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The map label for this gene is ilvD

Identifier: 68536387

GI number: 68536387

Start: 1537301

End: 1539148

Strand: Direct

Name: ilvD

Synonym: jk1303

Alternate gene names: 68536387

Gene position: 1537301-1539148 (Clockwise)

Preceding gene: 68536386

Following gene: 68536388

Centisome position: 62.43

GC content: 62.55

Gene sequence:

>1848_bases
ATGAACGCCATCCCATTGAGATCCGCCGTCACCACCCAGGGACGCAACGCTGCCGGCGCCCGCGCCCTGTGGCGTGCGAC
AGGCATGACGGATCAGGACTTCGAAAAGCCCATCATCGCCATTGCGAACTCGTACACGCAGTTTGTACCGGGCCACGTAC
ACCTGAAGGACGTGGGAGACATCGTCGCAGACGCCATCCGCGAAGCTGGTGGCGTTCCTCGCGAATTCAACACCATCGCC
GTCGACGATGGTATTGCTATGGGACACGCGGGAATGCTTTACTCGCTGCCTAGTCGCGAAGTTATTTCTGACGCCGTCGA
GTACATGGTCAACGGCCACGCCGCTGATGCGCTGGTGTGCATTTCCAACTGCGACAAGATCACGCCCGGCATGCTGAATG
CCGCCATGCGTCTGAACATCCCGGTGGTGTTCGTCTCCGGCGGTCCGATGGAGGCTGGCAAGGCCGTGGCCGTTGACGGT
GTCGTTCAGGCTCCCACGGATCTGATTACCGCCATCTCCGCCTCTGCATCCGACAAGGTCGACGCACAGGCACTGCTGGA
AGTTGAGTCCGCTGCCTGCCCGACGTGCGGCTCCTGCTCCGGCATGTTCACCGCCAACTCGATGAACTGTCTAACCGAGG
CGCTGGGCCTGTCCCTACCGGGCAATGGTTCCACCTTGGCGACTCACGCCAAGCGGAGAGACCTGTTCACCAAGGCTGGC
ACCACCATCGTTGAACTGTGCCGCCGCTACTACGGCGAGGGAGACGCCTCCGTCCTGCCGCGAAACATCGCCACCCGTGA
GGCCTTCGAAAACGCAATGGCGCTGGACATGGCCATGGGCGGATCTTCCAACACTGTGCTGCACATTCTCGCTGCCGCCC
AGGAGGGCGAGATCGATTTCGACCTGCACTCTATCGACCAGCTGTCCCGCGAAGTGCCGTGCCTGTCAAAGGTGTCCCCG
AACTCCGACTACCACATGGAAGATGTCCACCGCGGAGGCGGCATTCCCGCCATCCTCGGTGAGCTTTACCGAGCAGGCAA
GCTGAACGAAGGCGTCCACTCCGTTCACTCCGCCACGCTCAAGGAATGGCTCCTGTCCTGGGACATCCGCTCCGGGGCTG
CAACCGAGGAAGCTATCGAGCTGTTCCACGCCGCCCCCGGCGGAGTCCGCACAACCGCGCCATTCAGTACTGAGAACCGT
TGGTCCAGCTTGGACACCGACGCAGAGGGTGGCGTCATTCGCGATGTGGAACATGCGTACACCGCCGATGGCGGTCTGGT
TGTCCTCCGCGGCAACCTCGCCGAAGACGGCGCCGTAATCAAAGCCGCGGGTGTTGATCCGTCGATCTGGCACTTCGAAG
GCAAAGCGCTAGTCGTCGAATCCCAGGAAGAAGCCGTGCGCGTGATCCTGGACAAGAAAGTCAAGCCGGGCCACGTGGTA
GTCGTACGCTACGAAGGCCCCGCCGGCGGACCGGGAATGCAGGAAATGCTACACCCGACCGCTTTCCTCAAGGGCGCAGG
GCTTGGCAAGGAGTGCGCGCTAATCACCGACGGTCGATTCTCCGGCGGCACGTCCGGCCTGTCCGTCGGCCACATCTCCC
CTGAGGCTGCTCACGGCGGCTTGATTGGCTTGGTCCGCGACGGGGATCCGATCACGATCGACGTTCACGAGCGCCTTCTG
CAACTGAACATCTCCGACGAGGAGATCGAGCGCCGCCGTGCCGAAATGGAAGCTTCCGATAAGCCCTGGACTCCCACCAC
TCGTCAGCGCAAGGTCACCAAGGCGCTGCGCGCTTATGCCGCGATGGCAACCTCCGCTGACCGCGGAGCCGTCCGCGAAG
TGAAGTAG

Upstream 100 bases:

>100_bases
GAACCCAAGCCAGATATCGCGGGCCAGATAACACAACCGAAGAGAACTACTAACACTAGAGTACGAAGATTAGAACGACG
AGAAGAGAACCGTGAACAGT

Downstream 100 bases:

>100_bases
CCACCCCGCCCTGCCGCCGGTGCGCGGGGCCGTAGGGTGGAGGGCATGCATGTTTCACACCTCCAGCCCGATGCAATGAT
CCGCGTCCGTGACGCACACT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MNAIPLRSAVTTQGRNAAGARALWRATGMTDQDFEKPIIAIANSYTQFVPGHVHLKDVGDIVADAIREAGGVPREFNTIA
VDDGIAMGHAGMLYSLPSREVISDAVEYMVNGHAADALVCISNCDKITPGMLNAAMRLNIPVVFVSGGPMEAGKAVAVDG
VVQAPTDLITAISASASDKVDAQALLEVESAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAKRRDLFTKAG
TTIVELCRRYYGEGDASVLPRNIATREAFENAMALDMAMGGSSNTVLHILAAAQEGEIDFDLHSIDQLSREVPCLSKVSP
NSDYHMEDVHRGGGIPAILGELYRAGKLNEGVHSVHSATLKEWLLSWDIRSGAATEEAIELFHAAPGGVRTTAPFSTENR
WSSLDTDAEGGVIRDVEHAYTADGGLVVLRGNLAEDGAVIKAAGVDPSIWHFEGKALVVESQEEAVRVILDKKVKPGHVV
VVRYEGPAGGPGMQEMLHPTAFLKGAGLGKECALITDGRFSGGTSGLSVGHISPEAAHGGLIGLVRDGDPITIDVHERLL
QLNISDEEIERRRAEMEASDKPWTPTTRQRKVTKALRAYAAMATSADRGAVREVK

Sequences:

>Translated_615_residues
MNAIPLRSAVTTQGRNAAGARALWRATGMTDQDFEKPIIAIANSYTQFVPGHVHLKDVGDIVADAIREAGGVPREFNTIA
VDDGIAMGHAGMLYSLPSREVISDAVEYMVNGHAADALVCISNCDKITPGMLNAAMRLNIPVVFVSGGPMEAGKAVAVDG
VVQAPTDLITAISASASDKVDAQALLEVESAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAKRRDLFTKAG
TTIVELCRRYYGEGDASVLPRNIATREAFENAMALDMAMGGSSNTVLHILAAAQEGEIDFDLHSIDQLSREVPCLSKVSP
NSDYHMEDVHRGGGIPAILGELYRAGKLNEGVHSVHSATLKEWLLSWDIRSGAATEEAIELFHAAPGGVRTTAPFSTENR
WSSLDTDAEGGVIRDVEHAYTADGGLVVLRGNLAEDGAVIKAAGVDPSIWHFEGKALVVESQEEAVRVILDKKVKPGHVV
VVRYEGPAGGPGMQEMLHPTAFLKGAGLGKECALITDGRFSGGTSGLSVGHISPEAAHGGLIGLVRDGDPITIDVHERLL
QLNISDEEIERRRAEMEASDKPWTPTTRQRKVTKALRAYAAMATSADRGAVREVK
>Mature_615_residues
MNAIPLRSAVTTQGRNAAGARALWRATGMTDQDFEKPIIAIANSYTQFVPGHVHLKDVGDIVADAIREAGGVPREFNTIA
VDDGIAMGHAGMLYSLPSREVISDAVEYMVNGHAADALVCISNCDKITPGMLNAAMRLNIPVVFVSGGPMEAGKAVAVDG
VVQAPTDLITAISASASDKVDAQALLEVESAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAKRRDLFTKAG
TTIVELCRRYYGEGDASVLPRNIATREAFENAMALDMAMGGSSNTVLHILAAAQEGEIDFDLHSIDQLSREVPCLSKVSP
NSDYHMEDVHRGGGIPAILGELYRAGKLNEGVHSVHSATLKEWLLSWDIRSGAATEEAIELFHAAPGGVRTTAPFSTENR
WSSLDTDAEGGVIRDVEHAYTADGGLVVLRGNLAEDGAVIKAAGVDPSIWHFEGKALVVESQEEAVRVILDKKVKPGHVV
VVRYEGPAGGPGMQEMLHPTAFLKGAGLGKECALITDGRFSGGTSGLSVGHISPEAAHGGLIGLVRDGDPITIDVHERLL
QLNISDEEIERRRAEMEASDKPWTPTTRQRKVTKALRAYAAMATSADRGAVREVK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=65.0819672131148, Blast_Score=804, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=579, Percent_Identity=30.2245250431779, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=548, Percent_Identity=29.3795620437956, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1786464, Length=572, Percent_Identity=28.1468531468531, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=33.9344262295082, Blast_Score=326, Evalue=8e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_CORJK (Q4JUN3)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_251092.1
- STRING:   Q4JUN3
- GeneID:   3432449
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk1303
- NMPDR:   fig|306537.3.peg.2057
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   CJEI306537:JK1303-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65041; Mature: 65041

