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The map label for this gene is mutX [H]

Identifier: 66768276

GI number: 66768276

Start: 2359647

End: 2360135

Strand: Direct

Name: mutX [H]

Synonym: XC_1955

Alternate gene names: 66768276

Gene position: 2359647-2360135 (Clockwise)

Preceding gene: 66768275

Following gene: 66768278

Centisome position: 45.83

GC content: 65.03

Gene sequence:

>489_bases
ATGCCGCATACCCCGATTGTCGCCACGCTCGGCTACCTGCTGTCGCCGGATGGCACCCAGGTACTGATGATCCATCGCAA
CGCCCGCCCCGGGGATCATCACCTGGGCAAGTACAACGGGCTCGGCGGCAAACTGGAAGCCGATGAAGATGTGTTGGCCT
GCATGCGCCGCGAAATCCGCGAGGAAGCCGGCGTGGAATGCGGCCAGATGCAGCTGCGCGGCACCATCAGCTGGCCGGGC
TTCGGCAAGCAGGGCGAGGACTGGCTGGGATTCGTGTTCCTGATCCACAGCTTCGACGGCACGCCGCAAACCTCCAACCC
CGAAGGCACCCTGGAATGGGTCCCCATTGCGCAGATGGACCAGGTGCCGATGTGGGAGGGCGACCGCAACTTCCTGCCGC
TGGTGTTCGATGGCGACCCGCGTCCGTTCCATGGCGTGATGCCGTACCGGGACGGGCGCATGCAGTCGTGGTCGTATTCG
CGCGTGTGA

Upstream 100 bases:

>100_bases
GTCGCGCCGCCGCGCGCCAATGCGCAGCCCGCTGTCAGCTGATCGCTGCGCGGCGCGCAGCTTCGGTCATACTGATGTGC
TTCGTGTCTGATCGTTCGCC

Downstream 100 bases:

>100_bases
GGGTTGCGCGCGGTCTGCGGCGCAAGCATGCAATCTCGGTGACTGGGCTTAGCCATCACTGACGGCCGAACTGTGAAGCC
CACCGCACCGGCTTTGCCAA

Product: 7, 8-dihydro-8-oxoguanine-triphosphatase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MPHTPIVATLGYLLSPDGTQVLMIHRNARPGDHHLGKYNGLGGKLEADEDVLACMRREIREEAGVECGQMQLRGTISWPG
FGKQGEDWLGFVFLIHSFDGTPQTSNPEGTLEWVPIAQMDQVPMWEGDRNFLPLVFDGDPRPFHGVMPYRDGRMQSWSYS
RV

Sequences:

>Translated_162_residues
MPHTPIVATLGYLLSPDGTQVLMIHRNARPGDHHLGKYNGLGGKLEADEDVLACMRREIREEAGVECGQMQLRGTISWPG
FGKQGEDWLGFVFLIHSFDGTPQTSNPEGTLEWVPIAQMDQVPMWEGDRNFLPLVFDGDPRPFHGVMPYRDGRMQSWSYS
RV
>Mature_161_residues
PHTPIVATLGYLLSPDGTQVLMIHRNARPGDHHLGKYNGLGGKLEADEDVLACMRREIREEAGVECGQMQLRGTISWPGF
GKQGEDWLGFVFLIHSFDGTPQTSNPEGTLEWVPIAQMDQVPMWEGDRNFLPLVFDGDPRPFHGVMPYRDGRMQSWSYSR
V

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 18254; Mature: 18123

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHTPIVATLGYLLSPDGTQVLMIHRNARPGDHHLGKYNGLGGKLEADEDVLACMRREIR
CCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EEAGVECGQMQLRGTISWPGFGKQGEDWLGFVFLIHSFDGTPQTSNPEGTLEWVPIAQMD
HHHCCCCCEEEEEEEECCCCCCCCCCHHEEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
QVPMWEGDRNFLPLVFDGDPRPFHGVMPYRDGRMQSWSYSRV
CCCCCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PHTPIVATLGYLLSPDGTQVLMIHRNARPGDHHLGKYNGLGGKLEADEDVLACMRREIR
CCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
EEAGVECGQMQLRGTISWPGFGKQGEDWLGFVFLIHSFDGTPQTSNPEGTLEWVPIAQMD
HHHCCCCCEEEEEEEECCCCCCCCCCHHEEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
QVPMWEGDRNFLPLVFDGDPRPFHGVMPYRDGRMQSWSYSRV
CCCCCCCCCCEEEEEECCCCCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]