSANTGIIYRRTDLYPPVDLQVNVKSVGNTVLCTCLINEYGVQIFTVEHL
SAAQAGLGIDNIIIELNAPEVPIMDGSASPFVCLLLDAGIEELNSAKKFLRLKQTVRVEDGEKWAELRPFNGFTLDFTID
FNHPAINVDTQHCFFNFSSASFVHNISRARTFGFMRDIKDLQSRGFALGGSFNSAIIIDDYRVLNEDGLRFDDEFVRHKM
LDAIGDLFMCGHNLIGSFIAFKSGHTLNNKLLKTVLSCQEAWELATFSNASDLPLVF

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=74.4107744107744, Blast_Score=477, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_BLOPB (Q493P6)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277664.1
- ProteinModelPortal:   Q493P6
- SMR:   Q493P6
- STRING:   Q493P6
- GeneID:   3563086
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_151
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- BioCyc:   CBLO291272:BPEN_151-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33067; Mature: 33067

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKRVVQTTGVGLHTGKKVTLTLRPTSANTGIIYRRTDLYPPVDLQVNVKSVGNT
CCCHHHHHHHHHHCCCCEECCCEEEEEEEECCCCCCEEEEECCCCCCCCEEEEHHHCCCE
VLCTCLINEYGVQIFTVEHLSAAQAGLGIDNIIIELNAPEVPIMDGSASPFVCLLLDAGI
EEEEEEEHHCCEEEEEEEHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCEEEEEEHHCH
EELNSAKKFLRLKQTVRVEDGEKWAELRPFNGFTLDFTIDFNHPAINVDTQHCFFNFSSA
HHHHHHHHHHHHHHHEEECCCCCHHHCCCCCCEEEEEEEECCCCEEECCCCEEEEECCCH
SFVHNISRARTFGFMRDIKDLQSRGFALGGSFNSAIIIDDYRVLNEDGLRFDDEFVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCCHHHHHHHH
LDAIGDLFMCGHNLIGSFIAFKSGHTLNNKLLKTVLSCQEAWELATFSNASDLPLVF
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEC
>Mature Secondary Structure
MIKQRTLKRVVQTTGVGLHTGKKVTLTLRPTSANTGIIYRRTDLYPPVDLQVNVKSVGNT
CCCHHHHHHHHHHCCCCEECCCEEEEEEEECCCCCCEEEEECCCCCCCCEEEEHHHCCCE
VLCTCLINEYGVQIFTVEHLSAAQAGLGIDNIIIELNAPEVPIMDGSASPFVCLLLDAGI
EEEEEEEHHCCEEEEEEEHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCEEEEEEHHCH
EELNSAKKFLRLKQTVRVEDGEKWAELRPFNGFTLDFTIDFNHPAINVDTQHCFFNFSSA
HHHHHHHHHHHHHHHEEECCCCCHHHCCCCCCEEEEEEEECCCCEEECCCCEEEEECCCH
SFVHNISRARTFGFMRDIKDLQSRGFALGGSFNSAIIIDDYRVLNEDGLRFDDEFVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCCCCHHHHHHHH
LDAIGDLFMCGHNLIGSFIAFKSGHTLNNKLLKTVLSCQEAWELATFSNASDLPLVF
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA