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The map label for this gene is glxR [H]

Identifier: 68537067

GI number: 68537067

Start: 2299441

End: 2300124

Strand: Direct

Name: glxR [H]

Synonym: jk1972

Alternate gene names: 68537067

Gene position: 2299441-2300124 (Clockwise)

Preceding gene: 68537062

Following gene: 68537072

Centisome position: 93.38

GC content: 61.99

Gene sequence:

>684_bases
ATGGCAGAAGTATCCGAAATACTATCGAGGGCGGGCATTTTCCAGGGTGTTGAACCCAACGCAGTCCGCACCCTCATCGA
GCAGTTGGATACCGTCAAATTTCCTCGTGGCACCACCATCTTCGACGAGGGTGAGCCGGGCGACCGACTGTACATCATTA
TCAGCGGCAAGGTGAAGCTCGCCCGCCACTCGGTAGATGGGCGCGAGAACCTGCTGACTGTCATGGGCCCTTCCGACATG
TTCGGCGAGCTTTCCATCTTCGACCCTGGTCCCCGCACCTCATCCGCCGTCTGCGTGACGGAGTTGCAGGCAGCAACGAT
GGACTCCACGATGCTGCACAACTGGATCAGCGAACACCCGGAGATCGCCGAGCAGCTGCTGCGCGTGCTGGCCCGCCGCC
TGCGCCGCACCAATAATTCTCTGGCAGATCTGATTTTCACGGACGTTCCCGGCCGCGTAGCCAAGGCTCTGCTGCAACTG
GCGAACCGTTTCGGCACCCAGGAAGGCACCGCTTTGCGCGTTCACCACGACCTGACTCAGGAGGAGATCGCCCAGCTGGT
CGGTGCCTCCCGTGAGACCGTGAACAAGGCGCTGGCGGAGTTCGCCCACCGCGGCTGGATCCGCCTGGAGGGCAAGTCCG
TACTCATCTCGGACACTGAGCGCCTAGCCAAGCGCGCTCGCTAG

Upstream 100 bases:

>100_bases
ACAAAAGAGACGAACCATACATATATGGCGTGATGTACGCTACACAGGTGAGGTGGTTACCCGAGCCACCGCGATGCCAG
AAACGGAAGTGAAACTAAGG

Downstream 100 bases:

>100_bases
GGCTGCTCGCCACTTTTGGGCAGCGCTTGAGCGGCGCGCTCCGGGTGGAGCTTTAGATAACGCACAAAAAAGCCCGCGCC
TTCTGGTGCGGGCTTTTTCA

Product: CRP family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MAEVSEILSRAGIFQGVEPNAVRTLIEQLDTVKFPRGTTIFDEGEPGDRLYIIISGKVKLARHSVDGRENLLTVMGPSDM
FGELSIFDPGPRTSSAVCVTELQAATMDSTMLHNWISEHPEIAEQLLRVLARRLRRTNNSLADLIFTDVPGRVAKALLQL
ANRFGTQEGTALRVHHDLTQEEIAQLVGASRETVNKALAEFAHRGWIRLEGKSVLISDTERLAKRAR

Sequences:

>Translated_227_residues
MAEVSEILSRAGIFQGVEPNAVRTLIEQLDTVKFPRGTTIFDEGEPGDRLYIIISGKVKLARHSVDGRENLLTVMGPSDM
FGELSIFDPGPRTSSAVCVTELQAATMDSTMLHNWISEHPEIAEQLLRVLARRLRRTNNSLADLIFTDVPGRVAKALLQL
ANRFGTQEGTALRVHHDLTQEEIAQLVGASRETVNKALAEFAHRGWIRLEGKSVLISDTERLAKRAR
>Mature_226_residues
AEVSEILSRAGIFQGVEPNAVRTLIEQLDTVKFPRGTTIFDEGEPGDRLYIIISGKVKLARHSVDGRENLLTVMGPSDMF
GELSIFDPGPRTSSAVCVTELQAATMDSTMLHNWISEHPEIAEQLLRVLARRLRRTNNSLADLIFTDVPGRVAKALLQLA
NRFGTQEGTALRVHHDLTQEEIAQLVGASRETVNKALAEFAHRGWIRLEGKSVLISDTERLAKRAR

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=191, Percent_Identity=31.413612565445, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25165; Mature: 25034

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVSEILSRAGIFQGVEPNAVRTLIEQLDTVKFPRGTTIFDEGEPGDRLYIIISGKVKL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEEECCEEE
ARHSVDGRENLLTVMGPSDMFGELSIFDPGPRTSSAVCVTELQAATMDSTMLHNWISEHP
EHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
EIAEQLLRVLARRLRRTNNSLADLIFTDVPGRVAKALLQLANRFGTQEGTALRVHHDLTQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCH
EEIAQLVGASRETVNKALAEFAHRGWIRLEGKSVLISDTERLAKRAR
HHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC
>Mature Secondary Structure 
AEVSEILSRAGIFQGVEPNAVRTLIEQLDTVKFPRGTTIFDEGEPGDRLYIIISGKVKL
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEEECCEEE
ARHSVDGRENLLTVMGPSDMFGELSIFDPGPRTSSAVCVTELQAATMDSTMLHNWISEHP
EHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
EIAEQLLRVLARRLRRTNNSLADLIFTDVPGRVAKALLQLANRFGTQEGTALRVHHDLTQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCH
EEIAQLVGASRETVNKALAEFAHRGWIRLEGKSVLISDTERLAKRAR
HHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]