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The map label for this gene is fabG [C]

Identifier: 68537145

GI number: 68537145

Start: 2402833

End: 2403591

Strand: Direct

Name: fabG [C]

Synonym: jk2050

Alternate gene names: 68537145

Gene position: 2402833-2403591 (Clockwise)

Preceding gene: 68537144

Following gene: 68537150

Centisome position: 97.58

GC content: 63.24

Gene sequence:

>759_bases
ATGATTGATGCCGTTGGCAAACCCCAGTCCATCCTGCTTCTCGGCGGCGCGTCCGACATGGGCCTCGCCGTTGTCGAGGA
GTTCCTCTCTCGCGGTTCTGCCCGCGTGATCCTGGCCGCCCGTGCCGGCGAGTCTTTGGATGACGCCACCGCACGCATGA
ACGCCGCCGGTGCCAGCGAGGTCGTCACCGTTGCCTTCGACGCAGTGGATTTCGATTCCCACCCGCAGGTGTTCGAGGAG
ATCTTCAGCCATGGCGACGTGGACCTGGCCATTGTTGCGTTCGGAATCCTGGGCGATAACGAGAAGCAGTGGACCAACCA
GAAGTTGGCTGTGCAGGCCGCACAGGTGAACTTCACCGGCGCCGTCTCCGTCGGCGTGTTGCTGGCGGACTACATGAAGA
AGCAAGGCCACGGCCAGATTGTGGCGTTTTCCACCGTTGCCGGTGAGATGGTTCGCCGCTCCAACTTCGTCTACGGCTCC
ACAAAGGCTGGCCTGGATGGCTTCTACCGCATGCTCAACGAAGCTCTGCGTGGCTCCGGGGTGCGCGTGCTGACGGTCCG
CCCGGGCCAGGTCCGCACCAACATGACCAAGGACCTCGAGGATGCCCCGCTGACCGTGGACAAGGAAGACGTGGCCAAGG
CGATTGCCAAGGCCGTGGATAACCGCAAGTCCCTGATCTGGGTGCACCCCCTGTTCCGCCCGATCATGCTGATCCTGAAG
CACCTGCCGCTGCCGATCCTGCGCAAGCTGCCGCTGTAG

Upstream 100 bases:

>100_bases
CATCGACCCGACGGGGGTTTTCGCCTCCGACATGTCCCGCCGCCTCGAGCTGTAGCCCCTGCCCACAATAGTTGCCCCCC
ACCCCGAAAGAAGAGTCACA

Downstream 100 bases:

>100_bases
CTCCCCAGAGCCCCCATTCTGGGGTTTGACCGAGCCTCTCAGGCGAGCCCGCCACCACCCCCCTCACCCGCGTAAAAAGC
ACAAGCGCCGCTCCACACCC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIDAVGKPQSILLLGGASDMGLAVVEEFLSRGSARVILAARAGESLDDATARMNAAGASEVVTVAFDAVDFDSHPQVFEE
IFSHGDVDLAIVAFGILGDNEKQWTNQKLAVQAAQVNFTGAVSVGVLLADYMKKQGHGQIVAFSTVAGEMVRRSNFVYGS
TKAGLDGFYRMLNEALRGSGVRVLTVRPGQVRTNMTKDLEDAPLTVDKEDVAKAIAKAVDNRKSLIWVHPLFRPIMLILK
HLPLPILRKLPL

Sequences:

>Translated_252_residues
MIDAVGKPQSILLLGGASDMGLAVVEEFLSRGSARVILAARAGESLDDATARMNAAGASEVVTVAFDAVDFDSHPQVFEE
IFSHGDVDLAIVAFGILGDNEKQWTNQKLAVQAAQVNFTGAVSVGVLLADYMKKQGHGQIVAFSTVAGEMVRRSNFVYGS
TKAGLDGFYRMLNEALRGSGVRVLTVRPGQVRTNMTKDLEDAPLTVDKEDVAKAIAKAVDNRKSLIWVHPLFRPIMLILK
HLPLPILRKLPL
>Mature_252_residues
MIDAVGKPQSILLLGGASDMGLAVVEEFLSRGSARVILAARAGESLDDATARMNAAGASEVVTVAFDAVDFDSHPQVFEE
IFSHGDVDLAIVAFGILGDNEKQWTNQKLAVQAAQVNFTGAVSVGVLLADYMKKQGHGQIVAFSTVAGEMVRRSNFVYGS
TKAGLDGFYRMLNEALRGSGVRVLTVRPGQVRTNMTKDLEDAPLTVDKEDVAKAIAKAVDNRKSLIWVHPLFRPIMLILK
HLPLPILRKLPL

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the reduction of at C-2 of decaprenylphosphoryl 2-ket

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27154; Mature: 27154

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAVGKPQSILLLGGASDMGLAVVEEFLSRGSARVILAARAGESLDDATARMNAAGASE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCC
VVTVAFDAVDFDSHPQVFEEIFSHGDVDLAIVAFGILGDNEKQWTNQKLAVQAAQVNFTG
EEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEEHCCCCCHHHCCHHHEEEEEEECCCH
AVSVGVLLADYMKKQGHGQIVAFSTVAGEMVRRSNFVYGSTKAGLDGFYRMLNEALRGSG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCCCC
VRVLTVRPGQVRTNMTKDLEDAPLTVDKEDVAKAIAKAVDNRKSLIWVHPLFRPIMLILK
EEEEEECCCCEECCCCCCCCCCCCEECHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
HLPLPILRKLPL
HCCHHHHHHCCC
>Mature Secondary Structure
MIDAVGKPQSILLLGGASDMGLAVVEEFLSRGSARVILAARAGESLDDATARMNAAGASE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCC
VVTVAFDAVDFDSHPQVFEEIFSHGDVDLAIVAFGILGDNEKQWTNQKLAVQAAQVNFTG
EEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEEHCCCCCHHHCCHHHEEEEEEECCCH
AVSVGVLLADYMKKQGHGQIVAFSTVAGEMVRRSNFVYGSTKAGLDGFYRMLNEALRGSG
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCCCC
VRVLTVRPGQVRTNMTKDLEDAPLTVDKEDVAKAIAKAVDNRKSLIWVHPLFRPIMLILK
EEEEEECCCCEECCCCCCCCCCCCEECHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
HLPLPILRKLPL
HCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]