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The map label for this gene is hldE

Identifier: 71891854

GI number: 71891854

Start: 77297

End: 78730

Strand: Direct

Name: hldE

Synonym: BPEN_065

Alternate gene names: 71891854

Gene position: 77297-78730 (Clockwise)

Preceding gene: 71891852

Following gene: 71891855

Centisome position: 9.76

GC content: 34.03

Gene sequence:

>1434_bases
ATGACTGTTATTTTTCCAAATTTTTCTAAATCGAGTGTATTAATTGTAGGGGATGTTATGTTAGATCGATATTGGTATGG
GCCTACCGATAAGATTGCCCCAGAAGCACCTGTTCCGATTGTTAAGGTTAATAAAATTATAGATCGACCAGGTGGAGCTG
CCAACGTTGCAATGAATATTGCTTCTTTAGGTGCTCGATCGAGATTATTAGGATTAACTGGAGTTGATGAAGCAGCTAAA
ATTTTAAAAAAGCAACTTAACGAATCGAATATAAAATGGAATTTTATCTCAGTTAGAACATGTCCTACTATAATTAAATT
ACGAGTAATGTCACGTAATCAACAACTTATCAGATTAGATTTTGAACAATATTTTAATAATGTTGATACTACGAAATTAC
TTAAACAAGTTGAATTGTATTTACCAAAATATAAGGTATTAGTATTGTCTGATTATGCCAAGGGTTCTTTAAACTGCATA
GAAGAGATTATTAAATTGGCACGTTATATGAATGTACCGGTTATCGTAGACCCTAAAGGTATACAATTTTCTCGTTATAA
AGGAGCTACTTTATTAACTCCTAATATATCAGAATTTGAATCGATCGTAGGGTCTTGTCGTAATGAAAAAATTTTGATAA
ATAGAGCTCAAGAAATTATAATCGATTACAATTTATCAGCTTTATTGATTACACGCTCTGAAAGGGGTATGACTTTATGC
ACACGGTATGCAGCCCCATTATATTTTTCAACTCAGAAAAAGAAAGTATACCATGTAACTGGCGCTGGGGACACGGTAGT
TGGTGTACTGTCAGCAGCATTGTCTTCTGGTAAAAGTTTAGAAAAAGCATGTTTTTTAGCTAATTTGGCCGCTAGCGCGG
TAATAAAAAAATCTGGGACTTCTACTAGTAATGTAACTGAAATGAAAAATATTATGAATAGTCATATATGTACTACTTTG
CCTGTCGGTATATTAGATGAGAAAACGTTAAAACAGACAATATCTGTAGTTCGTAATAGAGGTGAAAAAATAGTCATGAC
TAATGGTGTCTTCGATATATTGCATTCTGGCCATGTAAGTTATTTGACTAATGCTAAAAAACTTGGCGATAGATTAATTG
TGGCCGTAAACAGTGATGGCTCAACGAGGCGTTTAAAAGGCAAAACAAGACCTATAAATACTTTAGAACAACGTATGTTT
ATATTAGCTGCTTTAACAGTCGTAGATTGGGTAGTGCCTTTTTATGAGGATACACCCTCAAGATTAGTTGCATACTTATC
TCCAGATTTTTTGGTAAAAGGAGGCGATTATCATGTATGTGATATCGAGGGAAGCCAAGGAGTGCTGAATCGTGGAGGGA
CAGTGCGTGTGTTAAATTTTCAAACTGGGTGTTCTAGCAGCAATATTATTAATGCTATTAAACGTAAAAATTAA

Upstream 100 bases:

>100_bases
GATTACTTACAAAATAATTTAATTTATTAATAATTTTAATATTATTATAATGTATAATTAGCTATGCTTTTATTTGTTCA
AGATGTTTATTGGGTAAATC

Downstream 100 bases:

>100_bases
AAGAATGTAAGGTAATTTATCATAAATATGTATTTTAGTATGATATTAAAATATAGCGAATGTTTAAGTCATGAGATGCG
CGTACGAGCGCGACAATACT

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTVIFPNFSKSSVLIVGDVMLDRYWYGPTDKIAPEAPVPIVKVNKIIDRPGGAANVAMNIASLGARSRLLGLTGVDEAAK
ILKKQLNESNIKWNFISVRTCPTIIKLRVMSRNQQLIRLDFEQYFNNVDTTKLLKQVELYLPKYKVLVLSDYAKGSLNCI
EEIIKLARYMNVPVIVDPKGIQFSRYKGATLLTPNISEFESIVGSCRNEKILINRAQEIIIDYNLSALLITRSERGMTLC
TRYAAPLYFSTQKKKVYHVTGAGDTVVGVLSAALSSGKSLEKACFLANLAASAVIKKSGTSTSNVTEMKNIMNSHICTTL
PVGILDEKTLKQTISVVRNRGEKIVMTNGVFDILHSGHVSYLTNAKKLGDRLIVAVNSDGSTRRLKGKTRPINTLEQRMF
ILAALTVVDWVVPFYEDTPSRLVAYLSPDFLVKGGDYHVCDIEGSQGVLNRGGTVRVLNFQTGCSSSNIINAIKRKN

Sequences:

>Translated_477_residues
MTVIFPNFSKSSVLIVGDVMLDRYWYGPTDKIAPEAPVPIVKVNKIIDRPGGAANVAMNIASLGARSRLLGLTGVDEAAK
ILKKQLNESNIKWNFISVRTCPTIIKLRVMSRNQQLIRLDFEQYFNNVDTTKLLKQVELYLPKYKVLVLSDYAKGSLNCI
EEIIKLARYMNVPVIVDPKGIQFSRYKGATLLTPNISEFESIVGSCRNEKILINRAQEIIIDYNLSALLITRSERGMTLC
TRYAAPLYFSTQKKKVYHVTGAGDTVVGVLSAALSSGKSLEKACFLANLAASAVIKKSGTSTSNVTEMKNIMNSHICTTL
PVGILDEKTLKQTISVVRNRGEKIVMTNGVFDILHSGHVSYLTNAKKLGDRLIVAVNSDGSTRRLKGKTRPINTLEQRMF
ILAALTVVDWVVPFYEDTPSRLVAYLSPDFLVKGGDYHVCDIEGSQGVLNRGGTVRVLNFQTGCSSSNIINAIKRKN
>Mature_476_residues
TVIFPNFSKSSVLIVGDVMLDRYWYGPTDKIAPEAPVPIVKVNKIIDRPGGAANVAMNIASLGARSRLLGLTGVDEAAKI
LKKQLNESNIKWNFISVRTCPTIIKLRVMSRNQQLIRLDFEQYFNNVDTTKLLKQVELYLPKYKVLVLSDYAKGSLNCIE
EIIKLARYMNVPVIVDPKGIQFSRYKGATLLTPNISEFESIVGSCRNEKILINRAQEIIIDYNLSALLITRSERGMTLCT
RYAAPLYFSTQKKKVYHVTGAGDTVVGVLSAALSSGKSLEKACFLANLAASAVIKKSGTSTSNVTEMKNIMNSHICTTLP
VGILDEKTLKQTISVVRNRGEKIVMTNGVFDILHSGHVSYLTNAKKLGDRLIVAVNSDGSTRRLKGKTRPINTLEQRMFI
LAALTVVDWVVPFYEDTPSRLVAYLSPDFLVKGGDYHVCDIEGSQGVLNRGGTVRVLNFQTGCSSSNIINAIKRKN

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=475, Percent_Identity=59.7894736842105, Blast_Score=601, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_BLOPB (Q493X3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277583.1
- HSSP:   O05155
- ProteinModelPortal:   Q493X3
- SMR:   Q493X3
- STRING:   Q493X3
- GeneID:   3563149
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_065
- eggNOG:   COG2870
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- ProtClustDB:   PRK11316
- BioCyc:   CBLO291272:BPEN_065-MONOMER
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 52690; Mature: 52559

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 264-264

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIFPNFSKSSVLIVGDVMLDRYWYGPTDKIAPEAPVPIVKVNKIIDRPGGAANVAMNI
CEEECCCCCCCCEEEEEEEHHHHEECCCCCCCCCCCCCCEEEEHHHHCCCCCCHHHHHHH
ASLGARSRLLGLTGVDEAAKILKKQLNESNIKWNFISVRTCPTIIKLRVMSRNQQLIRLD
HHCCCHHHEEECCCHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEECCCCEEEEEE
FEQYFNNVDTTKLLKQVELYLPKYKVLVLSDYAKGSLNCIEEIIKLARYMNVPVIVDPKG
HHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCC
IQFSRYKGATLLTPNISEFESIVGSCRNEKILINRAQEIIIDYNLSALLITRSERGMTLC
CEEECCCCCEEECCCHHHHHHHHHCCCCCEEEEECCEEEEEEECCEEEEEEECCCCCEEE
TRYAAPLYFSTQKKKVYHVTGAGDTVVGVLSAALSSGKSLEKACFLANLAASAVIKKSGT
HHHCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
STSNVTEMKNIMNSHICTTLPVGILDEKTLKQTISVVRNRGEKIVMTNGVFDILHSGHVS
CCCHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCHH
YLTNAKKLGDRLIVAVNSDGSTRRLKGKTRPINTLEQRMFILAALTVVDWVVPFYEDTPS
HHHCHHHCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RLVAYLSPDFLVKGGDYHVCDIEGSQGVLNRGGTVRVLNFQTGCSSSNIINAIKRKN
HEEEEECCCEEEECCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TVIFPNFSKSSVLIVGDVMLDRYWYGPTDKIAPEAPVPIVKVNKIIDRPGGAANVAMNI
EEECCCCCCCCEEEEEEEHHHHEECCCCCCCCCCCCCCEEEEHHHHCCCCCCHHHHHHH
ASLGARSRLLGLTGVDEAAKILKKQLNESNIKWNFISVRTCPTIIKLRVMSRNQQLIRLD
HHCCCHHHEEECCCHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEEECCCCEEEEEE
FEQYFNNVDTTKLLKQVELYLPKYKVLVLSDYAKGSLNCIEEIIKLARYMNVPVIVDPKG
HHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCC
IQFSRYKGATLLTPNISEFESIVGSCRNEKILINRAQEIIIDYNLSALLITRSERGMTLC
CEEECCCCCEEECCCHHHHHHHHHCCCCCEEEEECCEEEEEEECCEEEEEEECCCCCEEE
TRYAAPLYFSTQKKKVYHVTGAGDTVVGVLSAALSSGKSLEKACFLANLAASAVIKKSGT
HHHCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
STSNVTEMKNIMNSHICTTLPVGILDEKTLKQTISVVRNRGEKIVMTNGVFDILHSGHVS
CCCHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCHH
YLTNAKKLGDRLIVAVNSDGSTRRLKGKTRPINTLEQRMFILAALTVVDWVVPFYEDTPS
HHHCHHHCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RLVAYLSPDFLVKGGDYHVCDIEGSQGVLNRGGTVRVLNFQTGCSSSNIINAIKRKN
HEEEEECCCEEEECCCEEEEEECCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA