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The map label for this gene is deoD [H]

Identifier: 68536764

GI number: 68536764

Start: 1952866

End: 1953678

Strand: Direct

Name: deoD [H]

Synonym: jk1674

Alternate gene names: 68536764

Gene position: 1952866-1953678 (Clockwise)

Preceding gene: 68536762

Following gene: 68536765

Centisome position: 79.3

GC content: 65.68

Gene sequence:

>813_bases
ATGACTGCTTCCCCAAATCCATATGAATTGGCCGAAGAGGCTGCGGCGGCGTTGAAGAAGCGCACGGGCCTCGATTCCTA
CGACTGCGCCGTGGTGCTCGGCTCGGGGTGGCGCCCTGCCGCCGACGTGCTGTGCGAAGGCGCGGAAGATCTGCAGGAGT
TCCCGATGTCGGAGCTGCCGGGCTTTTTGGCTCCCACCGCGCAGGGGCACGGCGGCACGGTCCGCAGTGCGCGCATCGGC
GACCGCAACGTGCTGGTGCTGTTGGGCCGCACCCACGCCTACGAGGGCCACGAGCTATGGCGCACAGCCCATGCAGTCCG
CACCGCCGCTGCCGCGGGAGTGCAGACGATCGTGCTAACCAACGCCGCGGGTGGCCTGACCGAAGGCATGAAGGTGGGCG
AGCCGGTGTTGATTGCGGATCACATTAACTTCACCGCCAAGACGCCTCTGACGGGCGCGAACTTCGTGAACCTGGTGGAT
GCCTACAGCCCCGAACTACGCGCCAAGGTGCAGAAGCTGCGCCCAGGTATGCGCGAGGCCGTGTACGCGATGATGCCCGG
CCCACAGTACGAAACCCCGGCGGAGATCCACATGCTGCGCACCCTGGGCGCGGGCCTGGTGGGCATGTCCACGGTCTACG
AGACCATCGCCGCGCGCGAGGCGGATGTGGATGTACTGGGAATCTCGCTGGTCACGAACCTGGCGGCAGGAGTTACCGGC
GAACCCCTGAACCACGAGGAAGTCCTGCAGGCGGGCAAGGAAGCTGCCAACGACATGGGCAAGTTGCTCGGCGAGCTGGT
GAACAACCTATGA

Upstream 100 bases:

>100_bases
CCTGCGCGCGTTCCTGGGTGCCGTCTTGCACTTGAATACTCACGTCCCTCTCACTCTTACTGACCTTTTCAGTCTAGCGC
CTGCGGTATTCTTGGTTGGC

Downstream 100 bases:

>100_bases
GCCAGCTGAAGTTCGGCACCGCCGGCCTGCGCGCCAAGATCGGCCCCGGACCAGAGGAAATGAACGTCGGCACCGTCACC
CGCGCCACGGCTGGTGTGGC

Product: purine nucleoside phosphorylase

Products: NA

Alternate protein names: PNP; Inosine phosphorylase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTASPNPYELAEEAAAALKKRTGLDSYDCAVVLGSGWRPAADVLCEGAEDLQEFPMSELPGFLAPTAQGHGGTVRSARIG
DRNVLVLLGRTHAYEGHELWRTAHAVRTAAAAGVQTIVLTNAAGGLTEGMKVGEPVLIADHINFTAKTPLTGANFVNLVD
AYSPELRAKVQKLRPGMREAVYAMMPGPQYETPAEIHMLRTLGAGLVGMSTVYETIAAREADVDVLGISLVTNLAAGVTG
EPLNHEEVLQAGKEAANDMGKLLGELVNNL

Sequences:

>Translated_270_residues
MTASPNPYELAEEAAAALKKRTGLDSYDCAVVLGSGWRPAADVLCEGAEDLQEFPMSELPGFLAPTAQGHGGTVRSARIG
DRNVLVLLGRTHAYEGHELWRTAHAVRTAAAAGVQTIVLTNAAGGLTEGMKVGEPVLIADHINFTAKTPLTGANFVNLVD
AYSPELRAKVQKLRPGMREAVYAMMPGPQYETPAEIHMLRTLGAGLVGMSTVYETIAAREADVDVLGISLVTNLAAGVTG
EPLNHEEVLQAGKEAANDMGKLLGELVNNL
>Mature_269_residues
TASPNPYELAEEAAAALKKRTGLDSYDCAVVLGSGWRPAADVLCEGAEDLQEFPMSELPGFLAPTAQGHGGTVRSARIGD
RNVLVLLGRTHAYEGHELWRTAHAVRTAAAAGVQTIVLTNAAGGLTEGMKVGEPVLIADHINFTAKTPLTGANFVNLVDA
YSPELRAKVQKLRPGMREAVYAMMPGPQYETPAEIHMLRTLGAGLVGMSTVYETIAAREADVDVLGISLVTNLAAGVTGE
PLNHEEVLQAGKEAANDMGKLLGELVNNL

Specific function: Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=259, Percent_Identity=37.8378378378378, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1788746, Length=245, Percent_Identity=34.6938775510204, Blast_Score=138, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17541190, Length=287, Percent_Identity=32.404181184669, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6323238, Length=283, Percent_Identity=32.5088339222615, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45552887, Length=284, Percent_Identity=32.7464788732394, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45552885, Length=284, Percent_Identity=32.7464788732394, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24656090, Length=284, Percent_Identity=32.7464788732394, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24656093, Length=284, Percent_Identity=32.7464788732394, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24762376, Length=227, Percent_Identity=29.5154185022026, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR011269
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.1 [H]

Molecular weight: Translated: 28467; Mature: 28336

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASPNPYELAEEAAAALKKRTGLDSYDCAVVLGSGWRPAADVLCEGAEDLQEFPMSELP
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCHHHHHHCCHHHCC
GFLAPTAQGHGGTVRSARIGDRNVLVLLGRTHAYEGHELWRTAHAVRTAAAAGVQTIVLT
CCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEE
NAAGGLTEGMKVGEPVLIADHINFTAKTPLTGANFVNLVDAYSPELRAKVQKLRPGMREA
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHH
VYAMMPGPQYETPAEIHMLRTLGAGLVGMSTVYETIAAREADVDVLGISLVTNLAAGVTG
HHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
EPLNHEEVLQAGKEAANDMGKLLGELVNNL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TASPNPYELAEEAAAALKKRTGLDSYDCAVVLGSGWRPAADVLCEGAEDLQEFPMSELP
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCHHHHHHCCHHHCC
GFLAPTAQGHGGTVRSARIGDRNVLVLLGRTHAYEGHELWRTAHAVRTAAAAGVQTIVLT
CCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEE
NAAGGLTEGMKVGEPVLIADHINFTAKTPLTGANFVNLVDAYSPELRAKVQKLRPGMREA
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHH
VYAMMPGPQYETPAEIHMLRTLGAGLVGMSTVYETIAAREADVDVLGISLVTNLAAGVTG
HHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
EPLNHEEVLQAGKEAANDMGKLLGELVNNL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]