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The map label for this gene is menA [H]

Identifier: 68536971

GI number: 68536971

Start: 2191632

End: 2192528

Strand: Direct

Name: menA [H]

Synonym: jk1877

Alternate gene names: 68536971

Gene position: 2191632-2192528 (Clockwise)

Preceding gene: 68536970

Following gene: 68536974

Centisome position: 89.0

GC content: 68.0

Gene sequence:

>897_bases
ATGACTTCCACTCCCAGGCAGTATCCCGGCGCGACCCCGGCCCAGTGGCTGGAGGGAGCGCGCCCGCACACCTGGGCAAA
CGCCGTTGCCCCGGTGCTGGCTGGCACCGCGGCGGCCACCCTGGCAGGCGAGGCGAACCCACTTCGAGCCGTACTGGCCG
GGATTGTGGCTCTGGCGATGATCGTCGGCGTGAACTACGCCAACGACTATTCCGATGGCATCAAGGGGACGGACGATGAC
CGCTCCGGCCCGCTGCGCCTAACCGGCAGTGGGCTCGTGGAGCCGAAGAAGGTCAAGTACGCGGCATTCGCCTCCTTCGG
CGTGGGAGCGGTCGCCGGCATCGCGTTGAGCCTGCTGAGCGCCTGGTGGCTGGTCCTCGTCGGCGCAGCCTGCATCGCGG
GCGCATGGTTCTACACCGGCGGCAAGAACCCCTACGGCTACCGAGGACTGGGCGAAGTCGCGGTGTTCGTGTTCTTCGGC
CTGGTCGCGGTGCTGGGAACGGAATTCACCCAGACCGGCAGCGTGAGCTGGCGCGGCCTGCTGCTGGCCATCGCCGTCGG
CAGCCTATCCAGCGCCGTGAACCTAGCCAACAACTTGCGGGACATTCCTACTGACGCCGCCACCGGCAAGATCACCCTGG
CCGTTCGCCTGGGGGACGCAAACACCCGCCGCCTGTGGGTGGGGCTTGTTTCCCTGGCGGTAATCGTCACTATCGCCATC
AGCATCGGCCACTGGTGGGGGCTTATCGCCCTGCTGGCGGTTCCACTATTCGTGGTGGCAGCCCGCCCGGTGACCGGCGG
CGCGGAGGGCCGGGCGCTGATTCCCGTGCTGGGCATGCTGGGCCGCGGAATGCTGCTGTGGTCGGTACTGGAGTTTGCCG
CCGCCCTGCTGGCCTAA

Upstream 100 bases:

>100_bases
GAGCTTGGGTCCCGGCGCCTACGGACTAGACTGAAGAGGTTTGCGGCACCCCACAGGCGCGAGTGCCGCTCCCCAGTGCG
AGCCCCAAGAAAGGCGGACC

Downstream 100 bases:

>100_bases
GCTGGGTAGTCCCCTGCTGGCCTAGCCTGAGCAGCCCTGCTGATCCAGGCAGATCTAGCTTTGGGCTACGCGGGCGCCGG
GCCGAAGTCCACCCCGCGGA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTSTPRQYPGATPAQWLEGARPHTWANAVAPVLAGTAAATLAGEANPLRAVLAGIVALAMIVGVNYANDYSDGIKGTDDD
RSGPLRLTGSGLVEPKKVKYAAFASFGVGAVAGIALSLLSAWWLVLVGAACIAGAWFYTGGKNPYGYRGLGEVAVFVFFG
LVAVLGTEFTQTGSVSWRGLLLAIAVGSLSSAVNLANNLRDIPTDAATGKITLAVRLGDANTRRLWVGLVSLAVIVTIAI
SIGHWWGLIALLAVPLFVVAARPVTGGAEGRALIPVLGMLGRGMLLWSVLEFAAALLA

Sequences:

>Translated_298_residues
MTSTPRQYPGATPAQWLEGARPHTWANAVAPVLAGTAAATLAGEANPLRAVLAGIVALAMIVGVNYANDYSDGIKGTDDD
RSGPLRLTGSGLVEPKKVKYAAFASFGVGAVAGIALSLLSAWWLVLVGAACIAGAWFYTGGKNPYGYRGLGEVAVFVFFG
LVAVLGTEFTQTGSVSWRGLLLAIAVGSLSSAVNLANNLRDIPTDAATGKITLAVRLGDANTRRLWVGLVSLAVIVTIAI
SIGHWWGLIALLAVPLFVVAARPVTGGAEGRALIPVLGMLGRGMLLWSVLEFAAALLA
>Mature_297_residues
TSTPRQYPGATPAQWLEGARPHTWANAVAPVLAGTAAATLAGEANPLRAVLAGIVALAMIVGVNYANDYSDGIKGTDDDR
SGPLRLTGSGLVEPKKVKYAAFASFGVGAVAGIALSLLSAWWLVLVGAACIAGAWFYTGGKNPYGYRGLGEVAVFVFFGL
VAVLGTEFTQTGSVSWRGLLLAIAVGSLSSAVNLANNLRDIPTDAATGKITLAVRLGDANTRRLWVGLVSLAVIVTIAIS
IGHWWGLIALLAVPLFVVAARPVTGGAEGRALIPVLGMLGRGMLLWSVLEFAAALLA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=227, Percent_Identity=28.6343612334802, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790365, Length=286, Percent_Identity=38.4615384615385, Blast_Score=157, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17737429, Length=249, Percent_Identity=27.3092369477912, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 30678; Mature: 30547

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTPRQYPGATPAQWLEGARPHTWANAVAPVLAGTAAATLAGEANPLRAVLAGIVALAM
CCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IVGVNYANDYSDGIKGTDDDRSGPLRLTGSGLVEPKKVKYAAFASFGVGAVAGIALSLLS
HHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AWWLVLVGAACIAGAWFYTGGKNPYGYRGLGEVAVFVFFGLVAVLGTEFTQTGSVSWRGL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
LLAIAVGSLSSAVNLANNLRDIPTDAATGKITLAVRLGDANTRRLWVGLVSLAVIVTIAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
SIGHWWGLIALLAVPLFVVAARPVTGGAEGRALIPVLGMLGRGMLLWSVLEFAAALLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TSTPRQYPGATPAQWLEGARPHTWANAVAPVLAGTAAATLAGEANPLRAVLAGIVALAM
CCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IVGVNYANDYSDGIKGTDDDRSGPLRLTGSGLVEPKKVKYAAFASFGVGAVAGIALSLLS
HHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AWWLVLVGAACIAGAWFYTGGKNPYGYRGLGEVAVFVFFGLVAVLGTEFTQTGSVSWRGL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
LLAIAVGSLSSAVNLANNLRDIPTDAATGKITLAVRLGDANTRRLWVGLVSLAVIVTIAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
SIGHWWGLIALLAVPLFVVAARPVTGGAEGRALIPVLGMLGRGMLLWSVLEFAAALLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]