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIPLRSAVTTQGRNAAGARALWRATGMTDQDFEKPIIAIANSYTQFVPGHVHLKDVGD
CCCCCCCHHHCCCCCCCCCHHHHHHHCCCCCCHHCCCHHHHHCCHHHHCCCEEEHHHHHH
IVADAIREAGGVPREFNTIAVDDGIAMGHAGMLYSLPSREVISDAVEYMVNGHAADALVC
HHHHHHHHHCCCCCCCCEEEECCCCEECCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEE
ISNCDKITPGMLNAAMRLNIPVVFVSGGPMEAGKAVAVDGVVQAPTDLITAISASASDKV
ECCCCCCCCHHHHHEEEECCEEEEEECCCCCCCCEEEECCCHHCCHHHHHHHHCCCCCCC
DAQALLEVESAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAKRRDLFTKAG
CHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
TTIVELCRRYYGEGDASVLPRNIATREAFENAMALDMAMGGSSNTVLHILAAAQEGEIDF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEHEECCCCCCCEEEEEEECCCCCCEE
DLHSIDQLSREVPCLSKVSPNSDYHMEDVHRGGGIPAILGELYRAGKLNEGVHSVHSATL
CHHHHHHHHHCCCCHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
KEWLLSWDIRSGAATEEAIELFHAAPGGVRTTAPFSTENRWSSLDTDAEGGVIRDVEHAY
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCEEECCHHHH
TADGGLVVLRGNLAEDGAVIKAAGVDPSIWHFEGKALVVESQEEAVRVILDKKVKPGHVV
CCCCCEEEEECCCCCCCCEEEECCCCCCEEEECCCEEEEECHHHHHHHHHHCCCCCCEEE
VVRYEGPAGGPGMQEMLHPTAFLKGAGLGKECALITDGRFSGGTSGLSVGHISPEAAHGG
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCC
LIGLVRDGDPITIDVHERLLQLNISDEEIERRRAEMEASDKPWTPTTRQRKVTKALRAYA
EEEEEECCCEEEEEHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AMATSADRGAVREVK
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MNAIPLRSAVTTQGRNAAGARALWRATGMTDQDFEKPIIAIANSYTQFVPGHVHLKDVGD
CCCCCCCHHHCCCCCCCCCHHHHHHHCCCCCCHHCCCHHHHHCCHHHHCCCEEEHHHHHH
IVADAIREAGGVPREFNTIAVDDGIAMGHAGMLYSLPSREVISDAVEYMVNGHAADALVC
HHHHHHHHHCCCCCCCCEEEECCCCEECCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEE
ISNCDKITPGMLNAAMRLNIPVVFVSGGPMEAGKAVAVDGVVQAPTDLITAISASASDKV
ECCCCCCCCHHHHHEEEECCEEEEEECCCCCCCCEEEECCCHHCCHHHHHHHHCCCCCCC
DAQALLEVESAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHAKRRDLFTKAG
CHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
TTIVELCRRYYGEGDASVLPRNIATREAFENAMALDMAMGGSSNTVLHILAAAQEGEIDF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEHEECCCCCCCEEEEEEECCCCCCEE
DLHSIDQLSREVPCLSKVSPNSDYHMEDVHRGGGIPAILGELYRAGKLNEGVHSVHSATL
CHHHHHHHHHCCCCHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
KEWLLSWDIRSGAATEEAIELFHAAPGGVRTTAPFSTENRWSSLDTDAEGGVIRDVEHAY
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCEEECCHHHH
TADGGLVVLRGNLAEDGAVIKAAGVDPSIWHFEGKALVVESQEEAVRVILDKKVKPGHVV
CCCCCEEEEECCCCCCCCEEEECCCCCCEEEECCCEEEEECHHHHHHHHHHCCCCCCEEE
VVRYEGPAGGPGMQEMLHPTAFLKGAGLGKECALITDGRFSGGTSGLSVGHISPEAAHGG
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCC
LIGLVRDGDPITIDVHERLLQLNISDEEIERRRAEMEASDKPWTPTTRQRKVTKALRAYA
EEEEEECCCEEEEEHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AMATSADRGAVREVK
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA