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The map label for this gene is hemN [H]

Identifier: 68535671

GI number: 68535671

Start: 725716

End: 726945

Strand: Direct

Name: hemN [H]

Synonym: jk0599

Alternate gene names: 68535671

Gene position: 725716-726945 (Clockwise)

Preceding gene: 68535670

Following gene: 68535672

Centisome position: 29.47

GC content: 65.12

Gene sequence:

>1230_bases
ATGCATGGCCTTTATATCCACGTCCCCTTTTGCTCCACCCGCTGTGGCTACTGCGACTTCAACACGTACACCCCGCAGGA
GCTCAGCGCGGCCGACGGTGGCGCTGTAGAGGGCAACACCATCCCCGGCTACCTGGATGCCCTGGAGCGCGAGCTAGAGG
TCGCCGCCGAGGTGTGGGATTACCCCGGCGAGGTGCAGACCGTCTTCTTCGGTGGCGGCACGCCCTCCATGTTGGGCCAT
GAGGGGTTGGCCCGAGCGCTAAATGCCGCCCGCCGTACCGTGGGCCTTGCGGCAAACGCGGAGGTCACTACCGAGGCGAA
CCCGGAATCCACCAGCCCGGAGTTCTTCGCAGGCTTGCGCGAGGCGGGTTTCAACCGCATCTCCTTAGGCATGCAGTCCG
CGATGGGGCACGTGCTGAAGGTGCTGGAACGCCAGCACACCCCGGGCCGCCCTATTGAGGCCACCCGCGAGGCCAAGCGG
GCCGGTTTCGAGCACATCAACCTGGACGTCATCTACGGTACCCCCACCGAGACCGACGACGACCTGCGGCGCACCCTCGA
CGCGGTGCTGGAGGCCGACGTCGACCACGTTTCCGCCTATTCCCTGATCGTTGAGGACGGCACGGCCATGGCGCGCAAGG
TGCGGCGTGGCGAGCTGCCGGCCCCGGACGAGGACACGCTCGCTGATCGTTATGACGCCATCGATGCCCGCCTGCGGGAT
GCCGGATTTAACTGGTACGAGGTCTCTAACTGGGCCAAACCCGGCGGTGAATGCCAGCACAACCTGATCTATTGGCGCTC
CGGTCAGTGGTGGGGCGCCGGGCCCGGCGCCCATGGATGCGTGCGGCTGCGTGGGGAGGGGCACAGCGAGTCTGGCCTGG
TGAGGCTGGTGAATGCGAAGCGTCCGGCGACCTATTGGGATGGGCTGCTGGGGGAGGCCGAAGGGGCGTCAACAGGAAAG
GATGGCCTACCCGTGCCAGGGTCGGTGGTGACGACAGAGCGCCTCACCAACGACGACCTGCGTACCGAACAAGTGATGCT
GCAGTTGCGTTTGGCTGAAGGGCTGAAGCTAGTCGGTAGTGATGAGAACGCTGAGCTGGCGCAGGTGATCGAGCGCTACA
CGGGCCTGGGCCTGCTGGATAAACACGGCGAGCGCCTAAGATTGACGGATAAAGGGCGCTACCTGGCCGACGGGATCGTC
ACGGACATTGTGTTGGCGCTCGGGCTTTAA

Upstream 100 bases:

>100_bases
CGCTCGGGTGGAGGAGATCGTCGGCCGCCTGCAGCGGCGCAAGCGCGGCACTGCTGTCTAGTACCAGTACCGCCAGCACG
GCTAGTACTATGCACGTAGT

Downstream 100 bases:

>100_bases
GAGCCAATCGAGAGCTAATCGAGGCTGATCGGACTCACGCGAGGAGTGAAGGATTTGTCGAGCGGAACGGAACACAGAAG
AAACCAAGTGCTGCGGGCGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MHGLYIHVPFCSTRCGYCDFNTYTPQELSAADGGAVEGNTIPGYLDALERELEVAAEVWDYPGEVQTVFFGGGTPSMLGH
EGLARALNAARRTVGLAANAEVTTEANPESTSPEFFAGLREAGFNRISLGMQSAMGHVLKVLERQHTPGRPIEATREAKR
AGFEHINLDVIYGTPTETDDDLRRTLDAVLEADVDHVSAYSLIVEDGTAMARKVRRGELPAPDEDTLADRYDAIDARLRD
AGFNWYEVSNWAKPGGECQHNLIYWRSGQWWGAGPGAHGCVRLRGEGHSESGLVRLVNAKRPATYWDGLLGEAEGASTGK
DGLPVPGSVVTTERLTNDDLRTEQVMLQLRLAEGLKLVGSDENAELAQVIERYTGLGLLDKHGERLRLTDKGRYLADGIV
TDIVLALGL

Sequences:

>Translated_409_residues
MHGLYIHVPFCSTRCGYCDFNTYTPQELSAADGGAVEGNTIPGYLDALERELEVAAEVWDYPGEVQTVFFGGGTPSMLGH
EGLARALNAARRTVGLAANAEVTTEANPESTSPEFFAGLREAGFNRISLGMQSAMGHVLKVLERQHTPGRPIEATREAKR
AGFEHINLDVIYGTPTETDDDLRRTLDAVLEADVDHVSAYSLIVEDGTAMARKVRRGELPAPDEDTLADRYDAIDARLRD
AGFNWYEVSNWAKPGGECQHNLIYWRSGQWWGAGPGAHGCVRLRGEGHSESGLVRLVNAKRPATYWDGLLGEAEGASTGK
DGLPVPGSVVTTERLTNDDLRTEQVMLQLRLAEGLKLVGSDENAELAQVIERYTGLGLLDKHGERLRLTDKGRYLADGIV
TDIVLALGL
>Mature_409_residues
MHGLYIHVPFCSTRCGYCDFNTYTPQELSAADGGAVEGNTIPGYLDALERELEVAAEVWDYPGEVQTVFFGGGTPSMLGH
EGLARALNAARRTVGLAANAEVTTEANPESTSPEFFAGLREAGFNRISLGMQSAMGHVLKVLERQHTPGRPIEATREAKR
AGFEHINLDVIYGTPTETDDDLRRTLDAVLEADVDHVSAYSLIVEDGTAMARKVRRGELPAPDEDTLADRYDAIDARLRD
AGFNWYEVSNWAKPGGECQHNLIYWRSGQWWGAGPGAHGCVRLRGEGHSESGLVRLVNAKRPATYWDGLLGEAEGASTGK
DGLPVPGSVVTTERLTNDDLRTEQVMLQLRLAEGLKLVGSDENAELAQVIERYTGLGLLDKHGERLRLTDKGRYLADGIV
TDIVLALGL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=287, Percent_Identity=38.3275261324042, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1789325, Length=313, Percent_Identity=34.8242811501597, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI87082341, Length=257, Percent_Identity=28.7937743190661, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44504; Mature: 44504

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00024 HEMOPEXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGLYIHVPFCSTRCGYCDFNTYTPQELSAADGGAVEGNTIPGYLDALERELEVAAEVWD
CCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
YPGEVQTVFFGGGTPSMLGHEGLARALNAARRTVGLAANAEVTTEANPESTSPEFFAGLR
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCEECCCEEEECCCCCCCCHHHHHHHH
EAGFNRISLGMQSAMGHVLKVLERQHTPGRPIEATREAKRAGFEHINLDVIYGTPTETDD
HCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCHH
DLRRTLDAVLEADVDHVSAYSLIVEDGTAMARKVRRGELPAPDEDTLADRYDAIDARLRD
HHHHHHHHHHHHCHHHHEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AGFNWYEVSNWAKPGGECQHNLIYWRSGQWWGAGPGAHGCVRLRGEGHSESGLVRLVNAK
CCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCC
RPATYWDGLLGEAEGASTGKDGLPVPGSVVTTERLTNDDLRTEQVMLQLRLAEGLKLVGS
CCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHHCCEEECC
DENAELAQVIERYTGLGLLDKHGERLRLTDKGRYLADGIVTDIVLALGL
CCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHGLYIHVPFCSTRCGYCDFNTYTPQELSAADGGAVEGNTIPGYLDALERELEVAAEVWD
CCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
YPGEVQTVFFGGGTPSMLGHEGLARALNAARRTVGLAANAEVTTEANPESTSPEFFAGLR
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCEECCCEEEECCCCCCCCHHHHHHHH
EAGFNRISLGMQSAMGHVLKVLERQHTPGRPIEATREAKRAGFEHINLDVIYGTPTETDD
HCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCHH
DLRRTLDAVLEADVDHVSAYSLIVEDGTAMARKVRRGELPAPDEDTLADRYDAIDARLRD
HHHHHHHHHHHHCHHHHEEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AGFNWYEVSNWAKPGGECQHNLIYWRSGQWWGAGPGAHGCVRLRGEGHSESGLVRLVNAK
CCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCC
RPATYWDGLLGEAEGASTGKDGLPVPGSVVTTERLTNDDLRTEQVMLQLRLAEGLKLVGS
CCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHHCCEEECC
DENAELAQVIERYTGLGLLDKHGERLRLTDKGRYLADGIVTDIVLALGL
CCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]