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The map label for this gene is gltA [H]

Identifier: 68535496

GI number: 68535496

Start: 511171

End: 512448

Strand: Direct

Name: gltA [H]

Synonym: jk0426

Alternate gene names: 68535496

Gene position: 511171-512448 (Clockwise)

Preceding gene: 68535492

Following gene: 68535497

Centisome position: 20.76

GC content: 59.47

Gene sequence:

>1278_bases
ATGGCTACTGATAATCAGGACAAGGCCGTTCTCCACTACCCAGGTGGAGAGTACGAAATGGACATTGTCCGCGCCACCGA
AGGAAACGACGGTGTCGCACTGGGCAAGATGCTGGCAGAAACCGGCTTGACCACCCTGGATCCCGGCTACGTGAACACCG
GTTCCACCAAGTCCGCCATCACCTACATCGACGGTGCAAACGGCATCCTGCGTTACCGTGGCTACGACATTGCCGACCTG
GCCAACAACGCAACCTTCAACGAGGTTTCCTACCTGCTGATCAACGGCGAGCTGCCGAACAAGGAGCAGGCTGAGGAGTT
CAACACCAACATCCGCAACCACACCCTGCTGGATGAAGACTTCAAGGCACAGTTCCGCGTGTTCCCGCGCGACGCTCACC
CGATGAGCGTTCTGGCTTCCTCCCTGAACATTCTGTCCACCTACTACCAGGACTCCCTGGATCCGCTGAACCCGGATCAC
CAGAAGCTGAACACCTACCGCCTGATGGCGAAGGTGCCGATGCTGGCTGCTTACGCTTACCGCGCTTCCAAGGGTAAGCC
GTACATGTACCCGGATAACTCCATGAACGCGCGCCAGAACTTCCTGCGCCAGATGTTCGGCTACCCGACCGAGCCTTTCG
AGGATGACCCGGTGGTTACCAAGGCTCTGGACAAGCTGCTGATCCTGCACGCTGACCACGAGCAGAACTGCTCCACCTCC
ACCGTCCGCATGGTTGGTTCTTCCCAGGCCAACATGTTCGTCTCCATCGCCGCAGGCATCAACGCCCTGTCCGGCCCGCT
GCACGGCGGTGCTAACCAGGCTGTTCTGGAGATGCTGGAGGAGATCCACGCTAACGGTGGCGACGCTACCGAGTTCATGA
ACCGCGTGAAGAACAAGGAGCCGGGCGTGAAGCTGATGGGCTTCGGTCACCGCGTGTACAAGAACTACGATCCGCGTGCG
GCCATCGTCAAGGAGTCCGCTCACGAGATTCTGGATCACCTGGGTGGCGACCACCTGCTGGATCTGGCTATGAAGCTGGA
AGAGATTGCGCTGGCTGATGATTACTTCATCTCCCGCAAGCTCTACCCGAACGTGGACTTCTACACCGGCCTGATCTACC
GCGCTATGGGCTTCCCGACGGACTTCTTCACCGTCCTGTTCGCCATGGGTCGCCTGCCGGGCTGGATCGCTCACTACCTG
GAGCAGGTCAACGATCCGACCGCGAAGATCAACCGTCCGCGCCAGATCTACACCGGCGAGGGTGCGCGCAAGCTCTAA

Upstream 100 bases:

>100_bases
GTGTTCCGCTCCAACGGTGCCAGCGCAAGCTTTTACCAGAAAGTAATCGCTACAACATTCGCTGCGGGCAGGCACGTGAA
CATTTCAGAAAGGGATGTCA

Downstream 100 bases:

>100_bases
ACCCTGTGTGGTGACGCCCCCTCGGTGTGGCTGCGCGAAGCGCATGCCCCCAAGGGGGCTTTTCGCGTTTTGCTAGGGTG
GAGCCTCGAGAAGCTATCAG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MATDNQDKAVLHYPGGEYEMDIVRATEGNDGVALGKMLAETGLTTLDPGYVNTGSTKSAITYIDGANGILRYRGYDIADL
ANNATFNEVSYLLINGELPNKEQAEEFNTNIRNHTLLDEDFKAQFRVFPRDAHPMSVLASSLNILSTYYQDSLDPLNPDH
QKLNTYRLMAKVPMLAAYAYRASKGKPYMYPDNSMNARQNFLRQMFGYPTEPFEDDPVVTKALDKLLILHADHEQNCSTS
TVRMVGSSQANMFVSIAAGINALSGPLHGGANQAVLEMLEEIHANGGDATEFMNRVKNKEPGVKLMGFGHRVYKNYDPRA
AIVKESAHEILDHLGGDHLLDLAMKLEEIALADDYFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAMGRLPGWIAHYL
EQVNDPTAKINRPRQIYTGEGARKL

Sequences:

>Translated_425_residues
MATDNQDKAVLHYPGGEYEMDIVRATEGNDGVALGKMLAETGLTTLDPGYVNTGSTKSAITYIDGANGILRYRGYDIADL
ANNATFNEVSYLLINGELPNKEQAEEFNTNIRNHTLLDEDFKAQFRVFPRDAHPMSVLASSLNILSTYYQDSLDPLNPDH
QKLNTYRLMAKVPMLAAYAYRASKGKPYMYPDNSMNARQNFLRQMFGYPTEPFEDDPVVTKALDKLLILHADHEQNCSTS
TVRMVGSSQANMFVSIAAGINALSGPLHGGANQAVLEMLEEIHANGGDATEFMNRVKNKEPGVKLMGFGHRVYKNYDPRA
AIVKESAHEILDHLGGDHLLDLAMKLEEIALADDYFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAMGRLPGWIAHYL
EQVNDPTAKINRPRQIYTGEGARKL
>Mature_424_residues
ATDNQDKAVLHYPGGEYEMDIVRATEGNDGVALGKMLAETGLTTLDPGYVNTGSTKSAITYIDGANGILRYRGYDIADLA
NNATFNEVSYLLINGELPNKEQAEEFNTNIRNHTLLDEDFKAQFRVFPRDAHPMSVLASSLNILSTYYQDSLDPLNPDHQ
KLNTYRLMAKVPMLAAYAYRASKGKPYMYPDNSMNARQNFLRQMFGYPTEPFEDDPVVTKALDKLLILHADHEQNCSTST
VRMVGSSQANMFVSIAAGINALSGPLHGGANQAVLEMLEEIHANGGDATEFMNRVKNKEPGVKLMGFGHRVYKNYDPRAA
IVKESAHEILDHLGGDHLLDLAMKLEEIALADDYFISRKLYPNVDFYTGLIYRAMGFPTDFFTVLFAMGRLPGWIAHYLE
QVNDPTAKINRPRQIYTGEGARKL

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=398, Percent_Identity=27.8894472361809, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786939, Length=406, Percent_Identity=50.9852216748768, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=31.3513513513514, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17555174, Length=379, Percent_Identity=28.2321899736148, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=417, Percent_Identity=28.0575539568345, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324328, Length=385, Percent_Identity=27.5324675324675, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325257, Length=380, Percent_Identity=26.5789473684211, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24640126, Length=402, Percent_Identity=29.3532338308458, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24640124, Length=402, Percent_Identity=29.3532338308458, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356863, Length=394, Percent_Identity=26.3959390862944, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47429; Mature: 47298

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDNQDKAVLHYPGGEYEMDIVRATEGNDGVALGKMLAETGLTTLDPGYVNTGSTKSAI
CCCCCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
TYIDGANGILRYRGYDIADLANNATFNEVSYLLINGELPNKEQAEEFNTNIRNHTLLDED
EEEECCCCEEEECCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCC
FKAQFRVFPRDAHPMSVLASSLNILSTYYQDSLDPLNPDHQKLNTYRLMAKVPMLAAYAY
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RASKGKPYMYPDNSMNARQNFLRQMFGYPTEPFEDDPVVTKALDKLLILHADHEQNCSTS
HHCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCH
TVRMVGSSQANMFVSIAAGINALSGPLHGGANQAVLEMLEEIHANGGDATEFMNRVKNKE
HEEEECCCCCCEEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PGVKLMGFGHRVYKNYDPRAAIVKESAHEILDHLGGDHLLDLAMKLEEIALADDYFISRK
CCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
LYPNVDFYTGLIYRAMGFPTDFFTVLFAMGRLPGWIAHYLEQVNDPTAKINRPRQIYTGE
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCCCEEEECC
GARKL
CCCCC
>Mature Secondary Structure 
ATDNQDKAVLHYPGGEYEMDIVRATEGNDGVALGKMLAETGLTTLDPGYVNTGSTKSAI
CCCCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
TYIDGANGILRYRGYDIADLANNATFNEVSYLLINGELPNKEQAEEFNTNIRNHTLLDED
EEEECCCCEEEECCCCHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCC
FKAQFRVFPRDAHPMSVLASSLNILSTYYQDSLDPLNPDHQKLNTYRLMAKVPMLAAYAY
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RASKGKPYMYPDNSMNARQNFLRQMFGYPTEPFEDDPVVTKALDKLLILHADHEQNCSTS
HHCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCH
TVRMVGSSQANMFVSIAAGINALSGPLHGGANQAVLEMLEEIHANGGDATEFMNRVKNKE
HEEEECCCCCCEEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PGVKLMGFGHRVYKNYDPRAAIVKESAHEILDHLGGDHLLDLAMKLEEIALADDYFISRK
CCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
LYPNVDFYTGLIYRAMGFPTDFFTVLFAMGRLPGWIAHYLEQVNDPTAKINRPRQIYTGE
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHCCCCCEEEECC
GARKL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]