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The map label for this gene is echA4 [H]

Identifier: 68537112

GI number: 68537112

Start: 2354590

End: 2355678

Strand: Direct

Name: echA4 [H]

Synonym: jk2017

Alternate gene names: 68537112

Gene position: 2354590-2355678 (Clockwise)

Preceding gene: 68537110

Following gene: 68537114

Centisome position: 95.62

GC content: 61.52

Gene sequence:

>1089_bases
ATGTCAACCATCACCGCTTTTGCTTTGTGGTGGCTAACTGTCAACTATGTCGCGGCTGATCTGACAACCGTCACAACGCT
TTTCCCTGGAACACGTTGTCAACTATGTCCTGACTTCGGACACCACATCCTCCGCCATTTGAAACCGGCGCCCCCGAAAC
TTTTTCGGGGGCGCCCTTTTCGCATTCCCACTGATTCACCAAACCCGCCCGCACTGCCCGGCCCGTGCCTTAGTTTGGAA
TGCATGAACGCACCGAGCACGCCAACGAGCACTCCCCCCACCACTGCCCCTCTCGTTTCCACGGAATACTCCGAGTCCAT
TCCCGGCCTCGTTCACGTCCGCCTGAACCGCCCCAACAAGCTGAACTCGCTGACGATCGACCTGCTCCAGCAGCTCATCG
ATACCGCACACACGCTGCGCCGCGACCGCTCCGTCCGCGCCGTCATCCTCTCCGGCACAGACGGCAATTTCTCTTCCGGT
CTGGACTTCGCGGATACCCTGAAAAGCCCACCCCGTATGCTTTCGCATTTCATCCCGCGTCCCCTGCGCGGCACCAACAC
TTTCCAAGAAGCGCCGTGGGCGTGGCGTCGTCTGCCGTTTCCGGTGATTGCCGCGGTAGAGGGCTACTGTTTCGGCGGTG
GTGTCCAGATCGCTCTTGGTGCGGACTTTAGGTTTACTAGCAATGACGCCCACTGGTCCGTGTTGGAAGCGAAATGGGGC
CTGGTTCCGGACATGTCGGGGATCATGTCCCTGAAGCAGTTGCTGCCGATTGACGAGGTGAAGAGGCTGGCCATGACCGG
GGAGATCTTCTCCGGGGAGCGCGCCGCAGAGCTAGGCCTGGCCAGGGCTGCGGAGGATCCGCTGGCTGCGGCGGAGGAGT
TGGCGCGGCAGATCATTGAGCGTTCGCCGGACTCAGTGGCGTTGGCAAAGAAGCTGGTCGACGAGACGTGGGAACTTGGG
CCGCGGCGTACCTTCGCCAAGGAGCGGTTGCGCCAGGCACGGCTGCTGGTCAGCAAAAATGCGGCTATAGCGCGGAAGGC
TGCGCAGAAGAAGGTCCCGCCGAAGTTCCGCCCGCGCACGGTGCGCTAA

Upstream 100 bases:

>100_bases
TTGGCGACTGTGGTGACGGGTTCGCCTTGTTCGCGGACTGCCTTGACGATGGCGAGGTTGCGGTTGGGACTATTCATCTG
TCAACAATGTCGCAGCTGAG

Downstream 100 bases:

>100_bases
CGCGCGCTGCTAGTCCGCGAGCGTTCCCGCCTACTTCACGCTTCAGCTTTCCGCGCCGCCTACTTGCCGCGCGAGCTAGT
CCGCGGGCGTTCCCGTGGGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSTITAFALWWLTVNYVAADLTTVTTLFPGTRCQLCPDFGHHILRHLKPAPPKLFRGRPFRIPTDSPNPPALPGPCLSLE
CMNAPSTPTSTPPTTAPLVSTEYSESIPGLVHVRLNRPNKLNSLTIDLLQQLIDTAHTLRRDRSVRAVILSGTDGNFSSG
LDFADTLKSPPRMLSHFIPRPLRGTNTFQEAPWAWRRLPFPVIAAVEGYCFGGGVQIALGADFRFTSNDAHWSVLEAKWG
LVPDMSGIMSLKQLLPIDEVKRLAMTGEIFSGERAAELGLARAAEDPLAAAEELARQIIERSPDSVALAKKLVDETWELG
PRRTFAKERLRQARLLVSKNAAIARKAAQKKVPPKFRPRTVR

Sequences:

>Translated_362_residues
MSTITAFALWWLTVNYVAADLTTVTTLFPGTRCQLCPDFGHHILRHLKPAPPKLFRGRPFRIPTDSPNPPALPGPCLSLE
CMNAPSTPTSTPPTTAPLVSTEYSESIPGLVHVRLNRPNKLNSLTIDLLQQLIDTAHTLRRDRSVRAVILSGTDGNFSSG
LDFADTLKSPPRMLSHFIPRPLRGTNTFQEAPWAWRRLPFPVIAAVEGYCFGGGVQIALGADFRFTSNDAHWSVLEAKWG
LVPDMSGIMSLKQLLPIDEVKRLAMTGEIFSGERAAELGLARAAEDPLAAAEELARQIIERSPDSVALAKKLVDETWELG
PRRTFAKERLRQARLLVSKNAAIARKAAQKKVPPKFRPRTVR
>Mature_361_residues
STITAFALWWLTVNYVAADLTTVTTLFPGTRCQLCPDFGHHILRHLKPAPPKLFRGRPFRIPTDSPNPPALPGPCLSLEC
MNAPSTPTSTPPTTAPLVSTEYSESIPGLVHVRLNRPNKLNSLTIDLLQQLIDTAHTLRRDRSVRAVILSGTDGNFSSGL
DFADTLKSPPRMLSHFIPRPLRGTNTFQEAPWAWRRLPFPVIAAVEGYCFGGGVQIALGADFRFTSNDAHWSVLEAKWGL
VPDMSGIMSLKQLLPIDEVKRLAMTGEIFSGERAAELGLARAAEDPLAAAEELARQIIERSPDSVALAKKLVDETWELGP
RRTFAKERLRQARLLVSKNAAIARKAAQKKVPPKFRPRTVR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=176, Percent_Identity=32.3863636363636, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI194097323, Length=265, Percent_Identity=27.9245283018868, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI68989263, Length=216, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4502327, Length=277, Percent_Identity=24.5487364620939, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI20127408, Length=286, Percent_Identity=26.2237762237762, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI221142681, Length=217, Percent_Identity=31.3364055299539, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787659, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790281, Length=202, Percent_Identity=24.2574257425743, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=205, Percent_Identity=33.6585365853659, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17536985, Length=284, Percent_Identity=28.169014084507, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17554946, Length=283, Percent_Identity=25.0883392226148, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=192, Percent_Identity=28.125, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=224, Percent_Identity=23.6607142857143, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=201, Percent_Identity=24.3781094527363, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653139, Length=257, Percent_Identity=27.2373540856031, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129971, Length=250, Percent_Identity=25.6, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653477, Length=250, Percent_Identity=25.6, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920382, Length=240, Percent_Identity=25.8333333333333, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 39961; Mature: 39829

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTITAFALWWLTVNYVAADLTTVTTLFPGTRCQLCPDFGHHILRHLKPAPPKLFRGRPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCC
RIPTDSPNPPALPGPCLSLECMNAPSTPTSTPPTTAPLVSTEYSESIPGLVHVRLNRPNK
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEECCHHHCCCCEEEEEECCCCC
LNSLTIDLLQQLIDTAHTLRRDRSVRAVILSGTDGNFSSGLDFADTLKSPPRMLSHFIPR
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHCCC
PLRGTNTFQEAPWAWRRLPFPVIAAVEGYCFGGGVQIALGADFRFTSNDAHWSVLEAKWG
CCCCCCCHHHCCCHHHHCCCHHHHHHCCEEECCCEEEEEECCEEECCCCCCEEEEECCCC
LVPDMSGIMSLKQLLPIDEVKRLAMTGEIFSGERAAELGLARAAEDPLAAAEELARQIIE
CCCCHHHHHHHHHHCCHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
RSPDSVALAKKLVDETWELGPRRTFAKERLRQARLLVSKNAAIARKAAQKKVPPKFRPRT
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
VR
CC
>Mature Secondary Structure 
STITAFALWWLTVNYVAADLTTVTTLFPGTRCQLCPDFGHHILRHLKPAPPKLFRGRPF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCC
RIPTDSPNPPALPGPCLSLECMNAPSTPTSTPPTTAPLVSTEYSESIPGLVHVRLNRPNK
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEECCHHHCCCCEEEEEECCCCC
LNSLTIDLLQQLIDTAHTLRRDRSVRAVILSGTDGNFSSGLDFADTLKSPPRMLSHFIPR
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHCCC
PLRGTNTFQEAPWAWRRLPFPVIAAVEGYCFGGGVQIALGADFRFTSNDAHWSVLEAKWG
CCCCCCCHHHCCCHHHHCCCHHHHHHCCEEECCCEEEEEECCEEECCCCCCEEEEECCCC
LVPDMSGIMSLKQLLPIDEVKRLAMTGEIFSGERAAELGLARAAEDPLAAAEELARQIIE
CCCCHHHHHHHHHHCCHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
RSPDSVALAKKLVDETWELGPRRTFAKERLRQARLLVSKNAAIARKAAQKKVPPKFRPRT
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
VR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]