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The map label for this gene is dprE1 [H]

Identifier: 68537144

GI number: 68537144

Start: 2401375

End: 2402787

Strand: Direct

Name: dprE1 [H]

Synonym: jk2049

Alternate gene names: 68537144

Gene position: 2401375-2402787 (Clockwise)

Preceding gene: 68537143

Following gene: 68537145

Centisome position: 97.52

GC content: 64.76

Gene sequence:

>1413_bases
ATGGAATTGCACACCAGCACTCGTACCCTCACCGGGTGGGGTCGCACCGCCCCCACGACCGCCGAAGTTCTGTCTACGCA
GGATGTCGATCAGATTGCCGCCGCCGTCGCGCGCGTGGCCGACGATAACGCGGATAAGCCTAGCCACCTGCAGCGTGGCG
TGATCGCCCGCGGCATGGGCCGTAGCTACGGCGACCCGGCCATGAACGCCGGCGGGCTCGTCATCGACATGCAGCAGCTG
AACCGTATCCACAGCATCAACCCCGATACCGCCATCGTGGACGTCGATGCTGGCGTGACGTTGGACCAGCTGATGAAGGC
TGCTCTGCCCTATGGCCTGTGGGTGCCGGTGCTGCCCGGCACGCGCCAGGTGACCATCGGCGGCGCTATCGGCCCGGATA
TTCACGGTAAGAACCACCACTCTGCAGGTTCCTTCGGCGACCACGTCCGCTCCATGGAGCTGCTGGTGGCCGACGGGCGC
GTGCTGCACCTGACACCGGAGGGCTCCGCGGACGATCCGGACGGCGAACTGTTCTGGGCCACCGTCGGCGGCATGGGCCT
GACCGGCATCATCCTGCGCGCGACCATTGAGATGACGAAGACGGAGACCGCGTACTTCATCGCCGATGGAGACATGACGC
ACTCCCTGGACGAAACCATCGCCTTCCACTCCGATGGTTCGGAGCACAACTTCACCTACTCCTCCGCCTGGTTCGATGCC
ATCAGCCCGGAGCCGAAGCTGGGCCGCGCCGCAATCTCCCGCGGCTCCCTGGCCACCCTGGACCAGCTGAAGGAGTACGC
GCCGAAGCTGGCGAAGGATCCGCTGAAGTTCAAGGCCCCGCAGCTGATGACCGTGCCGGATATCTTCCCGAGCTTCACCA
TGAACAAGCTGTCCATGGTGGCTATCGGCGAGCTGTGGTGGCTGAAGTCCGGCGAGTACCGCAACCAGGTGCAGAACCTC
ACGCAGTTCTACCAGCCGCTGGATCTGATCGGCGAGTGGAACCGCGGCTATGGTTCCAAGGGCTTCCTGCAGTACCAGTT
CGTCGTGCCGACAGAGGCCGTGGAGCCGTTCAAGGAGATCATCCGCGACATCCAGGCTTCCGGTCACTATTCCGCACTGA
ACGTGTTCAAGCTGTTCGGCGAGGGCAACAAGGCCCCGCTGAGCTACCCGATGCCGGGCTGGAACGTCTGCGTGGACCTC
CCGATCAAGCCGGGCCTGGGTGCTTTCCTGGACGACCTGGACCGCCGCGTGATGGAATTCGGCGGCCGTCTGTACCTGGC
CAAGGAGTCCCGCACCTCTGCCGAGAACTTCCACAAGATGTACCCCGGCCTGCCCGGCTGGCTGGCCACCCGCAAGCGCA
TCGACCCGACGGGGGTTTTCGCCTCCGACATGTCCCGCCGCCTCGAGCTGTAG

Upstream 100 bases:

>100_bases
GTGACGCCGCCCACACCGCAACTGCGAAAACGCTGGCAACTTGAGCCGCACGCGGCGCCGCGCCCCGGAGTTGTCCCACC
CGGGCGCTAGGGTAGAGAAC

Downstream 100 bases:

>100_bases
CCCCTGCCCACAATAGTTGCCCCCCACCCCGAAAGAAGAGTCACAATGATTGATGCCGTTGGCAAACCCCAGTCCATCCT
GCTTCTCGGCGGCGCGTCCG

Product: putative FAD/FMN-containing dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MELHTSTRTLTGWGRTAPTTAEVLSTQDVDQIAAAVARVADDNADKPSHLQRGVIARGMGRSYGDPAMNAGGLVIDMQQL
NRIHSINPDTAIVDVDAGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVRSMELLVADGR
VLHLTPEGSADDPDGELFWATVGGMGLTGIILRATIEMTKTETAYFIADGDMTHSLDETIAFHSDGSEHNFTYSSAWFDA
ISPEPKLGRAAISRGSLATLDQLKEYAPKLAKDPLKFKAPQLMTVPDIFPSFTMNKLSMVAIGELWWLKSGEYRNQVQNL
TQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKEIIRDIQASGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDL
PIKPGLGAFLDDLDRRVMEFGGRLYLAKESRTSAENFHKMYPGLPGWLATRKRIDPTGVFASDMSRRLEL

Sequences:

>Translated_470_residues
MELHTSTRTLTGWGRTAPTTAEVLSTQDVDQIAAAVARVADDNADKPSHLQRGVIARGMGRSYGDPAMNAGGLVIDMQQL
NRIHSINPDTAIVDVDAGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVRSMELLVADGR
VLHLTPEGSADDPDGELFWATVGGMGLTGIILRATIEMTKTETAYFIADGDMTHSLDETIAFHSDGSEHNFTYSSAWFDA
ISPEPKLGRAAISRGSLATLDQLKEYAPKLAKDPLKFKAPQLMTVPDIFPSFTMNKLSMVAIGELWWLKSGEYRNQVQNL
TQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKEIIRDIQASGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDL
PIKPGLGAFLDDLDRRVMEFGGRLYLAKESRTSAENFHKMYPGLPGWLATRKRIDPTGVFASDMSRRLEL
>Mature_470_residues
MELHTSTRTLTGWGRTAPTTAEVLSTQDVDQIAAAVARVADDNADKPSHLQRGVIARGMGRSYGDPAMNAGGLVIDMQQL
NRIHSINPDTAIVDVDAGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVRSMELLVADGR
VLHLTPEGSADDPDGELFWATVGGMGLTGIILRATIEMTKTETAYFIADGDMTHSLDETIAFHSDGSEHNFTYSSAWFDA
ISPEPKLGRAAISRGSLATLDQLKEYAPKLAKDPLKFKAPQLMTVPDIFPSFTMNKLSMVAIGELWWLKSGEYRNQVQNL
TQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKEIIRDIQASGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDL
PIKPGLGAFLDDLDRRVMEFGGRLYLAKESRTSAENFHKMYPGLPGWLATRKRIDPTGVFASDMSRRLEL

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 51536; Mature: 51536

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHTSTRTLTGWGRTAPTTAEVLSTQDVDQIAAAVARVADDNADKPSHLQRGVIARGMG
CCCCCCCEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
RSYGDPAMNAGGLVIDMQQLNRIHSINPDTAIVDVDAGVTLDQLMKAALPYGLWVPVLPG
CCCCCCCCCCCCEEEEHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCC
TRQVTIGGAIGPDIHGKNHHSAGSFGDHVRSMELLVADGRVLHLTPEGSADDPDGELFWA
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHHEEEEEECCEEEEECCCCCCCCCCCCEEEE
TVGGMGLTGIILRATIEMTKTETAYFIADGDMTHSLDETIAFHSDGSEHNFTYSSAWFDA
EECCCCHHHHHHHHHHEEECCCEEEEEECCCCCCCHHHHEEECCCCCCCCEEEHHHHHHC
ISPEPKLGRAAISRGSLATLDQLKEYAPKLAKDPLKFKAPQLMTVPDIFPSFTMNKLSMV
CCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHEEHE
AIGELWWLKSGEYRNQVQNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKEI
EEHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHH
IRDIQASGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDLPIKPGLGAFLDDLDRRVMEF
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
GGRLYLAKESRTSAENFHKMYPGLPGWLATRKRIDPTGVFASDMSRRLEL
CCEEEEEECCCCCHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MELHTSTRTLTGWGRTAPTTAEVLSTQDVDQIAAAVARVADDNADKPSHLQRGVIARGMG
CCCCCCCEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
RSYGDPAMNAGGLVIDMQQLNRIHSINPDTAIVDVDAGVTLDQLMKAALPYGLWVPVLPG
CCCCCCCCCCCCEEEEHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCEEECCCC
TRQVTIGGAIGPDIHGKNHHSAGSFGDHVRSMELLVADGRVLHLTPEGSADDPDGELFWA
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHHEEEEEECCEEEEECCCCCCCCCCCCEEEE
TVGGMGLTGIILRATIEMTKTETAYFIADGDMTHSLDETIAFHSDGSEHNFTYSSAWFDA
EECCCCHHHHHHHHHHEEECCCEEEEEECCCCCCCHHHHEEECCCCCCCCEEEHHHHHHC
ISPEPKLGRAAISRGSLATLDQLKEYAPKLAKDPLKFKAPQLMTVPDIFPSFTMNKLSMV
CCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHEEHE
AIGELWWLKSGEYRNQVQNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKEI
EEHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHH
IRDIQASGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDLPIKPGLGAFLDDLDRRVMEF
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHH
GGRLYLAKESRTSAENFHKMYPGLPGWLATRKRIDPTGVFASDMSRRLEL
CCEEEEEECCCCCHHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]