BacMap

Definition	Corynebacterium jeikeium K411, complete genome.
Accession	NC_007164
Length	2,462,499

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The map label for this gene is ppiA [H]

Identifier: 68535095

GI number: 68535095

Start: 39145

End: 39669

Strand: Direct

Name: ppiA [H]

Synonym: jk0033

Alternate gene names: 68535095

Gene position: 39145-39669 (Clockwise)

Preceding gene: 68535092

Following gene: 68535096

Centisome position: 1.59

GC content: 62.1

Gene sequence:

>525_bases
GTGACTAATAAGACTGCAACCGCAATTCTGCACACCAACCAAGGCGATATCGCCATCGATCTGTTCGGCAACCACGCGCC
GGAGACCGTAGCCAACTTTGTTGGCCTGGCACAGGGCACCAAGGAGTACTCCCAGCCCAACGCCTCCGGTACCAACGAAG
GCCCGTTCTACGATGGTGCGATCTTCCACCGCATCATCGATGGCTTCATGATCCAGGGCGGCGACCCGACCGGCACCGGC
CGCGGCGGCCCGGGCTACCAGTTCGGCGACGAGTTCCACCCGGAGCTGCAGTTCGACCGTCCGTTCCTGCTGGCTATGGC
TAACGCTGGCCCCGGCACCAACGGCTCCCAGTTCTTCATCACGGTGACGGCCACCCCGCACCTGAACAACCGCCACACCA
TCTTCGGTGAGGTCACCGACAAGGAGTCCCAGAAGGTCGTCGCGAAGATCTCTCGCGTCGCAACCGACCGCATGGACCGC
CCGAACGACGACGTCGTTATCGAGTCTGTCGAGATCCAGGAGTAA

Upstream 100 bases:

>100_bases
CACCCATCCTAAAGAAAAATCCCCGCCAGGATGGGCAATACAGCTTTTGGGTCGCTAAGGTGCCGGAAGCCGTCGTGGCT
TTTTAGTACAATGGATCACT

Downstream 100 bases:

>100_bases
AAACTCCTTGCCGTGGCTGGACACGCAAGCCCGCCGGAATAGCCGGCGGTATTCCGTCACCAACGTATTCATCGCAGCCT
GCTGCCTTGTGTACGTGGTG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Rotamase A [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTNKTATAILHTNQGDIAIDLFGNHAPETVANFVGLAQGTKEYSQPNASGTNEGPFYDGAIFHRIIDGFMIQGGDPTGTG
RGGPGYQFGDEFHPELQFDRPFLLAMANAGPGTNGSQFFITVTATPHLNNRHTIFGEVTDKESQKVVAKISRVATDRMDR
PNDDVVIESVEIQE

Sequences:

>Translated_174_residues
MTNKTATAILHTNQGDIAIDLFGNHAPETVANFVGLAQGTKEYSQPNASGTNEGPFYDGAIFHRIIDGFMIQGGDPTGTG
RGGPGYQFGDEFHPELQFDRPFLLAMANAGPGTNGSQFFITVTATPHLNNRHTIFGEVTDKESQKVVAKISRVATDRMDR
PNDDVVIESVEIQE
>Mature_173_residues
TNKTATAILHTNQGDIAIDLFGNHAPETVANFVGLAQGTKEYSQPNASGTNEGPFYDGAIFHRIIDGFMIQGGDPTGTGR
GGPGYQFGDEFHPELQFDRPFLLAMANAGPGTNGSQFFITVTATPHLNNRHTIFGEVTDKESQKVVAKISRVATDRMDRP
NDDVVIESVEIQE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=171, Percent_Identity=47.3684210526316, Blast_Score=147, Evalue=3e-36,
Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=48.4472049689441, Blast_Score=140, Evalue=6e-34,
Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=43.1137724550898, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI19557636, Length=171, Percent_Identity=40.3508771929825, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4758950, Length=157, Percent_Identity=43.312101910828, Blast_Score=106, Evalue=8e-24,
Organism=Homo sapiens, GI4505991, Length=151, Percent_Identity=45.6953642384106, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI6631100, Length=157, Percent_Identity=41.4012738853503, Blast_Score=103, Evalue=5e-23,
Organism=Homo sapiens, GI42560244, Length=166, Percent_Identity=39.1566265060241, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI22547212, Length=167, Percent_Identity=40.1197604790419, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI7657473, Length=167, Percent_Identity=40.1197604790419, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI22547215, Length=167, Percent_Identity=40.1197604790419, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI4826932, Length=166, Percent_Identity=41.566265060241, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI10863927, Length=144, Percent_Identity=38.8888888888889, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI256017253, Length=130, Percent_Identity=40, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI221139811, Length=130, Percent_Identity=40, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI256017251, Length=130, Percent_Identity=40, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=39.2638036809816, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI310129267, Length=144, Percent_Identity=36.8055555555556, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI310120620, Length=144, Percent_Identity=36.8055555555556, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI5031987, Length=156, Percent_Identity=36.5384615384615, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI169164185, Length=136, Percent_Identity=39.7058823529412, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI169163623, Length=136, Percent_Identity=39.7058823529412, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI178057341, Length=130, Percent_Identity=39.2307692307692, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI209417936, Length=130, Percent_Identity=39.2307692307692, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI30102944, Length=130, Percent_Identity=39.2307692307692, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI219842199, Length=130, Percent_Identity=39.2307692307692, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI169163387, Length=136, Percent_Identity=39.7058823529412, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI310110104, Length=144, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI303305009, Length=156, Percent_Identity=37.8205128205128, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI20911035, Length=171, Percent_Identity=32.1637426900585, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI310127646, Length=141, Percent_Identity=36.1702127659575, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI310114371, Length=141, Percent_Identity=36.1702127659575, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI310119221, Length=141, Percent_Identity=36.1702127659575, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI150418007, Length=129, Percent_Identity=37.984496124031, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=39.5348837209302, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI5174637, Length=129, Percent_Identity=39.5348837209302, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI239751853, Length=160, Percent_Identity=33.125, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI113428306, Length=160, Percent_Identity=33.125, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI169214050, Length=160, Percent_Identity=33.125, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI310132444, Length=156, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI310113152, Length=156, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI27735045, Length=152, Percent_Identity=34.8684210526316, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI310127745, Length=134, Percent_Identity=35.8208955223881, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310119290, Length=134, Percent_Identity=35.8208955223881, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310114540, Length=134, Percent_Identity=35.8208955223881, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI14277126, Length=177, Percent_Identity=31.0734463276836, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786736, Length=179, Percent_Identity=36.8715083798883, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=49.3827160493827, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17506311, Length=171, Percent_Identity=46.1988304093567, Blast_Score=136, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=43.75, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71997782, Length=140, Percent_Identity=41.4285714285714, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17551284, Length=157, Percent_Identity=43.312101910828, Blast_Score=109, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17551282, Length=157, Percent_Identity=43.312101910828, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71980594, Length=170, Percent_Identity=37.0588235294118, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=45.859872611465, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71980590, Length=158, Percent_Identity=37.9746835443038, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17506307, Length=159, Percent_Identity=44.0251572327044, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17532641, Length=173, Percent_Identity=36.9942196531792, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17565860, Length=156, Percent_Identity=40.3846153846154, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=41.4012738853503, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17566266, Length=141, Percent_Identity=41.8439716312057, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17559074, Length=132, Percent_Identity=42.4242424242424, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=164, Percent_Identity=37.8048780487805, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32563659, Length=171, Percent_Identity=31.5789473684211, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=146, Percent_Identity=38.3561643835616, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323246, Length=166, Percent_Identity=39.7590361445783, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323562, Length=164, Percent_Identity=39.6341463414634, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320510, Length=179, Percent_Identity=39.6648044692737, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=162, Percent_Identity=39.5061728395062, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321848, Length=165, Percent_Identity=40.6060606060606, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322492, Length=186, Percent_Identity=34.4086021505376, Blast_Score=85, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319914, Length=173, Percent_Identity=31.7919075144509, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17986117, Length=168, Percent_Identity=43.452380952381, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI19922912, Length=169, Percent_Identity=45.5621301775148, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=39.1566265060241, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357249, Length=138, Percent_Identity=41.304347826087, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24650807, Length=157, Percent_Identity=43.312101910828, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=45.859872611465, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=37.956204379562, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17136360, Length=177, Percent_Identity=35.0282485875706, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45549139, Length=140, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24586038, Length=167, Percent_Identity=38.9221556886228, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24664125, Length=160, Percent_Identity=38.125, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357783, Length=160, Percent_Identity=38.125, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647301, Length=159, Percent_Identity=35.2201257861635, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355677, Length=179, Percent_Identity=29.0502793296089, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18825; Mature: 18694

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2 ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKTATAILHTNQGDIAIDLFGNHAPETVANFVGLAQGTKEYSQPNASGTNEGPFYDGA
CCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCHH
IFHRIIDGFMIQGGDPTGTGRGGPGYQFGDEFHPELQFDRPFLLAMANAGPGTNGSQFFI
HHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
TVTATPHLNNRHTIFGEVTDKESQKVVAKISRVATDRMDRPNDDVVIESVEIQE
EEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
TNKTATAILHTNQGDIAIDLFGNHAPETVANFVGLAQGTKEYSQPNASGTNEGPFYDGA
CCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCHH
IFHRIIDGFMIQGGDPTGTGRGGPGYQFGDEFHPELQFDRPFLLAMANAGPGTNGSQFFI
HHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
TVTATPHLNNRHTIFGEVTDKESQKVVAKISRVATDRMDRPNDDVVIESVEIQE
EEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]