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The map label for this gene is fumC [H]

Identifier: 68536540

GI number: 68536540

Start: 1712297

End: 1713700

Strand: Direct

Name: fumC [H]

Synonym: jk1454

Alternate gene names: 68536540

Gene position: 1712297-1713700 (Clockwise)

Preceding gene: 68536539

Following gene: 68536541

Centisome position: 69.53

GC content: 62.54

Gene sequence:

>1404_bases
ATGACCGAGCAAGAATTCCGCATTGAACACGACACGATGGGCGAGGTTAAGGTTCCCGCCAAGGCTCTGTGGCGTGCGCA
GACGCAGCGCGCGGTGGAGAACTTCCCGATCTCCGATCGCCCGCTGGAGTCCGCACAGATCCGCGCGATGGGTCTTTTGA
AGGCGGCCTGTGCACAGGTGAACAAGGACCGTGGCCTGCTGACCGACGAGCAGGCGGATGCCATCATCTCCGCCGCGAAG
GAAATCGCTGACGGCAAGCACGACGCTGAGTTCCCGATCGACGTGTTCCAGACCGGCTCCGGCACCTCTTCCAACATGAA
CACCAACGAGGTCATCGCCTCCATCGCCAAGAACAACGGCGTGGAGATCCACCCGAACGACCACGTGAACATGGGGCAGT
CCTCCAACGACACGTTCCCGACCGCTACCCACGTGGCCGCCACCCAGGCTGCTGTCAATGACCTGATTCCGGGTCTGAAG
GTTCTGCAGGAATCCCTGGCTAAGAAGGCCAAGGAGTGGGAGACGGTTGTTAAGTCCGGCCGCACCCACCTGATGGATGC
CGTCCCAGTGACCCTGGGCCAGGAGTTCTCCGGCTACGCCCGCCAGATCGAGGCAGGCATCGAGCGCGTTGAGGCCACCC
TGCCCCGCCTGGGTGAGCTGCCGATCGGTGGCACTGCAGTCGGCACCGGCCTGAACACCCCGGCTGACTTCGGCGCGAAC
GTTACCGCCGAGCTGGTGAAGCTGACCGGCGTGGAGCAGCTGCGCGAGGCTGAGAACCACTTTGAGGCACAAGCCAACCG
CGATGGCCTGGTTGAGTTCTCCGGTGCTATGCGCACCATCGCTGTCTCCCTGAACAAGATTGCCAACGACATCCGCTGGA
TGGGCTCCGGCCCGCTGACCGGTCTGGGCGAGATCCACCTGCCGGACCTGCAGCCGGGCTCTTCCATCATGCCGGGCAAG
GTCAACCCGGTTCTGTGTGAGACCGCAACCCAGGTTGCTGCACAGGTCATCGGTAACGACGCTGCCGTTGCCTTCGGCGG
TTCCCAGGGTGCGTTCGAGCTGAATGTGTTCATCCCGATGATGGCCCGCAACGTGCTGGAGTCTGCGAAGCTGCTGGCCA
ACACTGCCCGCGTATTCGCGGAGAAGCTGGTCGACGGCATTGAGCCGAACGAGGAGCGTATGCGCACTCTGGCTGAGTCC
TCCCCGTCCATCGTTACCCCGCTGAACTCTGCCATTGGCTACGAGGCTGCTGCGAAGGTTGCTAAGACTGCTCTCAAGGA
GGGCAAGACCATCCGCCAGACAGTTATCGACCTGGGCTTTGTCGACGGTGAAAAGCTGACCGAGGAGGAGCTGGATAAGC
GCCTCGACGTCCTGGCTATGGCAAACACCGACCGCGACAAGTAG

Upstream 100 bases:

>100_bases
CGAAAGACTATCCGCTTTCCCACGGTTCCCGGCTTTGAGCCCTTTGGTGGGTTCGAAGCGGGAGGCGTCAAAAACCTAAG
AAGATAAAGGTGATGAAAGA

Downstream 100 bases:

>100_bases
GCGAAAGCTAACTACTGACGCTGTTTTGTGGCCAGCTGGCTGGCTGGTCGGCAAGCTGACTGGCTGGTTGGCACGCTGGC
CAGTTGGCCGGCACACTGAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTEQEFRIEHDTMGEVKVPAKALWRAQTQRAVENFPISDRPLESAQIRAMGLLKAACAQVNKDRGLLTDEQADAIISAAK
EIADGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKNNGVEIHPNDHVNMGQSSNDTFPTATHVAATQAAVNDLIPGLK
VLQESLAKKAKEWETVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVEATLPRLGELPIGGTAVGTGLNTPADFGAN
VTAELVKLTGVEQLREAENHFEAQANRDGLVEFSGAMRTIAVSLNKIANDIRWMGSGPLTGLGEIHLPDLQPGSSIMPGK
VNPVLCETATQVAAQVIGNDAAVAFGGSQGAFELNVFIPMMARNVLESAKLLANTARVFAEKLVDGIEPNEERMRTLAES
SPSIVTPLNSAIGYEAAAKVAKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLDVLAMANTDRDK

Sequences:

>Translated_467_residues
MTEQEFRIEHDTMGEVKVPAKALWRAQTQRAVENFPISDRPLESAQIRAMGLLKAACAQVNKDRGLLTDEQADAIISAAK
EIADGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKNNGVEIHPNDHVNMGQSSNDTFPTATHVAATQAAVNDLIPGLK
VLQESLAKKAKEWETVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVEATLPRLGELPIGGTAVGTGLNTPADFGAN
VTAELVKLTGVEQLREAENHFEAQANRDGLVEFSGAMRTIAVSLNKIANDIRWMGSGPLTGLGEIHLPDLQPGSSIMPGK
VNPVLCETATQVAAQVIGNDAAVAFGGSQGAFELNVFIPMMARNVLESAKLLANTARVFAEKLVDGIEPNEERMRTLAES
SPSIVTPLNSAIGYEAAAKVAKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLDVLAMANTDRDK
>Mature_466_residues
TEQEFRIEHDTMGEVKVPAKALWRAQTQRAVENFPISDRPLESAQIRAMGLLKAACAQVNKDRGLLTDEQADAIISAAKE
IADGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKNNGVEIHPNDHVNMGQSSNDTFPTATHVAATQAAVNDLIPGLKV
LQESLAKKAKEWETVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVEATLPRLGELPIGGTAVGTGLNTPADFGANV
TAELVKLTGVEQLREAENHFEAQANRDGLVEFSGAMRTIAVSLNKIANDIRWMGSGPLTGLGEIHLPDLQPGSSIMPGKV
NPVLCETATQVAAQVIGNDAAVAFGGSQGAFELNVFIPMMARNVLESAKLLANTARVFAEKLVDGIEPNEERMRTLAESS
PSIVTPLNSAIGYEAAAKVAKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLDVLAMANTDRDK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=457, Percent_Identity=52.5164113785558, Blast_Score=447, Evalue=1e-126,
Organism=Escherichia coli, GI1787896, Length=453, Percent_Identity=49.8896247240618, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI87082375, Length=467, Percent_Identity=39.4004282655246, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=51.7391304347826, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=54.2056074766355, Blast_Score=332, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6324993, Length=456, Percent_Identity=50.219298245614, Blast_Score=426, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=50.2164502164502, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=50, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI78710009, Length=457, Percent_Identity=50.109409190372, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24662684, Length=451, Percent_Identity=47.450110864745, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24583245, Length=449, Percent_Identity=43.8752783964365, Blast_Score=373, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49952; Mature: 49821

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQEFRIEHDTMGEVKVPAKALWRAQTQRAVENFPISDRPLESAQIRAMGLLKAACAQV
CCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
NKDRGLLTDEQADAIISAAKEIADGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKNNG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHCCC
VEIHPNDHVNMGQSSNDTFPTATHVAATQAAVNDLIPGLKVLQESLAKKAKEWETVVKSG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAVPVTLGQEFSGYARQIEAGIERVEATLPRLGELPIGGTAVGTGLNTPADFGAN
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHCCCC
VTAELVKLTGVEQLREAENHFEAQANRDGLVEFSGAMRTIAVSLNKIANDIRWMGSGPLT
HHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHEECCCCCCC
GLGEIHLPDLQPGSSIMPGKVNPVLCETATQVAAQVIGNDAAVAFGGSQGAFELNVFIPM
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEHHHH
MARNVLESAKLLANTARVFAEKLVDGIEPNEERMRTLAESSPSIVTPLNSAIGYEAAAKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLDVLAMANTDRDK
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
TEQEFRIEHDTMGEVKVPAKALWRAQTQRAVENFPISDRPLESAQIRAMGLLKAACAQV
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
NKDRGLLTDEQADAIISAAKEIADGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKNNG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHCCC
VEIHPNDHVNMGQSSNDTFPTATHVAATQAAVNDLIPGLKVLQESLAKKAKEWETVVKSG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAVPVTLGQEFSGYARQIEAGIERVEATLPRLGELPIGGTAVGTGLNTPADFGAN
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHCCCC
VTAELVKLTGVEQLREAENHFEAQANRDGLVEFSGAMRTIAVSLNKIANDIRWMGSGPLT
HHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHEECCCCCCC
GLGEIHLPDLQPGSSIMPGKVNPVLCETATQVAAQVIGNDAAVAFGGSQGAFELNVFIPM
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEHHHH
MARNVLESAKLLANTARVFAEKLVDGIEPNEERMRTLAESSPSIVTPLNSAIGYEAAAKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLDVLAMANTDRDK
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]