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The map label for this gene is mmpL2 [H]

Identifier: 68536585

GI number: 68536585

Start: 1768179

End: 1770605

Strand: Direct

Name: mmpL2 [H]

Synonym: jk1499

Alternate gene names: 68536585

Gene position: 1768179-1770605 (Clockwise)

Preceding gene: 68536584

Following gene: 68536586

Centisome position: 71.8

GC content: 59.29

Gene sequence:

>2427_bases
ATGGCAAAATTCCTGTATCGAGTAGGCCGCTCCGCCTACTTCCACAAGTGGCGCTTCCTCGCCGTCTGGCTGATCGTGCT
GATCGGCGTGGGCACCGCCTCCGCACTGTTAACCAAACCAACCTCGCAGTCCTTCACCATCCCCAGCCTCGAGTCCATCG
AGACCCAGGACAGGATCAAGGAAGAGTTCCCCAATGGCGAAGACGCTGATCAGCTAGAGGCAGCCACGGGCAAGCTCGTG
GTCCAAGCCCCTGAAGGTCAGACTCTTGCCAAGGGCGAGGCTGCACAATCGACCGAAGACATCCTTCAGGCGCTGCAAAA
GCTCGATTTCCTGAAGGACAAGGAAAAACTCGTCTCCCCCGTGCTGGCCAGCGAAGGCATGCACCAGCAAATGGCTCCCA
TGAAGCAGAAGCAGGGAATGCCGAAGGAGCAGATTGCATCCGACATCGCTGCCCTGAGCCCGCTGAGCCCCGACAAGCGT
ACTGGCACCATCGAGGTTTCCTTCGATGCGGAAACTGCAGCAGACGTGCCCGCAGAGGACGTACAAAAGTTCGAGGATGC
AGTAAAGAACAACGAAGGCAACCTCAAGGTTGGATGGAGCGGTAACGCATTCCAGCAGCCGGAGATGAGCATGGCCTCCG
AAGCCATCGGCCTGGCGGTCGCCGCCATCGTGCTAATCGTCACCTTCGGCAGCCTCGTCGCCGCAGGCCTGCCCCTGCTC
TCCGCTGTAATCGGCGTTGGTACAGGAATCGGCATCGTCATGGCAGCCACCTCCCTAACGGACAACATCAACTCCATGAC
CCCCACACTGGCCTCCATGATCGGCCTGGCCGTGGGCATCGACTACGCGCTGTTTATCCTCTCCCGCTTCCGCAATGAAC
TGGTCGCCCATGTAAATGGCCAGGACCTGGAACCGAAGGAGCTGCAACAGAAGCTCAAGACGATTCCTGTCAAGGAACGC
GCCCACCTAGCTGGCCTAGCCGTCGGCAAGGCAGGCTCGGCCGTGGTCTTCGCAGGCCTTACGGTGCTGATTGCACTGGC
AGCACTATCCATCATTAACATTCCGTTCCTCACCGCGATGGCCTTGGCCGCCGCCGGTACCGTTGCCATCGCCGTGATCG
TCGCAATCACTCTACTGCCCGCCATCATGGGGCTCATTGGCACGAAGGTCTTCGCAGGTCGCGCTCCTATCGTCAAGGCG
CCGGACCCGGAAAACGAGAAGCCGACCATGGGGCTGAAGTGGGTGCGCATCATTCGCAAGAAGCCCGTCCTGTGGATGGT
AGGCGCAGCAGTATTGCTGATCCTGCTGGCCATCCCCGCGATGAACCTGCGCCTAGCAATGCCCTCTGATGGCTCTATGG
CCAAGGGCACCCCCAACCGCGTGGCCTACGAAATGACAGAGGAGGGATTCGGACCGGGCCGCAATGCCCCGATGATTGCC
CTGGTGGAGTACCCCGACCTAAATGACAAGGAAAAGGCTGCTGCTACCCAGCAGGCCGTTGCCACCCTCCAGAACACTGA
AGGCGTGGAAAACGCCCAAGTAGTGCAGGCCAACGGCGATCCGCGCAACCCATCCGACCTGGGTACTGCAGCCCAGGTAT
TGATCACCCCGTCCTACGGCGCAACGGATGCCCGTGCTGCCGATGTCCTGGAGCAGATGCGCAACGAAGAAGCTGGATAC
AACGAAAAAACCGGCGCAACCTACGCCATCACCGGCGTTACCCCAATGTACGAGGACATTTCTCAGCGGCTTTCGGACGT
CCTAATCCCCTACATTGCAATTGTCTTGGCACTTGCATTCGTTCTGCTGATGATCGTCTTCCGATCCATCTGGGTGCCGC
TAATCGCAGCGCTAGGCTTCGGCCTGTCGGTGGCCGCCACGTTCGGCGTCACCGTCGCACTGTGGCAGGAAGGCTTCGGC
GGGATTATTGACGACCCGCAGCCCATCATTTCCTTCCTGCCCATCATGCTGATCGGTATTGTCTTTGGCCTGGCCATGGA
CTACCAGGTCTTTCTGGTCACCCGCATGCGCGAGGGCTGGGCGCACGGCAAGACCGCCGGCAATGCCACCGCCAACGGCT
TCAAGCACGGTGCACGAGTGGTCACCGCAGCCGCGCTCATCATGATTTCGGTCTTCGCCGCCTTCATGATGGCCGATGAG
CCGTTTATTAAGGTTATGGGCTTTGCGTTGGCCACTGCCGTGTTCTTTGACGCCTTCATCGTCCGCATGGTCTTCATTCC
AGCGACCATGTTCCTACTGGACGAACATGCGTGGAAGTTCCCCAAGTGGCTGGGGAAGATCATTCCCGCTGTCGATATCG
AGGGCGAGAGCCTGGTTGGATTGAACGCTGACGGTAGCCGCACTCCAAATACACCTACCGAATCAGGTGAAGCAGATTCG
CGAGACGCAAAGGCCGGAGTAAAGTAA

Upstream 100 bases:

>100_bases
GCTGGTCGCCGACTAGGCGGAGTAGCGATTCGCTGCGCCCTCATCAAAAATATTTGCACAAGTCTTGCAACGTTTCGCAG
ACTGTGCAAATATTTTGCGC

Downstream 100 bases:

>100_bases
GGCGTCACTAAGGAAAGGTTGTGAAAGTGAGCTACGAAGGCGGAAAAAGCGTAGAGGCAGCAACGCCGAGCCTACGGGAT
CGCAAGAAGGCCGAAACCCG

Product: RND superfamily drug exporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MAKFLYRVGRSAYFHKWRFLAVWLIVLIGVGTASALLTKPTSQSFTIPSLESIETQDRIKEEFPNGEDADQLEAATGKLV
VQAPEGQTLAKGEAAQSTEDILQALQKLDFLKDKEKLVSPVLASEGMHQQMAPMKQKQGMPKEQIASDIAALSPLSPDKR
TGTIEVSFDAETAADVPAEDVQKFEDAVKNNEGNLKVGWSGNAFQQPEMSMASEAIGLAVAAIVLIVTFGSLVAAGLPLL
SAVIGVGTGIGIVMAATSLTDNINSMTPTLASMIGLAVGIDYALFILSRFRNELVAHVNGQDLEPKELQQKLKTIPVKER
AHLAGLAVGKAGSAVVFAGLTVLIALAALSIINIPFLTAMALAAAGTVAIAVIVAITLLPAIMGLIGTKVFAGRAPIVKA
PDPENEKPTMGLKWVRIIRKKPVLWMVGAAVLLILLAIPAMNLRLAMPSDGSMAKGTPNRVAYEMTEEGFGPGRNAPMIA
LVEYPDLNDKEKAAATQQAVATLQNTEGVENAQVVQANGDPRNPSDLGTAAQVLITPSYGATDARAADVLEQMRNEEAGY
NEKTGATYAITGVTPMYEDISQRLSDVLIPYIAIVLALAFVLLMIVFRSIWVPLIAALGFGLSVAATFGVTVALWQEGFG
GIIDDPQPIISFLPIMLIGIVFGLAMDYQVFLVTRMREGWAHGKTAGNATANGFKHGARVVTAAALIMISVFAAFMMADE
PFIKVMGFALATAVFFDAFIVRMVFIPATMFLLDEHAWKFPKWLGKIIPAVDIEGESLVGLNADGSRTPNTPTESGEADS
RDAKAGVK

Sequences:

>Translated_808_residues
MAKFLYRVGRSAYFHKWRFLAVWLIVLIGVGTASALLTKPTSQSFTIPSLESIETQDRIKEEFPNGEDADQLEAATGKLV
VQAPEGQTLAKGEAAQSTEDILQALQKLDFLKDKEKLVSPVLASEGMHQQMAPMKQKQGMPKEQIASDIAALSPLSPDKR
TGTIEVSFDAETAADVPAEDVQKFEDAVKNNEGNLKVGWSGNAFQQPEMSMASEAIGLAVAAIVLIVTFGSLVAAGLPLL
SAVIGVGTGIGIVMAATSLTDNINSMTPTLASMIGLAVGIDYALFILSRFRNELVAHVNGQDLEPKELQQKLKTIPVKER
AHLAGLAVGKAGSAVVFAGLTVLIALAALSIINIPFLTAMALAAAGTVAIAVIVAITLLPAIMGLIGTKVFAGRAPIVKA
PDPENEKPTMGLKWVRIIRKKPVLWMVGAAVLLILLAIPAMNLRLAMPSDGSMAKGTPNRVAYEMTEEGFGPGRNAPMIA
LVEYPDLNDKEKAAATQQAVATLQNTEGVENAQVVQANGDPRNPSDLGTAAQVLITPSYGATDARAADVLEQMRNEEAGY
NEKTGATYAITGVTPMYEDISQRLSDVLIPYIAIVLALAFVLLMIVFRSIWVPLIAALGFGLSVAATFGVTVALWQEGFG
GIIDDPQPIISFLPIMLIGIVFGLAMDYQVFLVTRMREGWAHGKTAGNATANGFKHGARVVTAAALIMISVFAAFMMADE
PFIKVMGFALATAVFFDAFIVRMVFIPATMFLLDEHAWKFPKWLGKIIPAVDIEGESLVGLNADGSRTPNTPTESGEADS
RDAKAGVK
>Mature_807_residues
AKFLYRVGRSAYFHKWRFLAVWLIVLIGVGTASALLTKPTSQSFTIPSLESIETQDRIKEEFPNGEDADQLEAATGKLVV
QAPEGQTLAKGEAAQSTEDILQALQKLDFLKDKEKLVSPVLASEGMHQQMAPMKQKQGMPKEQIASDIAALSPLSPDKRT
GTIEVSFDAETAADVPAEDVQKFEDAVKNNEGNLKVGWSGNAFQQPEMSMASEAIGLAVAAIVLIVTFGSLVAAGLPLLS
AVIGVGTGIGIVMAATSLTDNINSMTPTLASMIGLAVGIDYALFILSRFRNELVAHVNGQDLEPKELQQKLKTIPVKERA
HLAGLAVGKAGSAVVFAGLTVLIALAALSIINIPFLTAMALAAAGTVAIAVIVAITLLPAIMGLIGTKVFAGRAPIVKAP
DPENEKPTMGLKWVRIIRKKPVLWMVGAAVLLILLAIPAMNLRLAMPSDGSMAKGTPNRVAYEMTEEGFGPGRNAPMIAL
VEYPDLNDKEKAAATQQAVATLQNTEGVENAQVVQANGDPRNPSDLGTAAQVLITPSYGATDARAADVLEQMRNEEAGYN
EKTGATYAITGVTPMYEDISQRLSDVLIPYIAIVLALAFVLLMIVFRSIWVPLIAALGFGLSVAATFGVTVALWQEGFGG
IIDDPQPIISFLPIMLIGIVFGLAMDYQVFLVTRMREGWAHGKTAGNATANGFKHGARVVTAAALIMISVFAAFMMADEP
FIKVMGFALATAVFFDAFIVRMVFIPATMFLLDEHAWKFPKWLGKIIPAVDIEGESLVGLNADGSRTPNTPTESGEADSR
DAKAGVK

Specific function: Unknown

COG id: COG2409

COG function: function code R; Predicted drug exporters of the RND superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mmpL family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004869
- InterPro:   IPR000731 [H]

Pfam domain/function: PF03176 MMPL [H]

EC number: NA

Molecular weight: Translated: 85911; Mature: 85780

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50156 SSD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFLYRVGRSAYFHKWRFLAVWLIVLIGVGTASALLTKPTSQSFTIPSLESIETQDRIK
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
EEFPNGEDADQLEAATGKLVVQAPEGQTLAKGEAAQSTEDILQALQKLDFLKDKEKLVSP
HHCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
VLASEGMHQQMAPMKQKQGMPKEQIASDIAALSPLSPDKRTGTIEVSFDAETAADVPAED
HHHHCCCHHHHCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHH
VQKFEDAVKNNEGNLKVGWSGNAFQQPEMSMASEAIGLAVAAIVLIVTFGSLVAAGLPLL
HHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVIGVGTGIGIVMAATSLTDNINSMTPTLASMIGLAVGIDYALFILSRFRNELVAHVNG
HHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QDLEPKELQQKLKTIPVKERAHLAGLAVGKAGSAVVFAGLTVLIALAALSIINIPFLTAM
CCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAAAGTVAIAVIVAITLLPAIMGLIGTKVFAGRAPIVKAPDPENEKPTMGLKWVRIIRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHH
KPVLWMVGAAVLLILLAIPAMNLRLAMPSDGSMAKGTPNRVAYEMTEEGFGPGRNAPMIA
CCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEE
LVEYPDLNDKEKAAATQQAVATLQNTEGVENAQVVQANGDPRNPSDLGTAAQVLITPSYG
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHCCCEEEEEECCCC
ATDARAADVLEQMRNEEAGYNEKTGATYAITGVTPMYEDISQRLSDVLIPYIAIVLALAF
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLLMIVFRSIWVPLIAALGFGLSVAATFGVTVALWQEGFGGIIDDPQPIISFLPIMLIGI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VFGLAMDYQVFLVTRMREGWAHGKTAGNATANGFKHGARVVTAAALIMISVFAAFMMADE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFIKVMGFALATAVFFDAFIVRMVFIPATMFLLDEHAWKFPKWLGKIIPAVDIEGESLVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEE
LNADGSRTPNTPTESGEADSRDAKAGVK
ECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKFLYRVGRSAYFHKWRFLAVWLIVLIGVGTASALLTKPTSQSFTIPSLESIETQDRIK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
EEFPNGEDADQLEAATGKLVVQAPEGQTLAKGEAAQSTEDILQALQKLDFLKDKEKLVSP
HHCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
VLASEGMHQQMAPMKQKQGMPKEQIASDIAALSPLSPDKRTGTIEVSFDAETAADVPAED
HHHHCCCHHHHCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHH
VQKFEDAVKNNEGNLKVGWSGNAFQQPEMSMASEAIGLAVAAIVLIVTFGSLVAAGLPLL
HHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVIGVGTGIGIVMAATSLTDNINSMTPTLASMIGLAVGIDYALFILSRFRNELVAHVNG
HHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QDLEPKELQQKLKTIPVKERAHLAGLAVGKAGSAVVFAGLTVLIALAALSIINIPFLTAM
CCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAAAGTVAIAVIVAITLLPAIMGLIGTKVFAGRAPIVKAPDPENEKPTMGLKWVRIIRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHH
KPVLWMVGAAVLLILLAIPAMNLRLAMPSDGSMAKGTPNRVAYEMTEEGFGPGRNAPMIA
CCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEE
LVEYPDLNDKEKAAATQQAVATLQNTEGVENAQVVQANGDPRNPSDLGTAAQVLITPSYG
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHCCCEEEEEECCCC
ATDARAADVLEQMRNEEAGYNEKTGATYAITGVTPMYEDISQRLSDVLIPYIAIVLALAF
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLLMIVFRSIWVPLIAALGFGLSVAATFGVTVALWQEGFGGIIDDPQPIISFLPIMLIGI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VFGLAMDYQVFLVTRMREGWAHGKTAGNATANGFKHGARVVTAAALIMISVFAAFMMADE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFIKVMGFALATAVFFDAFIVRMVFIPATMFLLDEHAWKFPKWLGKIIPAVDIEGESLVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEE
LNADGSRTPNTPTESGEADSRDAKAGVK
ECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]