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The map label for this gene is purQ

Identifier: 68535419

GI number: 68535419

Start: 424993

End: 425664

Strand: Direct

Name: purQ

Synonym: jk0354

Alternate gene names: 68535419

Gene position: 424993-425664 (Clockwise)

Preceding gene: 68535418

Following gene: 68535420

Centisome position: 17.26

GC content: 66.22

Gene sequence:

>672_bases
GTGACCAGCCGCATTGGAGTGATCACCTTCCCCGGCACCCTCGACGACGTCGATGCCGTGCGCGCTGTGCGCCTGGCGGG
TGCGGAGCCGGTGGAGCTGTGGCACGCAGACGAGGACCTGAAGAACGTCGACGCTGTGGTCGTCCCCGGTGGCTTTTCCT
ACGGCGACTACCTGCGCGCCGGTGCTATCGCCGCCATCGCCCCGGCAATGAAGTCCGTGGTGGCTGCCGCGGAGCGCGGT
ACCCCGGTGCTGGGGATCTGCAACGGCTTCCAGATTCTGCAGGAAGCCGGCCTGCTCCCCGGAGCCCTCACCCGTAACGA
GGGGCTCCACTTCGTGTGCCGCGACATCTACCTGGACGTGGAAAACACATCCACGGCATGGACCAACCAGTTCGCCGAGG
GCACCAAGATCCTGGTGCCCTCGAAGCACGGTGAGGGGCGCTTCCAGGCCAGCGAGGAAACGCTGGAGCGCCTGGAGGGC
GAAGGCCGCGTGGTGTTCCGCTACGTCGAGAACCACAACGGCTCCCGCAACTCGATCGCCGGAGTGTGCAGCGAAAACGG
TCGCGTGGTTGGCCTTATGCCGCACCCGGAGCACGCCGTGGAAACCCTGACCGGCCCGTCCTTGGATGGCCTGGGGCTGT
TCCAGTCCGTTCTGTCTACGCTCGTTTCCTAA

Upstream 100 bases:

>100_bases
GCGCGAGGATCTGGAGAAGATCGCCTCCGACCTGCTGGCAAACACCGTGATCGAGGACTACGACGTGGTCGTCGAAGGCG
CAGATGTGGAGGCTAAGTAA

Downstream 100 bases:

>100_bases
TCTTTTTTCTTACAAGGAGCACCCGATCCTCATGATTCACAACGACACGGTCGCCGATGCTAAGGCCAACCCGGACCTGG
AGCAGCCGTATCACGAGCTG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTSRIGVITFPGTLDDVDAVRAVRLAGAEPVELWHADEDLKNVDAVVVPGGFSYGDYLRAGAIAAIAPAMKSVVAAAERG
TPVLGICNGFQILQEAGLLPGALTRNEGLHFVCRDIYLDVENTSTAWTNQFAEGTKILVPSKHGEGRFQASEETLERLEG
EGRVVFRYVENHNGSRNSIAGVCSENGRVVGLMPHPEHAVETLTGPSLDGLGLFQSVLSTLVS

Sequences:

>Translated_223_residues
MTSRIGVITFPGTLDDVDAVRAVRLAGAEPVELWHADEDLKNVDAVVVPGGFSYGDYLRAGAIAAIAPAMKSVVAAAERG
TPVLGICNGFQILQEAGLLPGALTRNEGLHFVCRDIYLDVENTSTAWTNQFAEGTKILVPSKHGEGRFQASEETLERLEG
EGRVVFRYVENHNGSRNSIAGVCSENGRVVGLMPHPEHAVETLTGPSLDGLGLFQSVLSTLVS
>Mature_222_residues
TSRIGVITFPGTLDDVDAVRAVRLAGAEPVELWHADEDLKNVDAVVVPGGFSYGDYLRAGAIAAIAPAMKSVVAAAERGT
PVLGICNGFQILQEAGLLPGALTRNEGLHFVCRDIYLDVENTSTAWTNQFAEGTKILVPSKHGEGRFQASEETLERLEGE
GRVVFRYVENHNGSRNSIAGVCSENGRVVGLMPHPEHAVETLTGPSLDGLGLFQSVLSTLVS

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=230, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=181, Percent_Identity=35.3591160220994, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24582111, Length=193, Percent_Identity=32.6424870466321, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582109, Length=193, Percent_Identity=32.6424870466321, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137292, Length=193, Percent_Identity=32.6424870466321, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_CORJK (Q4JXF1)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250124.1
- ProteinModelPortal:   Q4JXF1
- SMR:   Q4JXF1
- STRING:   Q4JXF1
- GeneID:   3432679
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0354
- NMPDR:   fig|306537.3.peg.1365
- eggNOG:   COG0047
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   CJEI306537:JK0354-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.3

Molecular weight: Translated: 23727; Mature: 23596

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 87-87 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRIGVITFPGTLDDVDAVRAVRLAGAEPVELWHADEDLKNVDAVVVPGGFSYGDYLRA
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCCCHHHHHHH
GAIAAIAPAMKSVVAAAERGTPVLGICNGFQILQEAGLLPGALTRNEGLHFVCRDIYLDV
HHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEE
ENTSTAWTNQFAEGTKILVPSKHGEGRFQASEETLERLEGEGRVVFRYVENHNGSRNSIA
CCCCCHHHHHHCCCCEEEEECCCCCCCEECCHHHHHHHCCCCCEEEEEEECCCCCCCCEE
GVCSENGRVVGLMPHPEHAVETLTGPSLDGLGLFQSVLSTLVS
EEECCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSRIGVITFPGTLDDVDAVRAVRLAGAEPVELWHADEDLKNVDAVVVPGGFSYGDYLRA
CCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCCCHHHHHHH
GAIAAIAPAMKSVVAAAERGTPVLGICNGFQILQEAGLLPGALTRNEGLHFVCRDIYLDV
HHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEE
ENTSTAWTNQFAEGTKILVPSKHGEGRFQASEETLERLEGEGRVVFRYVENHNGSRNSIA
CCCCCHHHHHHCCCCEEEEECCCCCCCEECCHHHHHHHCCCCCEEEEEEECCCCCCCCEE
GVCSENGRVVGLMPHPEHAVETLTGPSLDGLGLFQSVLSTLVS
EEECCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA