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The map label for this gene is hpt [H]

Identifier: 68535342

GI number: 68535342

Start: 340731

End: 341312

Strand: Direct

Name: hpt [H]

Synonym: jk0277

Alternate gene names: 68535342

Gene position: 340731-341312 (Clockwise)

Preceding gene: 68535341

Following gene: 68535343

Centisome position: 13.84

GC content: 61.51

Gene sequence:

>582_bases
ATGCACAGCGAGAAGAACTTCAACGTCCCGGAAAACCCATACGGCGACGATCTGGAAAGTATCCTCATCGATGAGGAAAC
GCTGCACGCCCGCATTAACGAGCTGGCCAAAGCCACCGCTGACCGCTTCCGCGACGAGGAAGACGACCTCATCCTGATCT
GCGTGCTGAAGGGCGCGGTGTTCTTCATCACCGACTTCGCGCGGGCGATCGACATTCCGACGCAGCTGGAGTTCATGGCC
GTGAGCTCCTACGGAAACTCCACCAGCTCCTCCGGCGTGGTGCGCATCCTGAAGGACCTGGACCGCGACATCGAGGGCCG
CAACGTGGTGATCGTCGAGGACATCATCGACTCCGGCCTGACCCTTTCCTGGCTGCTGAAGAACCTGCGCAACCGCAACC
CGAAGTCCCTGTCCGTCGTTACGCTGCTGCGCAAGCCGGAGGCGCAGAAGGTGCAGATCGACCTGGCCGAGGTCGGCTTT
GACATCCCCAACGAGTTCGTTGTGGGCTATGGCCTGGACTTTGCCGAGCGCTACCGCGACCTGCCCTACGTGGGCACCCT
GCACCCGCGCGTTTACCAGTAA

Upstream 100 bases:

>100_bases
CCAGGCAGGCACAAAACGGCGAAGCCAATGCAGCGGAGCCAAGACAGCGAAGCCACACTGCGAAAGCACTGCAAAACAAA
CGAGGAAAACGAGGTCTGCG

Downstream 100 bases:

>100_bases
AGCGCTAGATTTAAGCGACATAGAGAGCTGTTCGCACGGCATTTAGAACCAACAACACTCTAGGAAATATGGAAAAGAAG
AAGGTACTGAGGATCGCGGG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MHSEKNFNVPENPYGDDLESILIDEETLHARINELAKATADRFRDEEDDLILICVLKGAVFFITDFARAIDIPTQLEFMA
VSSYGNSTSSSGVVRILKDLDRDIEGRNVVIVEDIIDSGLTLSWLLKNLRNRNPKSLSVVTLLRKPEAQKVQIDLAEVGF
DIPNEFVVGYGLDFAERYRDLPYVGTLHPRVYQ

Sequences:

>Translated_193_residues
MHSEKNFNVPENPYGDDLESILIDEETLHARINELAKATADRFRDEEDDLILICVLKGAVFFITDFARAIDIPTQLEFMA
VSSYGNSTSSSGVVRILKDLDRDIEGRNVVIVEDIIDSGLTLSWLLKNLRNRNPKSLSVVTLLRKPEAQKVQIDLAEVGF
DIPNEFVVGYGLDFAERYRDLPYVGTLHPRVYQ
>Mature_193_residues
MHSEKNFNVPENPYGDDLESILIDEETLHARINELAKATADRFRDEEDDLILICVLKGAVFFITDFARAIDIPTQLEFMA
VSSYGNSTSSSGVVRILKDLDRDIEGRNVVIVEDIIDSGLTLSWLLKNLRNRNPKSLSVVTLLRKPEAQKVQIDLAEVGF
DIPNEFVVGYGLDFAERYRDLPYVGTLHPRVYQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=187, Percent_Identity=36.3636363636364, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI9910262, Length=192, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI87081689, Length=167, Percent_Identity=46.7065868263473, Blast_Score=169, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17510817, Length=192, Percent_Identity=31.7708333333333, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21858; Mature: 21858

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSEKNFNVPENPYGDDLESILIDEETLHARINELAKATADRFRDEEDDLILICVLKGAV
CCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHCHH
FFITDFARAIDIPTQLEFMAVSSYGNSTSSSGVVRILKDLDRDIEGRNVVIVEDIIDSGL
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEHHHHCCCC
TLSWLLKNLRNRNPKSLSVVTLLRKPEAQKVQIDLAEVGFDIPNEFVVGYGLDFAERYRD
CHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEHHHCCCCCCCCEEEECCCCHHHHHCC
LPYVGTLHPRVYQ
CCCEECCCCCCCC
>Mature Secondary Structure
MHSEKNFNVPENPYGDDLESILIDEETLHARINELAKATADRFRDEEDDLILICVLKGAV
CCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHCHH
FFITDFARAIDIPTQLEFMAVSSYGNSTSSSGVVRILKDLDRDIEGRNVVIVEDIIDSGL
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCEEEEHHHHCCCC
TLSWLLKNLRNRNPKSLSVVTLLRKPEAQKVQIDLAEVGFDIPNEFVVGYGLDFAERYRD
CHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEHHHCCCCCCCCEEEECCCCHHHHHCC
LPYVGTLHPRVYQ
CCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA