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The map label for this gene is mntH

Identifier: 66768268

GI number: 66768268

Start: 2351298

End: 2352632

Strand: Reverse

Name: mntH

Synonym: XC_1947

Alternate gene names: 66768268

Gene position: 2352632-2351298 (Counterclockwise)

Preceding gene: 66768272

Following gene: 66768267

Centisome position: 45.69

GC content: 65.39

Gene sequence:

>1335_bases
ATGTCCAGCGAGATCGTCCCGATCGCAGAACCCATTCGCCCAGCCGATGGTGGGCTGGGTGCCGCGCACGCCAGCGTTGC
CGTGCCCAAGGGTGGCCACTGGTGGTTCCGCTTGCTGGCGTTTCTGGGCCCTGGCTACATGGTCTCGGTCGGGTATATGG
ACCCGGGCAACTGGGCCACCGACCTGGCGGGCGGCTCGCAATTCGGTTATCTGCTGCTGTCGGTGATCCTGCTCTCCAAC
CTGATGGCCATCGTGCTGCAGGGGTTGTCGGCACGGCTGGGCATCGCCACCGGCCTGGACCTGGCGCAGGCCTGCCGCGC
ACGTTACCCGCGCGGCATCAACCTGGCGCTGTGGGGGCTGTGCGAGCTGGCCATCATCGCCTGCGATCTGGCCGAAGTGA
TCGGCACGGCGATCGCACTCAAGTTGCTGTTCGGCATTCCGCTGACACTGGGCGCCATCATCACTGCGCTGGACGTGGTG
TTGGTGTTGTTGCTGATGAACCGCGGCTTCCGTGCGCTGGAAGCGTTCGTCATGGCATTGCTGCTGGTGATCTTCGTGTG
CTTCGGCATCCAGATCGCGCTGGCGGCGCCGCCGATCGCCGCAGTGCTGGCCGGCTTCATTCCGCGTGCCGAAGTGGTGA
CCAACCCGCATGCGCTGTATCTGGCGATCGGAATCATCGGTGCCACCGTGATGCCGCATAACCTGTATCTGCACTCGTCG
ATCGTGCAAACGCGCGCATATCCGCGCACCGATGCAGGCCGCCGTTCGGCACTGCGCTGGGCAGTCACCGACAGCACCGT
GGCCTTGATGTTCGCGTTGTTCATCAACGCCGCCATCCTGATCCTGGCGGCGGCGGTGTTCCATGCGCAGGGCCGCACCG
ACGTGCAGGAGATCGAACAGGCGCACGCGCTGCTGGCACCGATGCTCGGCGTCGGCCTGGCCTCGACCCTGTTCGCAGTG
GCGTTGCTCGCCTCGGGCGTCAATTCGACAGTGACCGCAACCTTGGCCGGGCAGATCGTGATGGAAGGCTTCCTGCGCCT
GCGCTTGCCGCCGTGGATGCGCCGCCTGCTCACCCGCGGCATCGCCATCGTGCCGGTAGTGGTGGTGACCTGGCTGTATG
GCGAGGCCGGTACCGCCCGCTTGCTGGTCTTGAGCCAGGTGGTGCTGTCGATGCAGTTGCCGTTCGCGGTGATCCCGTTG
GTGCGCTTTGTCGCTGACCGCGGCTTGATGGGCGCATTGGTGGCGCCGGCATGGCTGGTGCGCCTTGCCTGGGTGATTGC
TCTGGTGATCGTTGGCCTGAACCTCAAGCTGCTTTGGGAATTCGCGTTGGGGTGA

Upstream 100 bases:

>100_bases
AGTGTGAAGCACGGCGCCGATCAATACGATTGAGATTGCCAATGCTCAACAGCATAGCACTTGCTATATCATCGGCCGCG
TCCCGTCTTTTCGCCCGCCC

Downstream 100 bases:

>100_bases
GAGGCAAGCGGGCGGCGGCACTGCGCACGCTTGTGCTTGCACGTGCCGGTCTTGCAGATGGTGCTAAAGGTGCACTGCGC
TGCATTGCACTGCACCGCCC

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSSEIVPIAEPIRPADGGLGAAHASVAVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSN
LMAIVLQGLSARLGIATGLDLAQACRARYPRGINLALWGLCELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITALDVV
LVLLLMNRGFRALEAFVMALLLVIFVCFGIQIALAAPPIAAVLAGFIPRAEVVTNPHALYLAIGIIGATVMPHNLYLHSS
IVQTRAYPRTDAGRRSALRWAVTDSTVALMFALFINAAILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAV
ALLASGVNSTVTATLAGQIVMEGFLRLRLPPWMRRLLTRGIAIVPVVVVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPL
VRFVADRGLMGALVAPAWLVRLAWVIALVIVGLNLKLLWEFALG

Sequences:

>Translated_444_residues
MSSEIVPIAEPIRPADGGLGAAHASVAVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSN
LMAIVLQGLSARLGIATGLDLAQACRARYPRGINLALWGLCELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITALDVV
LVLLLMNRGFRALEAFVMALLLVIFVCFGIQIALAAPPIAAVLAGFIPRAEVVTNPHALYLAIGIIGATVMPHNLYLHSS
IVQTRAYPRTDAGRRSALRWAVTDSTVALMFALFINAAILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAV
ALLASGVNSTVTATLAGQIVMEGFLRLRLPPWMRRLLTRGIAIVPVVVVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPL
VRFVADRGLMGALVAPAWLVRLAWVIALVIVGLNLKLLWEFALG
>Mature_443_residues
SSEIVPIAEPIRPADGGLGAAHASVAVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWATDLAGGSQFGYLLLSVILLSNL
MAIVLQGLSARLGIATGLDLAQACRARYPRGINLALWGLCELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITALDVVL
VLLLMNRGFRALEAFVMALLLVIFVCFGIQIALAAPPIAAVLAGFIPRAEVVTNPHALYLAIGIIGATVMPHNLYLHSSI
VQTRAYPRTDAGRRSALRWAVTDSTVALMFALFINAAILILAAAVFHAQGRTDVQEIEQAHALLAPMLGVGLASTLFAVA
LLASGVNSTVTATLAGQIVMEGFLRLRLPPWMRRLLTRGIAIVPVVVVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLV
RFVADRGLMGALVAPAWLVRLAWVIALVIVGLNLKLLWEFALG

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=405, Percent_Identity=38.7654320987654, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI295293167, Length=449, Percent_Identity=35.8574610244989, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI295293175, Length=449, Percent_Identity=35.8574610244989, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI295293173, Length=449, Percent_Identity=35.8574610244989, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI10835169, Length=449, Percent_Identity=35.8574610244989, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI295293171, Length=449, Percent_Identity=35.8574610244989, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI295293169, Length=449, Percent_Identity=35.8574610244989, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI295293178, Length=452, Percent_Identity=35.6194690265487, Blast_Score=223, Evalue=4e-58,
Organism=Escherichia coli, GI1788736, Length=410, Percent_Identity=40.9756097560976, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI193210616, Length=438, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71999499, Length=445, Percent_Identity=33.4831460674157, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17569473, Length=374, Percent_Identity=35.8288770053476, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71993856, Length=209, Percent_Identity=41.1483253588517, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323062, Length=407, Percent_Identity=42.5061425061425, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6324450, Length=418, Percent_Identity=38.0382775119617, Blast_Score=269, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6321841, Length=405, Percent_Identity=42.4691358024691, Blast_Score=266, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24648607, Length=469, Percent_Identity=33.0490405117271, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI281362176, Length=469, Percent_Identity=33.0490405117271, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24648609, Length=469, Percent_Identity=33.0490405117271, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI45553443, Length=448, Percent_Identity=33.9285714285714, Blast_Score=232, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_XANCP (Q8P8R8)

Other databases:

- EMBL:   AE008922
- RefSeq:   NP_637527.1
- GeneID:   998785
- GenomeReviews:   AE008922_GR
- KEGG:   xcc:XCC2171
- HOGENOM:   HBG312498
- OMA:   KFGYALL
- ProtClustDB:   PRK00701
- BioCyc:   XCAM190485:XCC2171-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 47102; Mature: 46971

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13a187e0)-; HASH(0x1602a580)-; HASH(0x1603569c)-; HASH(0x154c9044)-; HASH(0x16087fd4)-; HASH(0x16027bd4)-; HASH(0x1339c8d4)-; HASH(0x15e713c4)-; HASH(0x15cf58bc)-; HASH(0x15f89590)-; HASH(0x15a33300)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEIVPIAEPIRPADGGLGAAHASVAVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWAT
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHH
DLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRARYPRGINLALWGL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHH
CELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITALDVVLVLLLMNRGFRALEAFVMAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLVIFVCFGIQIALAAPPIAAVLAGFIPRAEVVTNPHALYLAIGIIGATVMPHNLYLHSS
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHH
IVQTRAYPRTDAGRRSALRWAVTDSTVALMFALFINAAILILAAAVFHAQGRTDVQEIEQ
HHHHCCCCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AHALLAPMLGVGLASTLFAVALLASGVNSTVTATLAGQIVMEGFLRLRLPPWMRRLLTRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IAIVPVVVVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVADRGLMGALVAPAWLV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
RLAWVIALVIVGLNLKLLWEFALG
HHHHHHHHHHHCCCHHHHHHHHCH
>Mature Secondary Structure 
SSEIVPIAEPIRPADGGLGAAHASVAVPKGGHWWFRLLAFLGPGYMVSVGYMDPGNWAT
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHH
DLAGGSQFGYLLLSVILLSNLMAIVLQGLSARLGIATGLDLAQACRARYPRGINLALWGL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHH
CELAIIACDLAEVIGTAIALKLLFGIPLTLGAIITALDVVLVLLLMNRGFRALEAFVMAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LLVIFVCFGIQIALAAPPIAAVLAGFIPRAEVVTNPHALYLAIGIIGATVMPHNLYLHSS
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHH
IVQTRAYPRTDAGRRSALRWAVTDSTVALMFALFINAAILILAAAVFHAQGRTDVQEIEQ
HHHHCCCCCCCCCHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AHALLAPMLGVGLASTLFAVALLASGVNSTVTATLAGQIVMEGFLRLRLPPWMRRLLTRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IAIVPVVVVTWLYGEAGTARLLVLSQVVLSMQLPFAVIPLVRFVADRGLMGALVAPAWLV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
RLAWVIALVIVGLNLKLLWEFALG
HHHHHHHHHHHCCCHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217